{"id":"https://openalex.org/W2148985681","doi":"https://doi.org/10.1093/annonc/mdp521","title":"A window of opportunity phase II study of enzastaurin in chemonaive patients with asymptomatic metastatic colorectal cancer","display_name":"A window of opportunity phase II study of enzastaurin in chemonaive patients with asymptomatic metastatic colorectal cancer","publication_year":2009,"publication_date":"2009-11-10","ids":{"openalex":"https://openalex.org/W2148985681","doi":"https://doi.org/10.1093/annonc/mdp521","mag":"2148985681","pmid":"https://pubmed.ncbi.nlm.nih.gov/19901015"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdp521","doi":"https://doi.org/10.1093/annonc/mdp521","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdp521","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1093/annonc/mdp521","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057158252","display_name":"Bengt L. G. Glimelius","orcid":"https://orcid.org/0000-0002-5440-791X","observed_orcids":["https://orcid.org/0000-0002-5440-791X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"B. Glimelius","raw_affiliation_strings":["Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden. bengt.glimelius@onkologi.uu.se","Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden","Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden. bengt.glimelius@onkologi.uu.se","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101627113","display_name":"Michael M. F. Lahn","orcid":"https://orcid.org/0000-0001-9371-0316","observed_orcids":["https://orcid.org/0000-0001-9371-0316"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Lahn","raw_affiliation_strings":["Early Phase Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Phase Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065561614","display_name":"Sulochana R. Gawande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Gawande","raw_affiliation_strings":["Early Phase Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Phase Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064692327","display_name":"Ann Cleverly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Cleverly","raw_affiliation_strings":["Early Phase Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Phase Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012662423","display_name":"Christelle Darstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Darstein","raw_affiliation_strings":["Early Phase Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Phase Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022619396","display_name":"Luna C. Musib","orcid":"https://orcid.org/0000-0002-6476-7919","observed_orcids":["https://orcid.org/0000-0002-6476-7919"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Musib","raw_affiliation_strings":["Early Phase Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Phase Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023090761","display_name":"Y. Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Liu","raw_affiliation_strings":["Department of Statistics, i3 Statprobe Inc., Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, i3 Statprobe Inc., Austin, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113511092","display_name":"K.-L.G. Spindler","orcid":"https://orcid.org/0000-0001-8781-3212","observed_orcids":["https://orcid.org/0000-0001-8781-3212"]},"institutions":[{"id":"https://openalex.org/I4210091196","display_name":"Vejle Sygehus","ror":"https://ror.org/00e8ar137","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I4210091196","https://openalex.org/I4210142184"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"K.L. Spindler","raw_affiliation_strings":["Department of Medical Oncology, Vejle Hospital, Vejle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Vejle Hospital, Vejle","institution_ids":["https://openalex.org/I4210091196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010199908","display_name":"Jan\u2010Erik Fr\u00f6din","orcid":"https://orcid.org/0000-0003-1985-2046","observed_orcids":["https://orcid.org/0000-0003-1985-2046"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J.-E. Fr\u00f6din","raw_affiliation_strings":["Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013720146","display_name":"\u00c5ke Berglund","orcid":"https://orcid.org/0000-0002-5240-3106","observed_orcids":["https://orcid.org/0000-0002-5240-3106"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"\u00c5. Berglund","raw_affiliation_strings":["Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113614070","display_name":"Per Bystr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P. Bystr\u00f6m","raw_affiliation_strings":["Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027286810","display_name":"Camilla Qvortrup","orcid":"https://orcid.org/0000-0001-9338-9841","observed_orcids":["https://orcid.org/0000-0001-9338-9841"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"C. Qvortrup","raw_affiliation_strings":["Department of Medical Oncology, Odense University Hospital, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048866467","display_name":"Anders Kristian Moeller Jakobsen","orcid":"https://orcid.org/0000-0003-2110-2615","observed_orcids":["https://orcid.org/0000-0003-2110-2615"]},"institutions":[{"id":"https://openalex.org/I4210091196","display_name":"Vejle Sygehus","ror":"https://ror.org/00e8ar137","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I4210091196","https://openalex.org/I4210142184"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"A. Jakobsen","raw_affiliation_strings":["Department of Medical Oncology, Vejle Hospital, Vejle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Vejle Hospital, Vejle","institution_ids":["https://openalex.org/I4210091196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068848511","display_name":"Per Pfeiffer","orcid":"https://orcid.org/0000-0002-2925-0586","observed_orcids":["https://orcid.org/0000-0002-2925-0586"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P. Pfeiffer","raw_affiliation_strings":["Department of Medical Oncology, Odense University Hospital, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5057158252"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I28166907"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":2.0863,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.87613734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"21","issue":"5","first_page":"1020","last_page":"1026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzastaurin","display_name":"enzastaurin","score":1.0},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chemotherapy-naive-patients","display_name":"chemotherapy-naive patients","score":0.859000027179718},{"id":"https://openalex.org/keywords/asymptomatic-disease","display_name":"asymptomatic disease","score":0.7120000123977661},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9340000152587891},{"id":"https://openalex.org/keywords/protein-kinase-c-inhibition","display_name":"protein kinase C inhibition","score":0.9340000152587891},{"id":"https://openalex.org/keywords/akt-inhibition","display_name":"AKT inhibition","score":0.984000027179718},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6539999842643738},{"id":"https://openalex.org/keywords/liver-transaminase-elevation","display_name":"liver transaminase elevation","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9227502942085266},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7945078611373901},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6205991506576538},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6171954274177551},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4650472402572632},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44697415828704834},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42419975996017456},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4240197241306305},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3850358724594116},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3405676484107971},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3388945758342743}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064546","descriptor_name":"Protein Kinase C beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/annonc/mdp521","doi":"https://doi.org/10.1093/annonc/mdp521","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdp521","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},{"id":"pmid:19901015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19901015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of oncology : official journal of the European Society for Medical Oncology","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/032ce6a0-d7aa-11de-b0fe-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/032ce6a0-d7aa-11de-b0fe-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glimelius, B, Lahn, M, Gawande, S, Cleverly, A, Darstein, C, Musib, L, Liu, Y, Spindler, K L, Fr\u00f6din, J-E, Berglund, A, Bystr\u00f6m, P, Qvortrup, C, Jakobsen, A & Pfeiffer, P 2010, 'A window of opportunity phase II study of enzastaurin in chemonaive patients with asymptomatic metastatic colorectal cancer', Annals of Oncology, vol. 21, no. 5, pp. 1020-1026. https://doi.org/10.1093/annonc/mdp521","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:annonc:mdp521v1","doi":null,"is_oa":false,"landing_page_url":"http://annonc.oxfordjournals.org/cgi/content/short/mdp521v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdp521","doi":"https://doi.org/10.1093/annonc/mdp521","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdp521","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W582648795","https://openalex.org/W1600640558","https://openalex.org/W1899319598","https://openalex.org/W1955382134","https://openalex.org/W1978300921","https://openalex.org/W1989374274","https://openalex.org/W2020319797","https://openalex.org/W2020830322","https://openalex.org/W2026531617","https://openalex.org/W2051563018","https://openalex.org/W2057510061","https://openalex.org/W2070193531","https://openalex.org/W2093070825","https://openalex.org/W2096719319","https://openalex.org/W2102111150","https://openalex.org/W2105895314","https://openalex.org/W2118971132","https://openalex.org/W2119597015","https://openalex.org/W2119943104","https://openalex.org/W2120601121","https://openalex.org/W2123523854","https://openalex.org/W2126372596","https://openalex.org/W2135848030","https://openalex.org/W2139248078","https://openalex.org/W2145224595","https://openalex.org/W2147041307","https://openalex.org/W2149991723","https://openalex.org/W2154021552","https://openalex.org/W2157769714","https://openalex.org/W2165476238","https://openalex.org/W2170491292","https://openalex.org/W2170495279","https://openalex.org/W2172187886","https://openalex.org/W4246299175"],"related_works":["https://openalex.org/W2102111150","https://openalex.org/W2510202473","https://openalex.org/W6902082720","https://openalex.org/W1521529922","https://openalex.org/W4255519171","https://openalex.org/W2096515375","https://openalex.org/W2029113696","https://openalex.org/W4252681934","https://openalex.org/W2005090101","https://openalex.org/W582648795"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}