{"id":"https://openalex.org/W2148745019","doi":"https://doi.org/10.1161/01.atv.0000148863.24445.b4","title":"Antiangiogenic Activity of Semisynthetic Biotechnological Heparins: Low-Molecular-Weight-Sulfated Escherichia coli K5 Polysaccharide Derivatives as Fibroblast Growth Factor Antagonists","display_name":"Antiangiogenic Activity of Semisynthetic Biotechnological Heparins: Low-Molecular-Weight-Sulfated Escherichia coli K5 Polysaccharide Derivatives as Fibroblast Growth Factor Antagonists","publication_year":2004,"publication_date":"2004-10-29","ids":{"openalex":"https://openalex.org/W2148745019","doi":"https://doi.org/10.1161/01.atv.0000148863.24445.b4","mag":"2148745019","pmid":"https://pubmed.ncbi.nlm.nih.gov/15514208"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.0000148863.24445.b4","doi":"https://doi.org/10.1161/01.atv.0000148863.24445.b4","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.0000148863.24445.b4","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.0000148863.24445.b4","source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.0000148863.24445.b4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005942566","display_name":"Marco Presta","orcid":"https://orcid.org/0000-0002-4398-8376","observed_orcids":["https://orcid.org/0000-0002-4398-8376"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Presta","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019992897","display_name":"Pasqua Oreste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pasqua Oreste","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000563099","display_name":"Giorgio Zoppetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Zoppetti","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035266557","display_name":"Mirella Belleri","orcid":"https://orcid.org/0000-0001-6674-0878","observed_orcids":["https://orcid.org/0000-0001-6674-0878"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mirella Belleri","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076365387","display_name":"Elena Tanghetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Tanghetti","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052540458","display_name":"Daria Leali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daria Leali","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054608868","display_name":"Chiara Urbinati","orcid":"https://orcid.org/0000-0002-0138-7871","observed_orcids":["https://orcid.org/0000-0002-0138-7871"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Urbinati","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011403015","display_name":"Antonella Bugatti","orcid":"https://orcid.org/0000-0001-5450-5774","observed_orcids":["https://orcid.org/0000-0001-5450-5774"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Bugatti","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013367044","display_name":"Roberto Ronca","orcid":"https://orcid.org/0000-0001-8979-7068","observed_orcids":["https://orcid.org/0000-0001-8979-7068"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Ronca","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014818296","display_name":"Stefania Nicoli","orcid":"https://orcid.org/0000-0001-7055-340X","observed_orcids":["https://orcid.org/0000-0001-7055-340X"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Nicoli","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080522012","display_name":"Emanuela Moroni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuela Moroni","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040070739","display_name":"Helena Stabile","orcid":"https://orcid.org/0000-0002-3514-9847","observed_orcids":["https://orcid.org/0000-0002-3514-9847"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Helena Stabile","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018130516","display_name":"Maura Camozzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maura Camozzi","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":null,"display_name":"German Andre\u0301s Hernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"German Andre\u0301s Hernandez","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053652045","display_name":"Stefania Maria Filomena Mitola","orcid":"https://orcid.org/0000-0002-5557-738X","observed_orcids":["https://orcid.org/0000-0002-5557-738X"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Mitola","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040921752","display_name":"Patrizia Dell\u2019Era","orcid":"https://orcid.org/0000-0001-6682-6321","observed_orcids":["https://orcid.org/0000-0001-6682-6321"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Patrizia Dell\u2019Era","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023138915","display_name":"Marco Rusnati","orcid":"https://orcid.org/0000-0001-9968-5908","observed_orcids":["https://orcid.org/0000-0001-9968-5908"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Rusnati","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054370212","display_name":"Dom\u00e9nico Ribatti","orcid":"https://orcid.org/0000-0003-4768-8431","observed_orcids":["https://orcid.org/0000-0003-4768-8431"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Ribatti","raw_affiliation_strings":["From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","Glycores 2000 Srl (P.O., G.Z.), Milano","the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M.P., M.B., E.T., D.L., C.U., A.B., R.R., S.N., E.M., H.S., M.C., G.A.H, S.M., P.D., M.R.), School of Medicine, University of Brescia; Glycores 2000 Srl (P.O., G.Z.), Milano; and the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750","https://openalex.org/I79940851"]},{"raw_affiliation_string":"Glycores 2000 Srl (P.O., G.Z.), Milano","institution_ids":[]},{"raw_affiliation_string":"the Department of Human Anatomy and Histology (D.R.), University of Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8074,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.64505723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"1","first_page":"71","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.20010000467300415,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.06509999930858612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.8980000019073486},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8199999928474426},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.824999988079071},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.8759999871253967},{"id":"https://openalex.org/keywords/heparan-sulfate-proteoglycans","display_name":"heparan sulfate proteoglycans","score":0.9120000004768372},{"id":"https://openalex.org/keywords/fgfr1","display_name":"FGFR1","score":0.7680000066757202},{"id":"https://openalex.org/keywords/alpha-v-beta3-integrin","display_name":"alpha v beta 3 integrin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.7889999747276306},{"id":"https://openalex.org/keywords/chick-embryo-chorioallantoic-membrane","display_name":"chick embryo chorioallantoic membrane","score":0.8799999952316284},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6777319312095642},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.6639503240585327},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.6635771989822388},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.5799190402030945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5727988481521606},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5633570551872253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.546269953250885},{"id":"https://openalex.org/C97230052","wikidata":"https://www.wikidata.org/wiki/Q3854334","display_name":"Chorioallantoic membrane","level":3,"score":0.5059427618980408},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.44885608553886414},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43770965933799744},{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.41838985681533813},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4133261442184448},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3597366213798523},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3448117971420288},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33763015270233154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27235329151153564},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.22738587856292725}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006495","descriptor_name":"Heparin, Low-Molecular-Weight","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006495","descriptor_name":"Heparin, Low-Molecular-Weight","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D006495","descriptor_name":"Heparin, Low-Molecular-Weight","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016667","descriptor_name":"Bacterial Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049033","descriptor_name":"Chorioallantoic Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1161/01.atv.0000148863.24445.b4","doi":"https://doi.org/10.1161/01.atv.0000148863.24445.b4","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.0000148863.24445.b4","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.0000148863.24445.b4","source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:15514208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15514208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unibs.it:11379/29210","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11379/29210","pdf_url":"http://hdl.handle.net/11379/29210","source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.928.2035","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.928.2035","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://atvb.ahajournals.org/content/25/1/71.full.pdf","raw_type":"text"},{"id":"pmh:oai:iris.uniroma1.it:11573/343137","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000226065900013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.uniba.it:11586/48102","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/48102","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1161/01.atv.0000148863.24445.b4","doi":"https://doi.org/10.1161/01.atv.0000148863.24445.b4","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.0000148863.24445.b4","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.0000148863.24445.b4","source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148745019.pdf","grobid_xml":"https://content.openalex.org/works/W2148745019.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W7707690","https://openalex.org/W147592962","https://openalex.org/W1494551606","https://openalex.org/W1514050185","https://openalex.org/W1564590530","https://openalex.org/W1599299094","https://openalex.org/W1650277859","https://openalex.org/W1751804092","https://openalex.org/W1878854037","https://openalex.org/W1938067578","https://openalex.org/W1963891523","https://openalex.org/W1996544895","https://openalex.org/W2009345525","https://openalex.org/W2014519464","https://openalex.org/W2019981734","https://openalex.org/W2023525921","https://openalex.org/W2027261163","https://openalex.org/W2028915127","https://openalex.org/W2030155901","https://openalex.org/W2033279380","https://openalex.org/W2036555544","https://openalex.org/W2041703901","https://openalex.org/W2046778136","https://openalex.org/W2050082215","https://openalex.org/W2056895491","https://openalex.org/W2072162018","https://openalex.org/W2074763334","https://openalex.org/W2074830112","https://openalex.org/W2075196907","https://openalex.org/W2080062167","https://openalex.org/W2081846517","https://openalex.org/W2095113001","https://openalex.org/W2099146799","https://openalex.org/W2107117443","https://openalex.org/W2107124774","https://openalex.org/W2109489238","https://openalex.org/W2114286636","https://openalex.org/W2120630263","https://openalex.org/W2123759534","https://openalex.org/W2129307844","https://openalex.org/W2154848828","https://openalex.org/W2242679990","https://openalex.org/W2283957630","https://openalex.org/W2316892465","https://openalex.org/W3173300771","https://openalex.org/W4230774514","https://openalex.org/W4242291721"],"related_works":["https://openalex.org/W7100871457","https://openalex.org/W2109489238","https://openalex.org/W7096760792","https://openalex.org/W2009345525","https://openalex.org/W2027261163","https://openalex.org/W2017327429","https://openalex.org/W2083432523","https://openalex.org/W2900982703","https://openalex.org/W2051560253","https://openalex.org/W2083566193"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Low-molecular-weight":[1],"heparin":[2,22,76],"(LMWH)":[3],"exerts":[4],"antitumor":[5],"activity":[6,49],"in":[7,102,150,154,156],"clinical":[8],"trials.":[9],"The":[10],"K5":[11,29,56,165],"polysaccharide":[12,30],"from":[13],"Escherichia":[14],"coli":[15],"has":[16],"the":[17,21,33,41,111,157,186,189],"same":[18],"structure":[19],"as":[20],"precursor.":[23],"Chemical":[24],"and":[25,47,94,127,144,152,170,173,179],"enzymatic":[26],"modifications":[27],"of":[28,35,50,53,84,113,121,191],"lead":[31],"to":[32,78,106,124],"production":[34],"biotechnological":[36],"heparin-like":[37,194],"compounds.":[38,196],"We":[39],"investigated":[40],"fibroblast":[42],"growth":[43],"factor-2":[44],"(FGF2)":[45],"antagonist":[46,178],"antiangiogenic":[48,180],"a":[51,79],"series":[52],"LMW":[54,163,193],"N,O-sulfated":[55,164],"derivatives.":[57],"METHODS":[58],"AND":[59],"RESULTS:":[60],"Surface":[61],"plasmon":[62],"resonance":[63],"analysis":[64],"showed":[65],"that":[66],"LMW-K5":[67,108,134],"derivatives":[68,109,166],"bind":[69],"FGF2,":[70],"thus":[71],"inhibiting":[72],"its":[73],"interaction":[74,143],"with":[75,86,176],"immobilized":[77],"BIAcore":[80],"sensor":[81],"chip.":[82],"Interaction":[83],"FGF2":[85,177],"tyrosine-kinase":[87],"receptors":[88],"(FGFRs),":[89],"heparan":[90],"sulfate":[91],"proteoglycans":[92],"(HSPGs),":[93],"alpha(v)beta3":[95],"integrin":[96,142],"is":[97],"required":[98],"for":[99,188],"biological":[100],"response":[101],"endothelial":[103,130,147],"cells.":[104],"Similar":[105],"LMWH,":[107,138],"abrogate":[110],"formation":[112],"HSPG/FGF2/FGFR":[114,169],"ternary":[115],"complexes":[116],"by":[117],"preventing":[118],"FGF2-mediated":[119,129,146],"attachment":[120],"FGFR1-overexpressing":[122],"cells":[123,126],"HSPG-bearing":[125],"inhibit":[128,140],"cell":[131,148],"proliferation.":[132],"However,":[133],"derivatives,":[135],"but":[136],"not":[137],"also":[139],"FGF2/alpha(v)beta3":[141,171],"consequent":[145],"sprouting":[149],"vitro":[151],"angiogenesis":[153],"vivo":[155],"chick":[158],"embryo":[159],"chorioallantoic":[160],"membrane.":[161],"CONCLUSIONS:":[162],"affect":[167],"both":[168],"interactions":[172],"are":[174],"endowed":[175],"activity.":[181],"These":[182],"compounds":[183],"may":[184],"provide":[185],"basis":[187],"design":[190],"novel":[192],"angiostatic":[195]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}