{"id":"https://openalex.org/W2148798174","doi":"https://doi.org/10.1080/00498250601175565","title":"The pharmacokinetics and disposition of MK-0524, a Prostaglandin D2receptor 1 antagonist, in rats, dogs and monkeys","display_name":"The pharmacokinetics and disposition of MK-0524, a Prostaglandin D2receptor 1 antagonist, in rats, dogs and monkeys","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2148798174","doi":"https://doi.org/10.1080/00498250601175565","mag":"2148798174","pmid":"https://pubmed.ncbi.nlm.nih.gov/17523054"},"language":"en","primary_location":{"id":"doi:10.1080/00498250601175565","doi":"https://doi.org/10.1080/00498250601175565","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00498250601175565","pdf_url":null,"source":{"id":"https://openalex.org/S48760969","display_name":"Xenobiotica","issn_l":"0049-8254","issn":["0049-8254","1366-5928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S. W. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. W. Chang","raw_affiliation_strings":["Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07065 , USA","Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07065 , USA","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"V. Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Reddy","raw_affiliation_strings":["Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014791053","display_name":"Tony Pereira","orcid":"https://orcid.org/0000-0002-2737-0314","observed_orcids":["https://orcid.org/0000-0002-2737-0314"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Pereira","raw_affiliation_strings":["Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. J. Dean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. J. Dean","raw_affiliation_strings":["Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101837854","display_name":"Yuanqing Xia","orcid":"https://orcid.org/0000-0002-5945-4424","observed_orcids":["https://orcid.org/0000-0002-5945-4424"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y.-Q. Xia","raw_affiliation_strings":["Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111735328","display_name":"Carmai Seto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Seto","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Frosst Center for Therapeutic Research, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Frosst Center for Therapeutic Research, Montreal, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079507222","display_name":"Ronald B. Franklin","orcid":"https://orcid.org/0000-0003-2618-0081","observed_orcids":["https://orcid.org/0000-0003-2618-0081"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. B. Franklin","raw_affiliation_strings":["Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111470558","display_name":"Bindhu V. Karanam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. V. Karanam","raw_affiliation_strings":["Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, USA","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3655,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.91305139,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"37","issue":"5","first_page":"514","last_page":"533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.10159999877214432,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9430000185966492},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.746999979019165},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8690000176429749},{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.9100000262260437},{"id":"https://openalex.org/keywords/clearance","display_name":"clearance","score":0.3240000009536743},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.734000027179718},{"id":"https://openalex.org/keywords/cross-species-comparison","display_name":"cross-species comparison","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7014896869659424},{"id":"https://openalex.org/C2779907587","wikidata":"https://www.wikidata.org/wiki/Q14901439","display_name":"Glucuronidation","level":4,"score":0.6496617197990417},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6396278738975525},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6160221695899963},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6024134159088135},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.5934028625488281},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5813650488853455},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5143061876296997},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4622068405151367},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4612753391265869},{"id":"https://openalex.org/C2779186261","wikidata":"https://www.wikidata.org/wiki/Q137786","display_name":"Glucuronide","level":3,"score":0.4503433406352997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33715176582336426},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3330857455730438},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26539379358291626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2283194363117218},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11694267392158508},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.09714573621749878},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020719","descriptor_name":"Glucuronides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020719","descriptor_name":"Glucuronides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/00498250601175565","doi":"https://doi.org/10.1080/00498250601175565","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00498250601175565","pdf_url":null,"source":{"id":"https://openalex.org/S48760969","display_name":"Xenobiotica","issn_l":"0049-8254","issn":["0049-8254","1366-5928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica","raw_type":"journal-article"},{"id":"pmid:17523054","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17523054","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica; the fate of foreign compounds in biological systems","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W54963308","https://openalex.org/W1485967434","https://openalex.org/W1792751488","https://openalex.org/W1803110866","https://openalex.org/W1839162061","https://openalex.org/W1967470820","https://openalex.org/W1974311863","https://openalex.org/W1981670728","https://openalex.org/W1998174682","https://openalex.org/W2048244406","https://openalex.org/W2079408175","https://openalex.org/W2086695833","https://openalex.org/W2103682415","https://openalex.org/W2113396465","https://openalex.org/W2135758343","https://openalex.org/W4244098017"],"related_works":["https://openalex.org/W2135758343","https://openalex.org/W2127911111","https://openalex.org/W2405404390","https://openalex.org/W2587940728","https://openalex.org/W2035058238","https://openalex.org/W4220853682","https://openalex.org/W2416466687","https://openalex.org/W1994691525","https://openalex.org/W1974311863","https://openalex.org/W164830943"],"abstract_inverted_index":{"MK-0524":[0,33,41,57,119,172,198],"is":[1],"a":[2],"potent,":[3],"selective":[4],"and":[5,30,39,45,60,63,72,81,85,91,111,124,130,145,155,160,190,196],"orally":[6],"active":[7],"Prosglandin":[8],"D(2)":[9],"Receptor":[10],"1":[11,90,112,144],"(DP(1))":[12],"antagonist":[13],"currently":[14],"under":[15],"clinical":[16],"development":[17],"for":[18],"the":[19,27,66,76,86,103,134,139,168,179,185,210,214],"treatment":[20],"of":[21,32,56,118,171,176,209],"niacin-induced":[22],"flushing.":[23],"Experiments":[24],"to":[25,58,120,178],"study":[26],"pharmacokinetics,":[28],"metabolism":[29],"excretion":[31,208],"were":[34,106,157],"conducted":[35],"in":[36,152,184,218],"rats,":[37,153],"dogs":[38,61,127,154],"monkeys.":[40],"displayed":[42],"linear":[43],"kinetics":[44],"rapid":[46,137],"absorption":[47,135],"following":[48],"an":[49],"oral":[50,116,149],"dose.":[51],"Following":[52,115],"intravenous":[53],"(i.v.)":[54],"administration":[55],"rats":[59,121,195],"(1":[62],"5":[64,93],"mg/kg),":[65,126,133],"mean":[67,140],"Cl(p)":[68],"was":[69,78,88,136,167,199],"approximately":[70,73,79,82,89,92],"2":[71],"6":[74],"ml/min/kg,":[75,108],"T(1/2)":[77],"7":[80],"13":[83],"h":[84,110],"Vd(ss)":[87],"L/kg,":[94,113],"respectively.":[95,114,162],"In":[96,192],"monkeys":[97,131,156],"dosed":[98],"i.v.":[99],"at":[100],"3":[101,109],"mg/kg,":[102],"corresponding":[104],"values":[105,151],"8":[107],"dosing":[117],"(5,":[122],"25":[123],"100":[125],"(5":[128],"mg/kg)":[129],"(3":[132],"with":[138,174],"C(max)":[141],"occurring":[142],"between":[143],"4":[146],"h.":[147],"Absolute":[148],"bioavailability":[150],"50,":[158],"70":[159],"8%,":[161],"The":[163],"major":[164,215],"circulating":[165],"metabolite":[166],"acyl":[169,203,211],"glucuronide":[170,177],"(M2),":[173],"ratios":[175],"parent":[180],"aglycone":[181],"being":[182],"highest":[183],"monkey":[186],"followed":[187,205],"by":[188,206],"dog":[189],"rat.":[191],"bile":[193],"duct-cannulated":[194],"dogs,":[197],"eliminated":[200],"primarily":[201],"via":[202],"glucuronidation":[204],"biliary":[207],"glucuronide,":[212],"M2,":[213],"drug-related":[216],"entity":[217],"bile.":[219]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
