{"id":"https://openalex.org/W2149449116","doi":"https://doi.org/10.1530/eje.0.1410361","title":"RETRACTED: Comparison of finasteride versus flutamide in the treatment of hirsutism","display_name":"RETRACTED: Comparison of finasteride versus flutamide in the treatment of hirsutism","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2149449116","doi":"https://doi.org/10.1530/eje.0.1410361","mag":"2149449116","pmid":"https://pubmed.ncbi.nlm.nih.gov/10526249"},"language":"en","primary_location":{"id":"doi:10.1530/eje.0.1410361","doi":"https://doi.org/10.1530/eje.0.1410361","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1410361","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043502287","display_name":"Leopoldo Falsetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Falsetti","raw_affiliation_strings":["Department of Gynaecological Endocrinology, University of Brescia , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecological Endocrinology, University of Brescia , Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013564524","display_name":"Alessandro Gambera","orcid":"https://orcid.org/0000-0003-2146-2688","observed_orcids":["https://orcid.org/0000-0003-2146-2688"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"A Gambera","raw_affiliation_strings":["Department of Gynaecological Endocrinology, University of Brescia , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecological Endocrinology, University of Brescia , Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014366972","display_name":"Laura Legrenzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Legrenzi","raw_affiliation_strings":["Department of Gynaecological Endocrinology, University of Brescia , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecological Endocrinology, University of Brescia , Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075906027","display_name":"Carmelo Iacobello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Iacobello","raw_affiliation_strings":["3rd Laboratory of Hormonology , Spedali Civili di Brescia , Italy","Department of Gynaecological Endocrinology, University of Brescia , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Laboratory of Hormonology , Spedali Civili di Brescia , Italy","institution_ids":["https://openalex.org/I4210103289"]},{"raw_affiliation_string":"Department of Gynaecological Endocrinology, University of Brescia , Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022911246","display_name":"Giovanna Bugari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Bugari","raw_affiliation_strings":["3rd Laboratory of Hormonology , Spedali Civili di Brescia , Italy","Department of Gynaecological Endocrinology, University of Brescia , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Laboratory of Hormonology , Spedali Civili di Brescia , Italy","institution_ids":["https://openalex.org/I4210103289"]},{"raw_affiliation_string":"Department of Gynaecological Endocrinology, University of Brescia , Italy","institution_ids":["https://openalex.org/I79940851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013564524"],"corresponding_institution_ids":["https://openalex.org/I79940851"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":2.0825,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.85725978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"141","issue":"4","first_page":"361","last_page":"367"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hirsutism","display_name":"hirsutism","score":0.8939999938011169},{"id":"https://openalex.org/keywords/finasteride","display_name":"finasteride","score":0.9660000205039978},{"id":"https://openalex.org/keywords/flutamide","display_name":"flutamide","score":1.0},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/idiopathic-hirsutism","display_name":"idiopathic hirsutism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ferriman-gallwey-score","display_name":"Ferriman-Gallwey score","score":0.902999997138977},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.8220000267028809},{"id":"https://openalex.org/keywords/transaminase-elevation","display_name":"transaminase elevation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/dry-skin","display_name":"dry skin","score":0.652999997138977},{"id":"https://openalex.org/keywords/retraction","display_name":"retraction","score":0.34299999475479126},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.4359999895095825},{"id":"https://openalex.org/keywords/5alpha-reductase","display_name":"5\u03b1-reductase","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2778313021","wikidata":"https://www.wikidata.org/wiki/Q418669","display_name":"Flutamide","level":5,"score":0.9006741046905518},{"id":"https://openalex.org/C2776371013","wikidata":"https://www.wikidata.org/wiki/Q1620594","display_name":"hirsutism","level":5,"score":0.9001375436782837},{"id":"https://openalex.org/C2775874879","wikidata":"https://www.wikidata.org/wiki/Q424167","display_name":"Finasteride","level":4,"score":0.8998048305511475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6524866819381714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5643165707588196},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5431572198867798},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.527431309223175},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.08843973278999329},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.052380651235580444},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.04632875323295593},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.04609003663063049},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.04350218176841736},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005485","descriptor_name":"Flutamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006628","descriptor_name":"Hirsutism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006628","descriptor_name":"Hirsutism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006628","descriptor_name":"Hirsutism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1530/eje.0.1410361","doi":"https://doi.org/10.1530/eje.0.1410361","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1410361","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:10526249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10526249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of endocrinology","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.619.3301","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.619.3301","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.eje-online.org/content/141/4/361.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W13668141","https://openalex.org/W19134920","https://openalex.org/W1487406657","https://openalex.org/W1489546637","https://openalex.org/W1971276002","https://openalex.org/W1979516829","https://openalex.org/W1984126687","https://openalex.org/W1989700537","https://openalex.org/W2006226464","https://openalex.org/W2007166173","https://openalex.org/W2010273632","https://openalex.org/W2020601385","https://openalex.org/W2036318462","https://openalex.org/W2044970382","https://openalex.org/W2047896601","https://openalex.org/W2062059398","https://openalex.org/W2064143069","https://openalex.org/W2071081310","https://openalex.org/W2077706510","https://openalex.org/W2079213361","https://openalex.org/W2084243772","https://openalex.org/W2084563603","https://openalex.org/W2089694050","https://openalex.org/W2093373436","https://openalex.org/W2104443550","https://openalex.org/W2108075479","https://openalex.org/W2167404127","https://openalex.org/W2168771527","https://openalex.org/W2262326805","https://openalex.org/W2337223826","https://openalex.org/W2345268293","https://openalex.org/W2404434717","https://openalex.org/W2471414636"],"related_works":["https://openalex.org/W7101240853","https://openalex.org/W2055440312","https://openalex.org/W2036318462","https://openalex.org/W2409493240","https://openalex.org/W2076885931","https://openalex.org/W2021988193","https://openalex.org/W1979517556","https://openalex.org/W2408419177","https://openalex.org/W2141066302","https://openalex.org/W2262326805"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"compare":[2],"the":[3,10,76,83,110,122,129,136,142,149,168,238,250,281],"effectiveness":[4],"of":[5,12,59,73,82,100,131,260,283],"finasteride":[6,54,114,202,273],"and":[7,21,31,41,79,102,115,125,145,153,160,175,181,189,210,216,225],"flutamide":[8,60,116,251,269,286],"in":[9,14,121,141,148,158,163,173,178,187,192,208,213,223,228,237,249,280],"treatment":[11,282],"hirsutism":[13,123,151,215,284],"patients":[15,34,247],"with":[16,22,39,43,75,80,243,268,272],"polycystic":[17],"ovary":[18],"syndrome":[19],"(PCOS)":[20],"idiopathic":[23,44,150,164,179,193,214,229],"hirsutism.":[24,45,165,194,230],"DESIGN:":[25],"Randomized":[26],"study.":[27],"PATIENTS:":[28],"One":[29],"hundred":[30],"ten":[32],"hirsute":[33],"were":[35,48,96,107,241],"selected:":[36],"64":[37],"women":[38],"PCOS":[40,143,159,174,188,209,224],"46":[42],"METHODS:":[46],"Patients":[47],"assigned":[49],"randomly":[50],"to":[51],"receive":[52],"5mg":[53],"once":[55],"daily":[56],"or":[57,235],"250mg":[58],"twice":[61],"daily,":[62],"for":[63,98],"12":[64,71,132],"consecutive":[65],"months.":[66,133],"Hirsutism":[67],"was":[68],"evaluated":[69],"at":[70,128],"months":[72,259],"therapy,":[74],"Ferriman-Gallwey":[77,137,169],"score":[78,138,170],"measurement":[81],"terminal":[84],"hair":[85,126,154,182],"diameters":[86,127],"(microm)":[87],"taken":[88,97],"from":[89],"four":[90],"different":[91],"body":[92],"areas.":[93],"Blood":[94],"samples":[95],"assessment":[99],"endocrine":[101],"hematochemical":[103,239],"parameters.":[104],"Side":[105],"effects":[106,234],"monitored":[108],"during":[109],"treatment.":[111,261],"RESULTS:":[112],"Both":[113,276],"induced":[117],"a":[118],"significant":[119],"decrease":[120],"scores":[124],"end":[130],"Finasteride":[134],"reduced":[135,167],"by":[139,146,156,161,171,176,184,190,206,211,221,226],"31.4%":[140],"cases":[144],"34.2%":[147],"cases,":[152],"diameter":[155,183],"27.0-34.1%":[157],"29.6-37.9%":[162],"Flutamide":[166,195],"56.7%":[172],"50.9%":[177],"hirsutism,":[180],"50.":[185],"3-60.0%":[186],"47.7-56.5%":[191],"did":[196],"not":[197],"induce":[198],"hormone":[199],"variations,":[200],"while":[201,245],"increased":[203],"testosterone":[204],"levels":[205,256],"40%":[207],"60%":[212],"decreased":[217],"3alpha-androstanediol":[218],"glucuronide":[219],"(3alpha-diolG)":[220],"66.7%":[222],"69.5%":[227],"No":[231],"important":[232],"side":[233],"changes":[236],"parameters":[240],"observed":[242],"finasteride,":[244],"two":[246],"(3.6%)":[248],"group":[252],"expressed":[253],"abnormal":[254],"transaminase":[255],"after":[257],"6":[258],"Dry":[262],"skin":[263],"also":[264],"appeared":[265],"significantly":[266],"more":[267,288],"(67.3%)":[270],"than":[271,290],"(23.6%).":[274],"CONCLUSIONS:":[275],"drugs":[277],"are":[278],"effective":[279,289],"but":[285],"is":[287],"finasteride.":[291]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}