{"id":"https://openalex.org/W2148917087","doi":"https://doi.org/10.1172/jci119886","title":"Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.","display_name":"Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W2148917087","doi":"https://doi.org/10.1172/jci119886","mag":"2148917087","pmid":"https://pubmed.ncbi.nlm.nih.gov/9525973","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/508708"},"language":"en","primary_location":{"id":"doi:10.1172/jci119886","doi":"https://doi.org/10.1172/jci119886","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci119886","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC508685","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064222916","display_name":"Raymond Evers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R Evers","raw_affiliation_strings":["Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands","Division of Molecular Biology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Division of Molecular Biology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073211182","display_name":"Marcel Kool","orcid":"https://orcid.org/0000-0002-6557-5468","observed_orcids":["https://orcid.org/0000-0002-6557-5468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kool","raw_affiliation_strings":["Division of Molecular Biology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042002328","display_name":"Liesbeth van Deemter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L van Deemter","raw_affiliation_strings":["Division of Molecular Biology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107304886","display_name":"Hans Janssen","orcid":"https://orcid.org/0000-0001-7480-793X","observed_orcids":["https://orcid.org/0000-0001-7480-793X"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H Janssen","raw_affiliation_strings":["Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands;","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063187405","display_name":"Jero Calafat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J Calafat","raw_affiliation_strings":["Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands;","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111443877","display_name":"Lauran C. J. M. Oomen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L C Oomen","raw_affiliation_strings":["Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands;","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087413894","display_name":"Coen C. Paulusma","orcid":"https://orcid.org/0000-0001-7284-1974","observed_orcids":["https://orcid.org/0000-0001-7284-1974"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C C Paulusma","raw_affiliation_strings":["Department of Gastroenterology, and \u0288 Department of Neurology, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, and \u0288 Department of Neurology, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044314042","display_name":"Ronald P.J. Oude Elferink","orcid":"https://orcid.org/0000-0002-1779-0833","observed_orcids":["https://orcid.org/0000-0002-1779-0833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R P Oude Elferink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032625076","display_name":"Frank Baas","orcid":"https://orcid.org/0000-0003-3912-5428","observed_orcids":["https://orcid.org/0000-0003-3912-5428","https://orcid.org/0000-0001-7520-0021"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F Baas","raw_affiliation_strings":["Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands","The Netherlands Cancer Insti-tute, Antoni Van Leeuwenhoek Huis, Division of Molecular Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"The Netherlands Cancer Insti-tute, Antoni Van Leeuwenhoek Huis, Division of Molecular Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045217576","display_name":"Alfred H. Schinkel","orcid":"https://orcid.org/0000-0002-4215-8602","observed_orcids":["https://orcid.org/0000-0002-4215-8602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A H Schinkel","raw_affiliation_strings":["Division of Molecular Biology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060054431","display_name":"Piet Borst","orcid":"https://orcid.org/0000-0002-2527-9541","observed_orcids":["https://orcid.org/0000-0002-2527-9541","https://orcid.org/0000-0002-5739-2178"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Borst","raw_affiliation_strings":["Division of Molecular Biology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":27.2028,"has_fulltext":true,"cited_by_count":630,"citation_normalized_percentile":{"value":0.99762146,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"101","issue":"7","first_page":"1310","last_page":"1319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apert-syndrome","display_name":"Apert syndrome","score":0.921999990940094},{"id":"https://openalex.org/keywords/fgfr2-mutations","display_name":"FGFR2 mutations","score":0.9049999713897705},{"id":"https://openalex.org/keywords/craniosynostosis","display_name":"craniosynostosis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/calvaria-cells","display_name":"calvaria cells","score":0.734000027179718},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8090000152587891},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.7990000247955322},{"id":"https://openalex.org/keywords/fgf2","display_name":"FGF2","score":0.6880000233650208},{"id":"https://openalex.org/keywords/subperiosteal-bone-formation","display_name":"subperiosteal bone formation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/mineralized-matrix","display_name":"mineralized matrix","score":0.4659999907016754},{"id":"https://openalex.org/keywords/mrp2","display_name":"MRP2","score":0.6179999709129333},{"id":"https://openalex.org/keywords/pharmaceutical-exports","display_name":"pharmaceutical exports","score":0.6779999732971191},{"id":"https://openalex.org/keywords/mdck-cells","display_name":"MDCK cells","score":0.6000000238418579},{"id":"https://openalex.org/keywords/cdna-expression","display_name":"cDNA expression","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2779918246","wikidata":"https://www.wikidata.org/wiki/Q613203","display_name":"Calvaria","level":3,"score":0.9514884948730469},{"id":"https://openalex.org/C2778715190","wikidata":"https://www.wikidata.org/wiki/Q618246","display_name":"Apert syndrome","level":3,"score":0.6956127285957336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5831150412559509},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5641160607337952},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5572540760040283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.536573052406311},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3710489273071289},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36148011684417725},{"id":"https://openalex.org/C2779302956","wikidata":"https://www.wikidata.org/wiki/Q378183","display_name":"Craniosynostosis","level":2,"score":0.3599119186401367},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.18011832237243652},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17283889651298523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15463697910308838},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14084777235984802},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027321","descriptor_name":"Anion Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1172/jci119886","doi":"https://doi.org/10.1172/jci119886","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci119886","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"doi:10.1172/jci928","doi":"https://doi.org/10.1172/jci928","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci928","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:170968","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC508685","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:9502772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9502772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmid:9525973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9525973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:508685","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC508685/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:508708","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC508708/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/75976f21-dd54-4c01-9fe9-70b1b1fb383d","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/75976f21-dd54-4c01-9fe9-70b1b1fb383d","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evers, R, Kool, M, van Deemter, L, Janssen, H, Calafat, J, Oomen, L C, Paulusma, C C, Oude Elferink, R P, Baas, F, Schinkel, A H & Borst, P 1998, 'Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA', Journal of clinical investigation, vol. 101, no. 7, pp. 1310-1319. https://doi.org/10.1172/JCI119886","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/62c3aacc-a417-4e99-97ce-9da4096bf0b4","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/drug-export-activity-of-the-human-canalicular-multispecific-organic-anion-transporter-in-polarized-kidney-mdck-cells-expressing-cmoat-mrp2-cdna(62c3aacc-a417-4e99-97ce-9da4096bf0b4).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of clinical investigation, 101(7), 1310 - 1319. The American Society for Clinical Investigation","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:170968","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC508685","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321008","display_name":"Universiteit van Amsterdam","ror":"https://ror.org/04dkp9463"},{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W1490964055","https://openalex.org/W1502426706","https://openalex.org/W1504784308","https://openalex.org/W1513451331","https://openalex.org/W1565186930","https://openalex.org/W1570281893","https://openalex.org/W1570865673","https://openalex.org/W1582980602","https://openalex.org/W1591990543","https://openalex.org/W1599886286","https://openalex.org/W1602488604","https://openalex.org/W1605102643","https://openalex.org/W1646404713","https://openalex.org/W1768069605","https://openalex.org/W1823445908","https://openalex.org/W1845771548","https://openalex.org/W1890023926","https://openalex.org/W1911655428","https://openalex.org/W1958256417","https://openalex.org/W1966310113","https://openalex.org/W1966665452","https://openalex.org/W1974338599","https://openalex.org/W1977225005","https://openalex.org/W1978293159","https://openalex.org/W1979642666","https://openalex.org/W1980427909","https://openalex.org/W1981856729","https://openalex.org/W1984028280","https://openalex.org/W1988177550","https://openalex.org/W1988190121","https://openalex.org/W1993444760","https://openalex.org/W2000980801","https://openalex.org/W2003632139","https://openalex.org/W2004804291","https://openalex.org/W2012841076","https://openalex.org/W2021550176","https://openalex.org/W2021759214","https://openalex.org/W2021841041","https://openalex.org/W2022026667","https://openalex.org/W2022142238","https://openalex.org/W2026288162","https://openalex.org/W2029055538","https://openalex.org/W2030542269","https://openalex.org/W2030763326","https://openalex.org/W2040906015","https://openalex.org/W2045627528","https://openalex.org/W2056581239","https://openalex.org/W2060029591","https://openalex.org/W2060216905","https://openalex.org/W2060531233","https://openalex.org/W2067112519","https://openalex.org/W2067732333","https://openalex.org/W2067898376","https://openalex.org/W2069009310","https://openalex.org/W2071008278","https://openalex.org/W2071600778","https://openalex.org/W2077045259","https://openalex.org/W2078998991","https://openalex.org/W2079200533","https://openalex.org/W2080722428","https://openalex.org/W2087378917","https://openalex.org/W2104281222","https://openalex.org/W2104691647","https://openalex.org/W2108966355","https://openalex.org/W2109354605","https://openalex.org/W2112136670","https://openalex.org/W2118215159","https://openalex.org/W2118234018","https://openalex.org/W2120825516","https://openalex.org/W2122043314","https://openalex.org/W2125876729","https://openalex.org/W2127337137","https://openalex.org/W2134676557","https://openalex.org/W2136054684","https://openalex.org/W2136564762","https://openalex.org/W2138792907","https://openalex.org/W2139495786","https://openalex.org/W2140370234","https://openalex.org/W2140403969","https://openalex.org/W2143862282","https://openalex.org/W2146791963","https://openalex.org/W2149994120","https://openalex.org/W2152117655","https://openalex.org/W2154283357","https://openalex.org/W2161392800","https://openalex.org/W2162097287","https://openalex.org/W2164057833","https://openalex.org/W2164646248","https://openalex.org/W2166628294","https://openalex.org/W2168070336","https://openalex.org/W2168095256","https://openalex.org/W2168117739","https://openalex.org/W2177086111","https://openalex.org/W2181394520","https://openalex.org/W2206242436","https://openalex.org/W2340565196","https://openalex.org/W2470478537"],"related_works":["https://openalex.org/W2087876890","https://openalex.org/W2042315393","https://openalex.org/W2003358724","https://openalex.org/W2097928320","https://openalex.org/W2017203191","https://openalex.org/W1966440275","https://openalex.org/W7097985354","https://openalex.org/W2074881343","https://openalex.org/W2133726073","https://openalex.org/W7098216845"],"abstract_inverted_index":{"Apert":[0,29,54,66,107,180,225],"syndrome,":[1],"associated":[2],"with":[3,33,58,103,170],"fibroblast":[4],"growth":[5,73],"factor":[6],"receptor":[7],"(FGFR)":[8],"2":[9],"mutations,":[10],"is":[11],"characterized":[12],"by":[13,156],"premature":[14,39,207],"fusion":[15],"of":[16,24,43,87,115,131,152,190],"cranial":[17],"sutures.":[18],"We":[19],"analyzed":[20],"proliferation":[21],"and":[22,31,47,68,122,134,206,221],"differentiation":[23],"calvaria":[25,56,62,91,101,146,160,174,208],"cells":[26,52,63,92,102,116,161,192],"derived":[27],"from":[28,65],"infants":[30,67],"fetuses":[32,69],"FGFR-2":[34,108,181],"mutations.":[35],"Histological":[36],"analysis":[37],"revealed":[38],"ossification,":[40],"increased":[41,112,167,201],"extent":[42],"subperiosteal":[44,202],"bone":[45,203],"formation,":[46],"alkaline":[48,88,132],"phosphatase-":[49,89],"positive":[50,90],"preosteoblastic":[51],"in":[53,74,78,98,117,143,149,163,187,224],"fetal":[55,100,145,159,173,211],"compared":[57,169],"age-matched":[59],"controls.":[60],"Preosteoblastic":[61],"isolated":[64],"showed":[70,127],"normal":[71,97,142],"cell":[72],"basal":[75],"conditions":[76],"or":[77],"response":[79],"to":[80,184,200],"exogenous":[81],"FGF-2.":[82],"In":[83],"contrast,":[84],"the":[85,104,118,129,188,195,218],"number":[86,189],"was":[93,165],"fourfold":[94],"higher":[95],"than":[96,141],"mutant":[99,144,158],"most":[105],"frequent":[106],"mutation":[109],"(Ser252Trp),":[110],"suggesting":[111],"maturation":[113],"rate":[114],"osteoblastic":[119],"lineage.":[120],"Biochemical":[121],"Northern":[123],"blot":[124],"analyses":[125],"also":[126,166],"that":[128,179,193],"expression":[130],"phosphatase":[133],"type":[135],"1":[136],"collagen":[137],"were":[138],"2-10-fold":[139],"greater":[140],"cells.":[147,175],"The":[148,176],"vitro":[150],"production":[151],"mineralized":[153],"matrix":[154,204],"formed":[155],"immortalized":[157,172],"cultured":[162],"aggregates":[164],"markedly":[168],"control":[171],"results":[177],"show":[178],"mutations":[182],"lead":[183],"an":[185],"increase":[186],"precursor":[191],"enter":[194],"osteogenic":[196],"pathway,":[197],"leading":[198],"ultimately":[199],"formation":[205],"ossification":[209],"during":[210],"development,":[212],"which":[213],"establishes":[214],"a":[215],"connection":[216],"between":[217],"altered":[219],"genotype":[220],"cellular":[222],"phenotype":[223],"syndromic":[226],"craniosynostosis.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}