{"id":"https://openalex.org/W2149108342","doi":"https://doi.org/10.1542/peds.110.5.1030-a","title":"Inhaled Steroids and Asthma","display_name":"Inhaled Steroids and Asthma","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2149108342","doi":"https://doi.org/10.1542/peds.110.5.1030-a","mag":"2149108342","pmid":"https://pubmed.ncbi.nlm.nih.gov/12415050"},"language":"en","primary_location":{"id":"doi:10.1542/peds.110.5.1030-a","doi":"https://doi.org/10.1542/peds.110.5.1030-a","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.110.5.1030-a","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PEDIATRICS","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078830607","display_name":"Michael S. Blaiss","orcid":"https://orcid.org/0000-0002-0733-9408","observed_orcids":["https://orcid.org/0000-0002-0733-9408"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. S. Blaiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065009035","display_name":"N.S. Eid","orcid":"https://orcid.org/0000-0001-8968-0986","observed_orcids":["https://orcid.org/0000-0001-8968-0986"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. S. Eid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021777025","display_name":"RONALD L. MORTON","orcid":"https://orcid.org/0000-0003-3302-735X","observed_orcids":["https://orcid.org/0000-0003-3302-735X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. L. Morton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109214576","display_name":"Stephen W. Looney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Looney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"110","issue":"5","first_page":"1030","last_page":"1031"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.20080000162124634,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.8799999952316284},{"id":"https://openalex.org/keywords/fluticasone","display_name":"fluticasone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7039999961853027},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6859999895095825},{"id":"https://openalex.org/keywords/corticosteroid-dose","display_name":"corticosteroid dose","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9841687679290771},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7408424615859985},{"id":"https://openalex.org/C2991922776","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Inhaled corticosteroids","level":3,"score":0.4369141161441803},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40622854232788086},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15759918093681335}],"mesh":[{"descriptor_ui":"D000068298","descriptor_name":"Fluticasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019983","descriptor_name":"Guideline Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1542/peds.110.5.1030-a","doi":"https://doi.org/10.1542/peds.110.5.1030-a","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.110.5.1030-a","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PEDIATRICS","raw_type":"journal-article"},{"id":"doi:10.1542/peds.110.5.1030b","doi":"https://doi.org/10.1542/peds.110.5.1030b","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.110.5.1030b","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:12415050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12415050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2010039853","https://openalex.org/W2043145107","https://openalex.org/W2058322471"],"related_works":["https://openalex.org/W2043145107","https://openalex.org/W1985697002","https://openalex.org/W2144386228","https://openalex.org/W1984012752","https://openalex.org/W1995880883","https://openalex.org/W1993075605","https://openalex.org/W2057590635","https://openalex.org/W3008336254","https://openalex.org/W1986763093","https://openalex.org/W2065414463"],"abstract_inverted_index":{"To":[0],"the":[1,14,31,38,46,54,82,109,113,174,178,184,186,217,219,279,285,296,306,315,329,332,348,355,364,373,376,385,402,407,417,432,441,462,469,509,532,587,603,612,626,631,642,657,672,680,687,705,709],"Editor.\u2014In":[2],"their":[3],"recent":[4],"article,":[5],"Eid":[6,365],"et":[7],"al1":[8],"report":[9],"an":[10,149],"observational":[11],"study":[12,35,374,496,536,550,706],"of":[13,16,28,30,49,58,63,100,117,127,145,162,173,189,231,261,266,271,278,350,388,406,443,446,534,589,599,628,633],"effects":[15,445],"inhaled":[17,263,447,600],"fluticasone":[18,64,118,293,301],"on":[19,89,95,103,156,164,592,693],"morning":[20,151,201],"serum":[21,191,202],"cortisol":[22,152,192,203,232,248,288,411],"in":[23,33,40,66,84,134,224,287,486,494,526,543,563,576,586,602,611,630,646,660,671,683,701],"children.":[24],"However,":[25,216,281,622],"additional":[26],"discussion":[27],"some":[29,367,425],"findings":[32],"this":[34,85,135,323,577,637,661],"would":[36],"benefit":[37],"clinician":[39],"interpreting":[41],"these":[42,146],"results.First,":[43],"according":[44],"to":[45,105,124,183,360,461,481,521,537,552,565,708],"National":[47],"Institutes":[48],"Health":[50],"(NIH)":[51],"Guidelines":[52],"for":[53,121,212,250,268,358,473,491,513,636,686],"Diagnosis":[55],"and":[56,76,92,227,243,384,439,484,524,567,596,669],"Management":[57],"Asthma,":[59],"a":[60,209,269,276,617],"high":[61,106],"dose":[62,116,166,297,614,638,662,689],"MDI":[65],"children":[67,83,101,122,426,438,566],"is":[68,129,159,194,236,275,398,422,530,554,580,616,677],"considered":[69],">440":[70],"\u03bcg/day;":[71,75],"medium":[72,104],"dose,":[73,78],"176\u2013440":[74],"low":[77,165],"88\u2013176":[79],"\u03bcg/day.2":[80],"Of":[81],"study,":[86,366],"43%":[87],"were":[88,94,102,137],"440":[90],"\u03bcg/day":[91],"47%":[93],"880":[96],"\u03bcg/day.":[97],"Thus,":[98],"90%":[99],"doses":[107,430],"per":[108],"NIH":[110],"guidelines.":[111],"Additionally,":[112],"highest":[114],"FDA-recommended":[115],"inhalation":[119],"powder":[120],"4":[123],"11":[125],"years":[126],"age":[128],"200":[130],"\u03bcg/day.Only":[131],"6":[132,609],"patients":[133,147,163,267,291,368,408,610],"analysis":[136],"using":[138],"low-dose":[139,157],"Flovent":[140,158],"(176":[141],"\u03bcg/day).":[142],"Only":[143],"1":[144,169,361,648,685],"had":[148,413],"abnormal":[150,410,635,659],"level.":[153],"One":[154],"patient":[155],"not":[160,399,500,531],"17%":[161,634],"but":[167,497],"rather":[168],"patient.":[170],"The":[171,196,255,547],"use":[172,260,349,598],"percent":[175],"implies":[176],"that":[177,199,258,284,420,424,505,555,568,608,656,697],"finding":[179],"can":[180,456],"be":[181,312,457,482,522,665],"generalized":[182],"population.Second,":[185],"clinical":[187],"relevance":[188],"isolated":[190],"levels":[193,249,412],"questionable.":[195],"authors":[197,220,256,418],"state":[198],"\u201cearly":[200],"level":[204],"has":[205],"been":[206],"accepted":[207],"as":[208,305],"reliable":[210],"test":[211],"HPA":[213,356],"axis":[214,357],"function.\u201d":[215],"reference":[218],"cite":[221],"states:":[222],"Furthermore,":[223],"assessing":[225],"cause":[226],"effect,":[228],"baseline":[229,316],"values":[230,317],"are":[233,573,653,691,698],"required.":[234],"This":[235,309,579],"important":[237],"because":[238,375],"many":[239,251],"factors,":[240],"including":[241],"previous":[242,259],"concomitant":[244],"medications,":[245],"may":[246,353,427],"affect":[247,354],"months":[252,383],"or":[253,294,336,540,545,559],"longer.":[254],"indicate":[257,625],"other":[262],"steroids":[264,352,371,467,507,601],"(84%":[265],"mean":[270,377,386],"nearly":[272],"2":[273],"years)":[274],"limitation":[277],"study.":[280],"they":[282],"conclude":[283],"increases":[286],"after":[289],"switching":[290],"from":[292,401,704],"decreasing":[295],"\u201cmost":[298],"likely":[299],"implicates":[300],"propionate":[302],"(FP)":[303],"therapy":[304],"causal":[307],"agent.\u201d":[308],"conclusion":[310],"cannot":[311,326,557],"reached":[313],"without":[314],"before":[318,331],"starting":[319],"FP":[320,378],"therapy.":[321],"Without":[322],"information,":[324],"one":[325,556],"deduce":[327],"whether":[328,404],"value":[330],"switch":[333],"was":[334,337,381,393],"decreased":[335],"actually":[338],"increased":[339],"(but":[340],"still":[341],"abnormal)":[342],"compared":[343,452],"with":[344,409,453,502],"baseline.":[345],"In":[346,363,436],"particular,":[347],"oral":[351,370,390,415,454],"up":[359],"year.4":[362],"received":[369,414,429],"during":[372],"treatment":[379],"duration":[380],"8":[382],"time":[387],"last":[389],"steroid":[391],"course":[392],"approximately":[394],"5":[395],"months.":[396],"It":[397],"clear":[400],"article":[403],"any":[405],"steroids.Finally,":[416],"note":[419],"\u201cit":[421],"possible":[423],"have":[428,479,519],"above":[431],"minimal":[433],"required":[434],"doses.\u201d":[435],"both":[437],"adults,":[440],"risk":[442],"systemic":[444],"steroids,":[448],"already":[449],"markedly":[450],"reduced":[451],"corticosteroids,":[455],"minimized":[458],"by":[459,640],"titrating":[460],"lowest":[463],"effective":[464,485,525],"dose.":[465],"Inhaled":[466],"offer":[468,508],"best":[470,510],"antiinflammatory":[471,511],"control":[472,512],"asthma":[474,514],"and,":[475,515],"when":[476,516],"used":[477,517,700],"appropriately,":[478,518],"proven":[480,520],"safe":[483,523],"children.Reply.\u2014We":[487],"thank":[488],"Dr":[489],"Blaiss":[490],"his":[492,503],"interest":[493],"our":[495,535,549],"we":[498,623,652],"do":[499],"agree":[501,607],"statement":[504],"\u201cinhaled":[506],"children.\u201d":[527],"Indeed,":[528],"it":[529],"intent":[533],"create":[538],"steroidophobia":[539],"instill":[541],"fear":[542],"physicians":[544],"patients.":[546],"message":[548],"tries":[551],"convey":[553],"generalize":[558],"transfer":[560],"safety":[561],"data":[562],"adults":[564],"more":[569,581],"prospective":[570],"long-term":[571,590],"studies":[572],"urgently":[574],"needed":[575,583],"regard.":[578],"acutely":[582],"now,":[584],"especially":[585],"era":[588],"trials":[591],"disease":[593],"modifying":[594],"strategies":[595],"early":[597],"very":[604,618],"young":[605],"asthmatic.We":[606],"176":[613,688],"group":[615,639,663,690],"small":[619],"sample":[620,707],"size.":[621],"did":[624],"lack":[627],"precision":[629],"estimate":[632],"presenting":[641],"95%":[643,654],"confidence":[644],"interval":[645],"Table":[647,684],"(0.01\u20130.60).":[649],"That":[650],"is,":[651],"confident":[655],"percentage":[658],"could":[664],"anywhere":[666],"between":[667],"1%":[668],"60%":[670],"population.":[673,711],"Even":[674],"though":[675],"\u201cn\u201d":[676],"quite":[678],"small,":[679],"results":[681],"presented":[682],"based":[692],"valid":[694],"statistical":[695],"methods":[696],"widely":[699],"making":[702],"generalizations":[703],"target":[710]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}