{"id":"https://openalex.org/W2149166386","doi":null,"title":"Successful ageing of nonagenarians is related to the sensitivity of NK cells to activation.","display_name":"Successful ageing of nonagenarians is related to the sensitivity of NK cells to activation.","publication_year":2008,"publication_date":"2008-12-01","ids":{"openalex":"https://openalex.org/W2149166386","mag":"2149166386","pmid":"https://pubmed.ncbi.nlm.nih.gov/19261980"},"language":"en","primary_location":{"id":"pmid:19261980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19261980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059269082","display_name":"Lucyna Kaszubowska","orcid":"https://orcid.org/0000-0002-8862-0954","observed_orcids":["https://orcid.org/0000-0002-8862-0954"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"L Kaszubowska","raw_affiliation_strings":["Department of Histology, Medical University of Gdansk, Gdansk, Poland. lkras@amg.gda.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, Medical University of Gdansk, Gdansk, Poland. lkras@amg.gda.pl","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082538126","display_name":"Agnieszka Dettlaff\u2010Pokora","orcid":"https://orcid.org/0000-0002-9308-5570","observed_orcids":["https://orcid.org/0000-0002-9308-5570"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Dettlaff-Pokora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109926334","display_name":"\u0141ukasz Hak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Hak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080803006","display_name":"Magdalena Szary\u0144ska","orcid":"https://orcid.org/0000-0002-9976-5833","observed_orcids":["https://orcid.org/0000-0002-9976-5833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Szarynska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Ryba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ryba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018401650","display_name":"Jolanta M. My\u015bliwska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Mysliwska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026614605","display_name":"Andrzej My\u015bliwski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Mysliwski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4017,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.60565977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"59 Suppl 9","issue":null,"first_page":"187","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/successful-aging","display_name":"successful aging","score":0.9399999976158142},{"id":"https://openalex.org/keywords/nonagenarians","display_name":"nonagenarians","score":0.9390000104904175},{"id":"https://openalex.org/keywords/oldest-old","display_name":"oldest old","score":0.515999972820282},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.8379999995231628},{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.6880000233650208},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.9075361490249634},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7522244453430176},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.694283664226532},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6779616475105286},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49103808403015137},{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.4756823778152466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45634540915489197},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.4476654529571533},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.41313862800598145},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.41107693314552307},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33362025022506714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32135123014450073},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2784010171890259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23813971877098083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12416189908981323},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12340906262397766},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10772353410720825}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19261980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19261980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:2149166386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19261980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W51762177","https://openalex.org/W900224136","https://openalex.org/W1522816379","https://openalex.org/W1524541446","https://openalex.org/W1538972034","https://openalex.org/W1562148296","https://openalex.org/W1586529568","https://openalex.org/W1830007925","https://openalex.org/W1969814796","https://openalex.org/W1977152010","https://openalex.org/W1981219082","https://openalex.org/W1986506996","https://openalex.org/W2000971601","https://openalex.org/W2002313780","https://openalex.org/W2011648441","https://openalex.org/W2012968343","https://openalex.org/W2015767891","https://openalex.org/W2017722202","https://openalex.org/W2019364329","https://openalex.org/W2034855558","https://openalex.org/W2044823601","https://openalex.org/W2053706133","https://openalex.org/W2062395030","https://openalex.org/W2067809407","https://openalex.org/W2077061617","https://openalex.org/W2077977710","https://openalex.org/W2082672875","https://openalex.org/W2086973683","https://openalex.org/W2095057453","https://openalex.org/W2096963943","https://openalex.org/W2107416858","https://openalex.org/W2113300169","https://openalex.org/W2119025201","https://openalex.org/W2137374430","https://openalex.org/W2146958257","https://openalex.org/W2410731586","https://openalex.org/W2417326987","https://openalex.org/W2474208914","https://openalex.org/W2992503005"],"related_works":["https://openalex.org/W2167371779","https://openalex.org/W1544840263","https://openalex.org/W2053706133","https://openalex.org/W2019364329","https://openalex.org/W2035706761","https://openalex.org/W2059703800","https://openalex.org/W2095057453","https://openalex.org/W1562148296","https://openalex.org/W2074551498","https://openalex.org/W1538972034"],"abstract_inverted_index":{"NK":[0,26,58,102,105,121,145,168],"cells":[1,29,59,103,122,146,169],"are":[2],"a":[3,23,48],"component":[4],"of":[5,17,25,51,64,69,101,123,139,147,159,167],"innate":[6],"immunity":[7],"which":[8],"activity":[9,77],"significantly":[10,135],"correlates":[11],"with":[12,143],"health":[13],"status.":[14],"The":[15,83,157],"aim":[16],"our":[18,160],"study":[19,161],"was":[20],"to":[21,47,128,134,173,185],"estimate":[22],"status":[24,166],"(natural":[27],"killer)":[28],"in":[30,78,98],"the":[31,87,94,99,111,115,124,129,148,164],"very":[32,125,179],"old":[33,39,130,149],"(mean":[34,41,54],"age":[35,42,55,96,181],"92+/-2":[36],"ys)":[37,44],"and":[38,75,80,104,114,150,170,182,187],"subjects":[40],"78+/-5":[43],"as":[45],"compared":[46],"control":[49],"group":[50],"young":[52],"individuals":[53],"25+/-4":[56],"ys).":[57],"were":[60,132],"characterized":[61],"by":[62],"measurement":[63],"their":[65,171],"cytotoxic":[66,106],"activity,":[67,107],"expression":[68],"intracellular":[70,137],"interferon":[71],"gamma,":[72],"telomere":[73],"length":[74],"telomerase":[76,117,155],"resting":[79],"activated":[81,120,142],"cells.":[82],"results":[84,158],"revealed":[85],"that":[86,163],"oldest":[88,151],"seniors":[89,152],"did":[90],"not":[91],"differ":[92],"from":[93],"other":[95],"groups":[97],"number":[100],"however,":[108],"they":[109],"displayed":[110],"shortest":[112],"telomeres":[113],"lowest":[116],"activity.":[118,156],"Surprisingly,":[119],"old,":[126],"similarly":[127],"subjects,":[131],"able":[133],"increase":[136],"level":[138],"IFNgamma.":[140],"Moreover,":[141],"IL-2":[144],"showed":[153],"increased":[154],"suggest":[162],"functional":[165],"sensitivity":[172],"activation":[174],"is":[175],"well":[176],"preserved":[177],"until":[178],"advanced":[180],"may":[183],"contribute":[184],"longevity":[186],"successful":[188],"ageing.":[189]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}