{"id":"https://openalex.org/W2149367169","doi":"https://doi.org/10.1128/iai.67.3.1461-1470.1999","title":"Safety and Immunogenicity of a Pseudomonas aeruginosa Hybrid Outer Membrane Protein F-I Vaccine in Human Volunteers","display_name":"Safety and Immunogenicity of a Pseudomonas aeruginosa Hybrid Outer Membrane Protein F-I Vaccine in Human Volunteers","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W2149367169","doi":"https://doi.org/10.1128/iai.67.3.1461-1470.1999","mag":"2149367169","pmid":"https://pubmed.ncbi.nlm.nih.gov/10024596","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/96482"},"language":"en","primary_location":{"id":"doi:10.1128/iai.67.3.1461-1470.1999","doi":"https://doi.org/10.1128/iai.67.3.1461-1470.1999","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.67.3.1461-1470.1999","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC96482","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062230443","display_name":"Erfan Mansouri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erfan Mansouri","raw_affiliation_strings":["<!--label omitted: 1-->Chirurgische Universita\u0308tsklinik der Universita\u0308t Freiburg, Freiburg,1","Chirurgische Universita\u0308tsklinik der Universita\u0308t Freiburg, Freiburg,1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Chirurgische Universita\u0308tsklinik der Universita\u0308t Freiburg, Freiburg,1","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Chirurgische Universita\u0308tsklinik der Universita\u0308t Freiburg, Freiburg,1","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022695657","display_name":"Josef Gabelsberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Josef Gabelsberger","raw_affiliation_strings":["<!--label omitted: 2-->Institut fu\u0308r Biochemie-Genzentrum-der LMU Mu\u0308nchen, Munich,2 and","Institut fu\u0308r Biochemie-Genzentrum-der LMU Mu\u0308nchen, Munich,2 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Institut fu\u0308r Biochemie-Genzentrum-der LMU Mu\u0308nchen, Munich,2 and","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Institut fu\u0308r Biochemie-Genzentrum-der LMU Mu\u0308nchen, Munich,2 and","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034280556","display_name":"Bernhard Knapp","orcid":"https://orcid.org/0000-0002-5714-7105","observed_orcids":["https://orcid.org/0000-0002-5714-7105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernhard Knapp","raw_affiliation_strings":["<!--label omitted: 3-->Chiron Behring GmbH, Marburg,3 Germany, and","Chiron Behring GmbH, Marburg,3 Germany, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Chiron Behring GmbH, Marburg,3 Germany, and","institution_ids":[]},{"raw_affiliation_string":"Chiron Behring GmbH, Marburg,3 Germany, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033276004","display_name":"Erika Hundt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika Hundt","raw_affiliation_strings":["<!--label omitted: 3-->Chiron Behring GmbH, Marburg,3 Germany, and","Chiron Behring GmbH, Marburg,3 Germany, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Chiron Behring GmbH, Marburg,3 Germany, and","institution_ids":[]},{"raw_affiliation_string":"Chiron Behring GmbH, Marburg,3 Germany, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013405576","display_name":"Uwe Lenz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uwe Lenz","raw_affiliation_strings":["<!--label omitted: 3-->Chiron Behring GmbH, Marburg,3 Germany, and","Chiron Behring GmbH, Marburg,3 Germany, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Chiron Behring GmbH, Marburg,3 Germany, and","institution_ids":[]},{"raw_affiliation_string":"Chiron Behring GmbH, Marburg,3 Germany, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111825126","display_name":"Klaus\u2010Dieter Hungerer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klaus-Dieter Hungerer","raw_affiliation_strings":["<!--label omitted: 3-->Chiron Behring GmbH, Marburg,3 Germany, and","Chiron Behring GmbH, Marburg,3 Germany, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Chiron Behring GmbH, Marburg,3 Germany, and","institution_ids":[]},{"raw_affiliation_string":"Chiron Behring GmbH, Marburg,3 Germany, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051362150","display_name":"H. E. Gilleland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry E. Gilleland","raw_affiliation_strings":["<!--label omitted: 4-->Department of Microbiology and Immunology, School of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana4","Department of Microbiology and Immunology, School of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 4-->Department of Microbiology and Immunology, School of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana4","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana4","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060243676","display_name":"John Staczek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Staczek","raw_affiliation_strings":["<!--label omitted: 4-->Department of Microbiology and Immunology, School of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana4","Department of Microbiology and Immunology, School of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 4-->Department of Microbiology and Immunology, School of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana4","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana4","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105463193","display_name":"Horst Domdey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Horst Domdey","raw_affiliation_strings":["<!--label omitted: 2-->Institut fu\u0308r Biochemie-Genzentrum-der LMU Mu\u0308nchen, Munich,2 and","Institut fu\u0308r Biochemie-Genzentrum-der LMU Mu\u0308nchen, Munich,2 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Institut fu\u0308r Biochemie-Genzentrum-der LMU Mu\u0308nchen, Munich,2 and","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Institut fu\u0308r Biochemie-Genzentrum-der LMU Mu\u0308nchen, Munich,2 and","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113540405","display_name":"Bernd-Ulrich v. Specht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd-Ulrich von Specht","raw_affiliation_strings":["<!--label omitted: 1-->Chirurgische Universita\u0308tsklinik der Universita\u0308t Freiburg, Freiburg,1","Chirurgische Universita\u0308tsklinik der Universita\u0308t Freiburg, Freiburg,1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Chirurgische Universita\u0308tsklinik der Universita\u0308t Freiburg, Freiburg,1","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Chirurgische Universita\u0308tsklinik der Universita\u0308t Freiburg, Freiburg,1","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6267,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.88974113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"67","issue":"3","first_page":"1461","last_page":"1470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oprf","display_name":"OprF","score":0.8040000200271606},{"id":"https://openalex.org/keywords/opri","display_name":"OprI","score":0.9950000047683716},{"id":"https://openalex.org/keywords/outer-membrane-proteins","display_name":"outer membrane proteins","score":0.7400000095367432},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.5370000004768372},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.7480000257492065},{"id":"https://openalex.org/keywords/complement-fixation","display_name":"complement fixation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/opsonization","display_name":"opsonization","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pyrogenicity","display_name":"pyrogenicity","score":0.734000027179718},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.826904296875},{"id":"https://openalex.org/C168507396","wikidata":"https://www.wikidata.org/wiki/Q14859847","display_name":"Antibody opsonization","level":4,"score":0.823219895362854},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7147631645202637},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.691248893737793},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6797807812690735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6502891778945923},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6315514445304871},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.5966358184814453},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.5116980075836182},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.5041102170944214},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4267594516277313},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4046475887298584},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2849351763725281},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22219786047935486},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12358930706977844},{"id":"https://openalex.org/C89372155","wikidata":"https://www.wikidata.org/wiki/Q420107","display_name":"Opsonin","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001428","descriptor_name":"Bacterial Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001428","descriptor_name":"Bacterial Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018272","descriptor_name":"Porins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1128/iai.67.3.1461-1470.1999","doi":"https://doi.org/10.1128/iai.67.3.1461-1470.1999","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.67.3.1461-1470.1999","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:284229","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC96482","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:96482","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/96482","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:10024596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10024596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:freidok.uni-freiburg.de:23274","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/23274","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infection & Immunity. - 67 (1998) , 1461 - 1470","raw_type":"article"},{"id":"pmh:oai:freidok.uni-freiburg.de:23298","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/23298","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infection and Immunity. - 1461-1470 (1999)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:284229","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC96482","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W56589406","https://openalex.org/W196941665","https://openalex.org/W1581563627","https://openalex.org/W1633763584","https://openalex.org/W1827637942","https://openalex.org/W1879483605","https://openalex.org/W1930641702","https://openalex.org/W1975085160","https://openalex.org/W1982819121","https://openalex.org/W2001825263","https://openalex.org/W2003090737","https://openalex.org/W2007418273","https://openalex.org/W2009095370","https://openalex.org/W2012380564","https://openalex.org/W2017463391","https://openalex.org/W2032656639","https://openalex.org/W2033771579","https://openalex.org/W2035336354","https://openalex.org/W2041052430","https://openalex.org/W2041168859","https://openalex.org/W2057004665","https://openalex.org/W2058979147","https://openalex.org/W2062968687","https://openalex.org/W2066432632","https://openalex.org/W2072447332","https://openalex.org/W2075210505","https://openalex.org/W2083233394","https://openalex.org/W2085938957","https://openalex.org/W2096341421","https://openalex.org/W2096374233","https://openalex.org/W2098377739","https://openalex.org/W2100757485","https://openalex.org/W2100798753","https://openalex.org/W2104063363","https://openalex.org/W2112728573","https://openalex.org/W2129577408","https://openalex.org/W2133806838","https://openalex.org/W2137216724","https://openalex.org/W2143760364","https://openalex.org/W2144523774","https://openalex.org/W2150284768","https://openalex.org/W2154068656","https://openalex.org/W2155719288","https://openalex.org/W2163464029","https://openalex.org/W2163758188","https://openalex.org/W2177842082","https://openalex.org/W2306218616","https://openalex.org/W2397278233","https://openalex.org/W2406057374","https://openalex.org/W2419441032","https://openalex.org/W2434802526","https://openalex.org/W2469434249","https://openalex.org/W4210954063","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2137216724","https://openalex.org/W2346007380","https://openalex.org/W2025175579","https://openalex.org/W2052671100","https://openalex.org/W2095123838","https://openalex.org/W1982931134","https://openalex.org/W2150284768","https://openalex.org/W2017474550","https://openalex.org/W2434802526","https://openalex.org/W1976053815"],"abstract_inverted_index":{"A":[0],"hybrid":[1],"protein":[2,10],"[Met-Ala-(His)6OprF190-342-OprI21-83]":[3],"consisting":[4],"of":[5,19,21,44,70,87,138,162,172],"the":[6,81,101,104,108,133,139,157,169],"mature":[7],"outer":[8],"membrane":[9],"I":[11],"(OprI)":[12],"and":[13,29,37,57,94,124,146,155],"amino":[14],"acids":[15],"190":[16],"to":[17,142],"342":[18],"OprF":[20,93,123],"Pseudomonas":[22],"aeruginosa":[23,92,164],"was":[24,96],"expressed":[25],"in":[26,40,98,158,178],"Escherichia":[27],"coli":[28],"purified":[30],"by":[31,151,156],"Ni2+":[32],"chelate-affinity":[33],"chromatography.":[34],"After":[35,80,107],"safety":[36],"pyrogenicity":[38],"evaluations":[39],"animals,":[41],"four":[42],"groups":[43],"eight":[45],"adult":[46],"human":[47],"volunteers":[48,99],"were":[49,77,114],"vaccinated":[50],"intramuscularly":[51],"three":[52],"times":[53],"at":[54],"4-week":[55],"intervals":[56],"revaccinated":[58],"6":[59,130],"months":[60,131],"later":[61],"with":[62],"either":[63],"500,":[64],"100,":[65],"50,":[66],"or":[67,103],"20":[68],"microg":[69],"OprF-OprI":[71,174],"adsorbed":[72],"onto":[73],"A1(OH)3.":[74],"All":[75],"vaccinations":[76],"well":[78],"tolerated.":[79],"first":[82],"vaccination,":[83,110],"a":[84,152],"significant":[85,111],"rise":[86],"antibody":[88,112,120],"titers":[89,113,121],"against":[90,122],"P.":[91,163],"OprI":[95,125],"measured":[97,115,129],"receiving":[100],"100-":[102],"500-microg":[105],"dose.":[106],"second":[109],"for":[116,176],"all":[117],"groups.":[118],"Elevated":[119],"could":[126,148],"still":[127],"be":[128,149],"after":[132],"third":[134],"vaccination.":[135],"The":[136],"capacity":[137],"elicited":[140],"antibodies":[141],"promote":[143],"complement":[144],"binding":[145],"opsonization":[147],"demonstrated":[150],"C1q-binding":[153],"assay":[154],"vitro":[159],"opsonophagocytic":[160],"uptake":[161],"bacteria.":[165],"These":[166],"data":[167],"support":[168],"continued":[170],"development":[171],"an":[173],"vaccine":[175],"use":[177],"humans.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}