{"id":"https://openalex.org/W2148667335","doi":"https://doi.org/10.1177/019262338701500205","title":"Spontaneous Mesotheliomas in Fischer Rats\u2014A Histological and Electron Microscopic Study","display_name":"Spontaneous Mesotheliomas in Fischer Rats\u2014A Histological and Electron Microscopic Study","publication_year":1987,"publication_date":"1987-02-01","ids":{"openalex":"https://openalex.org/W2148667335","doi":"https://doi.org/10.1177/019262338701500205","mag":"2148667335","pmid":"https://pubmed.ncbi.nlm.nih.gov/3616400"},"language":"en","primary_location":{"id":"doi:10.1177/019262338701500205","doi":"https://doi.org/10.1177/019262338701500205","is_oa":false,"landing_page_url":"https://doi.org/10.1177/019262338701500205","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hiroyuki Tanigawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Tanigawa","raw_affiliation_strings":["Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, 1\u201318\u20131 Kamiyoga, Setagaya-ku, Tokyo 158, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, 1\u201318\u20131 Kamiyoga, Setagaya-ku, Tokyo 158, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113595150","display_name":"Hiroshi Onodera","orcid":"https://orcid.org/0009-0000-7385-913X","observed_orcids":["https://orcid.org/0009-0000-7385-913X"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Onodera","raw_affiliation_strings":["Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, 1\u201318\u20131 Kamiyoga, Setagaya-ku, Tokyo 158, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, 1\u201318\u20131 Kamiyoga, Setagaya-ku, Tokyo 158, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111400856","display_name":"Akihiko Maekawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiko Maekawa","raw_affiliation_strings":["Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, 1\u201318\u20131 Kamiyoga, Setagaya-ku, Tokyo 158, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, 1\u201318\u20131 Kamiyoga, Setagaya-ku, Tokyo 158, Japan","institution_ids":["https://openalex.org/I4210151964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210151964"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.9757,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.83982451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"15","issue":"2","first_page":"157","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tumor-histology","display_name":"tumor histology","score":0.597000002861023},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.8500000238418579},{"id":"https://openalex.org/keywords/pleural-mesothelioma","display_name":"pleural mesothelioma","score":0.7770000100135803},{"id":"https://openalex.org/keywords/tumor-cell-morphology","display_name":"tumor cell morphology","score":0.5920000076293945},{"id":"https://openalex.org/keywords/histogenesis","display_name":"histogenesis","score":0.4909999966621399},{"id":"https://openalex.org/keywords/chemical-carcinogens","display_name":"chemical carcinogens","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C191548132","wikidata":"https://www.wikidata.org/wiki/Q2355306","display_name":"Histogenesis","level":3,"score":0.7455156445503235},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7272375226020813},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6943004131317139},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.6620082259178162},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.6128978729248047},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.5173367857933044},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.5109276175498962},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5012822151184082},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.4875275790691376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4533918499946594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4159894585609436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15128880739212036},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15121865272521973},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.08617639541625977},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/019262338701500205","doi":"https://doi.org/10.1177/019262338701500205","is_oa":false,"landing_page_url":"https://doi.org/10.1177/019262338701500205","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:3616400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3616400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W40955555","https://openalex.org/W128825882","https://openalex.org/W142476271","https://openalex.org/W159416972","https://openalex.org/W187877941","https://openalex.org/W1919589075","https://openalex.org/W1934438996","https://openalex.org/W1985696650","https://openalex.org/W2012648170","https://openalex.org/W2031863702","https://openalex.org/W2059557869","https://openalex.org/W2080811090","https://openalex.org/W2092159152","https://openalex.org/W2095619460","https://openalex.org/W2127955026","https://openalex.org/W2134920613","https://openalex.org/W2135700959","https://openalex.org/W2140874818","https://openalex.org/W2159896243","https://openalex.org/W2160732181","https://openalex.org/W2265989016","https://openalex.org/W2290898593","https://openalex.org/W2322479731","https://openalex.org/W2392089762","https://openalex.org/W2398908329","https://openalex.org/W2408964091","https://openalex.org/W2411691337","https://openalex.org/W2412165641","https://openalex.org/W2412264144","https://openalex.org/W2414207593","https://openalex.org/W2418836604","https://openalex.org/W2419153797","https://openalex.org/W4297976780"],"related_works":["https://openalex.org/W2158397009","https://openalex.org/W2408964091","https://openalex.org/W87800078","https://openalex.org/W2394884948","https://openalex.org/W2053627466","https://openalex.org/W2412393132","https://openalex.org/W3208122753","https://openalex.org/W2121896818","https://openalex.org/W2316266608","https://openalex.org/W2349230949"],"abstract_inverted_index":{"Seventeen":[0],"mesotheliomas":[1,30],"from":[2,67],"395":[3],"untreated":[4],"male":[5],"Fischer":[6,151],"344/DuCrj":[7],"rats":[8,153],"were":[9,31,50,76,86,102,112,154],"studied":[10],"by":[11],"light":[12],"and":[13,39,85,139,160,172],"electron":[14],"microscopy":[15],"to":[16,70,78,82],"define":[17],"the":[18,22,34,40,46,59,62,93,115,173],"morphological":[19,145],"characteristics":[20,146],"of":[21,27,61,120,147,169,181],"tumors.":[23],"In":[24],"16":[25],"out":[26],"17":[28],"rats,":[29],"observed":[32],"in":[33,89,150,158,165,175],"abdominal":[35],"and/or":[36],"scrotal":[37],"sac,":[38],"other":[41],"one":[42],"was":[43],"localized":[44],"on":[45],"pleura.":[47],"Grossly,":[48],"tumors":[49,149,171],"yellow-brown":[51],"with":[52,80,107,156,161],"various-sized":[53],"multiple":[54],"modules":[55],"growing":[56],"irregularly":[57],"over":[58],"surface":[60],"serosa.":[63],"Microscopically,":[64],"they":[65],"varied":[66],"complex":[68],"papillary":[69],"sessile":[71],"nodular":[72],"growths.":[73],"Tumor":[74],"cells":[75,94,122],"cuboidal":[77],"polygonal":[79],"round":[81],"oval":[83],"nuclei,":[84],"sometimes":[87],"arranged":[88],"tubule-like":[90],"structures.":[91],"Occasionally,":[92],"contained":[95],"Mowry's":[96],"colloidal":[97],"iron":[98],"positive":[99],"materials,":[100],"which":[101],"negative":[103],"following":[104,178],"prior":[105],"incubation":[106],"hyaluronidase.":[108],"Furthermore,":[109],"intracellular":[110],"keratins":[111],"detected":[113],"using":[114],"peroxidase-antiperoxidase":[116],"method.":[117],"Ultrastructural":[118],"features":[119],"tumor":[121],"included":[123],"numerous":[124],"microvilli,":[125],"a":[126,140],"basement":[127],"membrane,":[128],"junctional":[129],"complexes,":[130],"abundant":[131],"cytofilaments,":[132],"dilated":[133],"rough":[134],"surfaced":[135],"endoplasmic":[136],"reticulum":[137],"cisternae,":[138],"well-developed":[141],"Golgi":[142],"apparatus.":[143],"The":[144,167],"these":[148,170],"344":[152],"consistent":[155],"those":[157],"humans":[159],"experimentally":[162],"induced":[163],"counterparts":[164],"rats.":[166],"histogenesis":[168],"variability":[174],"their":[176],"incidence":[177],"oral":[179],"administration":[180],"chemical":[182],"carcinogens":[183],"is":[184],"discussed.":[185]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}