{"id":"https://openalex.org/W2149249593","doi":"https://doi.org/10.1161/strokeaha.108.520114","title":"Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury","display_name":"Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury","publication_year":2008,"publication_date":"2008-08-22","ids":{"openalex":"https://openalex.org/W2149249593","doi":"https://doi.org/10.1161/strokeaha.108.520114","mag":"2149249593","pmid":"https://pubmed.ncbi.nlm.nih.gov/18723421","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2726706"},"language":"en","primary_location":{"id":"doi:10.1161/strokeaha.108.520114","doi":"https://doi.org/10.1161/strokeaha.108.520114","is_oa":false,"landing_page_url":"https://doi.org/10.1161/strokeaha.108.520114","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2726706","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039368137","display_name":"Wei Yin","orcid":"https://orcid.org/0000-0002-4834-5783","observed_orcids":["https://orcid.org/0000-0002-4834-5783"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4210133905","display_name":"VA Pittsburgh Healthcare System","ror":"https://ror.org/02qm18h86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4391768195","display_name":"State Key Laboratory of Medical Neurobiology","ror":"https://ror.org/00nn53y54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Wei Yin","raw_affiliation_strings":["From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I24943067","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4391768195"]},{"raw_affiliation_string":"Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","institution_ids":["https://openalex.org/I4210110523","https://openalex.org/I4210133905"]},{"raw_affiliation_string":"the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026160301","display_name":"Armando P. Signore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4210133905","display_name":"VA Pittsburgh Healthcare System","ror":"https://ror.org/02qm18h86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4391768195","display_name":"State Key Laboratory of Medical Neurobiology","ror":"https://ror.org/00nn53y54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Armando P. Signore","raw_affiliation_strings":["From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","Armando P. Signore From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa","the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I24943067","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4391768195"]},{"raw_affiliation_string":"Armando P. Signore From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039087406","display_name":"Masanori Iwai","orcid":"https://orcid.org/0000-0002-9173-0652","observed_orcids":["https://orcid.org/0000-0002-9173-0652"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4210133905","display_name":"VA Pittsburgh Healthcare System","ror":"https://ror.org/02qm18h86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4391768195","display_name":"State Key Laboratory of Medical Neurobiology","ror":"https://ror.org/00nn53y54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Masanori Iwai","raw_affiliation_strings":["From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","Masanori Iwai From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa","the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I24943067","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4391768195"]},{"raw_affiliation_string":"Masanori Iwai From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001933449","display_name":"Guodong Cao","orcid":"https://orcid.org/0000-0003-2854-8951","observed_orcids":["https://orcid.org/0000-0003-2854-8951"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4210133905","display_name":"VA Pittsburgh Healthcare System","ror":"https://ror.org/02qm18h86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4391768195","display_name":"State Key Laboratory of Medical Neurobiology","ror":"https://ror.org/00nn53y54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Guodong Cao","raw_affiliation_strings":["From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","Guodong Cao From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa","the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I24943067","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4391768195"]},{"raw_affiliation_string":"Guodong Cao From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035723149","display_name":"Yanqin Gao","orcid":"https://orcid.org/0000-0002-4915-9819","observed_orcids":["https://orcid.org/0000-0002-4915-9819"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4210133905","display_name":"VA Pittsburgh Healthcare System","ror":"https://ror.org/02qm18h86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4391768195","display_name":"State Key Laboratory of Medical Neurobiology","ror":"https://ror.org/00nn53y54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yanqin Gao","raw_affiliation_strings":["From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","Yanqin Gao From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa","the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I24943067","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4391768195"]},{"raw_affiliation_string":"Yanqin Gao From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100450216","display_name":"Jun Chen","orcid":"https://orcid.org/0000-0002-8077-3403","observed_orcids":["https://orcid.org/0000-0002-8077-3403"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4210133905","display_name":"VA Pittsburgh Healthcare System","ror":"https://ror.org/02qm18h86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4391768195","display_name":"State Key Laboratory of Medical Neurobiology","ror":"https://ror.org/00nn53y54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jun Chen","raw_affiliation_strings":["From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","Jun Chen From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa","the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa; the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China; and Geriatric Research, Educational and Clinical Center (A.P.S., G.C., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I24943067","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4391768195"]},{"raw_affiliation_string":"Jun Chen From the Department of Neurology (W.Y., A.P.S., M.I., G.C., J.C.), University of Pittsburgh School of Medicine, Pa","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (G.C., Y.G., J.C.), Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.48,"has_fulltext":false,"cited_by_count":231,"citation_normalized_percentile":{"value":0.96236285,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"39","issue":"11","first_page":"3057","last_page":"3063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.39820000529289246,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hypoxic-ischemic-brain-injury","display_name":"hypoxic-ischemic brain injury","score":0.9589999914169312},{"id":"https://openalex.org/keywords/neonatal-brain-injury","display_name":"neonatal brain injury","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.6980000138282776},{"id":"https://openalex.org/keywords/pgc-1","display_name":"PGC-1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/nrf1","display_name":"NRF1","score":0.972000002861023},{"id":"https://openalex.org/keywords/tfam","display_name":"TFAM","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hsp60","display_name":"HSP60","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cox-iv","display_name":"cytochrome c oxidase subunit IV","score":0.9879999756813049},{"id":"https://openalex.org/keywords/citrate-synthase","display_name":"citrate synthase","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neuronal-mitochondria","display_name":"neuronal mitochondria","score":0.6000000238418579},{"id":"https://openalex.org/keywords/carotid-artery-ligation","display_name":"carotid artery ligation","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9177067279815674},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.550043523311615},{"id":"https://openalex.org/C2993714741","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemic injury","level":3,"score":0.4700701832771301},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.44161516427993774},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42052313685417175},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3906360864639282},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2887049913406372},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13779965043067932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002950","descriptor_name":"Citrate (si)-Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002950","descriptor_name":"Citrate (si)-Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018834","descriptor_name":"Chaperonin 60","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018834","descriptor_name":"Chaperonin 60","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1161/strokeaha.108.520114","doi":"https://doi.org/10.1161/strokeaha.108.520114","is_oa":false,"landing_page_url":"https://doi.org/10.1161/strokeaha.108.520114","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:18723421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18723421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2726706","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2726706","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stroke","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.489.2005","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.489.2005","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://stroke.ahajournals.org/content/39/11/3057.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.966.6076","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.966.6076","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://stroke.ahajournals.org/content/early/2008/08/21/STROKEAHA.108.520114.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2726706","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2726706","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stroke","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4775516931","display_name":"Neuroprotective effect of HSP27 in Cerebral Ischemia","funder_award_id":"R01NS056118","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5024739938","display_name":"Apoptosis Execution Pathways in Dopaminergic Cell Death","funder_award_id":"R01NS044178","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5274089583","display_name":"Neuroprotection in Models of Cerebral Ischemia","funder_award_id":"R01NS045048","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5553996682","display_name":"Programmed Cell Death Induced by Cerebral Ischemia","funder_award_id":"R01NS043802","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6147453513","display_name":"Inducible DNA repair in cerebral ischemia","funder_award_id":"R01NS036736","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1486163523","https://openalex.org/W1968192113","https://openalex.org/W2001709662","https://openalex.org/W2005085169","https://openalex.org/W2018427433","https://openalex.org/W2022089683","https://openalex.org/W2024267786","https://openalex.org/W2027936807","https://openalex.org/W2036851802","https://openalex.org/W2041013167","https://openalex.org/W2043217844","https://openalex.org/W2049395132","https://openalex.org/W2066742589","https://openalex.org/W2088467602","https://openalex.org/W2090466426","https://openalex.org/W2092706071","https://openalex.org/W2096361448","https://openalex.org/W2096754987","https://openalex.org/W2098902167","https://openalex.org/W2099547258","https://openalex.org/W2107324877","https://openalex.org/W2116642215","https://openalex.org/W2118029488","https://openalex.org/W2121456628","https://openalex.org/W2127876602","https://openalex.org/W2128919887","https://openalex.org/W2133119989","https://openalex.org/W2136967026","https://openalex.org/W2159355518","https://openalex.org/W2163815564","https://openalex.org/W4231277199"],"related_works":["https://openalex.org/W7097588544","https://openalex.org/W3172386163","https://openalex.org/W2046770749","https://openalex.org/W3010562153","https://openalex.org/W2778314770","https://openalex.org/W2735196544","https://openalex.org/W2041013167","https://openalex.org/W4412862158","https://openalex.org/W1990764872","https://openalex.org/W7162208401"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Mitochondrial":[3],"biogenesis":[4,69],"is":[5,53],"regulated":[6,30],"through":[7],"the":[8,20,63,137,187,209,252,257],"coordinated":[9],"actions":[10],"of":[11,74,99,104,132,140,219,251,256],"both":[12],"nuclear":[13,148],"and":[14,38,123,152,163,176,195,198,200,221],"mitochondrial":[15,68,106,141,153,193,243],"genomes":[16],"to":[17,87,178,181,226],"ensure":[18],"that":[19],"organelles":[21],"are":[22],"replenished":[23],"on":[24],"a":[25,71,248],"regular":[26],"basis.":[27],"This":[28],"highly":[29],"process":[31],"has":[32],"been":[33],"well":[34,55],"defined":[35],"in":[36,44,70,190,206,208],"skeletal":[37],"heart":[39],"muscle,":[40],"but":[41],"its":[42],"role":[43],"neuronal":[45],"cells,":[46],"particularly":[47],"when":[48],"under":[49],"stress":[50],"or":[51],"injury,":[52],"not":[54,234],"understood.":[56],"In":[57],"this":[58],"study,":[59],"we":[60],"report":[61],"for":[62,136],"first":[64],"time":[65,118],"rapidly":[66,241],"increased":[67,171,205,224],"rat":[72],"model":[73],"neonatal":[75],"hypoxic/ischemic":[76],"brain":[77,105,239],"injury":[78,240],"(H-I).":[79],"METHODS:":[80],"Postnatal":[81],"day":[82],"7":[83],"rats":[84],"were":[85,126,158,204,223],"subjected":[86],"H-I":[88,238],"induced":[89],"by":[90,96,128,160],"unilateral":[91],"carotid":[92],"artery":[93],"ligation":[94],"followed":[95],"2.5":[97],"hours":[98,173,183,228],"hypoxia.":[100],"The":[101],"relative":[102],"amount":[103],"DNA":[107],"(mtDNA)":[108],"was":[109,169,233],"measured":[110],"semiquantitatively":[111],"using":[112],"long":[113],"fragment":[114],"PCR":[115],"at":[116],"various":[117],"points":[119],"after":[120,174,184,214,229],"H-I.":[121,185,215],"HSP60":[122,197],"COXIV":[124],"proteins":[125,196],"detected":[127],"Western":[129,161],"blot.":[130],"Expression":[131],"three":[133],"genes":[134],"critical":[135],"transcriptional":[138],"regulation":[139],"biogenesis,":[142,244],"peroxisome":[143],"proliferator-activated":[144],"receptor":[145],"coactivator-1":[146],"(PGC-1),":[147],"respiratory":[149],"factor-1":[150],"(NRF-1),":[151],"transcription":[154],"factor":[155],"A":[156],"(TFAM),":[157],"examined":[159],"blot":[162],"RT-PCR.":[164],"RESULTS:":[165],"Brain":[166],"mtDNA":[167,191],"content":[168],"markedly":[170],"6":[172,225],"H-I,":[175,230],"continued":[177],"increase":[179],"up":[180],"24":[182,227],"Paralleling":[186],"temporal":[188],"change":[189],"content,":[192],"number":[194],"COXIV,":[199],"citrate":[201],"synthase":[202],"activity":[203],"neurons":[207],"cortical":[210,217],"infarct":[211],"border":[212],"zone":[213],"Moreover,":[216],"expression":[218],"NRF-1":[220],"TFAM":[222],"whereas":[231],"PGC-1":[232],"changed.":[235],"CONCLUSIONS:":[236],"Neonatal":[237],"induces":[242],"which":[245],"may":[246],"constitute":[247],"novel":[249],"component":[250],"endogenous":[253],"repair":[254],"mechanisms":[255],"brain.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
