{"id":"https://openalex.org/W2149478455","doi":"https://doi.org/10.1083/jcb.107.5.1759","title":"Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity.","display_name":"Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity.","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W2149478455","doi":"https://doi.org/10.1083/jcb.107.5.1759","mag":"2149478455","pmid":"https://pubmed.ncbi.nlm.nih.gov/2846586","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115311"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.107.5.1759","doi":"https://doi.org/10.1083/jcb.107.5.1759","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.107.5.1759","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055249819","display_name":"Monique Arpin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Arpin","raw_affiliation_strings":["Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019594272","display_name":"Eric Pringault","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E Pringault","raw_affiliation_strings":["Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090833281","display_name":"Joelle Finidori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J Finidori","raw_affiliation_strings":["Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025362386","display_name":"Alphonse Garc\u0131\u0301a","orcid":"https://orcid.org/0000-0002-6269-8980","observed_orcids":["https://orcid.org/0000-0002-6269-8980"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Garcia","raw_affiliation_strings":["Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001879472","display_name":"Jean\u2010Marc Jeltsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J M Jeltsch","raw_affiliation_strings":["Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108378403","display_name":"Joel S. Vandekerckhove","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J Vandekerckhove","raw_affiliation_strings":["Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011990510","display_name":"Daniel Louvard","orcid":"https://orcid.org/0000-0001-5956-7755","observed_orcids":["https://orcid.org/0000-0001-5956-7755","https://orcid.org/0009-0001-3425-5373"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D Louvard","raw_affiliation_strings":["Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, D\u00e9partement de Biologie Mol\u00e9culaire, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157536573"],"apc_list":null,"apc_paid":null,"fwci":2.5254,"has_fulltext":false,"cited_by_count":127,"citation_normalized_percentile":{"value":0.90630923,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"107","issue":"5","first_page":"1759","last_page":"1766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/villin","display_name":"villin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/actin-binding-proteins","display_name":"actin-binding proteins","score":0.8339999914169312},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.8029999732971191},{"id":"https://openalex.org/keywords/calcium-regulation","display_name":"calcium regulation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/actin-bundling","display_name":"actin bundling","score":0.7239999771118164},{"id":"https://openalex.org/keywords/microvilli","display_name":"microvilli","score":0.8100000023841858},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/kidney-proximal-tubule","display_name":"kidney proximal tubule","score":0.7400000095367432},{"id":"https://openalex.org/keywords/gelsolin","display_name":"gelsolin","score":0.7429999709129333},{"id":"https://openalex.org/keywords/severin","display_name":"Severin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dalteparin","display_name":"dalteparin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.4000000059604645},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2781470882","wikidata":"https://www.wikidata.org/wiki/Q24786102","display_name":"Villin","level":3,"score":0.9904252886772156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7868062257766724},{"id":"https://openalex.org/C80722340","wikidata":"https://www.wikidata.org/wiki/Q18297560","display_name":"Gelsolin","level":3,"score":0.6736742258071899},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.6318489909172058},{"id":"https://openalex.org/C130861313","wikidata":"https://www.wikidata.org/wiki/Q3775363","display_name":"Actin-binding protein","level":5,"score":0.6251657009124756},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5509726405143738},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5407450795173645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4149993360042572},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.38760387897491455},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.34931445121765137},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34196504950523376},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2100028097629547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13846075534820557}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018260","descriptor_name":"Gelsolin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.107.5.1759","doi":"https://doi.org/10.1083/jcb.107.5.1759","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.107.5.1759","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2115311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:2846586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2846586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.7496","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.7496","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/fb/e0/J_Cell_Biol_1988_Nov_1_107(5)_1759-1766.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.334.3089","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.3089","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jcb.rupress.org/content/107/5/1759.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2115311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1493485729","https://openalex.org/W1590345945","https://openalex.org/W1660104588","https://openalex.org/W1728123378","https://openalex.org/W1930601960","https://openalex.org/W1930834491","https://openalex.org/W1963617268","https://openalex.org/W1963675686","https://openalex.org/W1975304761","https://openalex.org/W1981014117","https://openalex.org/W2001139858","https://openalex.org/W2005412295","https://openalex.org/W2005923495","https://openalex.org/W2011836510","https://openalex.org/W2012226455","https://openalex.org/W2014735625","https://openalex.org/W2017615910","https://openalex.org/W2021785626","https://openalex.org/W2022943729","https://openalex.org/W2023151777","https://openalex.org/W2025763720","https://openalex.org/W2027807422","https://openalex.org/W2036178039","https://openalex.org/W2045600432","https://openalex.org/W2060333964","https://openalex.org/W2066160869","https://openalex.org/W2069313761","https://openalex.org/W2073975294","https://openalex.org/W2077430389","https://openalex.org/W2078119356","https://openalex.org/W2090712867","https://openalex.org/W2091239909","https://openalex.org/W2091400786","https://openalex.org/W2135977869","https://openalex.org/W2138270253","https://openalex.org/W2149044554","https://openalex.org/W2153148743","https://openalex.org/W2153816320","https://openalex.org/W2154128645","https://openalex.org/W2172673878","https://openalex.org/W2172852338","https://openalex.org/W2175999997","https://openalex.org/W2267138050","https://openalex.org/W2407298103"],"related_works":["https://openalex.org/W7098332402","https://openalex.org/W2045600432","https://openalex.org/W2197066073","https://openalex.org/W2092302879","https://openalex.org/W2039031678","https://openalex.org/W2132429545","https://openalex.org/W1853751891","https://openalex.org/W1493668668","https://openalex.org/W3033612853","https://openalex.org/W1834472429"],"abstract_inverted_index":{"Villin":[0,41],"is":[1,18,42,55,75,94,109,124,154,157,161],"a":[2,19,43,89,100,105],"calcium-regulated":[3],"actin-binding":[4,175],"protein":[5,17],"that":[6,72,188],"caps,":[7],"severs,":[8],"and":[9,36,52,118,132,142,183],"bundles":[10,25],"actin":[11,24,164],"filaments":[12],"in":[13,50,103,140,200],"vitro.":[14],"This":[15],"92,500-D":[16],"major":[20],"constituent":[21],"of":[22,29,34,47,77,88,181,198],"the":[23,27,30,68,86,137,195],"within":[26],"microvilli":[28],"brush":[31],"border":[32],"surface":[33],"intestinal":[35,59],"kidney":[37],"proximal":[38],"tubule":[39],"cells.":[40],"very":[44],"early":[45],"marker":[46],"cells":[48],"involved":[49],"absorption":[51],"its":[53,174],"expression":[54],"highly":[56,125],"increased":[57],"during":[58],"cell":[60,203],"differentiation.":[61],"The":[62,80,121,150],"amino":[63],"acid":[64],"sequence":[65,70],"deduced":[66],"from":[67],"cDNA":[69],"revealed":[71],"human":[73],"villin":[74,158,199],"composed":[76],"three":[78,112,128],"domains.":[79],"first":[81],"two":[82,145],"domains":[83],"appear":[84],"as":[85],"result":[87],"duplication:":[90],"their":[91],"structural":[92],"organization":[93],"similar.":[95],"We":[96,186],"can":[97],"then":[98],"define":[99],"basic":[101,134,146],"unit":[102],"which":[104,153],"slightly":[106],"hydrophilic":[107],"motif":[108],"followed":[110],"by":[111,179],"hydrophobic":[113],"motifs,":[114],"similar":[115],"between":[116],"themselves":[117],"regularly":[119],"spaced.":[120],"duplicated":[122],"domain":[123,152],"homologous":[126],"to":[127,194],"other":[129],"actin-severing":[130],"proteins":[131,166],"this":[133],"structure":[135],"represents":[136],"whole":[138],"molecule":[139],"severin":[141],"fragmin,":[143],"while":[144],"units":[147],"compose":[148],"gelsolin.":[149],"third":[151],"carboxy":[155],"terminal":[156],"specific:":[159],"it":[160,189],"unique":[162],"among":[163],"modulating":[165],"so":[167],"far":[168],"known.":[169],"It":[170],"could":[171],"account":[172],"for":[173],"properties":[176],"(dual":[177],"regulation":[178],"calcium":[180],"severing":[182],"bundling":[184],"activities).":[185],"propose":[187],"may":[190],"also":[191],"be":[192],"related":[193],"subcellular":[196],"localization":[197],"different":[201],"epithelial":[202],"types.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}