{"id":"https://openalex.org/W2149025098","doi":null,"title":"Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae","display_name":"Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae","publication_year":2015,"publication_date":"2015-11-06","ids":{"openalex":"https://openalex.org/W2149025098","mag":"2149025098"},"language":"en","primary_location":{"id":"mag:2149025098","doi":null,"is_oa":false,"landing_page_url":"https://guoa.ub.gu.se/bitstream/2077/39129/3/gupea_2077_39129_3.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080589456","display_name":"Sandra Malmgren Hill","orcid":"https://orcid.org/0000-0001-7969-097X","observed_orcids":["https://orcid.org/0000-0001-7969-097X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sandra Malmgren Hill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080589456"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-aging","display_name":"cellular aging","score":0.8029999732971191},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.6919999718666077},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9290000200271606},{"id":"https://openalex.org/keywords/aging-factors","display_name":"aging factors","score":0.515999972820282},{"id":"https://openalex.org/keywords/cellular-rejuvenation","display_name":"cellular rejuvenation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.9549999833106995},{"id":"https://openalex.org/keywords/retrograde-transport","display_name":"retrograde transport","score":0.8560000061988831},{"id":"https://openalex.org/keywords/vacuoles","display_name":"vacuoles","score":0.7049999833106995},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9399999976158142},{"id":"https://openalex.org/keywords/genome-wide-screen","display_name":"genome-wide screen","score":0.734000027179718},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.5440000295639038},{"id":"https://openalex.org/keywords/cellular-fitness","display_name":"cell fitness","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6443002820014954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6439863443374634},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5715685486793518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5105017423629761},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47450515627861023},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.43759018182754517},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.3658928871154785},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2683766484260559},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13219156861305237},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2149025098","doi":null,"is_oa":false,"landing_page_url":"https://guoa.ub.gu.se/bitstream/2077/39129/3/gupea_2077_39129_3.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":181,"referenced_works":["https://openalex.org/W66742448","https://openalex.org/W112555532","https://openalex.org/W1485116839","https://openalex.org/W1498174224","https://openalex.org/W1540286737","https://openalex.org/W1568630971","https://openalex.org/W1575149476","https://openalex.org/W1597191685","https://openalex.org/W1875835053","https://openalex.org/W1887315258","https://openalex.org/W1964297184","https://openalex.org/W1964482047","https://openalex.org/W1967025628","https://openalex.org/W1969342645","https://openalex.org/W1969615465","https://openalex.org/W1971944286","https://openalex.org/W1972121275","https://openalex.org/W1972464577","https://openalex.org/W1972615369","https://openalex.org/W1972950841","https://openalex.org/W1973205231","https://openalex.org/W1973859442","https://openalex.org/W1975396085","https://openalex.org/W1977796112","https://openalex.org/W1979717090","https://openalex.org/W1980431043","https://openalex.org/W1981747529","https://openalex.org/W1981840094","https://openalex.org/W1984571004","https://openalex.org/W1987738803","https://openalex.org/W1988518686","https://openalex.org/W1989253040","https://openalex.org/W1991557802","https://openalex.org/W1992663222","https://openalex.org/W1993091967","https://openalex.org/W1997982747","https://openalex.org/W1999032458","https://openalex.org/W1999477136","https://openalex.org/W1999921360","https://openalex.org/W2000409052","https://openalex.org/W2002090084","https://openalex.org/W2005997790","https://openalex.org/W2006022142","https://openalex.org/W2009128541","https://openalex.org/W2010292457","https://openalex.org/W2011317736","https://openalex.org/W2012418095","https://openalex.org/W2013110945","https://openalex.org/W2013339424","https://openalex.org/W2017117976","https://openalex.org/W2017525855","https://openalex.org/W2017529721","https://openalex.org/W2018659819","https://openalex.org/W2018694503","https://openalex.org/W2019341627","https://openalex.org/W2020677693","https://openalex.org/W2021309301","https://openalex.org/W2022051404","https://openalex.org/W2022161896","https://openalex.org/W2023095530","https://openalex.org/W2024238110","https://openalex.org/W2024782183","https://openalex.org/W2025426978","https://openalex.org/W2028945975","https://openalex.org/W2029265132","https://openalex.org/W2032022203","https://openalex.org/W2033221692","https://openalex.org/W2037825839","https://openalex.org/W2040224436","https://openalex.org/W2044287438","https://openalex.org/W2045777307","https://openalex.org/W2045929752","https://openalex.org/W2046481514","https://openalex.org/W2047945565","https://openalex.org/W2048432477","https://openalex.org/W2051621675","https://openalex.org/W2052661082","https://openalex.org/W2054059225","https://openalex.org/W2054502486","https://openalex.org/W2054758448","https://openalex.org/W2054791517","https://openalex.org/W2056595894","https://openalex.org/W2057162313","https://openalex.org/W2057385026","https://openalex.org/W2058035711","https://openalex.org/W2058462185","https://openalex.org/W2058484936","https://openalex.org/W2059462364","https://openalex.org/W2060595290","https://openalex.org/W2061050157","https://openalex.org/W2063269133","https://openalex.org/W2063713887","https://openalex.org/W2064421218","https://openalex.org/W2067202227","https://openalex.org/W2067395327","https://openalex.org/W2068213179","https://openalex.org/W2068275754","https://openalex.org/W2069384750","https://openalex.org/W2070997089","https://openalex.org/W2071816222","https://openalex.org/W2074111563","https://openalex.org/W2074134296","https://openalex.org/W2074467340","https://openalex.org/W2078023359","https://openalex.org/W2078511860","https://openalex.org/W2082602163","https://openalex.org/W2082649271","https://openalex.org/W2083621902","https://openalex.org/W2085175631","https://openalex.org/W2088381487","https://openalex.org/W2089897141","https://openalex.org/W2090363184","https://openalex.org/W2091535737","https://openalex.org/W2092538690","https://openalex.org/W2092587339","https://openalex.org/W2094371012","https://openalex.org/W2095384215","https://openalex.org/W2097125495","https://openalex.org/W2097164847","https://openalex.org/W2098812571","https://openalex.org/W2099627867","https://openalex.org/W2100598897","https://openalex.org/W2101717366","https://openalex.org/W2102795115","https://openalex.org/W2103296967","https://openalex.org/W2105754268","https://openalex.org/W2106244962","https://openalex.org/W2108470302","https://openalex.org/W2109281577","https://openalex.org/W2109350663","https://openalex.org/W2110435452","https://openalex.org/W2113279188","https://openalex.org/W2115446988","https://openalex.org/W2115527176","https://openalex.org/W2117061686","https://openalex.org/W2117905612","https://openalex.org/W2119194326","https://openalex.org/W2119651404","https://openalex.org/W2120662385","https://openalex.org/W2124466665","https://openalex.org/W2124904972","https://openalex.org/W2130303726","https://openalex.org/W2133102806","https://openalex.org/W2135020156","https://openalex.org/W2135532366","https://openalex.org/W2135682056","https://openalex.org/W2136201006","https://openalex.org/W2136829516","https://openalex.org/W2138083025","https://openalex.org/W2139316770","https://openalex.org/W2140664473","https://openalex.org/W2140955159","https://openalex.org/W2141747730","https://openalex.org/W2143500687","https://openalex.org/W2143659623","https://openalex.org/W2144534399","https://openalex.org/W2146675224","https://openalex.org/W2147300658","https://openalex.org/W2148505202","https://openalex.org/W2149761960","https://openalex.org/W2149930529","https://openalex.org/W2150925238","https://openalex.org/W2151007518","https://openalex.org/W2151325719","https://openalex.org/W2154164675","https://openalex.org/W2158059089","https://openalex.org/W2159826688","https://openalex.org/W2160182641","https://openalex.org/W2162179975","https://openalex.org/W2164454836","https://openalex.org/W2165186407","https://openalex.org/W2168591052","https://openalex.org/W2168634908","https://openalex.org/W2169060533","https://openalex.org/W2171671996","https://openalex.org/W2186273128","https://openalex.org/W2307142541","https://openalex.org/W2323175837","https://openalex.org/W2410155406","https://openalex.org/W3171781738","https://openalex.org/W7098997929"],"related_works":["https://openalex.org/W7028170078","https://openalex.org/W2006192534","https://openalex.org/W2588507906","https://openalex.org/W2114123456","https://openalex.org/W3031579022","https://openalex.org/W1869632046","https://openalex.org/W2597385525","https://openalex.org/W1984571004","https://openalex.org/W1954132003","https://openalex.org/W2774418701"],"abstract_inverted_index":{"The":[0,78,105,332],"process":[1,133,202,307],"of":[2,29,41,70,86,107,144,173,179,194,203,230,256,273,308,349],"aging":[3,14,54,87,103,118,338],"is":[4,15,97,163,217,221,278,339],"defined":[5],"as":[6,20,117],"a":[7,37,132,201,238,291],"time-dependent":[8],"decline":[9],"in":[10,80,120,135,299,320],"cellular":[11,64,146,354],"functionality,":[12],"and":[13,33,44,109,142,166,251,283,288,325,337,356],"thought":[16],"to":[17,75,115,285,328],"have":[18,156,198],"evolved":[19,200],"organisms":[21],"were":[22],"optimized":[23],"for":[24,247,294,315],"reproduction,":[25],"at":[26,59],"the":[27,67,84,90,95,139,145,171,188,192,214,234,257,271,286,295,306,316,323],"cost":[28],"an":[30,164,312],"imperfect":[31],"repair":[32],"maintenance":[34],"system.":[35,151],"As":[36],"consequence,":[38],"different":[39],"kinds":[40],"dysfunctional":[42,51],"components":[43,143],"damage":[45,161,209,249],"accumulate":[46],"over":[47],"time.":[48],"Eventually":[49],"these":[50,350],"components,":[52],"termed":[53],"factors,":[55],"reach":[56],"critical":[57],"levels":[58,348],"which":[60],"they":[61],"interfere":[62],"with":[63,322],"systems,":[65],"causing":[66],"age-related":[68],"loss":[69],"function":[71],"that":[72,94,134,158,207,210,244,270,305,346],"ultimately":[73],"leads":[74],"cell":[76,130,190,216],"death.":[77],"investment":[79],"propagation":[81],"also":[82,199],"encompasses":[83],"retention":[85,193],"factors":[88,119],"within":[89,187],"progenitor":[91],"cell,":[92],"so":[93,206],"progeny":[96],"born":[98],"rejuvenated,":[99],"free":[100],"from":[101],"damaging":[102],"factors.":[104],"accumulation":[106],"oxidized":[108],"aggregated":[110,330],"proteins":[111,125],"has":[112],"been":[113],"established":[114,157],"act":[116],"several":[121,255],"organisms.":[122],"These":[123],"damaged":[124],"are":[126,245],"asymmetrically":[127],"distributed":[128],"during":[129],"division,":[131],"yeast":[136],"relies":[137],"on":[138,280],"actin":[140],"cytoskeleton":[141],"protein":[147,180,335],"quality":[148,184],"control":[149,185],"(PQC)":[150],"In":[152,237],"my":[153],"work,":[154],"I":[155],"this":[159,248,263,266,300],"asymmetric":[160],"segregation":[162],"active":[165],"factordependent":[167],"process,":[168],"accomplished":[169],"through":[170],"actions":[172],"two":[174],"interconnected":[175],"systems.":[176],"Mainly,":[177],"sequestration":[178,272],"aggregates":[181,231,274],"into":[182,213,233,275],"certain":[183],"sites":[186],"mother":[189,235],"ensures":[191],"damage,":[195],"but":[196],"cells":[197],"aggregate":[204,309],"removal":[205,220,310],"any":[208],"accidentally":[211],"leaks":[212],"daughter":[215],"removed.":[218],"This":[219],"achieved":[222],"either":[223],"by":[224,227,342],"degradation":[225],"or":[226],"retrograde":[228],"transport":[229,282],"back":[232],"cell.":[236],"genome-wide":[239],"screen":[240],"we":[241,268,289,303],"identified":[242,290,351],"functions":[243],"required":[246],"distribution,":[250],"could":[252],"further":[253,340],"pinpoint":[254],"asymmetry":[258],"generating":[259],"genes":[260],"(AGGs)":[261],"regulating":[262],"process.":[264,301],"Through":[265],"approach,":[267],"found":[269,304],"protective":[276],"inclusions":[277],"dependent":[279],"vesicle":[281],"fusion":[284],"vacuole,":[287],"novel":[292],"role":[293,314],"vacuole":[296],"adaptor":[297],"Vac17":[298],"Additionally,":[302],"includes":[311],"unexpected":[313],"metacaspase":[317],"Mca1,":[318],"acting":[319],"conjunction":[321],"proteasome":[324],"PQC":[326],"system":[327],"degrade":[329],"proteins.":[331],"link":[333],"between":[334],"aggregation":[336],"reinforced":[341],"our":[343],"data":[344],"demonstrating":[345],"altered":[347],"AGGs":[352],"affect":[353],"fitness":[355],"longevity.":[357]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
