{"id":"https://openalex.org/W2148802014","doi":"https://doi.org/10.1002/emmm.201000080","title":"Angiotensin II revisited: new roles in inflammation, immunology and aging","display_name":"Angiotensin II revisited: new roles in inflammation, immunology and aging","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2148802014","doi":"https://doi.org/10.1002/emmm.201000080","mag":"2148802014","pmid":"https://pubmed.ncbi.nlm.nih.gov/20597104","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3377325"},"language":"en","primary_location":{"id":"doi:10.1002/emmm.201000080","doi":"https://doi.org/10.1002/emmm.201000080","is_oa":true,"landing_page_url":"https://doi.org/10.1002/emmm.201000080","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/emmm.201000080","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/emmm.201000080","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090115261","display_name":"Ariela Benigni","orcid":"https://orcid.org/0000-0002-4721-5485","observed_orcids":["https://orcid.org/0000-0002-4721-5485"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ariela Benigni","raw_affiliation_strings":["Mario Negri Institute for Pharmacological Research, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058960327","display_name":"Paola Cassis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Cassis","raw_affiliation_strings":["Mario Negri Institute for Pharmacological Research, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023556434","display_name":"Giuseppe Remuzzi","orcid":"https://orcid.org/0000-0002-6194-3446","observed_orcids":["https://orcid.org/0000-0002-6194-3446"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giuseppe Remuzzi","raw_affiliation_strings":["Mario Negri Institute for Pharmacological Research, Bergamo, Italy","Unit of Nephrology and Dialysis, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]},{"raw_affiliation_string":"Unit of Nephrology and Dialysis, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023556434"],"corresponding_institution_ids":["https://openalex.org/I19630809"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":{"value":7990,"currency":"USD","value_usd":7990},"fwci":3.4906,"has_fulltext":true,"cited_by_count":771,"citation_normalized_percentile":{"value":0.95503814,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"2","issue":"7","first_page":"247","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":1.0},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/immunology","display_name":"immunology","score":0.7540000081062317},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9959999918937683},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.7440000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6959999799728394},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9179999828338623},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.6769999861717224},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9710000157356262},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.5329999923706055},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7751443386077881},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6314212083816528},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5782460570335388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43226420879364014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3247101306915283},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21905887126922607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19961696863174438}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/emmm.201000080","doi":"https://doi.org/10.1002/emmm.201000080","is_oa":true,"landing_page_url":"https://doi.org/10.1002/emmm.201000080","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/emmm.201000080","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3377325","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3377325","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Mol Med","raw_type":"Text"},{"id":"pmid:20597104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20597104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO molecular medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/emmm.201000080","doi":"https://doi.org/10.1002/emmm.201000080","is_oa":true,"landing_page_url":"https://doi.org/10.1002/emmm.201000080","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/emmm.201000080","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148802014.pdf","grobid_xml":"https://content.openalex.org/works/W2148802014.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W10316846","https://openalex.org/W113185000","https://openalex.org/W180946569","https://openalex.org/W1490285206","https://openalex.org/W1497461844","https://openalex.org/W1579113972","https://openalex.org/W1593501931","https://openalex.org/W1760461988","https://openalex.org/W1963784744","https://openalex.org/W1965650317","https://openalex.org/W1966944979","https://openalex.org/W1967645451","https://openalex.org/W1969501720","https://openalex.org/W1973138815","https://openalex.org/W1974562777","https://openalex.org/W1974814786","https://openalex.org/W1975978426","https://openalex.org/W1980794416","https://openalex.org/W1981132320","https://openalex.org/W1981809254","https://openalex.org/W1987514832","https://openalex.org/W1992563074","https://openalex.org/W1995817686","https://openalex.org/W2000314850","https://openalex.org/W2004843485","https://openalex.org/W2005998322","https://openalex.org/W2006436888","https://openalex.org/W2009507490","https://openalex.org/W2014398586","https://openalex.org/W2016698332","https://openalex.org/W2018824646","https://openalex.org/W2018884025","https://openalex.org/W2019750766","https://openalex.org/W2021345753","https://openalex.org/W2025672718","https://openalex.org/W2026639881","https://openalex.org/W2027201636","https://openalex.org/W2031150814","https://openalex.org/W2031370342","https://openalex.org/W2033847819","https://openalex.org/W2035053904","https://openalex.org/W2036706643","https://openalex.org/W2036960544","https://openalex.org/W2038460784","https://openalex.org/W2041007292","https://openalex.org/W2043200338","https://openalex.org/W2045112738","https://openalex.org/W2045619262","https://openalex.org/W2048900216","https://openalex.org/W2048955066","https://openalex.org/W2049062066","https://openalex.org/W2050071967","https://openalex.org/W2050174401","https://openalex.org/W2051632982","https://openalex.org/W2052265065","https://openalex.org/W2052321977","https://openalex.org/W2052813773","https://openalex.org/W2056038215","https://openalex.org/W2057584928","https://openalex.org/W2057726446","https://openalex.org/W2058713776","https://openalex.org/W2064327398","https://openalex.org/W2067034692","https://openalex.org/W2067432590","https://openalex.org/W2069830368","https://openalex.org/W2071831134","https://openalex.org/W2072052992","https://openalex.org/W2073587768","https://openalex.org/W2074747030","https://openalex.org/W2076215691","https://openalex.org/W2076722320","https://openalex.org/W2076927324","https://openalex.org/W2085667634","https://openalex.org/W2086924452","https://openalex.org/W2087324698","https://openalex.org/W2087465913","https://openalex.org/W2087533627","https://openalex.org/W2088736558","https://openalex.org/W2089221056","https://openalex.org/W2090602346","https://openalex.org/W2091304964","https://openalex.org/W2092392023","https://openalex.org/W2094294849","https://openalex.org/W2096352923","https://openalex.org/W2097532633","https://openalex.org/W2097805169","https://openalex.org/W2099438717","https://openalex.org/W2100747450","https://openalex.org/W2106462989","https://openalex.org/W2106563803","https://openalex.org/W2106607972","https://openalex.org/W2107779094","https://openalex.org/W2109757648","https://openalex.org/W2110182057","https://openalex.org/W2114224597","https://openalex.org/W2117795062","https://openalex.org/W2122026830","https://openalex.org/W2123150238","https://openalex.org/W2124579523","https://openalex.org/W2125484955","https://openalex.org/W2126862979","https://openalex.org/W2128921112","https://openalex.org/W2129288474","https://openalex.org/W2130015016","https://openalex.org/W2131098432","https://openalex.org/W2134899427","https://openalex.org/W2135447029","https://openalex.org/W2140909944","https://openalex.org/W2142563692","https://openalex.org/W2143515869","https://openalex.org/W2145357314","https://openalex.org/W2145879452","https://openalex.org/W2150542380","https://openalex.org/W2153626991","https://openalex.org/W2156632978","https://openalex.org/W2158027695","https://openalex.org/W2159280118","https://openalex.org/W2161694484","https://openalex.org/W2164034521","https://openalex.org/W2164237992","https://openalex.org/W2164871064","https://openalex.org/W2165700415","https://openalex.org/W2168800815","https://openalex.org/W2171783221","https://openalex.org/W2256886791","https://openalex.org/W2269581839","https://openalex.org/W2315512556","https://openalex.org/W2326358619","https://openalex.org/W2913696875","https://openalex.org/W2972550292","https://openalex.org/W4231762600","https://openalex.org/W4247759744"],"related_works":["https://openalex.org/W4311111494","https://openalex.org/W2021345753","https://openalex.org/W4313444691","https://openalex.org/W3140274665","https://openalex.org/W1982322897","https://openalex.org/W2417152361","https://openalex.org/W1006857582","https://openalex.org/W2045141953","https://openalex.org/W2065413005","https://openalex.org/W2075604884"],"abstract_inverted_index":{"That":[0],"the":[1,23,98,120,135,138],"renin-angiotensin":[2],"system":[3,139],"(RAS)":[4],"is":[5,18],"involved":[6],"in":[7,22,55,92,106,109,128,140],"regulation":[8],"of":[9,52,58,122,137],"blood":[10],"pressure,":[11],"vasoconstriction,":[12],"sodium":[13],"intake":[14],"and":[15,39,89,112,125,130,147],"potassium":[16],"excretion":[17],"well":[19],"established.":[20],"Studies":[21],"last":[24],"few":[25],"years":[26],"have":[27],"however":[28],"documented":[29],"new":[30],"roles":[31,136],"for":[32,101],"this":[33],"molecule":[34,38],"as":[35,42],"a":[36,43],"pro-inflammatory":[37],"more":[40],"recently":[41],"possible":[44],"pro-fibrotic":[45],"agent":[46],"that":[47,72],"contributes":[48,73],"to":[49,61,74,133],"progressive":[50],"deterioration":[51],"organ":[53],"function":[54],"disease.":[56],"Binding":[57],"Ang":[59,82,103,123],"II":[60,83,104,124],"its":[62,126],"receptors":[63],"(in":[64],"particular":[65],"AT(1))":[66],"mediates":[67],"intracellular":[68],"free":[69],"radical":[70],"generation":[71],"tissue":[75,114,142],"damage":[76],"by":[77],"promoting":[78],"mitochondrial":[79],"dysfunction.":[80],"Blocking":[81],"signalling":[84,105],"protects":[85],"against":[86],"neurodegenerative":[87],"processes":[88],"promotes":[90],"longevity":[91],"rodents.":[93],"Altogether":[94],"these":[95],"findings":[96],"open":[97],"unanticipated":[99],"perspective":[100],"exploring":[102],"therapeutic":[107],"interventions":[108],"inflammatory":[110],"diseases":[111],"aging-related":[113],"injury.":[115],"This":[116],"review":[117],"extends":[118],"from":[119],"discovery":[121],"implications":[127],"renal":[129],"cardiovascular":[131],"physiology":[132],"cover":[134],"inflammation,":[141],"injury,":[143],"autoimmunity,":[144],"oxidative":[145],"stress":[146],"aging.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":36},{"year":2025,"cited_by_count":45},{"year":2024,"cited_by_count":74},{"year":2023,"cited_by_count":68},{"year":2022,"cited_by_count":73},{"year":2021,"cited_by_count":116},{"year":2020,"cited_by_count":90},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":48},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":36},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}