{"id":"https://openalex.org/W2149016997","doi":"https://doi.org/10.1086/518234","title":"Clinical, Immunological, and Epidemiological Importance of Antituberculosis T Cell Responses in HIV-Infected Africans","display_name":"Clinical, Immunological, and Epidemiological Importance of Antituberculosis T Cell Responses in HIV-Infected Africans","publication_year":2007,"publication_date":"2007-05-23","ids":{"openalex":"https://openalex.org/W2149016997","doi":"https://doi.org/10.1086/518234","mag":"2149016997","pmid":"https://pubmed.ncbi.nlm.nih.gov/17516410"},"language":"en","primary_location":{"id":"doi:10.1086/518234","doi":"https://doi.org/10.1086/518234","is_oa":false,"landing_page_url":"https://doi.org/10.1086/518234","pdf_url":null,"source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041286625","display_name":"Molebogeng X. Rangaka","orcid":"https://orcid.org/0000-0001-9594-188X","observed_orcids":["https://orcid.org/0000-0001-9594-188X"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"M. X. Rangaka","raw_affiliation_strings":["Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","Medicins Sans Frontieres, Khayelitsha site B, Khayelitsha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]},{"raw_affiliation_string":"Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","institution_ids":["https://openalex.org/I4405266898"]},{"raw_affiliation_string":"Medicins Sans Frontieres, Khayelitsha site B, Khayelitsha","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016042953","display_name":"Lavanya Diwakar","orcid":"https://orcid.org/0000-0003-4369-6637","observed_orcids":["https://orcid.org/0000-0003-4369-6637"]},"institutions":[{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"L. Diwakar","raw_affiliation_strings":["Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","institution_ids":["https://openalex.org/I4405266898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082159533","display_name":"Ronnett Seldon","orcid":"https://orcid.org/0000-0002-0357-7222","observed_orcids":["https://orcid.org/0000-0002-0357-7222"]},"institutions":[{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"R. Seldon","raw_affiliation_strings":["Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","institution_ids":["https://openalex.org/I4405266898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089652265","display_name":"Gilles Van Cutsem","orcid":"https://orcid.org/0000-0002-8972-4480","observed_orcids":["https://orcid.org/0000-0002-8972-4480"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. van Cutsem","raw_affiliation_strings":["Medicins Sans Frontieres, Khayelitsha site B, Khayelitsha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicins Sans Frontieres, Khayelitsha site B, Khayelitsha","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009435222","display_name":"Graeme Meintjes","orcid":"https://orcid.org/0000-0003-1196-4414","observed_orcids":["https://orcid.org/0000-0003-1196-4414"]},"institutions":[{"id":"https://openalex.org/I4210158272","display_name":"GF Jooste Hospital","ror":"https://ror.org/00f9c2f73","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210158272"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"G. A. Meintjes","raw_affiliation_strings":["G.F. Jooste Hospital, Manenberg, South Africa","Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G.F. Jooste Hospital, Manenberg, South Africa","institution_ids":["https://openalex.org/I4210158272"]},{"raw_affiliation_string":"Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","institution_ids":["https://openalex.org/I4405266898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091154429","display_name":"Chelsea Morroni","orcid":"https://orcid.org/0000-0002-2026-6039","observed_orcids":["https://orcid.org/0000-0002-2026-6039"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"C. Morroni","raw_affiliation_strings":["School of Public Health, University of Cape Town, Cape Town"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University of Cape Town, Cape Town","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Mouton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"P. Mouton","raw_affiliation_strings":["Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","Medicins Sans Frontieres, Khayelitsha site B, Khayelitsha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","institution_ids":["https://openalex.org/I4405266898"]},{"raw_affiliation_string":"Medicins Sans Frontieres, Khayelitsha site B, Khayelitsha","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023370526","display_name":"Muki Shehu Shey","orcid":"https://orcid.org/0000-0002-8776-4737","observed_orcids":["https://orcid.org/0000-0002-8776-4737"]},"institutions":[{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"M. S. Shey","raw_affiliation_strings":["Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","institution_ids":["https://openalex.org/I4405266898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034322602","display_name":"Gary Maartens","orcid":"https://orcid.org/0000-0003-3080-6606","observed_orcids":["https://orcid.org/0000-0003-3080-6606"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"G. Maartens","raw_affiliation_strings":["Department of Medicine, University of Cape Town, Cape Town","Division of Pharmacology, University of Cape Town, Cape Town","Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cape Town, Cape Town","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"Division of Pharmacology, University of Cape Town, Cape Town","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","institution_ids":["https://openalex.org/I4405266898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029827704","display_name":"Katalin Andrea Wilkinson","orcid":"https://orcid.org/0000-0002-9796-2040","observed_orcids":["https://orcid.org/0000-0002-9796-2040"]},"institutions":[{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","ZA"],"is_corresponding":false,"raw_author_name":"K. A. Wilkinson","raw_affiliation_strings":["Division of Medicine, Imperial College London, United Kingdom","Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine, Imperial College London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","institution_ids":["https://openalex.org/I4405266898"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029089921","display_name":"Robert John Wilkinson","orcid":"https://orcid.org/0000-0002-2753-1800","observed_orcids":["https://orcid.org/0000-0002-2753-1800","https://orcid.org/0000-0001-8966-5217"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4210158272","display_name":"GF Jooste Hospital","ror":"https://ror.org/00f9c2f73","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210158272"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","ZA"],"is_corresponding":true,"raw_author_name":"R. J. Wilkinson","raw_affiliation_strings":["Department of Medicine, University of Cape Town, Cape Town","Division of Medicine, Imperial College London, United Kingdom","G.F. Jooste Hospital, Manenberg, South Africa","Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cape Town, Cape Town","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"Division of Medicine, Imperial College London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"G.F. Jooste Hospital, Manenberg, South Africa","institution_ids":["https://openalex.org/I4210158272"]},{"raw_affiliation_string":"Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Cape Town","institution_ids":["https://openalex.org/I4405266898"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029089921"],"corresponding_institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4210158272","https://openalex.org/I4405266898","https://openalex.org/I47508984"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":9.6847,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.98586444,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"44","issue":"12","first_page":"1639","last_page":"1646"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-tuberculosis","display_name":"HIV-associated tuberculosis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/interferon-gamma-release-assay","display_name":"interferon-gamma release assay","score":0.8479999899864197},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.6349999904632568},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis-antigens","display_name":"Mycobacterium tuberculosis antigens","score":0.8669999837875366},{"id":"https://openalex.org/keywords/latent-tuberculosis-infection","display_name":"latent tuberculosis infection","score":0.722000002861023},{"id":"https://openalex.org/keywords/pulmonary-tuberculosis-diagnosis","display_name":"pulmonary tuberculosis diagnosis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.8939999938011169},{"id":"https://openalex.org/keywords/purified-protein-derivative","display_name":"purified protein derivative","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hiv-coinfection","display_name":"HIV coinfection","score":0.7720000147819519},{"id":"https://openalex.org/keywords/south-africa","display_name":"South Africa","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.8529200553894043},{"id":"https://openalex.org/C2776247216","wikidata":"https://www.wikidata.org/wiki/Q29505","display_name":"Tuberculin","level":3,"score":0.7657605409622192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7546883225440979},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6747300624847412},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6684023141860962},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6660393476486206},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.46843013167381287},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4526902139186859},{"id":"https://openalex.org/C2779806340","wikidata":"https://www.wikidata.org/wiki/Q4254929","display_name":"Latent tuberculosis","level":4,"score":0.42374327778816223},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.17616680264472961},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08610495924949646}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013019","descriptor_name":"South Africa","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014374","descriptor_name":"Tuberculin Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1086/518234","doi":"https://doi.org/10.1086/518234","is_oa":false,"landing_page_url":"https://doi.org/10.1086/518234","pdf_url":null,"source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:17516410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17516410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","raw_type":"Comparative Study"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1491448","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1491448/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CLINICAL INFECTIOUS DISEASES , 44 (12) pp. 1639-1646. (2007)","raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/3301d8e8-806c-4b3e-a530-de07b449f11e","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/3301d8e8-806c-4b3e-a530-de07b449f11e","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rangaka, M X, Diwakar, L, Seldon, R, van Cutsem, G, Meintjes, G A, Morroni, C, Mouton, P, Shey, M S, Maartens, G, Wilkinson, K A, Wilkinson, R J & Diwakar, L 2007, 'Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans', Clinical Infectious Diseases, vol. 44, no. 12, pp. 1639-46. https://doi.org/10.1086/518234","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2602281208","display_name":"Understanding tuberculosis in Cape Town, South Africa","funder_award_id":"072070","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322482","display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky","ror":"https://ror.org/053avzc18"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W621985138","https://openalex.org/W1552600293","https://openalex.org/W1610934367","https://openalex.org/W1967036949","https://openalex.org/W1967622121","https://openalex.org/W1968713190","https://openalex.org/W1971661340","https://openalex.org/W1971675185","https://openalex.org/W1987531965","https://openalex.org/W1996511651","https://openalex.org/W2017793579","https://openalex.org/W2032833657","https://openalex.org/W2033702088","https://openalex.org/W2035796116","https://openalex.org/W2055666958","https://openalex.org/W2060263894","https://openalex.org/W2080969088","https://openalex.org/W2097640558","https://openalex.org/W2100757327","https://openalex.org/W2100894095","https://openalex.org/W2101528550","https://openalex.org/W2108723412","https://openalex.org/W2113724100","https://openalex.org/W2116616469","https://openalex.org/W2129851742","https://openalex.org/W2132180171","https://openalex.org/W2139996374","https://openalex.org/W2144010669","https://openalex.org/W2144128004","https://openalex.org/W2144472266","https://openalex.org/W2150151832","https://openalex.org/W2153250672","https://openalex.org/W2157950610","https://openalex.org/W2159022800","https://openalex.org/W2160239525","https://openalex.org/W2162228209","https://openalex.org/W2168466885","https://openalex.org/W2396803800"],"related_works":["https://openalex.org/W2049340389","https://openalex.org/W2033702088","https://openalex.org/W2162148281","https://openalex.org/W2033041534","https://openalex.org/W2015588562","https://openalex.org/W7100276116","https://openalex.org/W1986957434","https://openalex.org/W2133195160","https://openalex.org/W2037023586","https://openalex.org/W1983258000"],"abstract_inverted_index":{"BACKGROUND:":[0],"Human":[1],"immunodeficiency":[2],"virus":[3],"(HIV)-associated":[4],"tuberculosis":[5,55,84,90,128,152,174,206,247,283],"is":[6,33,289],"a":[7,34,147],"major":[8],"cause":[9],"of":[10,16,26,150,202,222,235,281],"mortality":[11],"in":[12,22,50,77,91,108,116,155,199,248,284],"Africa.":[13,94],"The":[14,96,265],"assay":[15,64,102,164],"T":[17],"cell":[18,218,233,276],"interferon-":[19],"gamma":[20],"released":[21],"response":[23,185,228],"to":[24,104,126,186,255,268,278],"antigens":[25,129],"greater":[27],"specificity":[28,243],"than":[29,259],"purified":[30,105],"protein":[31,106,137,195],"derivative":[32,107],"useful":[35],"improvement":[36],"over":[37],"the":[38,72,124,170,181,200,223,231,270],"Mantoux":[39,73],"tuberculin":[40,74],"skin":[41,75,97,260],"test,":[42],"but":[43,180],"few":[44],"studies":[45],"have":[46],"evaluated":[47],"interferon-gamma":[48,57],"secretion":[49,58],"HIV-infected":[51,78,86,203,249],"individuals.":[52,250],"METHODS:":[53],"Mycobacterium":[54],"antigen-specific":[56],"was":[59,197],"assessed":[60],"by":[61,230,262],"whole":[62,100],"blood":[63,101,163],"and":[65,79,85,99,140,158,175,192,241,274,291],"enzyme-linked":[66,182,225,271],"immunospot,":[67],"which":[68],"were":[69,111,143],"compared":[70,113],"with":[71,88,114,178,205,286],"test":[76,98],"HIV-uninfected":[80],"individuals":[81],"without":[82,173],"active":[83,245,282],"patients":[87,285],"pulmonary":[89,246],"Khayelitsha,":[92],"South":[93],"RESULTS:":[95],"responses":[103,115,125,165],"HIV-positive":[109,159,171,176],"subjects":[110,118,172,177,204],"decreased,":[112],"HIV-negative":[117,157],"(P":[119,207],"<":[120,208],".001).":[121],"By":[122],"contrast,":[123],"M.":[127],"(early":[130],"secreted":[131,188],"antigenic":[132,189],"target":[133,190],"6,":[134],"culture":[135,193],"filtrate":[136,194],"10,":[138],"TB10.3,":[139],"alpha-crystallin":[141],"2)":[142],"less":[144,257],"affected,":[145],"indicating":[146],"high":[148],"prevalence":[149],"latent":[151],"(approximately":[153],"80%)":[154],"both":[156],"subject":[160],"groups.":[161],"Whole":[162],"did":[166],"not":[167],"differ":[168],"between":[169],"tuberculosis,":[179],"immunospot":[183,226,272],"method":[184,227,273],"early":[187],"6":[191],"10":[196],"higher":[198],"group":[201,214],"or":[209],"=":[210],".04),":[211],"although":[212],"this":[213],"had":[215,238],"lower":[216],"CD4+":[217,232,275],"counts.":[219],"A":[220],"ratio":[221],"combined":[224],"divided":[229],"count":[234,277],">":[236],"1.0":[237],"88%":[239],"sensitivity":[240],"80%":[242],"for":[244],"CONCLUSIONS:":[251],"Interferon-gamma":[252],"release":[253],"appears":[254],"be":[256],"impaired":[258],"testing":[261],"HIV":[263,287],"coinfection.":[264],"novel":[266],"potential":[267],"relate":[269],"assist":[279],"diagnosis":[280],"infection":[288],"important":[290],"deserves":[292],"further":[293],"evaluation.":[294]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}