{"id":"https://openalex.org/W2149489038","doi":"https://doi.org/10.1128/jvi.01134-14","title":"Restriction of HIV-1 by Rhesus TRIM5\u03b1 Is Governed by Alpha Helices in the Linker2 Region","display_name":"Restriction of HIV-1 by Rhesus TRIM5\u03b1 Is Governed by Alpha Helices in the Linker2 Region","publication_year":2014,"publication_date":"2014-05-29","ids":{"openalex":"https://openalex.org/W2149489038","doi":"https://doi.org/10.1128/jvi.01134-14","mag":"2149489038","pmid":"https://pubmed.ncbi.nlm.nih.gov/24872590","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136267"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01134-14","doi":"https://doi.org/10.1128/jvi.01134-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01134-14","pdf_url":"https://jvi.asm.org/content/jvi/88/16/8911.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/88/16/8911.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031699269","display_name":"Jaya Sastri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaya Sastri","raw_affiliation_strings":["Cellular and Molecular Biochemistry Program, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biochemistry Program, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Laura Johnsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Johnsen","raw_affiliation_strings":["Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003533945","display_name":"Nikolai Smolin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolai Smolin","raw_affiliation_strings":["Department of Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045282872","display_name":"Sabrina Imam","orcid":"https://orcid.org/0009-0003-4281-3368","observed_orcids":["https://orcid.org/0009-0003-4281-3368"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabrina Imam","raw_affiliation_strings":["Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Santanu Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santanu Mukherjee","raw_affiliation_strings":["Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008062584","display_name":"Zana Lukic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zana Lukic","raw_affiliation_strings":["Integrative Cell Biology Program, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Cell Biology Program, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019468532","display_name":"Alberto Brandariz-N\u00fa\u00f1ez","orcid":"https://orcid.org/0000-0002-0640-1599","observed_orcids":["https://orcid.org/0000-0002-0640-1599"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alberto Brandariz-Nu\u00f1ez","raw_affiliation_strings":["Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068004698","display_name":"Seth L. Robia","orcid":"https://orcid.org/0000-0002-1193-9510","observed_orcids":["https://orcid.org/0000-0002-1193-9510"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth L. Robia","raw_affiliation_strings":["Department of Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083959244","display_name":"Felipe Diaz\u2010Griffero","orcid":"https://orcid.org/0000-0002-7021-6152","observed_orcids":["https://orcid.org/0000-0002-7021-6152"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felipe Diaz-Griffero","raw_affiliation_strings":["Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043937432","display_name":"Christopher M. Wiethoff","orcid":"https://orcid.org/0000-0001-9102-7492","observed_orcids":["https://orcid.org/0000-0001-9102-7492"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Wiethoff","raw_affiliation_strings":["Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103005037","display_name":"Edward M. Campbell","orcid":"https://orcid.org/0000-0001-5665-9195","observed_orcids":["https://orcid.org/0000-0001-5665-9195"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward M. Campbell","raw_affiliation_strings":["Cellular and Molecular Biochemistry Program, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","Integrative Cell Biology Program, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biochemistry Program, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"Integrative Cell Biology Program, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8919,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73285568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"88","issue":"16","first_page":"8911","last_page":"8923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trim5alpha","display_name":"TRIM5\u03b1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hiv-1-restriction","display_name":"HIV-1 restriction","score":0.9679999947547913},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.9419999718666077},{"id":"https://openalex.org/keywords/alpha-helix","display_name":"alpha-helix","score":0.8799999952316284},{"id":"https://openalex.org/keywords/protein-assembly","display_name":"protein assembly","score":0.6320000290870667},{"id":"https://openalex.org/keywords/coiled-coil-domain","display_name":"coiled-coil domain","score":0.925000011920929},{"id":"https://openalex.org/keywords/antiviral-restriction-factors","display_name":"antiviral restriction factors","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tripartite-motif-proteins","display_name":"tripartite motif proteins","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8638874888420105},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6083818674087524},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5572801828384399},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4253080189228058},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3560328483581543},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.01134-14","doi":"https://doi.org/10.1128/jvi.01134-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01134-14","pdf_url":"https://jvi.asm.org/content/jvi/88/16/8911.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4136267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:24872590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24872590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.01134-14","doi":"https://doi.org/10.1128/jvi.01134-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01134-14","pdf_url":"https://jvi.asm.org/content/jvi/88/16/8911.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1497222943","display_name":"Modulation of retroviral uncoating by cellular factors","funder_award_id":"R01AI087390","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3395336405","display_name":"Structure Changes of Ion-motive ATPases","funder_award_id":"R01HL106189","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3626931960","display_name":"The Cell Biology of TRIM5alpha","funder_award_id":"R01AI093258","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3764877941","display_name":"Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking, and Assembly of HIV (CHEETAH Center)","funder_award_id":"P50GM082545","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5855312072","display_name":"Loyola Research Computing Core","funder_award_id":"G20RR030939","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320313677","display_name":"Arthur J. Schmitt Foundation","ror":"https://ror.org/02vbje032"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149489038.pdf"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1963507800","https://openalex.org/W1965849042","https://openalex.org/W1966078827","https://openalex.org/W1967737979","https://openalex.org/W1974030600","https://openalex.org/W1976499671","https://openalex.org/W1976617857","https://openalex.org/W1978498560","https://openalex.org/W1979762554","https://openalex.org/W1991398215","https://openalex.org/W1991794210","https://openalex.org/W1997318570","https://openalex.org/W2006105386","https://openalex.org/W2008632464","https://openalex.org/W2011068404","https://openalex.org/W2012780464","https://openalex.org/W2023559737","https://openalex.org/W2028811194","https://openalex.org/W2032499969","https://openalex.org/W2033388772","https://openalex.org/W2035266068","https://openalex.org/W2035687084","https://openalex.org/W2041638382","https://openalex.org/W2046700028","https://openalex.org/W2047791613","https://openalex.org/W2050333027","https://openalex.org/W2050400345","https://openalex.org/W2051777873","https://openalex.org/W2067174909","https://openalex.org/W2075431236","https://openalex.org/W2079664946","https://openalex.org/W2081693079","https://openalex.org/W2082314789","https://openalex.org/W2090592602","https://openalex.org/W2097660625","https://openalex.org/W2102679105","https://openalex.org/W2103030200","https://openalex.org/W2106693353","https://openalex.org/W2114859237","https://openalex.org/W2116773729","https://openalex.org/W2125275092","https://openalex.org/W2126098576","https://openalex.org/W2136372912","https://openalex.org/W2138468602","https://openalex.org/W2147703962","https://openalex.org/W2148372587","https://openalex.org/W2150860726","https://openalex.org/W2151766144","https://openalex.org/W2152301430","https://openalex.org/W2152550969","https://openalex.org/W2156829363","https://openalex.org/W2160171025","https://openalex.org/W2160544821","https://openalex.org/W2163135670","https://openalex.org/W2165070219","https://openalex.org/W2168298661","https://openalex.org/W3151837896"],"related_works":["https://openalex.org/W153276394","https://openalex.org/W2547278612","https://openalex.org/W7009461252","https://openalex.org/W2724532922","https://openalex.org/W2148372587","https://openalex.org/W2006105386","https://openalex.org/W2770989565","https://openalex.org/W2349168064","https://openalex.org/W2011068404","https://openalex.org/W1808823753"],"abstract_inverted_index":{"UNLABELLED:":[0],"TRIM5\u03b1":[1,13,61,82,143,187,198,292,359],"proteins":[2,14,199,221,242,261,360],"are":[3],"a":[4,146,350],"potent":[5],"barrier":[6],"to":[7,18,25,86,122,131,157,246,268,317],"the":[8,26,44,51,58,76,84,102,114,118,123,142,153,160,184,194,206,215,244,251,254,257,266,286,303,318,327,339,344,355,369],"cross-species":[9],"transmission":[10],"of":[11,28,46,60,79,117,141,159,169,197,208,214,220,240,290,297,307,329,358,372],"retroviruses.":[12],"exhibit":[15,127],"an":[16,128],"ability":[17,85,130,245],"self-associate":[19],"at":[20],"many":[21],"levels,":[22],"ultimately":[23],"leading":[24],"formation":[27,100,328],"protein":[29,170,248,273],"assemblies":[30,38,48,65,89,134,249],"with":[31,338],"hexagonal":[32],"symmetry":[33],"in":[34,41,49,90,148,250,259,285,343],"vitro":[35],"and":[36,57,92,107,135,167,175,189,191,231,265,295,305,314,364],"cytoplasmic":[37,88,133],"when":[39],"expressed":[40],"cells.":[42],"However,":[43,256],"role":[45],"these":[47,64,178],"restriction,":[50],"determinants":[52,185,258,371],"that":[53,72,97,112,193,226,282,325,326],"mediate":[54],"their":[55],"formation,":[56],"organization":[59],"molecules":[62],"within":[63,75,152],"have":[66,275],"remained":[67],"unclear.":[68],"Here":[69,279],"we":[70,280],"show":[71,281],"\u03b1-helical":[73,115,150],"elements":[74,151],"Linker2":[77,103,119,154,287],"region":[78,104,155,289],"rhesus":[80,291],"macaque":[81],"govern":[83,293],"form":[87,132,247],"cells":[91],"restrict":[93,136],"HIV-1":[94,137,298],"infection.":[95,138,299],"Mutations":[96],"reduce":[98],"\u03b1-helix":[99],"by":[101,335,353],"disrupt":[105,302],"assembly":[106,174,188,264,270,294,304,313,370],"restriction.":[108,176],"More":[109],"importantly,":[110],"mutations":[111,301,311],"enhance":[113,312],"content":[116],"region,":[120],"relative":[121,316],"wild-type":[124,319],"protein,":[125],"also":[126],"increased":[129,203],"Molecular":[139],"modeling":[140],"dimer":[144],"suggests":[145,324],"model":[147],"which":[149,269,354],"dock":[156],"\u03b1-helices":[158],"coiled-coil":[161,340],"domain,":[162],"likely":[163],"establishing":[164],"proper":[165],"orientation":[166],"spacing":[168],"domains":[171],"necessary":[172],"for":[173,263],"Collectively,":[177],"studies":[179,348],"provide":[180,365],"critical":[181],"insight":[182,367],"into":[183,368],"governing":[186],"restriction":[190,224,296,306,315],"demonstrate":[192],"antiviral":[195,356],"potency":[196],"can":[200,361],"be":[201,362],"significantly":[202],"without":[204],"altering":[205],"affinity":[207],"SPRY/capsid":[209],"binding.":[210],"IMPORTANCE:":[211],"Many":[212],"members":[213],"tripartite":[216],"motif":[217],"(TRIM)":[218],"family":[219,374],"act":[222],"as":[223],"factors":[225],"directly":[227],"inhibit":[228],"viral":[229],"infection":[230],"activate":[232],"innate":[233],"immune":[234],"signaling":[235],"pathways.":[236],"Another":[237],"common":[238],"feature":[239],"TRIM":[241,260,272,373],"is":[243,333],"nucleus":[252],"or":[253],"cytoplasm.":[255],"required":[262],"degree":[267],"affects":[271],"function":[274],"been":[276],"poorly":[277],"understood.":[278],"alpha":[283],"helices":[284],"(L2)":[288],"Helix-disrupting":[300],"HIV-1,":[308],"while":[309],"helix-stabilizing":[310],"protein.":[320],"Circular":[321],"dichroism":[322],"analysis":[323],"this":[330],"helical":[331],"structure":[332],"supported":[334],"intermolecular":[336],"interactions":[337],"(CC)":[341],"domain":[342],"CCL2":[345],"dimer.":[346],"These":[347],"reveal":[349],"novel":[351],"mechanism":[352],"activity":[357],"regulated":[363],"detailed":[366],"proteins.":[375]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}