{"id":"https://openalex.org/W2149134901","doi":"https://doi.org/10.7326/0003-4819-146-9-200705010-00009","title":"Systematic Review: Agranulocytosis Induced by Nonchemotherapy Drugs","display_name":"Systematic Review: Agranulocytosis Induced by Nonchemotherapy Drugs","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2149134901","doi":"https://doi.org/10.7326/0003-4819-146-9-200705010-00009","mag":"2149134901","pmid":"https://pubmed.ncbi.nlm.nih.gov/17470834"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-146-9-200705010-00009","doi":"https://doi.org/10.7326/0003-4819-146-9-200705010-00009","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-146-9-200705010-00009","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053228230","display_name":"Frank Andersohn","orcid":"https://orcid.org/0000-0003-3514-9238","observed_orcids":["https://orcid.org/0000-0003-3514-9238"]},"institutions":[{"id":"https://openalex.org/I4210113759","display_name":"Leibniz Institute for Prevention Research and Epidemiology - BIPS","ror":"https://ror.org/02c22vc57","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210113759"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Andersohn","raw_affiliation_strings":["From Charit\u00e9\u2014Universitaetsmedizin Berlin, Berlin, Germany, and Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Charit\u00e9\u2014Universitaetsmedizin Berlin, Berlin, Germany, and Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany","institution_ids":["https://openalex.org/I4210113759","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016971133","display_name":"Christine Konzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113759","display_name":"Leibniz Institute for Prevention Research and Epidemiology - BIPS","ror":"https://ror.org/02c22vc57","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210113759"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine Konzen","raw_affiliation_strings":["From Charit\u00e9\u2014Universitaetsmedizin Berlin, Berlin, Germany, and Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Charit\u00e9\u2014Universitaetsmedizin Berlin, Berlin, Germany, and Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany","institution_ids":["https://openalex.org/I4210113759","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043350936","display_name":"Edeltraut Garbe","orcid":"https://orcid.org/0000-0002-5408-1462","observed_orcids":["https://orcid.org/0000-0002-5408-1462"]},"institutions":[{"id":"https://openalex.org/I4210113759","display_name":"Leibniz Institute for Prevention Research and Epidemiology - BIPS","ror":"https://ror.org/02c22vc57","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210113759"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Edeltraut Garbe","raw_affiliation_strings":["From Charit\u00e9\u2014Universitaetsmedizin Berlin, Berlin, Germany, and Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Charit\u00e9\u2014Universitaetsmedizin Berlin, Berlin, Germany, and Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany","institution_ids":["https://openalex.org/I4210113759","https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7466,"has_fulltext":false,"cited_by_count":489,"citation_normalized_percentile":{"value":0.96437448,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"146","issue":"9","first_page":"657","last_page":"665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.11999999731779099,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-agranulocytosis","display_name":"drug-induced agranulocytosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8809999823570251},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.9039999842643738},{"id":"https://openalex.org/keywords/carbimazole","display_name":"carbimazole","score":0.8569999933242798},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dapsone","display_name":"dapsone","score":0.9179999828338623},{"id":"https://openalex.org/keywords/metamizole","display_name":"dipyrone","score":0.8119999766349792},{"id":"https://openalex.org/keywords/methimazole","display_name":"methimazole","score":0.9800000190734863},{"id":"https://openalex.org/keywords/penicillin-g","display_name":"penicillin G","score":0.8880000114440918},{"id":"https://openalex.org/keywords/procainamide","display_name":"procainamide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/propylthiouracil","display_name":"propylthiouracil","score":0.996999979019165},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sulfasalazine","display_name":"sulfasalazine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ticlopidine","display_name":"ticlopidine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/fatal-complication","display_name":"fatal complication","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9560486078262329},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.5983759164810181},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5612359046936035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5270745158195496},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34184980392456055},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3238130509853363},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1791606843471527}],"mesh":[{"descriptor_ui":"D000380","descriptor_name":"Agranulocytosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000380","descriptor_name":"Agranulocytosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000380","descriptor_name":"Agranulocytosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.7326/0003-4819-146-9-200705010-00009","doi":"https://doi.org/10.7326/0003-4819-146-9-200705010-00009","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-146-9-200705010-00009","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:17470834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17470834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.694.5181","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.694.5181","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://annals.org/data/Journals/AIM/20135/0000605-200705010-00009.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W57693968","https://openalex.org/W1978633784","https://openalex.org/W1982192328","https://openalex.org/W1990247331","https://openalex.org/W1993552694","https://openalex.org/W1997382119","https://openalex.org/W2027893772","https://openalex.org/W2028266864","https://openalex.org/W2033406940","https://openalex.org/W2037166076","https://openalex.org/W2041723789","https://openalex.org/W2061060120","https://openalex.org/W2067857166","https://openalex.org/W2068407011","https://openalex.org/W2078200660","https://openalex.org/W2108713627","https://openalex.org/W2122479998","https://openalex.org/W2140626313","https://openalex.org/W2154277076","https://openalex.org/W2162024756","https://openalex.org/W2169280430","https://openalex.org/W2238685482","https://openalex.org/W2290685943","https://openalex.org/W2318774080","https://openalex.org/W4214631360","https://openalex.org/W4242623561","https://openalex.org/W4246483858"],"related_works":["https://openalex.org/W1995004469","https://openalex.org/W7099687458","https://openalex.org/W2089835135","https://openalex.org/W2169737900","https://openalex.org/W2052921270","https://openalex.org/W2078200660","https://openalex.org/W2126066908","https://openalex.org/W2086126246","https://openalex.org/W7021128821","https://openalex.org/W2912718913"],"abstract_inverted_index":{"BACKGROUND:":[0],"Nonchemotherapy":[1],"drug-induced":[2,79,276,298],"agranulocytosis":[3,96,113],"is":[4,10],"a":[5,13,188,205,229,250],"rare":[6],"adverse":[7],"reaction":[8],"that":[9,40],"characterized":[11],"by":[12,97],"decrease":[14],"in":[15,54,65,116,120,124,129],"peripheral":[16],"neutrophil":[17,189,206],"count":[18,190,207],"to":[19,27,46,57,62,142],"less":[20,192],"than":[21,148,169,193,201,264],"0.5":[22],"x":[23,195,211],"10(9)":[24,196,212],"cells/L":[25,197,213],"due":[26],"immunologic":[28],"or":[29,43,59,139,173,214,255,281],"cytotoxic":[30],"mechanisms.":[31],"PURPOSE:":[32],"To":[33],"systematically":[34],"review":[35],"case":[36,73],"reports":[37,53,74,150,271],"of":[38,67,75,108,112,134,171,177,209,233,253,275,310],"drugs":[39,136,294],"are":[41],"definitely":[42,138],"probably":[44,140],"related":[45,141],"agranulocytosis.":[47,80,143,299],"DATA":[48,81,104],"SOURCES:":[49],"English-language":[50],"and":[51,64,89,95,127,164,183,285,290],"German-language":[52],"MEDLINE":[55],"(1966":[56],"2006)":[58,63],"EMBASE":[60],"(1989":[61],"bibliographies":[66],"retrieved":[68],"articles.":[69],"STUDY":[70],"SELECTION:":[71],"Published":[72],"patients":[76,186,246,265],"with":[77,187,204,224,307],"nonchemotherapy":[78,297],"EXTRACTION:":[82],"One":[83],"reviewer":[84],"abstracted":[85],"details":[86],"about":[87],"cases":[88,111,179],"assessed":[90],"causality":[91],"between":[92,181],"drug":[93],"intake":[94],"using":[98],"World":[99],"Health":[100],"Organization":[101],"assessment":[102],"criteria.":[103],"SYNTHESIS:":[105],"Causality":[106],"assessments":[107],"980":[109],"reported":[110],"were":[114,137,151],"definite":[115,172],"56":[117],"(6%),":[118],"probable":[119,174],"436":[121],"(44%),":[122],"possible":[123],"481":[125],"(49%),":[126],"unlikely":[128],"7":[130],"(1%).":[131],"A":[132],"total":[133],"125":[135],"Drugs":[144],"for":[145,167],"which":[146],"more":[147,168],"10":[149],"available":[152],"(carbimazole,":[153],"clozapine,":[154],"dapsone,":[155],"dipyrone,":[156],"methimazole,":[157],"penicillin":[158],"G,":[159],"procainamide,":[160],"propylthiouracil,":[161],"rituximab,":[162],"sulfasalazine,":[163],"ticlopidine)":[165],"accounted":[166],"50%":[170],"reports.":[175],"Proportions":[176],"fatal":[178,199,256],"decreased":[180],"1966":[182],"2006.":[184],"More":[185],"nadir":[191,208],"0.1":[194,210],"had":[198,228,249],"complications":[200,257],"did":[202],"those":[203],"greater":[215],"(10%":[216],"vs.":[217,237,259],"3%;":[218],"P":[219,240,261],"<":[220],"0.001).":[221],"Patients":[222],"treated":[223],"hematopoietic":[225],"growth":[226],"factors":[227],"shorter":[230],"median":[231],"duration":[232],"neutropenia":[234],"(8":[235],"days":[236],"9":[238],"days;":[239],"=":[241,262],"0.015)":[242],"and,":[243],"among":[244],"asymptomatic":[245],"at":[247],"diagnosis,":[248],"lower":[251],"proportion":[252],"infectious":[254],"(14%":[258],"29%;":[260],"0.030)":[263],"without":[266],"such":[267],"treatment.":[268,312],"LIMITATIONS:":[269],"Case":[270,300],"cannot":[272],"provide":[273],"rates":[274],"complications,":[277],"sometimes":[278,286],"incompletely":[279],"assess":[280],"describe":[282],"important":[283],"details,":[284],"emphasize":[287],"atypical":[288],"features":[289],"outcomes.":[291],"CONCLUSIONS:":[292],"Many":[293],"can":[295],"cause":[296],"fatality":[301],"may":[302],"be":[303],"decreasing":[304],"over":[305],"time":[306],"the":[308],"availability":[309],"better":[311]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":40},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":34},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
