{"id":"https://openalex.org/W2149061805","doi":"https://doi.org/10.1002/stem.2116","title":"CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling During the Early-Stage Cell Reprogramming","display_name":"CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling During the Early-Stage Cell Reprogramming","publication_year":2015,"publication_date":"2015-07-22","ids":{"openalex":"https://openalex.org/W2149061805","doi":"https://doi.org/10.1002/stem.2116","mag":"2149061805","pmid":"https://pubmed.ncbi.nlm.nih.gov/26201266","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4832376"},"language":"en","primary_location":{"id":"doi:10.1002/stem.2116","doi":"https://doi.org/10.1002/stem.2116","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.2116","pdf_url":"https://academic.oup.com/stmcls/article-pdf/33/10/2961/42015387/stmcls_33_10_2961.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/stmcls/article-pdf/33/10/2961/42015387/stmcls_33_10_2961.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110253453","display_name":"Bo-Hua Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Bo-Hua Jiang","raw_affiliation_strings":["Institute of Oral Biology National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oral Biology National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074727195","display_name":"Wei\u2010Yi Chen","orcid":"https://orcid.org/0000-0002-0661-6899","observed_orcids":["https://orcid.org/0000-0002-0661-6899"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Yi Chen","raw_affiliation_strings":["Institute of Biochemistry and Molecular Biology National Yang-Ming University, Taipei, Taiwan","VGH-YM Genomic/Cancer Research Center National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"VGH-YM Genomic/Cancer Research Center National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113527878","display_name":"Hsin-Yang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Yang Li","raw_affiliation_strings":["Department of Obstetrics and Gynecology Taipei Veterans General Hospital, Taipei, Taiwan","School of Medicine National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000624061","display_name":"Yueh Chien","orcid":"https://orcid.org/0000-0002-1528-9252","observed_orcids":["https://orcid.org/0000-0002-1528-9252"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yueh Chien","raw_affiliation_strings":["Department of Medical Research and Education Taipei Veterans General Hospital, Taipei, Taiwan","Institute of Pharmacology National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Institute of Pharmacology National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045550389","display_name":"Wei\u2010Chao Chang","orcid":"https://orcid.org/0000-0003-1669-0037","observed_orcids":["https://orcid.org/0000-0003-1669-0037"]},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Chao Chang","raw_affiliation_strings":["Department of Biotechnology Asia University, Taichung, Taiwan","Graduate Institute of Cancer Biology and Center for Molecular Medicine China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Graduate Institute of Cancer Biology and Center for Molecular Medicine China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112711559","display_name":"Pei-Chen Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-Chen Hsieh","raw_affiliation_strings":["Institute of Biochemistry and Molecular Biology National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473021","display_name":"Ping Wu","orcid":"https://orcid.org/0000-0002-7020-6237","observed_orcids":["https://orcid.org/0000-0002-7020-6237"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ping Wu","raw_affiliation_strings":["Department of Medical Research and Education Taipei Veterans General Hospital, Taipei, Taiwan","Institute of Pharmacology National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Institute of Pharmacology National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078997304","display_name":"Chieh-Yu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chieh-Yu Chen","raw_affiliation_strings":["Institute of Biochemistry and Molecular Biology National Yang-Ming University, Taipei, Taiwan","VGH-YM Genomic/Cancer Research Center National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"VGH-YM Genomic/Cancer Research Center National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439358","display_name":"Hui-Yung Song","orcid":"https://orcid.org/0000-0003-3295-1938","observed_orcids":["https://orcid.org/0000-0003-3295-1938"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui-Yung Song","raw_affiliation_strings":["Institute of Pharmacology National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055540051","display_name":"Chian\u2010Shiu Chien","orcid":"https://orcid.org/0000-0001-9666-1273","observed_orcids":["https://orcid.org/0000-0001-9666-1273"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chian-Shiu Chien","raw_affiliation_strings":["Department of Medical Research and Education Taipei Veterans General Hospital, Taipei, Taiwan","Institute of Oral Biology National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Institute of Oral Biology National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110050374","display_name":"Yen-Jen Sung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-Jen Sung","raw_affiliation_strings":["Institute of Anatomy and Cell Biology, School of Medicine National Yang-Ming University, Taipei, Taiwan","School of Medicine National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy and Cell Biology, School of Medicine National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"School of Medicine National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047465008","display_name":"Shih\u2010Hwa Chiou","orcid":"https://orcid.org/0000-0002-8651-5755","observed_orcids":["https://orcid.org/0000-0002-8651-5755","https://orcid.org/0000-0002-2481-5357"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shih-Hwa Chiou","raw_affiliation_strings":["Department of Medical Research and Education Taipei Veterans General Hospital, Taipei, Taiwan","Genomics Research Center Academia Sinica, Taipei, Taiwan","Institute of Clinical Medicine National Yang-Ming University, Taipei, Taiwan","Institute of Pharmacology National Yang-Ming University, Taipei, Taiwan","School of Medicine National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Genomics Research Center Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210087491"]},{"raw_affiliation_string":"Institute of Clinical Medicine National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"Institute of Pharmacology National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"School of Medicine National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5047465008"],"corresponding_institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I4210087491","https://openalex.org/I4387156312"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":{"value":4477,"currency":"USD","value_usd":4477},"fwci":1.5777,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.82853294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"33","issue":"10","first_page":"2961","last_page":"2972"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chd1l","display_name":"CHD1L","score":1.0},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":1.0},{"id":"https://openalex.org/keywords/poly-adp-ribosyl-ation","display_name":"poly(ADP-ribosyl)ation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.953000009059906},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dna-helicase","display_name":"DNA helicase","score":0.8709999918937683},{"id":"https://openalex.org/keywords/macrodomain","display_name":"macrodomain","score":0.8090000152587891},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.925000011920929},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":0.9980000257492065},{"id":"https://openalex.org/keywords/esrrb","display_name":"ESRRB","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.8563690185546875},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7785465717315674},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.7364860773086548},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7253994345664978},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.7039499282836914},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5613672137260437},{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.4612923860549927},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.42324966192245483},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38768672943115234},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.32577773928642273},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.3066578507423401},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24904626607894897},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20912355184555054},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.17432597279548645},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.14947694540023804},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.09129559993743896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/stem.2116","doi":"https://doi.org/10.1002/stem.2116","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.2116","pdf_url":"https://academic.oup.com/stmcls/article-pdf/33/10/2961/42015387/stmcls_33_10_2961.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4832376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4832376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"Text"},{"id":"pmid:26201266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26201266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"},{"id":"mag:3216519080","doi":null,"is_oa":false,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832376","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1002/stem.2116","doi":"https://doi.org/10.1002/stem.2116","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.2116","pdf_url":"https://academic.oup.com/stmcls/article-pdf/33/10/2961/42015387/stmcls_33_10_2961.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3574516352","display_name":null,"funder_award_id":"CI-102/103","funder_id":"https://openalex.org/F4320324350","funder_display_name":"Yen Tjing Ling Medical Foundation"},{"id":"https://openalex.org/G3577750078","display_name":"Cell Tracking and Differentiation Agent for Induced Pluripotent Stem Cells Based on Mesoporous Silica Nanoparticles (II)","funder_award_id":"MOST104-2627-M010-004","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G4552024946","display_name":null,"funder_award_id":"Stem Cell Project E99-101","funder_id":"https://openalex.org/F4320327358","funder_display_name":"Taipei Veterans General Hospital"},{"id":"https://openalex.org/G642272525","display_name":null,"funder_award_id":"NHRI-EX102-10258SI","funder_id":"https://openalex.org/F4320322845","funder_display_name":"National Health Research Institutes"},{"id":"https://openalex.org/G7490903586","display_name":"Investigation of Cytokine-Based Epigenetical Regulation in the Cancer Stem-Like Property and Reprogramming in Malignant Glioma (I)","funder_award_id":"MOST103-2321-B010-025","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G7933180068","display_name":"(104IN1015) Development of Novel Subretinal Biocompatible-Scaffold for the Treatment of Human Retinal Diseases (I)","funder_award_id":"MOST104-2325-B010-006","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322845","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29"},{"id":"https://openalex.org/F4320323275","display_name":"National Yang-Ming University","ror":"https://ror.org/009h5ks85"},{"id":"https://openalex.org/F4320323900","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95"},{"id":"https://openalex.org/F4320324350","display_name":"Yen Tjing Ling Medical Foundation","ror":"https://ror.org/00gp69y42"},{"id":"https://openalex.org/F4320327358","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149061805.pdf","grobid_xml":"https://content.openalex.org/works/W2149061805.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1489824848","https://openalex.org/W1553005193","https://openalex.org/W1966083128","https://openalex.org/W1970147959","https://openalex.org/W1971918585","https://openalex.org/W1978727518","https://openalex.org/W1983786929","https://openalex.org/W1989645169","https://openalex.org/W1992397774","https://openalex.org/W1994011134","https://openalex.org/W1999391198","https://openalex.org/W2023997559","https://openalex.org/W2028835848","https://openalex.org/W2033568291","https://openalex.org/W2035398180","https://openalex.org/W2050087669","https://openalex.org/W2056679680","https://openalex.org/W2057706543","https://openalex.org/W2072859865","https://openalex.org/W2079599988","https://openalex.org/W2083984635","https://openalex.org/W2088875346","https://openalex.org/W2095491090","https://openalex.org/W2113253176","https://openalex.org/W2118937292","https://openalex.org/W2119642223","https://openalex.org/W2123355890","https://openalex.org/W2125734502","https://openalex.org/W2125987139","https://openalex.org/W2147690311","https://openalex.org/W2151522898","https://openalex.org/W2152492589","https://openalex.org/W2157243724","https://openalex.org/W2160073632","https://openalex.org/W2330103599"],"related_works":["https://openalex.org/W3216519080","https://openalex.org/W2079599988","https://openalex.org/W2048500533","https://openalex.org/W2079994749","https://openalex.org/W7098010531","https://openalex.org/W2027591636","https://openalex.org/W2775166823","https://openalex.org/W7030217127","https://openalex.org/W3006306334","https://openalex.org/W3005083102"],"abstract_inverted_index":{"PARP1":[0,78,95],"and":[1,40,63,77,82,99,117,146],"poly(ADP-ribosyl)ation":[2],"(PARylation)":[3],"have":[4],"been":[5],"shown":[6],"to":[7,123],"be":[8],"essential":[9],"for":[10],"the":[11,18,57,60,64,73,91,101,124],"initial":[12],"steps":[13],"of":[14,23,59,67,75,87,94,103,127],"cellular":[15],"reprogramming.":[16,48,105],"However,":[17],"mechanism":[19],"underlying":[20],"PARP1/PARylation-regulated":[21,143],"activation":[22],"pluripotency":[24,46,84,97,128,147],"loci":[25,98],"remains":[26],"undetermined.":[27],"Here,":[28],"we":[29,107],"demonstrate":[30],"that":[31,51,109],"CHD1L,":[32],"a":[33,114,137],"DNA":[34,118],"helicase,":[35],"possesses":[36],"chromatin":[37,139],"remodeling":[38],"activity":[39,93],"interacts":[41],"with":[42],"PARP1/PARylation":[43],"in":[44,142,148],"regulating":[45],"during":[47],"We":[49],"found":[50,108],"this":[52],"interaction":[53],"is":[54],"mediated":[55],"through":[56],"interplay":[58],"CHD1L":[61,76,88,135],"macro-domain":[62],"PAR":[65],"moiety":[66],"PARylated-PARP1.":[68],"Chromatin":[69],"immunoprecipitation":[70],"assays":[71],"demonstrated":[72],"co-occupancy":[74],"at":[79,96],"Pou5f1,":[80],"Nanog,":[81],"Esrrb":[83],"loci.":[85,129],"Knockdown":[86],"significantly":[89],"blocked":[90],"binding":[92],"inhibited":[100],"efficiency":[102],"PARP1-driven":[104],"Notably,":[106],"CHD1L-promoted":[110],"reprogramming":[111,145],"requires":[112],"both":[113],"PARP1-interacting":[115],"domain":[116],"helicase":[119],"activity,":[120],"partly":[121],"contributing":[122],"chromatin-remodeling":[125],"states":[126],"Taken":[130],"together,":[131],"these":[132],"results":[133],"identify":[134],"as":[136],"key":[138],"remodeler":[140],"involved":[141],"early-stage":[144],"stem":[149],"cells.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":11},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}