{"id":"https://openalex.org/W2149179230","doi":null,"title":"Lipid differences in rod outer segment membranes of rats with P23H and S334ter opsin mutations.","display_name":"Lipid differences in rod outer segment membranes of rats with P23H and S334ter opsin mutations.","publication_year":2005,"publication_date":"2005-05-12","ids":{"openalex":"https://openalex.org/W2149179230","mag":"2149179230","pmid":"https://pubmed.ncbi.nlm.nih.gov/15928607"},"language":"en","primary_location":{"id":"pmid:15928607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15928607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104440272","display_name":"Rex E. Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126000","display_name":"Dean McGee Eye Institute","ror":"https://ror.org/036kn0x67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126000"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rex E Martin","raw_affiliation_strings":["Department of Cell Biology, Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA","institution_ids":["https://openalex.org/I4210126000","https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063284895","display_name":"Steven J. Fliesler","orcid":"https://orcid.org/0000-0002-2557-142X","observed_orcids":["https://orcid.org/0000-0002-2557-142X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven J Fliesler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059891728","display_name":"Richard S. Brush","orcid":"https://orcid.org/0000-0002-8527-5315","observed_orcids":["https://orcid.org/0000-0002-8527-5315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard S Brush","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Michael J Richards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J Richards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061884037","display_name":"Stephen A Hopkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen A Hopkins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004338167","display_name":"Robert E. Anderson","orcid":"https://orcid.org/0000-0001-5664-6968","observed_orcids":["https://orcid.org/0000-0001-5664-6968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert E Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3055,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.6227634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"11","issue":null,"first_page":"338","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rod-outer-segment-membranes","display_name":"rod outer segment membranes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":0.8840000033378601},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.8859999775886536},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9070000052452087},{"id":"https://openalex.org/keywords/omega-6-fatty-acids","display_name":"omega-6 fatty acids","score":0.9179999828338623},{"id":"https://openalex.org/keywords/dietary-fatty-acid-supplementation","display_name":"dietary fatty acid supplementation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/linseed-oil","display_name":"linseed oil","score":0.8230000138282776},{"id":"https://openalex.org/keywords/safflower-oil","display_name":"safflower oil","score":0.9850000143051147},{"id":"https://openalex.org/keywords/phospholipid-fatty-acid-composition","display_name":"phospholipid fatty acid composition","score":0.8320000171661377},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.8930000066757202},{"id":"https://openalex.org/keywords/phosphatidylethanolamine","display_name":"phosphatidylethanolamine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/phosphatidylserine","display_name":"phosphatidylserine","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.7019621133804321},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.6041266322135925},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.5750264525413513},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.5673980712890625},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5473567843437195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49847412109375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4400598704814911},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43100759387016296},{"id":"https://openalex.org/C2781170229","wikidata":"https://www.wikidata.org/wiki/Q426095","display_name":"Phosphatidylethanolamine","level":5,"score":0.43009406328201294},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4186992347240448},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3368357717990875},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1058579683303833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008043","descriptor_name":"Linseed Oil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012450","descriptor_name":"Safflower Oil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017299","descriptor_name":"Rod Opsins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017299","descriptor_name":"Rod Opsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15928607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15928607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:2149179230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15928607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1854954188","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY012190","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3948148410","display_name":"Mentoring Vision Research In Oklahoma","funder_award_id":"P20RR017703","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5464804163","display_name":"ISOPRENOID METABOLISM IN THE RETINA","funder_award_id":"R01EY007361","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5509712900","display_name":"Second Messengers in the Retina","funder_award_id":"R01EY000871","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G781448320","display_name":"Lipid Metabolism in the Retina","funder_award_id":"R01EY004149","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W9706752","https://openalex.org/W10755661","https://openalex.org/W11460051","https://openalex.org/W78454140","https://openalex.org/W139562477","https://openalex.org/W180765966","https://openalex.org/W1482319154","https://openalex.org/W1488129830","https://openalex.org/W1516102547","https://openalex.org/W1520551789","https://openalex.org/W1523492509","https://openalex.org/W1543989159","https://openalex.org/W1568101544","https://openalex.org/W1586173198","https://openalex.org/W1739691545","https://openalex.org/W1937890466","https://openalex.org/W1965592788","https://openalex.org/W1968877752","https://openalex.org/W1970384111","https://openalex.org/W1977085484","https://openalex.org/W1978126359","https://openalex.org/W1981636985","https://openalex.org/W1985235161","https://openalex.org/W1985248851","https://openalex.org/W1993813725","https://openalex.org/W1997082516","https://openalex.org/W2007753996","https://openalex.org/W2009982210","https://openalex.org/W2010358621","https://openalex.org/W2011660780","https://openalex.org/W2013238661","https://openalex.org/W2019362915","https://openalex.org/W2024160751","https://openalex.org/W2036362519","https://openalex.org/W2038635553","https://openalex.org/W2046565250","https://openalex.org/W2052471298","https://openalex.org/W2053102875","https://openalex.org/W2057314625","https://openalex.org/W2062641080","https://openalex.org/W2063383052","https://openalex.org/W2067472329","https://openalex.org/W2087421641","https://openalex.org/W2095411350","https://openalex.org/W2099310340","https://openalex.org/W2100726346","https://openalex.org/W2114305841","https://openalex.org/W2114859465","https://openalex.org/W2144964513","https://openalex.org/W2152145980","https://openalex.org/W2152311269","https://openalex.org/W2160830583","https://openalex.org/W2164949873","https://openalex.org/W2183693608","https://openalex.org/W2283906695","https://openalex.org/W2412588346"],"related_works":["https://openalex.org/W2412588346","https://openalex.org/W10755661","https://openalex.org/W2060116791","https://openalex.org/W139562477","https://openalex.org/W1964087948","https://openalex.org/W1968877752","https://openalex.org/W2069460352","https://openalex.org/W2121883986","https://openalex.org/W1978126359","https://openalex.org/W2015812139"],"abstract_inverted_index":{"PURPOSE:":[0],"Retinal":[1],"degenerations":[2,357],"and":[3,19,21,27,33,38,49,71,74,107,126,135,145,161,170,177,208,224,236,265,269,325,334,358,376],"diets":[4,59,103,113],"low":[5],"in":[6,17,25,56,61,148,212,259,263,276,329,348,367,390],"n-3":[7,62,88],"fatty":[8,50,66,89,101,131,137,182],"acids":[9],"are":[10],"associated":[11],"with":[12,22,36,190],"decreased":[13],"docosahexaenoic":[14],"acid":[15,51,132,138,183],"(22:6n-3)":[16],"retina":[18,26],"plasma":[20],"sterol":[23],"abnormalities":[24],"sperm.":[28],"Using":[29],"wild":[30],"type":[31],"(WT)":[32],"transgenic":[34,76,287,307],"rats":[35,78,163,230,288,308],"P23H":[37,73,268,333],"S334ter":[39,75,270,335],"opsin":[40],"mutations,":[41],"we":[42],"evaluated":[43],"retinal":[44,297,356,394],"cholesterol":[45,47,134,168,290,298,304,395,411],"levels,":[46],"synthesis,":[48],"compositions":[52,139],"of":[53,129,140,154,187,205,218,226,234,239,251,267,282,286,306,314,320,332,346,382,385,400,410],"phospholipid":[54,374],"classes":[55],"animals":[57],"fed":[58,80,164,229,243,246,255],"enriched":[60],"or":[63,91,388,406],"n-6":[64,100],"polyunsaturated":[65],"acids.":[67],"METHODS:":[68],"Pregnant":[69],"WT":[70,160,294,315,338],"heterozygous":[72],"(TG)":[77],"were":[79,109,121,150,156,175,195,210,261,280,289,309,327],"safflower":[81],"(safflower":[82],"oil":[83,93,95],"[SO],":[84],"high":[85,97],"n-6,":[86],"trace":[87],"acids)":[90,102],"flaxseed":[92],"(flaxseed":[94],"[FO],":[96],"n-3,":[98],"moderate":[99],"beginning":[104],"at":[105],"E15,":[106],"pups":[108],"continued":[110],"on":[111],"the":[112,127,136,391,413],"after":[114],"weaning.":[115],"Rod":[116],"outer":[117],"segment":[118],"(ROS)":[119],"membranes":[120,285,331],"prepared":[122],"from":[123,312,412],"55-day-old":[124],"rats,":[125],"ratios":[128],"total":[130,180],"to":[133,158,179,197,293,337,342,355,372],"phosphatidylcholine":[141],"(PC),":[142],"phosphatidylethanolamine":[143],"(PE),":[144],"phosphatidylserine":[146],"(PS)":[147],"ROS":[149,181,227,284,330],"determined.":[151],"Intravitreal":[152],"injections":[153],"[3H]acetate":[155],"given":[157],"35-day-old":[159],"TG":[162],"standard":[165],"chow-diets.":[166],"Endogenous":[167,318],"mass":[169],"de":[171],"novo":[172],"[3H]cholesterol":[173],"synthesis":[174,299],"measured":[176],"normalized":[178],"content.":[184],"Multivariate":[185],"analysis":[186],"variance":[188],"(ANOVA)":[189],"post":[191],"hoc":[192],"Newman-Keuls":[193],"tests":[194],"used":[196],"determine":[198],"statistical":[199],"differences.":[200],"RESULTS:":[201],"The":[202,363],"relative":[203,292,383],"levels":[204,233,238,250,305,319],"PC,":[206,222,386],"PE,":[207],"PS":[209,266],"similar":[211],"all":[213],"three":[214],"rat":[215,349],"strains":[216],"independent":[217,281],"diet.":[219,283],"Total":[220],"lipids,":[221],"PS,":[223,387],"PE":[225,389],"FO":[228],"had":[231,248],"higher":[232,249],"22:6n-3":[235,326,347,368],"lower":[237],"22:5n-6":[240,252],"than":[241,253],"those":[242,254,313],"SO.":[244],"Rats":[245],"SO":[247],"FO.":[256],"Significant":[257],"increases":[258],"18:1n-9":[260],"seen":[262],"PC":[264],"rats;":[271],"arachidonate":[272],"(20:4n-6)":[273],"increased":[274,403,408],"only":[275],"PE.":[277],"These":[278],"changes":[279],"enriched,":[291],"ROS,":[295,350],"yet":[296],"was":[300,369,377],"not":[301,310,370,378],"altered.":[302],"Plasma":[303],"different":[311],"rats.":[316,339],"CONCLUSIONS:":[317],"cholesterol,":[321],"18:1n-9,":[322],"20:4n-6,":[323],"22:5n-6,":[324],"altered":[328],"compared":[336],"There":[340],"appear":[341],"be":[343,397],"two":[344],"pools":[345],"one":[351,359],"that":[352,360],"is":[353,361],"sensitive":[354],"not.":[362],"stress":[364],"induced":[365],"reduction":[366],"specific":[371],"any":[373],"class":[375],"caused":[379],"by":[380],"alteration":[381],"amounts":[384],"membrane.":[392],"Elevated":[393],"may":[396],"a":[398],"result":[399],"either":[401],"an":[402,407],"half":[404],"life":[405],"uptake":[409],"blood.":[414]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}