{"id":"https://openalex.org/W2148872425","doi":"https://doi.org/10.1093/gerona/58.4.m331","title":"Management of Alzheimer's Disease","display_name":"Management of Alzheimer's Disease","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W2148872425","doi":"https://doi.org/10.1093/gerona/58.4.m331","mag":"2148872425","pmid":"https://pubmed.ncbi.nlm.nih.gov/12663697"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/58.4.m331","doi":"https://doi.org/10.1093/gerona/58.4.m331","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/58.4.m331","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008190526","display_name":"George Thomas Grossberg","orcid":"https://orcid.org/0000-0002-1493-3931","observed_orcids":["https://orcid.org/0000-0002-1493-3931"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. T. Grossberg","raw_affiliation_strings":["Department of Psychiatry, Division of Geriatric Psychiatry, Saint Louis University School of Medicine, St. Louis, Missouri, USA","Department of Psychiatry, Division of Geriatric Psychiatry, Saint Louis University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Division of Geriatric Psychiatry, Saint Louis University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Department of Psychiatry, Division of Geriatric Psychiatry, Saint Louis University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019304624","display_name":"Abhilash K. Desai","orcid":"https://orcid.org/0000-0002-7420-2057","observed_orcids":["https://orcid.org/0000-0002-7420-2057"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. K. Desai","raw_affiliation_strings":["Department of Psychiatry, Division of Geriatric Psychiatry, Saint Louis University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Division of Geriatric Psychiatry, Saint Louis University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":1.5325,"has_fulltext":false,"cited_by_count":110,"citation_normalized_percentile":{"value":0.83277592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"4","first_page":"M331","last_page":"M353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.6460000276565552},{"id":"https://openalex.org/keywords/disease-management","display_name":"disease management","score":0.7519999742507935},{"id":"https://openalex.org/keywords/early-onset-alzheimer-s-disease","display_name":"early-onset Alzheimer's disease","score":0.7879999876022339},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.9649999737739563},{"id":"https://openalex.org/keywords/behavioral-and-psychological-symptoms","display_name":"behavioral and psychological symptoms","score":0.8349999785423279},{"id":"https://openalex.org/keywords/caregiver-burden","display_name":"caregiver burden","score":0.8970000147819519},{"id":"https://openalex.org/keywords/disease-staging","display_name":"disease staging","score":0.42399999499320984},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.4309999942779541},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.4090000092983246},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.6179999709129333},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.8410000205039978},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.3149999976158142},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.6380000114440918},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.49399998784065247},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.4059999883174896},{"id":"https://openalex.org/keywords/incidence-and-prevalence","display_name":"incidence and prevalence","score":0.4050000011920929},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6022489070892334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3947816491127014},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16695058345794678}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000529","descriptor_name":"Complementary Therapies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001521","descriptor_name":"Behavior Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003376","descriptor_name":"Counseling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005192","descriptor_name":"Family Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010353","descriptor_name":"Patient Education as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011320","descriptor_name":"Primary Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017028","descriptor_name":"Caregivers","qualifier_ui":"Q000193","qualifier_name":"education","is_major_topic":false},{"descriptor_ui":"D017028","descriptor_name":"Caregivers","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/gerona/58.4.m331","doi":"https://doi.org/10.1093/gerona/58.4.m331","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/58.4.m331","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},{"id":"pmid:12663697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12663697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":172,"referenced_works":["https://openalex.org/W8541533","https://openalex.org/W43808059","https://openalex.org/W68901995","https://openalex.org/W90819564","https://openalex.org/W101525007","https://openalex.org/W157163224","https://openalex.org/W189042985","https://openalex.org/W1551908896","https://openalex.org/W1627243100","https://openalex.org/W1630027882","https://openalex.org/W1644143258","https://openalex.org/W1657936130","https://openalex.org/W1744271464","https://openalex.org/W1847168837","https://openalex.org/W1867692464","https://openalex.org/W1902793302","https://openalex.org/W1966791814","https://openalex.org/W1968750846","https://openalex.org/W1972445309","https://openalex.org/W1974130870","https://openalex.org/W1974701449","https://openalex.org/W1975975999","https://openalex.org/W1976023110","https://openalex.org/W1978342865","https://openalex.org/W1978487641","https://openalex.org/W1980226703","https://openalex.org/W1980945280","https://openalex.org/W1981827912","https://openalex.org/W1982113114","https://openalex.org/W1983145147","https://openalex.org/W1983159577","https://openalex.org/W1989386156","https://openalex.org/W1989538668","https://openalex.org/W1990805071","https://openalex.org/W1990965418","https://openalex.org/W1991113376","https://openalex.org/W1991176470","https://openalex.org/W1993818042","https://openalex.org/W1995993981","https://openalex.org/W1996603221","https://openalex.org/W2000837493","https://openalex.org/W2001857101","https://openalex.org/W2003106226","https://openalex.org/W2004031015","https://openalex.org/W2008743346","https://openalex.org/W2010891279","https://openalex.org/W2013669235","https://openalex.org/W2013866848","https://openalex.org/W2015449679","https://openalex.org/W2015514721","https://openalex.org/W2019098555","https://openalex.org/W2019503633","https://openalex.org/W2019632502","https://openalex.org/W2022954666","https://openalex.org/W2023034715","https://openalex.org/W2023506257","https://openalex.org/W2026222408","https://openalex.org/W2027520066","https://openalex.org/W2030079540","https://openalex.org/W2030540777","https://openalex.org/W2030689331","https://openalex.org/W2030817295","https://openalex.org/W2030976463","https://openalex.org/W2037968780","https://openalex.org/W2038074592","https://openalex.org/W2040850193","https://openalex.org/W2042256015","https://openalex.org/W2044241508","https://openalex.org/W2044837170","https://openalex.org/W2045836468","https://openalex.org/W2046209489","https://openalex.org/W2047095305","https://openalex.org/W2048880995","https://openalex.org/W2049683617","https://openalex.org/W2051753984","https://openalex.org/W2051996699","https://openalex.org/W2052496664","https://openalex.org/W2053401836","https://openalex.org/W2054096290","https://openalex.org/W2054363136","https://openalex.org/W2054727147","https://openalex.org/W2056638435","https://openalex.org/W2057346271","https://openalex.org/W2058723245","https://openalex.org/W2059221358","https://openalex.org/W2059729306","https://openalex.org/W2064649894","https://openalex.org/W2064887457","https://openalex.org/W2065052203","https://openalex.org/W2067162295","https://openalex.org/W2071641964","https://openalex.org/W2073535093","https://openalex.org/W2076676029","https://openalex.org/W2076908811","https://openalex.org/W2083633251","https://openalex.org/W2083665247","https://openalex.org/W2083811803","https://openalex.org/W2084550262","https://openalex.org/W2084675121","https://openalex.org/W2085884379","https://openalex.org/W2085916454","https://openalex.org/W2086089095","https://openalex.org/W2088361570","https://openalex.org/W2092427755","https://openalex.org/W2092914302","https://openalex.org/W2098738387","https://openalex.org/W2099740162","https://openalex.org/W2100072124","https://openalex.org/W2101776930","https://openalex.org/W2102698273","https://openalex.org/W2107057917","https://openalex.org/W2108206449","https://openalex.org/W2108851081","https://openalex.org/W2109946269","https://openalex.org/W2110290389","https://openalex.org/W2112549296","https://openalex.org/W2113539936","https://openalex.org/W2114248765","https://openalex.org/W2115953036","https://openalex.org/W2116249921","https://openalex.org/W2117864586","https://openalex.org/W2118004491","https://openalex.org/W2119038590","https://openalex.org/W2120080197","https://openalex.org/W2122422419","https://openalex.org/W2122692162","https://openalex.org/W2122900522","https://openalex.org/W2125993125","https://openalex.org/W2128007559","https://openalex.org/W2128037426","https://openalex.org/W2129579471","https://openalex.org/W2129678592","https://openalex.org/W2130901979","https://openalex.org/W2131373320","https://openalex.org/W2133029179","https://openalex.org/W2133710857","https://openalex.org/W2135093451","https://openalex.org/W2137762426","https://openalex.org/W2140320787","https://openalex.org/W2144460602","https://openalex.org/W2148206024","https://openalex.org/W2149614271","https://openalex.org/W2151290451","https://openalex.org/W2153407657","https://openalex.org/W2153631628","https://openalex.org/W2155048137","https://openalex.org/W2155217186","https://openalex.org/W2156220037","https://openalex.org/W2158957669","https://openalex.org/W2160619416","https://openalex.org/W2162206869","https://openalex.org/W2165358329","https://openalex.org/W2166389826","https://openalex.org/W2170580964","https://openalex.org/W2170894861","https://openalex.org/W2171405125","https://openalex.org/W2172225284","https://openalex.org/W2312802409","https://openalex.org/W2315051698","https://openalex.org/W2326200998","https://openalex.org/W2411075130","https://openalex.org/W2429021542","https://openalex.org/W2437004936","https://openalex.org/W2607257274","https://openalex.org/W2775750683","https://openalex.org/W2912402341","https://openalex.org/W3143060430","https://openalex.org/W4231712045","https://openalex.org/W4233470361","https://openalex.org/W4238556094","https://openalex.org/W4248271248","https://openalex.org/W4250877486"],"related_works":["https://openalex.org/W6964916319","https://openalex.org/W6893166691","https://openalex.org/W4244943129","https://openalex.org/W2940252124","https://openalex.org/W608341515","https://openalex.org/W2395794980","https://openalex.org/W7099040995","https://openalex.org/W3046208420","https://openalex.org/W4411744052","https://openalex.org/W2923489582"],"abstract_inverted_index":{"ALZHEIMER'S":[0],"disease":[1,26,206,274,283,751,1193,1216,1953,2141,2340,4022,4214,5168,5329,6086,6366,7030,7788],"(AD)":[2],"is":[3,152,183,191,456,487,505,523,533,828,872,961,1155,1189,1313,1401,1428,1441,1451,1458,1550,1562,1631,1687,1694,1783,1815,1867,2051,2080,2109,2145,2174,2185,2297,2479,2489,3234,3273,3437,3464,3485,3608,3661,3709,3722,3761,3822,3928,3970,4028,4126,4185,4226,4269,4442,4451,4532,4624,4635,4646,4699,4704,4752,4773,4849,4868,4899,4913,4937,4941,4978,5003,5040,5049,5057,5083,5100,5221,5377,5412,5433,5442,5473,5490,5708,5799,5978,5983,6161,6168,6311,6470,6479,6546,6663,6669,6676,6683,6726,6794,6928,6958,7065,7215,7293,7307,7319,7465,7526,7540,7553,7618,7687,7865,7912,7976,8017,8026,8037,8105,8181,8188,8251,8319,8364,8395,8630,8670,8676,8716,8875,8891,9059,9249,9302,9489,9746,9793,9809,9814],"a":[4,24,29,113,145,160,209,213,285,303,538,630,677,735,840,873,895,962,1142,1145,1182,1391,1422,1553,1596,1604,1609,1627,1681,1698,1705,1749,1803,1865,2002,2052,2075,2276,2298,2302,2355,2385,2398,2405,2825,2929,3008,3046,3187,3276,4189,4273,4321,4331,4348,4359,4370,4467,4509,4825,4903,4927,4964,5044,5068,5075,5140,5383,5455,5478,5480,5519,5535,5587,5700,5834,6063,6102,6174,6468,6527,6544,6549,6600,6636,6774,6779,6857,6893,6901,6932,6951,6956,6980,7015,7105,7132,7272,7336,7380,7389,7395,7646,7840,7852,8056,8416,8428,8770,8837,8860,8867,8892,8941,9337,9355,9364,9643,9658,9739,9917],"devastating":[5],"and":[6,10,37,57,65,67,174,188,201,218,239,319,350,353,426,445,453,465,470,547,556,559,565,572,591,599,626,629,657,665,683,693,701,710,712,752,806,813,847,876,902,919,940,946,964,972,990,1006,1031,1035,1045,1060,1063,1068,1074,1088,1110,1124,1152,1160,1168,1195,1206,1224,1248,1256,1263,1281,1293,1307,1336,1341,1382,1457,1472,1485,1494,1647,1658,1674,1704,1721,1725,1828,1847,1861,1869,1885,1910,1924,1949,1968,1980,2014,2036,2044,2093,2137,2202,2326,2329,2370,2388,2397,2415,2420,2428,2446,2465,2556,2584,2727,2782,2842,2845,2864,2880,2899,2901,2908,2926,2985,3020,3103,3129,3219,3227,3240,3260,3293,3346,3359,3370,3410,3451,3473,3480,3500,3534,3538,3547,3588,3591,3632,3650,3671,3698,3786,3801,3805,3829,3871,3920,3965,4046,4063,4072,4091,4119,4135,4143,4208,4235,4284,4306,4390,4400,4448,4486,4490,4563,4619,4654,4674,4765,4821,4887,4908,4910,5007,5013,5046,5067,5093,5129,5189,5342,5428,5559,5574,5585,5617,5635,5656,5727,5792,5826,5860,5884,5899,5945,5968,5999,6006,6031,6071,6089,6124,6225,6258,6271,6329,6359,6367,6402,6410,6431,6450,6552,6568,6639,6672,6685,6707,6746,6803,6841,6863,6874,6910,6923,7055,7092,7128,7154,7230,7352,7419,7447,7474,7501,7579,7645,7677,7691,7694,7714,7716,7737,7754,7767,7789,7826,7835,7849,7873,7937,7954,8034,8093,8156,8171,8194,8222,8272,8285,8307,8321,8334,8341,8383,8415,8432,8448,8452,8461,8485,8513,8523,8525,8570,8597,8604,8609,8677,8718,8737,8778,8781,8803,8814,8827,8852,8864,8887,8894,8910,8919,8950,8960,8981,8994,9009,9014,9020,9043,9079,9081,9093,9124,9126,9156,9169,9176,9197,9215,9232,9241,9263,9268,9279,9288,9291,9298,9314,9352,9378,9391,9402,9424,9426,9445,9482,9505,9520,9558,9569,9612,9634,9637,9663,9684,9706,9717,9729,9743,9833,9875,9907],"debilitating":[7],"neurodegenerative":[8],"condition":[9,41,871,6781],"the":[11,18,52,60,97,101,122,127,132,147,246,249,273,276,282,325,331,388,404,429,478,482,501,506,509,518,524,563,566,577,580,595,668,681,719,722,750,766,801,810,815,819,824,831,836,856,859,870,885,917,926,935,944,975,997,1008,1025,1033,1053,1056,1081,1149,1153,1158,1163,1166,1169,1171,1192,1201,1207,1215,1240,1265,1298,1305,1321,1326,1331,1337,1354,1363,1371,1375,1395,1402,1410,1414,1470,1488,1516,1531,1560,1568,1620,1689,1716,1737,1754,1757,1764,1822,1838,1854,1857,1874,1882,1892,1896,1986,1996,2017,2022,2061,2086,2104,2113,2135,2143,2148,2158,2165,2180,2197,2211,2220,2240,2283,2290,2320,2333,2336,2341,2348,2359,2402,2413,2432,2437,2450,2477,2493,2515,2518,2524,2540,2562,2569,2577,2710,2745,2756,2776,2796,2801,2857,2871,2885,2896,2958,3053,3064,3087,3134,3153,3213,3263,3301,3431,3439,3516,3522,3564,3583,3586,3653,3714,3742,3789,3803,3820,3824,3976,3989,4017,4021,4032,4043,4051,4068,4073,4082,4155,4196,4219,4224,4240,4281,4287,4311,4316,4338,4365,4419,4427,4499,4536,4539,4548,4576,4581,4592,4628,4633,4638,4649,4760,4778,4783,4794,4813,4850,4870,4883,4891,4983,4988,4999,5008,5136,5144,5167,5183,5192,5198,5205,5211,5242,5295,5423,5462,5471,5540,5583,5604,5626,5667,5685,5712,5750,5757,5763,5774,5782,5802,5812,5822,5842,5854,5882,5925,5928,5934,5955,6130,6151,6217,6330,6342,6377,6465,6483,6489,6492,6512,6518,6535,6565,6573,6616,6633,6653,6686,6717,6728,6743,6749,6763,6768,6786,6907,6969,6972,6985,6990,7023,7029,7032,7043,7046,7060,7073,7144,7161,7166,7190,7195,7211,7218,7226,7233,7311,7323,7326,7360,7403,7415,7420,7486,7557,7577,7599,7605,7625,7630,7666,7707,7784,7787,7804,7863,7868,7881,7890,7907,7910,7963,8002,8060,8072,8111,8119,8143,8184,8197,8203,8270,8309,8327,8339,8360,8381,8391,8437,8471,8498,8535,8540,8588,8643,8658,8679,8725,8731,8745,8749,8763,8773,8784,8797,8843,8846,8856,8927,8931,8935,9056,9063,9068,9084,9097,9117,9135,9212,9222,9274,9283,9296,9330,9414,9437,9512,9523,9599,9605,9668,9859,9912],"most":[12,123,268,1690,2245,2718,2950,3033,3745,6239,6320,7681,8367],"common":[13,1430,7965,8631,9552],"cause":[14,3542],"of":[15,31,47,59,71,77,116,149,159,162,178,216,231,248,278,293,311,328,330,347,383,390,424,447,481,520,526,605,623,632,637,721,745,759,765,787,797,834,861,898,923,959,1000,1010,1015,1028,1038,1055,1083,1187,1203,1214,1229,1309,1362,1374,1393,1397,1421,1475,1519,1533,1566,1574,1599,1624,1636,1639,1654,1665,1701,1715,1718,1740,1856,1881,1916,1959,1966,1970,1973,1988,1998,2013,2024,2078,2090,2107,2115,2139,2161,2213,2222,2339,2380,2401,2404,2439,2457,2463,2467,2495,2504,2606,2620,2649,2664,2719,2750,2775,2778,2856,2859,2873,2887,2895,2910,2939,2996,3052,3075,3111,3127,3133,3136,3138,3254,3271,3279,3296,3300,3324,3374,3387,3415,3449,3495,3518,3524,3566,3585,3673,3716,3759,3770,3777,3788,3827,3861,3875,3883,3889,3932,3950,3957,3978,4020,4026,4035,4053,4070,4075,4084,4121,4138,4157,4163,4178,4198,4247,4267,4295,4324,4328,4352,4374,4396,4406,4415,4430,4471,4511,4586,4599,4632,4715,4756,4763,4770,4788,4841,4854,4872,4885,4930,4955,4963,4993,5071,5077,5090,5098,5105,5118,5138,5143,5146,5156,5163,5166,5207,5210,5218,5273,5317,5350,5353,5431,5483,5669,5680,5687,5715,5805,5824,5838,5857,5869,5881,5906,5927,5943,5970,6013,6065,6158,6219,6231,6273,6347,6362,6372,6376,6382,6459,6467,6491,6517,6534,6537,6618,6626,6751,6885,6895,6934,7042,7062,7075,7088,7107,7116,7146,7163,7183,7222,7238,7280,7313,7325,7328,7359,7366,7369,7462,7481,7503,7559,7581,7584,7602,7607,7632,7648,7669,7675,7684,7689,7696,7709,7711,7725,7730,7739,7741,7752,7778,7786,7806,7821,7843,7855,7857,7875,7892,7962,8004,8024,8030,8062,8065,8074,8088,8113,8116,8121,8147,8151,8178,8269,8280,8336,8369,8408,8418,8430,8439,8444,8446,8500,8546,8591,8845,8862,8869,8926,8938,8997,9046,9065,9116,9121,9195,9205,9224,9277,9329,9342,9358,9366,9416,9439,9456,9473,9514,9535,9563,9576,9591,9595,9601,9607,9628,9631,9681,9732,9757,9797,9803,9862],"dementia":[16,1004,1087,1642,1648,1917,3003,3143,3282,3400,5828,6004,6088,6171,6180,7147,7585,7697,7879,8025,8187,8689,9832,9850],"in":[17,51,96,126,212,245,489,707,734,778,830,843,982,996,1007,1024,1032,1051,1061,1080,1091,1104,1161,1219,1431,1436,1447,1453,1461,1487,1552,1587,1668,1736,1763,1934,1984,2016,2055,2068,2128,2195,2203,2233,2268,2322,2358,2361,2436,2547,2568,2610,2709,2715,2755,2762,2812,2819,2833,2875,2917,2957,2981,3035,3056,3084,3089,3231,3376,3380,3412,3438,3553,3582,3618,3638,3682,3733,3741,3749,3764,3823,3841,3855,3881,3896,3909,3954,4016,4078,4101,4170,4181,4205,4232,4237,4297,4401,4569,4591,4604,4612,4637,4684,4687,4720,4741,4793,4857,4998,5032,5126,5161,5173,5224,5538,5590,5676,5690,5699,5737,5756,5781,5807,5811,5821,5833,5841,5853,5862,5871,5879,5933,5954,5962,6002,6052,6055,6058,6119,6129,6150,6170,6216,6244,6267,6326,6413,6448,6585,6602,6702,6727,6953,6964,7028,7086,7097,7104,7143,7148,7160,7165,7176,7189,7200,7225,7283,7295,7309,7315,7345,7499,7547,7586,7604,7613,7634,7651,7720,7727,7776,7783,7793,7814,7859,7878,7895,7972,8059,8081,8098,8132,8356,8425,8510,8542,8632,8642,8645,8666,8748,8957,8963,8984,8987,9105,9187,9256,9363,9420,9427,9469,9533,9544,9553,9574,9614,9616,9650,9671,9690,9775,9858],"elderly.":[19],"AD":[20,84,95,105,234,259,271,305,334,376,527,546,618,728,746,760,772,788,901,960,1278,1312,1434,1465,1504,1577,1743,1899,2033,2095,2281,2427,2590,2688,2698,2822,2835,2942,2953,3121,3184,3196,3251,3639,3688,3702,3828,3844,3866,3902,3936,3953,3992,4015,4339,4590,4614,4792,4858,4956,4997,5114,5147,5298,5324,5359,5514,5741,5810,5839,5876,5932,5952,5966,6040,6125,6220,6250,6270,6811,6886,6973,7164,7184,7188,7242,7473,7519,7546,7633,7685,7728,7975,7980,8091,8152,8318,8363,8466,8563,8741,8756,8841,8859,8966,9032,9554,9577,9615,9672,9682,9710,9733,9758,9776,9781],"may":[21,729,887,977,1069,1235,1352,1386,1919,2192,2271,2304,2314,2343,2375,2591,2932,3010,3031,3311,3354,3420,3456,3514,3531,3541,3622,3647,3677,3690,3838,4009,4092,4132,4149,4202,4212,4717,4729,4947,5134,5287,5313,5346,5369,5394,5682,5717,5730,5993,6035,6047,6098,6197,6302,6369,6875,6982,7193,7475,7574,7623,7929,7957,7968,8136,8424,8578,8757,8768,8929,9000,9006,9033,9051,9508],"not":[22,1442,1459,1769,1784,1890,2153,2383,2532,2655,3175,3509,3753,3810,4525,4664,4774,4889,4918,4979,5084,5238,5304,5386,5413,5434,5523,6082,6134,6162,6199,6234,6505,6522,6581,6813,6983,7018,7399,7508,7541,7554,7641,8265,8805,8947,9145,9209,9218,9493,9582,9620,9646,9773],"be":[23,475,515,608,673,730,762,774,791,929,1232,1272,1347,1353,1388,1506,1713,1729,1745,1795,1834,1982,2006,2217,2272,2315,2377,2384,2390,2454,2474,2535,2543,2574,2643,2690,2700,2733,2760,2773,2805,2810,2849,2867,2892,2905,2915,2933,3011,3032,3061,3209,3258,3312,3355,3423,3570,3580,3623,3636,3796,3832,3839,3904,4010,4203,4410,4423,4519,4567,4682,4718,4730,4746,4799,5030,5179,5259,5314,5347,5395,5401,5460,5732,5819,6048,6223,6345,6387,6508,6515,6555,6559,6596,6609,6629,6643,6649,6692,6720,6756,6832,6854,6876,6889,7034,7084,7174,7426,7476,7663,7924,7998,8096,8200,8209,8217,8238,8247,8256,8494,8508,8519,8527,8532,8579,8682,8769,8806,8930,9024,9103,9308,9317,9467,9509,9657,9767,9786,9796,9826,9842],"single":[25],"but":[27,1894,3026,3186,3575,5103,5593,6080,6437,6503,7274,8253,8282,8324,9143,9189,9404],"rather":[28,2499,8618],"group":[30,5605,5627,5752,5765,5770,5776,6132,6153,7346,7418,9405],"diseases":[32],"with":[33,233,258,270,295,306,375,528,545,576,680,718,725,748,867,900,934,980,1002,1136,1212,1277,1311,1433,1464,1479,1501,1570,1576,1641,1697,1742,1841,1898,1936,2167,2407,2426,2549,2551,2589,2674,2685,2697,2795,2821,2861,2941,2952,3002,3077,3096,3114,3120,3183,3229,3250,3275,3286,3398,3641,3701,3735,3784,3898,3952,3960,3980,3991,4002,4014,4147,4218,4229,4432,4483,4498,4552,4571,4660,4668,4689,4748,4759,4824,4832,4905,5016,5034,5074,5132,5323,5358,5367,5405,5465,5477,5513,5518,5615,5692,5704,5784,5809,5875,5931,6069,6076,6087,6092,6104,6121,6139,6209,6246,6269,6297,6323,6352,6500,6587,6681,6735,6810,6859,6871,6878,6892,7099,7125,7187,7260,7301,7333,7379,7432,7438,7451,7472,7478,7491,7518,7615,7748,7833,7861,7897,7974,8067,8083,8101,8161,8186,8232,8290,8317,8329,8338,8352,8362,8375,8465,8470,8548,8558,8574,8688,8740,8755,8840,8858,8879,8885,8900,8965,9031,9038,9070,9203,9326,9339,9584,9648,9687,9783,9799,9830,9846,9869,9895],"overlapping":[34],"pathogenetic":[35],"mechanisms":[36,196],"clinical":[38,172,757,988,1077,1555,1848,2234,3573,4333,4597,5154,5232,7731,7798,9545],"manifestations.":[39],"The":[40,134,205,451,570,743,756,889,993,1020,1047,1076,1099,1245,1252,1399,1572,1622,1859,2502,2740,3170,3756,3768,4160,4263,4290,4437,4695,4896,4933,5037,5054,5095,5153,5215,5768,6112,6155,6457,6624,6790,6883,7213,7435,7680,7723,8149,8176,8354,8625,8653,8809,9111,9199,9370],"accounts":[42],"for":[43,256,324,542,584,617,698,738,855,1072,1148,1222,1239,1267,1405,1413,1445,1496,1513,1530,1559,1580,1603,1615,1680,1733,1748,1786,1812,1864,2099,2424,2744,2923,2969,3000,3159,3215,3337,3344,3350,3365,3371,3791,3923,3935,3975,4012,4050,4275,4384,4426,4440,4501,4583,4609,4785,4863,4990,5448,5502,5545,5561,5642,5777,5789,5801,5913,5960,6067,6226,6319,6399,6487,6541,6548,6666,6673,6797,6801,6806,6856,7072,7141,7150,7158,7220,7241,7268,7406,7470,7545,7556,7627,7823,7889,8001,8011,8090,8110,8288,8303,8311,8314,8331,8651,8816,8877,8897,9091,9304,9336,9459,9623,9755,9789,9820,9844,9888,9911,9927,9930],"an":[44,261,307,361,1526,1544,1563,2393,2544,3313,3384,3833,3929,3971,4168,5562,5979,6022,7542,7887,8127,8300],"estimated":[45,80,1632],"60\u201370%":[46],"all":[48,298,1387,1637,3160,3351,3413,3924,4298,5269,5548,5778,6400,6501,7209,7794,8476,9307,9780],"dementing":[49,1750,5976,6015,7795],"disorders":[50,628,1735,5977,6016,6074,6097,9597],"elderly":[53,1456,2587,2708,7587],"(1).":[54],"Between":[55],"5%":[56],"10%":[58,292],"population":[61],"aged":[62],"65":[63],"years":[64,76,359,382,7153],"older,":[66,5939],"up":[68,881,5602,6651,9804],"to":[69,81,94,111,154,322,399,435,474,562,652,658,732,817,822,865,879,916,932,954,970,1094,1132,1141,1165,1174,1210,1274,1291,1304,1409,1508,1540,1594,1601,1608,1678,1731,1777,1790,1802,1810,1836,1853,1931,2073,2097,2119,2133,2147,2171,2177,2183,2199,2216,2229,2231,2242,2250,2274,2308,2317,2417,2481,2491,2534,2573,2593,2603,2692,2738,2764,2789,2827,2848,2851,2869,2877,2955,2967,3007,3147,3201,3211,3262,3317,3382,3425,3429,3466,3470,3481,3488,3504,3556,3579,3604,3610,3614,3625,3655,3663,3679,3703,3707,3727,3731,3849,3858,3900,3906,3942,3948,4055,4113,4174,4271,4285,4303,4308,4345,4368,4382,4409,4422,4434,4464,4466,4521,4529,4550,4588,4706,4734,4790,4806,4834,4926,4969,4995,5111,5178,5194,5261,5282,5388,5392,5403,5415,5420,5494,5507,5556,5580,5582,5597,5603,5644,5694,5719,5723,5739,5818,5831,5918,5964,5973,6020,6084,6190,6201,6211,6248,6263,6332,6446,6507,6531,6554,6572,6614,6652,6697,6700,6742,6815,6843,6846,6888,7002,7019,7036,7058,7077,7083,7095,7101,7123,7173,7180,7265,7289,7377,7392,7401,7425,7430,7495,7529,7565,7596,7662,7867,7905,7923,7985,8019,8077,8145,8167,8192,8202,8211,8213,8230,8235,8480,8488,8493,8496,8505,8507,8515,8518,8526,8538,8599,8627,8672,8742,8795,8832,8905,8907,8933,8953,8972,9026,9061,9082,9089,9094,9147,9166,9220,9285,9294,9319,9385,9449,9466,9517,9522,9656,9678,9703,9766,9795,9805,9816,9822,9825,9828,9834,9838,9841,9848,9865,9920],"50%":[70],"those":[72,386,979,3244,5528,6188,6997,8720,9617,9845],"older":[73,2612,3139,3161,6321],"than":[74,291,395,1435,1542,2500,3013,4459,4920,5649,5735,5773,5950,6054,6137,6147,6275,6279,6818,8040,8619,9555,9561,9738],"85":[75],"age,":[78],"are":[79,92,339,344,642,647,650,1302,1481,1578,1613,1808,2266,2654,2682,2721,2792,2839,2963,2992,3122,3298,3363,3527,3551,3596,3773,3847,3868,3912,4059,4379,5020,5025,5124,5277,5332,5937,5958,6081,6110,6230,6261,6393,6397,6404,6416,6438,6443,6812,6921,6941,7000,7049,7056,7444,7594,7701,7729,7746,7903,7983,8014,8126,8142,8154,8298,8347,8405,8467,8483,8503,8554,8572,8615,8665,8727,8751,8883,9131,9144,9255,9324,9492,9549,9685,9719,9772],"suffer":[82,1643],"from":[83,108,131,1115,3142,3145,3877,3914,4188,4251,4315,4846,5290,5372,5417,5504,5986,6039,6101,8261,9134,9661],"(2).":[85],"One":[86,4838,7961],"hundred":[87],"thousand":[88],"deaths":[89],"per":[90,6898],"year":[91,4349,4371,4611,6899],"attributed":[93],"United":[98,128,2711,4593,4795,5000,7191,7227],"States.":[99,4594,4796,5001,7228],"In":[100,119,225,914,968,2040,2111,2310,2335,3444,3520,3713,3739,5265,5409,5534,5743,5902,6930,7335,7489,7940,8587,8991],"last":[102],"50":[103],"years,":[104,411],"has":[106,2256,2280,2292,4313,4480,4547,4676,5176,5204,5237,6975,7069,7138,7170,7640,8775,8969,9382],"grown":[107],"relative":[109],"obscurity":[110],"becoming":[112],"defining":[114],"characteristic":[115],"industrialized":[117],"society.":[118],"1950,":[120],"at":[121,137,242,284,493,1877,2021,2186,3063,3124,3675,3872,4276,4280,4882,5241,6564,6714,6762,7206,7780,8406,8714,8721,9398],"200,000":[124],"people":[125,232,374,1640,2653,2667,3242,8633,8687,8878],"States":[129,2712,7192],"suffered":[130,7388],"ailment.":[133],"total":[135,161,499],"stands":[136],"4":[138,4445,4461,4476,4802,4922,5041,5052,7108,7246,7361],"million":[139,164],"today":[140],"(3).":[141],"By":[142,6988],"2050,":[143],"barring":[144],"cure,":[146],"number":[148,897,3189,7647],"U.S.":[150,4044],"sufferers":[151,165],"expected":[153,3848],"reach":[155,2858],"16":[156,6804],"million,":[157],"out":[158,2855,2894,2909,7368],"80":[163],"worldwide":[166],"(4).":[167],"Despite":[168],"consensus":[169],"on":[170,264,315,360,579,602,675,1323,1359,1377,1380,1424,1469,2085,2248,3245,3322,3572,4200,4337,4364,4387,4616,4972,5333,5454,5551,5572,5577,5608,5631,5637,5654,5659,5910,6287,6635,6838,6900,7236,7277,7734,7871,8401,8611,9067,9096,9748],"both":[171,199,2412,2993,4388,7433,7712,7824,9077],"(5)":[173],"neuropathologic":[175],"(6)":[176],"definitions":[177],"AD,":[179,296,301,491,835,925,1016,1139,2677,4139,5696,6056,6324,7103,7492,7862,7906,8592,8636,8880,9340,9474],"only":[180,793,1891,3176,3762,4264,5187,5202,6113,8266,9408],"limited":[181,6083,9146],"information":[182,1408,8220],"known":[184,1190,7667],"about":[185,380,654,1176,1191,1317,1634,1760,2528,2736,3079,3094,3117,3798,5904,8491,8684,8693,8701,8735,8744],"its":[186,754,2187,3225,3474,4076,4517,5318,5351,7223,9664],"etiology":[187],"pathogenesis.":[189],"It":[190,1781,1814,2173,2208,2488,3607,4645,4728,7169,7397,8669,8902],"probably":[192,1688],"caused":[193],"by":[194,223,422,458,794,1581,1619,1799,1873,1900,2046,2928,3238,3478,3667,4042,4080,4153,4453,4535,4556,4580,4627,4648,4782,4880,4915,4987,5338,6561,6631,7045,7467,7839,7880,7914,7918,8534,8581,9498,9511,9721,9871,9876],"several":[195,4102,8042],"that":[197,373,535,771,869,884,1301,1427,1549,1633,1771,1792,1817,2048,2103,2179,2278,2300,2517,2882,3174,3303,3307,3490,3506,3600,3907,3988,4130,4195,4210,4223,4516,4843,4944,5019,5257,5381,5447,5606,5625,5628,5711,5728,5991,6029,6043,6127,6283,6783,6938,7068,7251,7258,7535,7570,7621,7705,7717,7810,7909,7928,7967,8165,8183,8195,8577,8663,8712,8719,8724,8762,8772,8787,8799,8819,8872,8916,9130,9301,9312,9332,9490,9529,9769,9812],"include":[198,589,978,1181,1236,1939,6079,7758,7932,8264,8379,9142,9173,9229,9626],"genetic":[200,1146,1476,1520],"environmental":[202,1944,7836,7915,8007],"influences":[203,7916,7927],"(7).":[204],"manifests":[207],"as":[208,227,229,437,441,462,850,852,1018,1042,1097,1108,1119,1244,1284,1297,1320,1370,1390,1850,2065,2067,2259,2392,2508,2937,3165,3167,3330,3391,3729,3780,3853,3892,4031,4141,4326,4508,4560,4640,4804,4810,4939,5113,5148,5525,5527,5672,5674,5697,5888,6178,6187,6426,6610,6612,6722,6724,6881,6906,7672,8047,8275,8277,8475,8555,8850,9087,9476,9642,9667,9855,9885,9915],"relentless":[210],"decline":[211,355,472,4180,6772,6952],"broad":[214,9356],"range":[215,3144,8445,9455],"intellectual":[217,1282],"functional":[219,354,471,1932,2035,2058,2100,4620,7562,7755,8961,8979,9028,9679],"abilities,":[220],"followed":[221,5560,7838],"eventually":[222],"death.":[224],"addition,":[226,2041,3521,3740,5903,7941,8992],"many":[228,521,1454,1462,2936,5880,7468,7942,8099,8898],"90%":[230,764,1664,2938,7777],"demonstrate":[235],"clinically":[236,3497,6509],"significant":[237,841,2053,5588,5754,5786,5849,6550,7275],"behavioral":[238,715,1039,1092,4134,5858,5883,6000,6865,7297,7582,7608,7690,7834,7876,7893,7901,7959,7970,7995,8012,8063,8079,8114,8123,9261,9433,9457,9471,9723,9836,9928],"psychological":[240,4136,7692,8575,8585],"symptoms":[241,423,433,1205,1208,3890,4137,5488,5689,5915,6001,6143,7695,7743,7902,8013,8036,8045,8115,9472,9548,9580,9587,9590,9611,9641,9676,9697,9713,9737],"some":[243,2363,3178,3299,3501,3619,3842,4233,4631,4721,4942,5278,5378,6965,7781,8133,9204,9250,9704,9810],"point":[244,495,2516,7782],"course":[247,2438,5926,6218,6884,7785,8844,9606],"illness,":[250,1657],"causing":[251,2056],"severe":[252,452,490,1644,3857,3899,4690,5724,6588,7374,9849],"emotional":[253,1645,7510,8473],"suffering.":[254],"Caring":[255,1558,8313],"patients":[257,269,294,415,496,544,682,912,1001,1073,1135,1276,1310,1463,1575,1741,1897,1918,1935,1992,2096,2127,2228,2425,2550,2588,2673,2696,2820,2860,2940,2951,3001,3249,3379,3550,3621,3640,3689,3700,3734,3845,3854,3867,3897,3910,3951,3979,4013,4207,4234,4329,4431,4522,4570,4688,4722,4859,5033,5286,5299,5322,5449,5691,5808,5840,5874,5907,5953,6068,6120,6208,6245,6268,6284,6322,6336,6586,6690,6809,6911,6998,7098,7393,7471,7490,7517,7588,7614,7779,7860,7896,7973,8066,8082,8092,8134,8153,8306,8404,8547,8593,8659,8680,8726,8732,8739,9565,9652,9683,9777,9782,9829,9867,9901],"imposes":[260],"immense":[262],"burden":[263,486,504,512,1396,1623,4156,9401],"caregivers":[265,868,908,1259,1586,1638,1649,1666,1807,1823,1839,1893,1915,2047,2062,2563,2846,2865,2962,4152,8094,8358,8541,8798,8810,9315,9899,9904],"(8).":[266],"Although":[267,517,4750,6238,8085,8940],"develop":[272,281,537,3402,6734],"after":[275,800,1606,4412,4710,6454,6773,6971],"age":[277,287,389],"65,":[279],"5\u201310%":[280],"younger":[286],"(early-onset":[288],"AD).":[289,3862],"Less":[290],"almost":[297,340,498],"being":[299,1483,5101,8691],"early-onset":[300,332,726,1137,1502],"have":[302,1650,2239,2533,2713,2824,3181,4039,4094,4098,4243,4398,4601,4663,5087,5108,5191,5270,5305,5327,5509,5946,6017,6021,6206,6233,6241,6294,6433,6580,6836,6868,6913,6949,7051,7654,7661,7790,7802,8497,8565,8635,8648,9163,9182,9191,9208,9345,9463,9527,9541,9571,9759],"familial":[304,333,727,1138,1503],"autosomal":[308],"dominant":[309],"pattern":[310],"inheritance.":[312],"Abnormal":[313],"genes":[314,338],"chromosomes":[316],"21,":[317],"14,":[318],"1":[320,4610,4753,7358,7885],"appear":[321,434,9219],"account":[323,611],"vast":[326],"majority":[327,1573,7724,8150],"cases":[329,1030,2360,7182,8100],"(9\u201311).":[335],"All":[336,2695,6203],"these":[337,432,911,956,2028,2486,2751,2837,3496,3645,3799,5267,5914,5922,5971,6014,6159,6288,6391,6525,6918,6939,7652,7807,7815,8544,8710,9206,9258,9564,9579],"fully":[341,5180],"penetrant.":[342],"There":[343,3484,3595,4125,4184,5376,5707,5982,7410,7423,7617,9248,9808],"3":[345,381,479,696,1253,3723,4299,4916,5424,6695,6703,6823,7370],"stages":[346,480,833,2131,2338,3826,3860,4019,5175,5726,8590,9861],"AD\u2014mild,":[348],"moderate,":[349],"severe\u2014with":[351],"cognitive":[352,467,1761,2038,2975,4115,4354,4376,4389,4617,5591,6094,6538,7007,7281,7560,7753,9589,9669,9873],"stretching":[356],"over":[357,4165,5234,5294,5309,5924,7151,7210,8420],"5\u20138":[358],"average":[362],"(range":[363],"2\u201320":[364],"years)":[365],"(Table":[366,568,6916,7771,8174],"1)":[367],"(12).":[368],"A":[369,620,784,951,2618,2646,2661,2920,3268,4951,5060,7456,9454,9486],"recent":[370,8942],"study":[371,1491,1670,5062,5623,5703,5868,6118,7340],"indicates":[372,770,6028],"often":[377,420,1767,2601,2840,3405,6337,8299,8348,9132,9718],"die":[378,3850],"within":[379,2449],"diagnosis,":[384,862],"especially":[385,1286,4831,6057],"above":[387],"85\u2014a":[391],"far":[392,3151],"grimmer":[393],"prognosis":[394,2138,8571],"was":[396,4418,4575,4607,4777,4815,4961,4982,5629,5771,5816,6133,7081,7119,7156,7398,7411,9361],"previously":[397],"thought":[398],"exist":[400],"(13).":[401],"Without":[402],"treatment,":[403,6946],"initial,":[405],"mild":[406,2676,2834,4054,4433,4587,4789,4994,5693,5738,5963,6210,6247,6378,6445,7076,7100,8122,8562,9831],"stage":[407,431,455,1012,1880],"usually":[408,6417,6444],"lasts":[409],"2\u20133":[410],"during":[412,1753,2282,6419,6482,6497,8373,9041,9604],"which":[413,2168,2269,2362,2720,3232,4605,4703,4742,5539,8021,8357,8423,8646],"time":[414,816,860,1600,3706,7047],"show":[416,4330,4358,7006],"short-term":[417,7497,7571],"memory":[418],"impairment,":[419,2976],"accompanied":[421],"anxiety":[425,8035],"depression.":[427,1046,1098,9592],"During":[428,667,1157],"moderate":[430,4056,4435,4589,4791,4996,5695,5740,5965,6212,6249,6447,7078,7102,9847],"abate,":[436],"neuropsychiatric":[438,510,5688,5758],"manifestations":[439],"such":[440,461,1017,1041,1095,1107,1118,1243,1296,1319,1369,2301,2311,2372,2507,2853,3329,3390,3779,3891,4140,4559,5887,6177,6186,6425,6905,7671,8046,8849,9475,9914],"visual":[442],"hallucinations,":[443,5892,7762],"delusions,":[444,5891,7761,9726],"reversal":[446],"sleep":[448,5363,7765,9441],"patterns":[449],"emerge.":[450],"final":[454],"characterized":[457],"motor":[459,463,2633,5895],"signs":[460,2605,2628,3302,7693,8937,9613],"rigidity":[464],"prominent":[466,9716],"decline.":[468,5598,6095,7756],"Cognitive":[469,9852],"tend":[473],"linear":[476],"throughout":[477,8842],"disease,":[483,6358,7947,7951],"whereas":[484,4356,5116,5762,9443],"caregiver":[485,1561,1866,1886,2986,2990,7715,8389,8654,9351,9387,9400,9506],"high":[488,2974,2989,3125,3873],"since":[492,7305],"this":[494,586,1407,2255,2616,3525,3576,4449,4557,4911,5023,5047,5106,5157,5219,5228,5638,5744,5863,6603,7117,7306,7639,8800],"require":[497,4890],"care;":[500],"physical":[502,1122,1656,2091,3554,7938,8009],"care":[503,511,848,891,1066,1819,2020,2043,2045,2070,2079,2083,2403,2459,2583,2968,2998,3083,3342,3660,3751,3934,3969,3984,3998,4003,4008,7686,9419],"greatest,":[507],"although":[508,2254,4630,6106,6511,8131],"can":[513,761,773,790,838,1127,1976,1981,2030,2668,3060,3831,5258,5399,5459,6386,6628,6642,6658,6962,6994,7521,7817,8095,8216,8594,9102,9306],"also":[514,1128,1695,1746,1782,1895,2175,2193,2209,3070,3199,3257,4093,4127,4150,4221,5326,5400,5683,5994,6099,6198,6435,8227,8283,8325,8435,8752,9192,9435],"considerable.":[516],"focus":[519],"physicians":[522,536,649,863,3306],"management":[525,540,551,744,966,1009,1037,3888,3977,7688,7856,7874,7891,8061,8146,8180],"cholinesterase":[529],"inhibitors":[530],"(ChEI),":[531],"it":[532,1450,1630,2270,2313,3436,3507,4256,4506,4546,4744,4845,5411,6557,6662,6668,6675,6725,8016,9058,9813],"crucial":[534],"global":[539,4117,7090,7513],"strategy":[541,3974],"their":[543,548,603,655,663,684,903,1588,1772,1797,1830,1921,2025,2129,2140,2155,2611,2704,2716,3072,3090,3107,3195,3319,3705,3856,3955,5130,5310,6373,7253,7735,8233,8421,8568,8667,8694,8702,8834,8908,9429,9691,9922],"caregivers.":[549,1075,1710,1738,3206,8353,8376,9524,9692],"Global":[550],"includes":[552],"early":[553,832,2130,2435,3825,5532,5673,6030,6215,6996,7027,8560,8589,8936,9860],"accurate":[554,763,807],"diagnosis":[555,758,786,808,827,999,1027,1082,1164,1448,2114,2144,2381,8569],"providing":[557,1384,1406,8396],"counseling":[558,1514,8583],"pharmacological":[560,920],"treatment":[561,581,615,921,1197,2440,3526,3885,3921,3973,4034,4052,4429,4585,4787,4960,4992,5517,5531,5836,6701,7074,7145,7162,7259,7314,7431,7544,7558,7606,7805,8112,8120,8129,9213],"patient":[564,571,703,837,945,1154,1167,1569,1605,2122,2198,2277,2291,2321,2349,2364,2406,2416,2478,2578,2726,3361,3654,3804,3821,3990,4312,4967,5263,5384,5472,6604,6769,6974,7033,7713,7825,7990,8340,8361,8382,8392,9069,9338,9452,9504],"family/caregiver":[567,2731],"2).":[569],"family":[573,886,904,1058,1151,1288,1582,1683,2162,2414,2451,2961,3029,3042,3179,3335,3806,8328,8343,8764,9278,9299,9343,9353,9446,9898],"must":[574,588,607,672,1712,1728,1833,2152,2389,2732,2742,3172,3208,6344,6912,8199,8226,8531],"agree":[575],"physician":[578,814,892,927,973,1400,1758,2741,3171,4291],"ultimately":[582],"selected":[583],"use;":[585],"decision":[587,3368,3577],"duration":[590,4074],"cost":[592],"considerations.":[593]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}