{"id":"https://openalex.org/W2149116091","doi":"https://doi.org/10.1097/01.shk.0000180074.69143.77","title":"IMPLICATION OF TOLL-LIKE RECEPTOR AND TUMOR NECROSIS FACTOR \u03b1 SIGNALING IN SEPTIC SHOCK","display_name":"IMPLICATION OF TOLL-LIKE RECEPTOR AND TUMOR NECROSIS FACTOR \u03b1 SIGNALING IN SEPTIC SHOCK","publication_year":2005,"publication_date":"2005-08-31","ids":{"openalex":"https://openalex.org/W2149116091","doi":"https://doi.org/10.1097/01.shk.0000180074.69143.77","mag":"2149116091","pmid":"https://pubmed.ncbi.nlm.nih.gov/16135957"},"language":"en","primary_location":{"id":"doi:10.1097/01.shk.0000180074.69143.77","doi":"https://doi.org/10.1097/01.shk.0000180074.69143.77","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.shk.0000180074.69143.77","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057394028","display_name":"Wen\u2010Jye Lin","orcid":"https://orcid.org/0000-0001-8821-9813","observed_orcids":["https://orcid.org/0000-0001-8821-9813"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wen-Jye Lin","raw_affiliation_strings":["The Campbell Family Institute for Breast Cancer Research, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Campbell Family Institute for Breast Cancer Research, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I4405278476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023385055","display_name":"Wen\u2010Chen Yeh","orcid":"https://orcid.org/0000-0002-8837-8301","observed_orcids":["https://orcid.org/0000-0002-8837-8301"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wen-Chen Yeh","raw_affiliation_strings":["Address reprint requests to Dr. Wen-Chen Yeh, The Campbell Family Institute for Breast Cancer Research, University Health Network and Department of Medical Biophysics, University of Toronto, 620 University Avenue, Suite 706, Toronto, Ontario, Canada M5G 2C1. E-mail: [email\u00a0protected]","The Campbell Family Institute for Breast Cancer Research, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Dr. Wen-Chen Yeh, The Campbell Family Institute for Breast Cancer Research, University Health Network and Department of Medical Biophysics, University of Toronto, 620 University Avenue, Suite 706, Toronto, Ontario, Canada M5G 2C1. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I4405278476"]},{"raw_affiliation_string":"The Campbell Family Institute for Breast Cancer Research, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I4405278476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1072,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.75655431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"3","first_page":"206","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.13050000369548798,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lipopolysaccharide-signaling","display_name":"lipopolysaccharide signaling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.765999972820282},{"id":"https://openalex.org/keywords/monocytes-macrophages","display_name":"monocytes/macrophages","score":0.7599999904632568},{"id":"https://openalex.org/keywords/signal-transducers","display_name":"signal transducers","score":0.7129999995231628},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.7922706604003906},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6924273371696472},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6693319082260132},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6690953969955444},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6327489614486694},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5811319947242737},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5550557971000671},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.543849766254425},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5359595417976379},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4966896176338196},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4535086154937744},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44308358430862427},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4264023005962372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.336112916469574},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2946561872959137},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19068074226379395}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053592","descriptor_name":"Interleukin-1 Receptor-Associated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/01.shk.0000180074.69143.77","doi":"https://doi.org/10.1097/01.shk.0000180074.69143.77","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.shk.0000180074.69143.77","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:16135957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16135957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.612.8563","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.612.8563","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.urmc.rochester.edu/george-whipple-lab/professors-investigators/documents/lin11.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1490324197","https://openalex.org/W1532865172","https://openalex.org/W1671427082","https://openalex.org/W1968328677","https://openalex.org/W1969501356","https://openalex.org/W1973680986","https://openalex.org/W1978174408","https://openalex.org/W1978837231","https://openalex.org/W1978926805","https://openalex.org/W1979595147","https://openalex.org/W1979758228","https://openalex.org/W1986308149","https://openalex.org/W1992024672","https://openalex.org/W1994696929","https://openalex.org/W2003534444","https://openalex.org/W2013052118","https://openalex.org/W2017728303","https://openalex.org/W2020969008","https://openalex.org/W2027583953","https://openalex.org/W2029501678","https://openalex.org/W2032282478","https://openalex.org/W2032514624","https://openalex.org/W2033643030","https://openalex.org/W2034829165","https://openalex.org/W2039109795","https://openalex.org/W2045068005","https://openalex.org/W2047376205","https://openalex.org/W2049286784","https://openalex.org/W2052648717","https://openalex.org/W2056092077","https://openalex.org/W2064558057","https://openalex.org/W2066420604","https://openalex.org/W2074562878","https://openalex.org/W2087867048","https://openalex.org/W2089394364","https://openalex.org/W2097747132","https://openalex.org/W2098336582","https://openalex.org/W2112296339","https://openalex.org/W2114347295","https://openalex.org/W2120633856","https://openalex.org/W2122482353","https://openalex.org/W2145532819","https://openalex.org/W2157086104","https://openalex.org/W2332955492","https://openalex.org/W2336331566","https://openalex.org/W2405557332"],"related_works":["https://openalex.org/W7100027167","https://openalex.org/W1985976782","https://openalex.org/W142170321","https://openalex.org/W3130915721","https://openalex.org/W2332431760","https://openalex.org/W2359109917","https://openalex.org/W1972492206","https://openalex.org/W2154022424","https://openalex.org/W2077195824","https://openalex.org/W2907060331"],"abstract_inverted_index":{"Septic":[0],"shock":[1,30],"is":[2,31,48,76],"initiated":[3],"by":[4,86,119,131,142],"a":[5,32,49,61,137],"systemic":[6],"inflammatory":[7,64,69,94,139],"response":[8,72],"to":[9,15,59,73,78,83,168],"microbial":[10],"infection":[11],"that":[12,84],"frequently":[13],"leads":[14],"impaired":[16],"perfusion":[17],"and":[18,56,92,121,156],"multiple":[19],"organ":[20],"failure.":[21],"Because":[22],"of":[23,27,52,63,68,89,103,152,161,177],"its":[24,122],"high":[25],"risk":[26],"death,":[28],"septic":[29,80],"major":[33],"problem":[34],"particularly":[35],"for":[36,173],"patients":[37],"in":[38,71,100,113],"the":[39,101,115,174],"intensive":[40],"care":[41],"unit.":[42],"In":[43,105],"general,":[44],"bacterial":[45,74],"lipopolysaccharide":[46],"(LPS)":[47],"strong":[50],"activator":[51],"various":[53],"immune":[54],"responses":[55],"stimulates":[57],"monocytes/macrophages":[58],"release":[60],"variety":[62],"cytokines.":[65],"However,":[66],"overproduction":[67],"factors":[70],"infections":[75],"known":[77],"cause":[79],"shock,":[81],"similar":[82],"induced":[85,141],"LPS.":[87],"Studies":[88],"LPS-signaling":[90],"pathways":[91,117,155],"downstream":[93],"cytokines":[95],"may":[96,165],"have":[97],"critical":[98,157],"implications":[99],"treatment":[102],"sepsis.":[104,178],"recent":[106],"years,":[107],"there":[108],"has":[109],"been":[110],"significant":[111],"progress":[112],"understanding":[114],"signaling":[116,154],"activated":[118],"LPS":[120,143],"receptor":[123,125],"Toll-like":[124],"4":[126],"(TLR4),":[127],"as":[128,130],"well":[129],"tumor":[132],"necrosis":[133],"factor":[134],"alpha":[135],"(TNFalpha),":[136],"potent":[138],"cytokine":[140],"stimulation.":[144],"This":[145],"review":[146],"briefly":[147],"summarizes":[148],"our":[149],"current":[150],"knowledge":[151],"these":[153],"signal":[158,163],"transducers.":[159],"Characterization":[160],"key":[162],"transducers":[164],"allow":[166],"us":[167],"identify":[169],"tractable,":[170],"novel":[171],"targets":[172],"therapeutic":[175],"interventions":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}