{"id":"https://openalex.org/W2149019730","doi":"https://doi.org/10.1371/journal.pbio.1001987","title":"Structural and Mechanistic Basis of Zinc Regulation Across the E. coli Zur Regulon","display_name":"Structural and Mechanistic Basis of Zinc Regulation Across the E. coli Zur Regulon","publication_year":2014,"publication_date":"2014-11-04","ids":{"openalex":"https://openalex.org/W2149019730","doi":"https://doi.org/10.1371/journal.pbio.1001987","mag":"2149019730","pmid":"https://pubmed.ncbi.nlm.nih.gov/25369000","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219657"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pbio.1001987","doi":"https://doi.org/10.1371/journal.pbio.1001987","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.1001987","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001987&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001987&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071622675","display_name":"Benjamin A. Gilston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin A. Gilston","raw_affiliation_strings":["Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057524603","display_name":"Suning Wang","orcid":"https://orcid.org/0000-0003-0889-251X","observed_orcids":["https://orcid.org/0000-0003-0889-251X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suning Wang","raw_affiliation_strings":["Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047800035","display_name":"Mason D. Marcus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mason D. Marcus","raw_affiliation_strings":["Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085251592","display_name":"M\u00f3nica A. Canalizo-Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M\u00f3nica A. Canalizo-Hern\u00e1ndez","raw_affiliation_strings":["Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066534101","display_name":"Elden P. Swindell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elden P. Swindell","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065077055","display_name":"Yi Xue","orcid":"https://orcid.org/0000-0002-9921-8637","observed_orcids":["https://orcid.org/0000-0002-9921-8637","https://orcid.org/0009-0000-2364-9556"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Xue","raw_affiliation_strings":["Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034562839","display_name":"Alfonso Mondrag\u00f3n","orcid":"https://orcid.org/0000-0002-0423-6323","observed_orcids":["https://orcid.org/0000-0002-0423-6323"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alfonso Mondrag\u00f3n","raw_affiliation_strings":["Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081257186","display_name":"Thomas V. O\u2019Halloran","orcid":"https://orcid.org/0000-0001-8732-5059","observed_orcids":["https://orcid.org/0000-0001-8732-5059"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas V. O'Halloran","raw_affiliation_strings":["Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America","Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America","Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]},{"raw_affiliation_string":"Department of Chemistry and The Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]},{"raw_affiliation_string":"Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034562839","https://openalex.org/A5081257186"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":6.0303,"has_fulltext":true,"cited_by_count":115,"citation_normalized_percentile":{"value":0.97146665,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"12","issue":"11","first_page":"e1001987","last_page":"e1001987"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-regulation","display_name":"zinc regulation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/metalloregulation","display_name":"metalloregulation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8169999718666077},{"id":"https://openalex.org/keywords/salt-bridges","display_name":"salt bridges","score":0.7789999842643738},{"id":"https://openalex.org/keywords/zinc-uptake","display_name":"zinc uptake","score":0.34599998593330383},{"id":"https://openalex.org/keywords/gene-repression","display_name":"gene repression","score":0.47999998927116394},{"id":"https://openalex.org/keywords/promoter-binding-affinity","display_name":"promoter binding affinity","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C62361671","wikidata":"https://www.wikidata.org/wiki/Q1754612","display_name":"Regulon","level":4,"score":0.9507019519805908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.909214973449707},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.5081508159637451},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4028889536857605},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3243873715400696},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.3164728581905365},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11517855525016785},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018085","descriptor_name":"Regulon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pbio.1001987","doi":"https://doi.org/10.1371/journal.pbio.1001987","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.1001987","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001987&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3196643","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219657","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4219657","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219657","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biol","raw_type":"Text"},{"id":"pmid:25369000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25369000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.723.1594","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.723.1594","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://sites.northwestern.edu/ohalloran/files/2015/03/Gilston_et_al_2014-25uq4ay.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f3850d6e0af944b6981c9546c2fcd0fc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f3850d6e0af944b6981c9546c2fcd0fc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Biology, Vol 12, Iss 11, p e1001987 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1228679","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Structural_and_Mechanistic_Basis_of_Zinc_Regulation_Across_the_E_coli_Zur_Regulon/1228679","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pbio.1001987","doi":"https://doi.org/10.1371/journal.pbio.1001987","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.1001987","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001987&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5792209259","display_name":"The Coding, Decoding, Transfer, and Translation of Information in Cancer","funder_award_id":"U54CA143869","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000289266","display_name":null,"funder_award_id":"GM038784","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880892","display_name":"Metalloregulation by MerR and Fur Protein Families","funder_award_id":"R01GM038784","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000891045","display_name":"The Robert H. Lurie Comprehensive Cancer Center","funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149019730.pdf","grobid_xml":"https://content.openalex.org/works/W2149019730.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W2636846","https://openalex.org/W88594106","https://openalex.org/W255996521","https://openalex.org/W1513508587","https://openalex.org/W1517316728","https://openalex.org/W1562374859","https://openalex.org/W1596689072","https://openalex.org/W1896819824","https://openalex.org/W1925104015","https://openalex.org/W1970053569","https://openalex.org/W1971607996","https://openalex.org/W1971706626","https://openalex.org/W1974248955","https://openalex.org/W1976136586","https://openalex.org/W1978836455","https://openalex.org/W1980584256","https://openalex.org/W1981779495","https://openalex.org/W1982757640","https://openalex.org/W1983705122","https://openalex.org/W1983725277","https://openalex.org/W1985064257","https://openalex.org/W1986391807","https://openalex.org/W1989041026","https://openalex.org/W1994066836","https://openalex.org/W1994829379","https://openalex.org/W2001641653","https://openalex.org/W2002419486","https://openalex.org/W2003090592","https://openalex.org/W2005067834","https://openalex.org/W2008122960","https://openalex.org/W2011138772","https://openalex.org/W2011515525","https://openalex.org/W2020024628","https://openalex.org/W2023693194","https://openalex.org/W2026765312","https://openalex.org/W2026911129","https://openalex.org/W2028892831","https://openalex.org/W2033731486","https://openalex.org/W2035594105","https://openalex.org/W2037763527","https://openalex.org/W2041530643","https://openalex.org/W2043915983","https://openalex.org/W2051328663","https://openalex.org/W2051485869","https://openalex.org/W2055228856","https://openalex.org/W2058170418","https://openalex.org/W2060367669","https://openalex.org/W2071510721","https://openalex.org/W2072284723","https://openalex.org/W2073169023","https://openalex.org/W2085328815","https://openalex.org/W2088167775","https://openalex.org/W2090075451","https://openalex.org/W2090196960","https://openalex.org/W2090811119","https://openalex.org/W2091035197","https://openalex.org/W2091552877","https://openalex.org/W2092688531","https://openalex.org/W2098798603","https://openalex.org/W2106744394","https://openalex.org/W2106882534","https://openalex.org/W2110830984","https://openalex.org/W2111026193","https://openalex.org/W2114622716","https://openalex.org/W2117175955","https://openalex.org/W2117725451","https://openalex.org/W2121293808","https://openalex.org/W2121890443","https://openalex.org/W2122339645","https://openalex.org/W2122558603","https://openalex.org/W2124026197","https://openalex.org/W2127660025","https://openalex.org/W2134558250","https://openalex.org/W2134640814","https://openalex.org/W2138956992","https://openalex.org/W2139286759","https://openalex.org/W2139802399","https://openalex.org/W2143496335","https://openalex.org/W2144081223","https://openalex.org/W2147431408","https://openalex.org/W2155844132","https://openalex.org/W2156450502","https://openalex.org/W2156485109","https://openalex.org/W2157917726","https://openalex.org/W2161006313","https://openalex.org/W2163295499","https://openalex.org/W2163618966","https://openalex.org/W2164079892","https://openalex.org/W2168026977","https://openalex.org/W2171266347","https://openalex.org/W2171925124","https://openalex.org/W2180229411","https://openalex.org/W2324971294","https://openalex.org/W2412963709","https://openalex.org/W2610992557","https://openalex.org/W6603555831"],"related_works":["https://openalex.org/W6892315889","https://openalex.org/W7097522242","https://openalex.org/W4391787104","https://openalex.org/W2060367669","https://openalex.org/W1971706626","https://openalex.org/W3004695264","https://openalex.org/W2156450502","https://openalex.org/W2051328663","https://openalex.org/W7098852879","https://openalex.org/W3164620277"],"abstract_inverted_index":{"Commensal":[0],"microbes,":[1],"whether":[2],"they":[3],"are":[4,8],"beneficial":[5],"or":[6,15,169],"pathogenic,":[7],"sensitive":[9],"to":[10,34,74,96,135],"host":[11],"processes":[12],"that":[13,80,124,234,243,252],"starve":[14],"swamp":[16],"the":[17,40,45,49,59,68,75,99,105,131,136,143,187,235,253,257,263],"prokaryote":[18],"with":[19,166,173,262],"large":[20],"fluctuations":[21],"in":[22,36,63,109,155,188,212,220],"local":[23],"zinc":[24,37,51,157],"concentration.":[25],"To":[26],"understand":[27],"how":[28],"microorganisms":[29],"coordinate":[30],"a":[31,88,114,139,156,229],"dynamic":[32],"response":[33,265],"changes":[35],"availability":[38],"at":[39,56,180,193,266],"molecular":[41,46],"level,":[42],"we":[43],"evaluated":[44],"mechanism":[47],"of":[48,58,70,92,102,104,116,130,138,142,186,195,208,216,237,256],"zinc-sensing":[50],"uptake":[52,239],"regulator":[53,240],"(Zur)":[54],"protein":[55,83],"each":[57,103,194],"known":[60],"Zur-regulated":[61,106],"genes":[62],"Escherichia":[64],"coli.":[65],"We":[66,146,232],"solved":[67],"structure":[69],"zinc-loaded":[71],"Zur":[72,154,171,182,209],"bound":[73],"P(znuABC)":[76],"promoter":[77,162,248],"and":[78,122,222,251],"show":[79],"this":[81,148,226],"metalloregulatory":[82],"represses":[84],"gene":[85,149],"expression":[86],"by":[87,153,214],"highly":[89],"cooperative":[90],"binding":[91,191,204],"two":[93,170],"adjacent":[94],"dimers":[95,172,242],"essentially":[97],"encircle":[98],"core":[100],"element":[101],"promoters.":[107,184,268],"Cooperativity":[108],"these":[110],"protein-DNA":[111,132,176],"interactions":[112,259],"requires":[113],"pair":[115],"asymmetric":[117],"salt":[118],"bridges":[119],"between":[120],"Arg52":[121],"Asp49'":[123],"connect":[125],"otherwise":[126],"independent":[127],"dimers.":[128],"Analysis":[129],"interface":[133],"led":[134],"discovery":[137],"new":[140],"member":[141],"Zur-regulon:":[144],"pliG.":[145],"demonstrate":[147],"is":[150],"directly":[151,260],"regulated":[152],"responsive":[158],"manner.":[159],"The":[160,206],"pliG":[161],"forms":[163],"stable":[164],"complexes":[165],"either":[167],"one":[168],"significantly":[174,250],"less":[175],"cooperativity":[177],"than":[178],"observed":[179,211],"other":[181],"regulon":[183],"Comparison":[185],"vitro":[189],"Zur-DNA":[190,203,258],"affinity":[192],"four":[196],"Zur-regulon":[197],"promoters":[198],"reveals":[199],"ca.":[200],"10,000-fold":[201],"variation":[202],"constants.":[205],"degree":[207],"repression":[210],"vivo":[213],"comparison":[215],"transcript":[217],"copy":[218],"number":[219,236],"wild-type":[221],"\u0394zur":[223],"strains":[224],"parallels":[225],"trend":[227],"spanning":[228],"100-fold":[230],"difference.":[231],"conclude":[233],"ferric":[238],"(Fur)-family":[241],"bind":[244],"within":[245],"any":[246],"given":[247],"varies":[249],"thermodynamic":[254],"profile":[255],"correlates":[261],"physiological":[264],"different":[267]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
