{"id":"https://openalex.org/W214948707","doi":null,"title":"Crypt regeneration in adult human colonic mucosa during prolonged organ culture.","display_name":"Crypt regeneration in adult human colonic mucosa during prolonged organ culture.","publication_year":1982,"publication_date":"1982-05-01","ids":{"openalex":"https://openalex.org/W214948707","mag":"214948707","pmid":"https://pubmed.ncbi.nlm.nih.gov/7107511","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1167886"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:340683","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1167886","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1167886","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"P V Senior","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P V Senior","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046967337","display_name":"C. J. Pritchett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C J Pritchett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108483419","display_name":"J. P. Sunter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Sunter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D R Appleton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Appleton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109316679","display_name":"Watson Aj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Watson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1932,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.89693053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"134","issue":"Pt 3","first_page":"459","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crypt-cell-proliferation","display_name":"crypt cell proliferation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/goblet-cell-differentiation","display_name":"goblet cell differentiation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/columnar-epithelium","display_name":"columnar epithelium","score":0.7279999852180481},{"id":"https://openalex.org/keywords/lamina-propria","display_name":"lamina propria","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mucosal-function","display_name":"mucosal function","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.9147669076919556},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.8512113094329834},{"id":"https://openalex.org/C28483552","wikidata":"https://www.wikidata.org/wiki/Q3634161","display_name":"Organ culture","level":3,"score":0.7467055916786194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5856261253356934},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5334396958351135},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5126701593399048},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.47305789589881897},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.45884832739830017},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4395516514778137},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4310901463031769},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4289969205856323},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.31493258476257324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20378383994102478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15110251307487488},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.13389843702316284},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:europepmc.org:340683","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1167886","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:7107511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7107511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of anatomy","raw_type":"Journal Article"},{"id":"mag:214948707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7107511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:340683","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1167886","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W146066951","https://openalex.org/W150720575","https://openalex.org/W1408833436","https://openalex.org/W1540688794","https://openalex.org/W1556002985","https://openalex.org/W1984979265","https://openalex.org/W1987151798","https://openalex.org/W2003476744","https://openalex.org/W2032496677","https://openalex.org/W2044723240","https://openalex.org/W2059502588","https://openalex.org/W2067284480","https://openalex.org/W2125103854","https://openalex.org/W2132785209","https://openalex.org/W2166093302","https://openalex.org/W2408996459"],"related_works":["https://openalex.org/W2053137162","https://openalex.org/W2319661135","https://openalex.org/W2422102727","https://openalex.org/W1556002985","https://openalex.org/W2034460036","https://openalex.org/W7037787905","https://openalex.org/W2036069305","https://openalex.org/W146066951","https://openalex.org/W1975131597","https://openalex.org/W2063380064"],"abstract_inverted_index":{"Using":[0],"a":[1,86,221],"system":[2,222],"designed":[3],"to":[4,27,129,194,236],"preserve,":[5],"in":[6,22,74,100,226],"vitro,":[7],"both":[8],"the":[9,12,33,40,68,75,88,101,107,119,130,160,173,200,227],"epithelial":[10,110,139],"and":[11,30,123,143,151,166,179,232,239],"connective":[13],"tissue":[14],"elements,":[15],"we":[16],"have":[17,31],"maintained":[18],"adult":[19,214],"colonic":[20,216],"mucosa":[21,217],"organ":[23],"culture":[24,163,212],"for":[25],"up":[26],"336":[28,167],"hours":[29,125],"investigated":[32],"sequential":[34],"morphological":[35],"changes":[36,62],"which":[37],"occur.":[38],"During":[39],"first":[41],"48":[42],"hours,":[43],"normal":[44,156,176],"micro-architecture":[45],"is":[46,50,77,170,183,207,218],"preserved,":[47],"but":[48],"there":[49],"progressive":[51],"loss":[52],"of":[53,98,132,147,154,162,175,180,213,229,233],"cytoplasmic":[54],"mucin":[55],"from":[56,67],"crypt":[57,76,177],"cells.":[58],"Subsequently,":[59],"accelerated":[60],"degenerative":[61],"develop;":[63],"cells":[64,81,99,140,149],"are":[65,82,90],"lost":[66,80],"crypts":[69,89,135],"and,":[70],"because":[71],"cell":[72],"proliferation":[73],"reduced,":[78],"these":[79,190],"not":[83,199],"replaced.":[84],"For":[85],"time,":[87],"represented":[91],"by":[92,137,185],"discrete":[93],"acinar":[94],"formations":[95],"or":[96,198],"clusters":[97],"lamina":[102],"propria,":[103],"apparently":[104],"discontinuous":[105],"with":[106],"intact":[108],"surface":[109],"layer.":[111],"These":[112],"remnants":[113],"manifest":[114],"intense":[115],"proliferative":[116],"activity":[117],"during":[118],"period":[120],"between":[121,141,164],"72":[122],"96":[124],"after":[126],"explantation,":[127],"leading":[128],"restoration":[131],"well":[133],"formed":[134],"lined":[136],"columnar":[138],"120":[142],"144":[144],"hours;":[145],"differentiation":[146,182],"goblet":[148],"ensues":[150],"this":[152],"state":[153],"virtually":[155],"structure":[157,178],"persists":[158],"until":[159],"termination":[161],"186":[165],"hours.":[168],"It":[169],"concluded":[171],"that":[172,209],"determination":[174],"crypt-cell":[181],"governed":[184],"intrinsic":[186],"control":[187],"mechanisms":[188],"although":[189],"may":[191,223],"be":[192,204,224],"subject":[193],"extrinsic":[195],"modulation.":[196],"Whether":[197],"degeneration":[201],"phase":[202],"can":[203],"eliminated,":[205],"it":[206],"clear":[208],"long":[210],"term":[211],"human":[215],"possible.":[219],"Such":[220],"useful":[225],"study":[228],"mucosal":[230,234],"function":[231],"response":[235],"drugs,":[237],"carcinogens":[238],"trophic":[240],"factors.":[241]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
