{"id":"https://openalex.org/W2149133018","doi":"https://doi.org/10.1002/biof.5520190312","title":"Expression of \u03b2\u2010catenin in external auditory canal cholesteatoma (EACC)","display_name":"Expression of \u03b2\u2010catenin in external auditory canal cholesteatoma (EACC)","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2149133018","doi":"https://doi.org/10.1002/biof.5520190312","mag":"2149133018","pmid":"https://pubmed.ncbi.nlm.nih.gov/14757970"},"language":"en","primary_location":{"id":"doi:10.1002/biof.5520190312","doi":"https://doi.org/10.1002/biof.5520190312","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biof.5520190312","pdf_url":null,"source":{"id":"https://openalex.org/S75531928","display_name":"BioFactors","issn_l":"0951-6433","issn":["0951-6433","1872-8081"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111826261","display_name":"Ramin Naim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ramin Naim","raw_affiliation_strings":["Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany. ramin.naim@hno.ma.uni-heidelberg.de","Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany. ramin.naim@hno.ma.uni-heidelberg.de","institution_ids":["https://openalex.org/I4210156450"]},{"raw_affiliation_string":"Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Frank Riedel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Riedel","raw_affiliation_strings":["Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011254043","display_name":"Gregor M. Bran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gregor Bran","raw_affiliation_strings":["Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113610887","display_name":"Karl H\u00f6rmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl H\u00f6rmann","raw_affiliation_strings":["Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111826261"],"corresponding_institution_ids":["https://openalex.org/I4210156450"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.1667,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56171946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"3-4","first_page":"189","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors","score":0.47530001401901245,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors","score":0.47530001401901245,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.2687999904155731,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.06830000132322311,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/external-auditory-canal-cholesteatoma","display_name":"external auditory canal cholesteatoma","score":0.9480000138282776},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.8299999833106995},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/epithelial-hyperplasia","display_name":"epithelial hyperplasia","score":0.7680000066757202},{"id":"https://openalex.org/keywords/keratin-debris","display_name":"keratin debris","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2780725665","wikidata":"https://www.wikidata.org/wiki/Q558230","display_name":"Cholesteatoma","level":2,"score":0.8130005598068237},{"id":"https://openalex.org/C3019630126","wikidata":"https://www.wikidata.org/wiki/Q258328","display_name":"Auditory canal","level":2,"score":0.5962297320365906},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5202180743217468},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.44793710112571716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4191698133945465},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.24325424432754517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16948068141937256},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.12320983409881592},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08560207486152649},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.07004344463348389},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002781","descriptor_name":"Cholesteatoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002781","descriptor_name":"Cholesteatoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004424","descriptor_name":"Ear Canal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/biof.5520190312","doi":"https://doi.org/10.1002/biof.5520190312","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biof.5520190312","pdf_url":null,"source":{"id":"https://openalex.org/S75531928","display_name":"BioFactors","issn_l":"0951-6433","issn":["0951-6433","1872-8081"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors","raw_type":"journal-article"},{"id":"pmid:14757970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14757970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors (Oxford, England)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324159","display_name":"Universit\u00e4t Mannheim","ror":"https://ror.org/031bsb921"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1491991731","https://openalex.org/W1861095564","https://openalex.org/W1981752846","https://openalex.org/W1991557802","https://openalex.org/W1998776819","https://openalex.org/W2005177530","https://openalex.org/W2035081796","https://openalex.org/W2036053197","https://openalex.org/W2064157150","https://openalex.org/W2070715920","https://openalex.org/W2076959105","https://openalex.org/W2088956647","https://openalex.org/W2090481320","https://openalex.org/W2095348610","https://openalex.org/W2109016302","https://openalex.org/W2118886920","https://openalex.org/W2119486893","https://openalex.org/W2125282225","https://openalex.org/W2151876618","https://openalex.org/W2163287575","https://openalex.org/W2402995472"],"related_works":["https://openalex.org/W151459209","https://openalex.org/W2047277578","https://openalex.org/W7015951362","https://openalex.org/W2034814922","https://openalex.org/W1974143691","https://openalex.org/W2183876658","https://openalex.org/W2051579990","https://openalex.org/W2051825485","https://openalex.org/W1979099034","https://openalex.org/W2069579739"],"abstract_inverted_index":{"External":[0],"auditory":[1,12,77],"canal":[2,13],"cholesteatoma":[3],"(EACC)":[4],"is":[5,15,36,170,182],"a":[6,236],"chronic":[7],"inflammation":[8],"of":[9,17,23,32,41,46,56,66,88,98,111,119,132,147,156,174,191,199,209,220,224,239],"the":[10,24,39,42,64,99,120,129,133,145,148,154,188,196,200,212],"external":[11],"and":[14,30,59,62,74,85,222],"composed":[16],"hyperproliferative":[18],"epithelium.":[19],"The":[20,140],"upward":[21],"migration":[22],"epithelial":[25],"cells":[26,176],"requires":[27],"permanent":[28],"breakdown":[29],"reformation":[31],"intercellular":[33],"connection.":[34],"This":[35],"established":[37],"by":[38,177],"modulation":[40],"adherent":[43],"junctions":[44],"consisting":[45],"an":[47],"E-Cadherin-beta-catenin":[48],"complex.":[49],"Dissociated":[50],"beta-catenin":[51,92,105,158,162,181,194,210,240],"intranuclearly":[52],"enables":[53],"persistent":[54],"activation":[55],"downstream":[57],"transcription":[58],"growth":[60,179],"factors":[61],"decreases":[63],"integrity":[65],"tissue.":[67],"In":[68,128,185,228],"our":[69],"study":[70,231],"we":[71,203],"examined":[72],"EACC":[73,115],"normal":[75],"meatal":[76],"skin":[78],"taken":[79],"from":[80],"16":[81],"patients":[82],"between":[83],"23":[84],"74":[86],"years":[87],"age.":[89],"Immunostaining":[90],"for":[91,95,126,193],"was":[93,106,138,142,159,163],"used":[94],"semiquantitative":[96],"description":[97],"specimens":[100],"after":[101],"assessing":[102],"hematoxylin-eosin-stained":[103],"slides.":[104],"expressed":[107],"in":[108,114,195,218,242],"all":[109],"layers":[110,198],"AMS-epithelium,":[112],"whereas":[113],"only":[116,135],"basal":[117],"layer":[118,131],"matrix":[121],"epithelium":[122,134],"showed":[123],"positive":[124],"immunostaining":[125,141],"beta-catenin.":[127],"suprabasal":[130,197],"faint":[136],"reactivity":[137],"detectable.":[139],"restricted":[143],"to":[144,166,187],"membrane":[146],"cells.":[149],"We":[150],"assumed":[151,204],"that":[152,172],"either":[153],"content":[155],"membranous":[157],"decreased":[160],"or":[161,207],"changed":[164],"due":[165],"molecular":[167],"modification.":[168],"It":[169],"known":[171],"stimulation":[173],"endothelial":[175],"certain":[178],"factors,":[180],"maximally":[183],"phosphorylated.":[184],"regard":[186],"increased":[189],"loss":[190,208],"immunoreactivity":[192],"hyperplastic":[201],"EACC-matrix,":[202],"bio-molecular":[205],"modification":[206],"decreasing":[211],"cell-cell-integrity.":[213],"Furthermore,":[214],"this":[215,230],"might":[216],"result":[217],"desquamation":[219],"keratinocytes":[221],"accumulation":[223],"dead":[225],"keratin":[226],"debrids.":[227],"sum,":[229],"should":[232],"be":[233],"understood":[234],"as":[235],"descriptive":[237],"analysis":[238],"expression":[241],"EACC.":[243]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}