{"id":"https://openalex.org/W2149093225","doi":"https://doi.org/10.1016/j.chembiol.2005.09.012","title":"High-Throughput Screening of Enzyme Libraries: Thiolactonases Evolved by Fluorescence-Activated Sorting of Single Cells in Emulsion Compartments","display_name":"High-Throughput Screening of Enzyme Libraries: Thiolactonases Evolved by Fluorescence-Activated Sorting of Single Cells in Emulsion Compartments","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W2149093225","doi":"https://doi.org/10.1016/j.chembiol.2005.09.012","mag":"2149093225","pmid":"https://pubmed.ncbi.nlm.nih.gov/16356845"},"language":"en","primary_location":{"id":"doi:10.1016/j.chembiol.2005.09.012","doi":"https://doi.org/10.1016/j.chembiol.2005.09.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2005.09.012","pdf_url":"http://www.cell.com/article/S1074552105003042/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1074552105003042/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062362384","display_name":"Amir Aharoni","orcid":"https://orcid.org/0000-0003-2701-6996","observed_orcids":["https://orcid.org/0000-0003-2701-6996"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Amir Aharoni","raw_affiliation_strings":["Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014141606","display_name":"Gil Amitai","orcid":"https://orcid.org/0000-0002-2954-2503","observed_orcids":["https://orcid.org/0000-0002-2954-2503"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gil Amitai","raw_affiliation_strings":["Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056833410","display_name":"Kalia Bernath-Levin","orcid":"https://orcid.org/0000-0002-4470-2982","observed_orcids":["https://orcid.org/0000-0002-4470-2982"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Kalia Bernath","raw_affiliation_strings":["Casali Institute of Applied Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel","Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Casali Institute of Applied Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001377522","display_name":"Shlomo Magdassi","orcid":"https://orcid.org/0000-0002-6794-0553","observed_orcids":["https://orcid.org/0000-0002-6794-0553"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shlomo Magdassi","raw_affiliation_strings":["Casali Institute of Applied Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Casali Institute of Applied Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022018631","display_name":"Dan S. Tawfik","orcid":"https://orcid.org/0000-0002-5914-8240","observed_orcids":["https://orcid.org/0000-0002-5914-8240"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Dan S. Tawfik","raw_affiliation_strings":["Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022018631"],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":null,"apc_paid":null,"fwci":4.8914,"has_fulltext":false,"cited_by_count":232,"citation_normalized_percentile":{"value":0.96700718,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"12","first_page":"1281","last_page":"1289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.06920000165700912,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.652999997138977},{"id":"https://openalex.org/keywords/fluorescence-activated-cell-sorting","display_name":"fluorescence-activated cell sorting","score":0.7710000276565552},{"id":"https://openalex.org/keywords/water-in-oil-emulsions","display_name":"water-in-oil emulsions","score":0.8259999752044678},{"id":"https://openalex.org/keywords/in-vitro-compartmentalization","display_name":"in vitro compartmentalization","score":0.8289999961853027},{"id":"https://openalex.org/keywords/single-cell-screening","display_name":"single-cell screening","score":0.6779999732971191},{"id":"https://openalex.org/keywords/enzyme-libraries","display_name":"enzyme libraries","score":0.49900001287460327},{"id":"https://openalex.org/keywords/water-in-oil-in-water-emulsion","display_name":"water-in-oil-in-water emulsion","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6074109673500061},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.5916248559951782},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.48972442746162415},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.47693270444869995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4736933708190918},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.4707907736301422},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.470193475484848},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.468424916267395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46519434452056885},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.4417654275894165},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.4383801221847534},{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.4239114224910736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4200735092163086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3439098298549652},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2942090630531311},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004655","descriptor_name":"Emulsions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019020","descriptor_name":"Directed Molecular Evolution","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D043303","descriptor_name":"Aryldialkylphosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043303","descriptor_name":"Aryldialkylphosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043303","descriptor_name":"Aryldialkylphosphatase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.chembiol.2005.09.012","doi":"https://doi.org/10.1016/j.chembiol.2005.09.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2005.09.012","pdf_url":"http://www.cell.com/article/S1074552105003042/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biology","raw_type":"journal-article"},{"id":"pmid:16356845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16356845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.chembiol.2005.09.012","doi":"https://doi.org/10.1016/j.chembiol.2005.09.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2005.09.012","pdf_url":"http://www.cell.com/article/S1074552105003042/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2149093225.pdf"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1493227903","https://openalex.org/W1495758322","https://openalex.org/W1498780407","https://openalex.org/W1537729646","https://openalex.org/W1968658378","https://openalex.org/W1971486985","https://openalex.org/W1972873109","https://openalex.org/W1977186059","https://openalex.org/W1986064397","https://openalex.org/W1999195584","https://openalex.org/W1999851613","https://openalex.org/W2003533660","https://openalex.org/W2005767394","https://openalex.org/W2011513747","https://openalex.org/W2017181323","https://openalex.org/W2018061929","https://openalex.org/W2020080086","https://openalex.org/W2021395497","https://openalex.org/W2026057748","https://openalex.org/W2028370433","https://openalex.org/W2038498074","https://openalex.org/W2043059568","https://openalex.org/W2045654196","https://openalex.org/W2047458942","https://openalex.org/W2056255325","https://openalex.org/W2068297182","https://openalex.org/W2070187840","https://openalex.org/W2070569816","https://openalex.org/W2072183005","https://openalex.org/W2073660401","https://openalex.org/W2074588113","https://openalex.org/W2080249432","https://openalex.org/W2083288707","https://openalex.org/W2097651998","https://openalex.org/W2117753040","https://openalex.org/W2133911454","https://openalex.org/W2136445320","https://openalex.org/W2153133904","https://openalex.org/W2161414810","https://openalex.org/W2161964918","https://openalex.org/W2171280873","https://openalex.org/W2327952105","https://openalex.org/W4211045835","https://openalex.org/W4256475235","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1971486985","https://openalex.org/W2045654196","https://openalex.org/W1967088720","https://openalex.org/W1993554361","https://openalex.org/W2014916384","https://openalex.org/W2200999990","https://openalex.org/W2153588917","https://openalex.org/W2023178883","https://openalex.org/W3122662750","https://openalex.org/W4296959976"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
