{"id":"https://openalex.org/W2148964367","doi":"https://doi.org/10.1128/aac.14.3.462","title":"Single-Dose Doxycycline for Cholera","display_name":"Single-Dose Doxycycline for Cholera","publication_year":1978,"publication_date":"1978-09-01","ids":{"openalex":"https://openalex.org/W2148964367","doi":"https://doi.org/10.1128/aac.14.3.462","mag":"2148964367","pmid":"https://pubmed.ncbi.nlm.nih.gov/708024","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/352482"},"language":"en","primary_location":{"id":"doi:10.1128/aac.14.3.462","doi":"https://doi.org/10.1128/aac.14.3.462","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.14.3.462","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352482","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041377151","display_name":"David Allen Sack","orcid":"https://orcid.org/0000-0002-9338-5119","observed_orcids":["https://orcid.org/0000-0002-9338-5119"]},"institutions":[{"id":"https://openalex.org/I205889620","display_name":"International Centre for Diarrhoeal Disease Research","ror":"https://ror.org/04vsvr128","country_code":"BD","type":"facility","lineage":["https://openalex.org/I205889620"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"David A. Sack","raw_affiliation_strings":["The Cholera Research Laboratory, Dacca, Bangladesh,2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Cholera Research Laboratory, Dacca, Bangladesh,2","institution_ids":["https://openalex.org/I205889620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022818072","display_name":"M. Sirajul Islam","orcid":"https://orcid.org/0000-0002-9673-7589","observed_orcids":["https://orcid.org/0000-0002-9673-7589"]},"institutions":[{"id":"https://openalex.org/I1339176976","display_name":"Mercy Medical Center","ror":"https://ror.org/009raxq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339176976"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I205889620","display_name":"International Centre for Diarrhoeal Disease Research","ror":"https://ror.org/04vsvr128","country_code":"BD","type":"facility","lineage":["https://openalex.org/I205889620"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["BD","US"],"is_corresponding":false,"raw_author_name":"Sirajul Islam","raw_affiliation_strings":["Division of Geographic Medicine, The Johns Hopkins University, Baltimore City Hospital, Baltimore, Maryland 212241","The Cholera Research Laboratory, Dacca, Bangladesh,","and The Division of Geographic Medicine, The Johns Hopkins University, Baltimore City Hospital, Baltimore, Maryland 21224'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geographic Medicine, The Johns Hopkins University, Baltimore City Hospital, Baltimore, Maryland 212241","institution_ids":["https://openalex.org/I1339176976","https://openalex.org/I145311948","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"The Cholera Research Laboratory, Dacca, Bangladesh,","institution_ids":["https://openalex.org/I205889620"]},{"raw_affiliation_string":"and The Division of Geographic Medicine, The Johns Hopkins University, Baltimore City Hospital, Baltimore, Maryland 21224'","institution_ids":["https://openalex.org/I1339176976","https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111962433","display_name":"H. Rabbani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339176976","display_name":"Mercy Medical Center","ror":"https://ror.org/009raxq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339176976"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I205889620","display_name":"International Centre for Diarrhoeal Disease Research","ror":"https://ror.org/04vsvr128","country_code":"BD","type":"facility","lineage":["https://openalex.org/I205889620"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["BD","US"],"is_corresponding":false,"raw_author_name":"Hassan Rabbani","raw_affiliation_strings":["Division of Geographic Medicine, The Johns Hopkins University, Baltimore City Hospital, Baltimore, Maryland 212241","The Cholera Research Laboratory, Dacca, Bangladesh,","and The Division of Geographic Medicine, The Johns Hopkins University, Baltimore City Hospital, Baltimore, Maryland 21224'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geographic Medicine, The Johns Hopkins University, Baltimore City Hospital, Baltimore, Maryland 212241","institution_ids":["https://openalex.org/I1339176976","https://openalex.org/I145311948","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"The Cholera Research Laboratory, Dacca, Bangladesh,","institution_ids":["https://openalex.org/I205889620"]},{"raw_affiliation_string":"and The Division of Geographic Medicine, The Johns Hopkins University, Baltimore City Hospital, Baltimore, Maryland 21224'","institution_ids":["https://openalex.org/I1339176976","https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040901329","display_name":"Asma Islam","orcid":"https://orcid.org/0000-0003-0233-0444","observed_orcids":["https://orcid.org/0000-0003-0233-0444"]},"institutions":[{"id":"https://openalex.org/I1339176976","display_name":"Mercy Medical Center","ror":"https://ror.org/009raxq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339176976"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asma Islam","raw_affiliation_strings":["Division of Geographic Medicine, The Johns Hopkins University, Baltimore City Hospital, Baltimore, Maryland 212241"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geographic Medicine, The Johns Hopkins University, Baltimore City Hospital, Baltimore, Maryland 212241","institution_ids":["https://openalex.org/I1339176976","https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.13748618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"14","issue":"3","first_page":"462","last_page":"464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cholera","display_name":"cholera","score":0.9789999723434448},{"id":"https://openalex.org/keywords/vibrio-cholerae","display_name":"Vibrio cholerae","score":0.9729999899864197},{"id":"https://openalex.org/keywords/single-dose-antibiotic-therapy","display_name":"single-dose antibiotic therapy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.7760000228881836},{"id":"https://openalex.org/keywords/antibiotic-uptake","display_name":"antibiotic uptake","score":0.4020000100135803},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.6029999852180481},{"id":"https://openalex.org/keywords/stool-culture","display_name":"stool culture","score":0.7139999866485596},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.9658100605010986},{"id":"https://openalex.org/C2780722889","wikidata":"https://www.wikidata.org/wiki/Q12090","display_name":"Cholera","level":2,"score":0.8140208721160889},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.7578037977218628},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.713167130947113},{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.6871768832206726},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6672999262809753},{"id":"https://openalex.org/C2778643871","wikidata":"https://www.wikidata.org/wiki/Q160821","display_name":"Vibrio cholerae","level":3,"score":0.6374412775039673},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5429274439811707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4444865882396698},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.23006677627563477},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.15916311740875244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1304364800453186},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.060487300157547},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002771","descriptor_name":"Cholera","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.14.3.462","doi":"https://doi.org/10.1128/aac.14.3.462","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.14.3.462","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:352482","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352482","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:708024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/708024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:352482","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352482","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W22685768","https://openalex.org/W61857418","https://openalex.org/W202799576","https://openalex.org/W207247961","https://openalex.org/W1771646220","https://openalex.org/W2300949575"],"related_works":["https://openalex.org/W2075254062","https://openalex.org/W2112056383","https://openalex.org/W207247961","https://openalex.org/W2089830519","https://openalex.org/W2058307863","https://openalex.org/W2145854371","https://openalex.org/W1972138771","https://openalex.org/W7217008854","https://openalex.org/W2972730169","https://openalex.org/W143861274"],"abstract_inverted_index":{"To":[0],"determine":[1],"the":[2,8,69,72,99,113,126,133,148],"efficacy":[3],"of":[4,10,24,29,32,47,74,79,84,89,122,132,150,164],"single-dose":[5],"doxycycline":[6,33,127,154],"in":[7,19,37,57,71,103,112,130,169],"treatment":[9],"cholera,":[11,153],"we":[12],"carried":[13],"out":[14],"a":[15,26,156,161],"randomized":[16],"prospective":[17],"trial":[18],"65":[20],"patients.":[21],"Treatment":[22],"consisted":[23],"either":[25],"single":[27,162],"dose":[28,163],"200":[30,165],"mg":[31,50,166],"(or":[34,54],"4":[35,52],"mg/kg":[36,56,168],"patients":[38,58,107],"less":[39,59],"than":[40,60,117],"15":[41,61],"years":[42,62],"old)":[43],"or":[44,82],"multiple":[45],"doses":[46],"doxycycline,":[48],"500":[49],"over":[51],"days":[53],"10":[55],"old).":[63],"There":[64],"were":[65],"no":[66],"differences":[67],"between":[68],"groups":[70,105],"volumes":[73,78],"intravenous":[75],"fluid":[76],"required,":[77],"diarrheal":[80],"stool,":[81],"durations":[83],"diarrhea.":[85,140],"The":[86],"mean":[87],"duration":[88],"positive":[90],"stool":[91,114],"cultures":[92],"for":[93,98,115,152],"Vibrio":[94],"cholerae":[95],"was":[96,128],"similar":[97],"two":[100],"groups,":[101],"although":[102,145],"both":[104],"several":[106],"continued":[108],"to":[109],"excrete":[110],"Vibrios":[111],"more":[116],"3":[118],"days.":[119],"Blood":[120],"levels":[121],"antibiotic":[123],"demonstrated":[124],"that":[125,144,160],"absorbed":[129],"spite":[131],"rapid":[134],"transit":[135],"time":[136],"associated":[137],"with":[138],"severe":[139],"These":[141],"results":[142],"suggest":[143],"tetracycline":[146],"remains":[147],"drug":[149],"choice":[151],"is":[155,171],"reasonable":[157],"alternative,":[158],"and":[159],"(4":[167],"children)":[170],"effective":[172],"clinically.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}