{"id":"https://openalex.org/W2148661978","doi":"https://doi.org/10.1667/rr3397.1","title":"Cellular Monitoring of the Nuclear Factor \u03baB Pathway for Assessment of Space Environmental Radiation","display_name":"Cellular Monitoring of the Nuclear Factor \u03baB Pathway for Assessment of Space Environmental Radiation","publication_year":2005,"publication_date":"2005-10-01","ids":{"openalex":"https://openalex.org/W2148661978","doi":"https://doi.org/10.1667/rr3397.1","mag":"2148661978","pmid":"https://pubmed.ncbi.nlm.nih.gov/16187762"},"language":"en","primary_location":{"id":"doi:10.1667/rr3397.1","doi":"https://doi.org/10.1667/rr3397.1","is_oa":false,"landing_page_url":"https://doi.org/10.1667/rr3397.1","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109273352","display_name":"Christa Baumstark\u2010Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898391981","display_name":"Deutsches Zentrum f\u00fcr Luft- und Raumfahrt e. V. (DLR)","ror":"https://ror.org/04bwf3e34","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2898391981"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christa Baumstark-Khan","raw_affiliation_strings":["German Aerospace Centre (DLR), Institute of Aerospace Medicine, Linder H\u00f6he, D-51147 K\u00f6ln, Germany. christa.baumstark-khan@dlr.de","German Aerospace Centre (DLR), Institute of Aerospace Medicine, Linder H\u00f6he, D-51147 K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Aerospace Centre (DLR), Institute of Aerospace Medicine, Linder H\u00f6he, D-51147 K\u00f6ln, Germany. christa.baumstark-khan@dlr.de","institution_ids":["https://openalex.org/I2898391981"]},{"raw_affiliation_string":"German Aerospace Centre (DLR), Institute of Aerospace Medicine, Linder H\u00f6he, D-51147 K\u00f6ln, Germany","institution_ids":["https://openalex.org/I2898391981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074265667","display_name":"Christine Elisabeth Hellweg","orcid":"https://orcid.org/0000-0002-2223-3580","observed_orcids":["https://orcid.org/0000-0002-2223-3580"]},"institutions":[{"id":"https://openalex.org/I2898391981","display_name":"Deutsches Zentrum f\u00fcr Luft- und Raumfahrt e. V. (DLR)","ror":"https://ror.org/04bwf3e34","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2898391981"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine E. Hellweg","raw_affiliation_strings":["German Aerospace Centre (DLR), Institute of Aerospace Medicine, Linder H\u00f6he, D-51147 K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Aerospace Centre (DLR), Institute of Aerospace Medicine, Linder H\u00f6he, D-51147 K\u00f6ln, Germany","institution_ids":["https://openalex.org/I2898391981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000535558","display_name":"Andrea Arenz","orcid":"https://orcid.org/0000-0001-8958-3107","observed_orcids":["https://orcid.org/0000-0001-8958-3107"]},"institutions":[{"id":"https://openalex.org/I2898391981","display_name":"Deutsches Zentrum f\u00fcr Luft- und Raumfahrt e. V. (DLR)","ror":"https://ror.org/04bwf3e34","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2898391981"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrea Arenz","raw_affiliation_strings":["German Aerospace Centre (DLR), Institute of Aerospace Medicine, Linder H\u00f6he, D-51147 K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Aerospace Centre (DLR), Institute of Aerospace Medicine, Linder H\u00f6he, D-51147 K\u00f6ln, Germany","institution_ids":["https://openalex.org/I2898391981"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053558804","display_name":"Matthias M. Meier","orcid":"https://orcid.org/0000-0003-0918-6473","observed_orcids":["https://orcid.org/0000-0003-0918-6473"]},"institutions":[{"id":"https://openalex.org/I2898391981","display_name":"Deutsches Zentrum f\u00fcr Luft- und Raumfahrt e. V. (DLR)","ror":"https://ror.org/04bwf3e34","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2898391981"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias M. Meier","raw_affiliation_strings":["German Aerospace Centre (DLR), Institute of Aerospace Medicine, Linder H\u00f6he, D-51147 K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Aerospace Centre (DLR), Institute of Aerospace Medicine, Linder H\u00f6he, D-51147 K\u00f6ln, Germany","institution_ids":["https://openalex.org/I2898391981"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109273352"],"corresponding_institution_ids":["https://openalex.org/I2898391981"],"apc_list":null,"apc_paid":null,"fwci":1.5282,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.82453658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"164","issue":"4","first_page":"527","last_page":"530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.05079999938607216,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/space-radiation","display_name":"space radiation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/argon-ions","display_name":"argon ions","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.878000020980835},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6919999718666077},{"id":"https://openalex.org/keywords/biological-effects-of-radiation","display_name":"biological effects of radiation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/let","display_name":"LET","score":0.3199999928474426},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"flow cytometry","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6339499354362488},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5456271171569824},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4915247857570648},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.4867701530456543},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.47826969623565674},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4539860785007477},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4402756094932556},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42955392599105835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3638949692249298},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3616656959056854},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31683623790740967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2147565484046936},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003359","descriptor_name":"Cosmic Radiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020450","descriptor_name":"Heavy Ions","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1667/rr3397.1","doi":"https://doi.org/10.1667/rr3397.1","is_oa":false,"landing_page_url":"https://doi.org/10.1667/rr3397.1","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},{"id":"pmid:16187762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16187762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation research","raw_type":"Journal Article"},{"id":"pmh:10.1667/RR3397.1","doi":null,"is_oa":false,"landing_page_url":"http://www.bioone.org/doi/10.1667/RR3397.1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402358","display_name":"BioOne Complete (BioOne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210111627","host_organization_name":"BioOne","host_organization_lineage":["https://openalex.org/I4210111627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W151784005","https://openalex.org/W176066471","https://openalex.org/W1497061219","https://openalex.org/W1568529372","https://openalex.org/W1963289746","https://openalex.org/W1965168699","https://openalex.org/W1970227011","https://openalex.org/W1983398917","https://openalex.org/W1998226582","https://openalex.org/W1998574404","https://openalex.org/W2023735966","https://openalex.org/W2029276835","https://openalex.org/W2038890616","https://openalex.org/W2044296969","https://openalex.org/W2051994734","https://openalex.org/W2053102794","https://openalex.org/W2054097003","https://openalex.org/W2068962163","https://openalex.org/W2092515229","https://openalex.org/W2106877484","https://openalex.org/W2115308311","https://openalex.org/W2127650036","https://openalex.org/W2130952513","https://openalex.org/W2169226851","https://openalex.org/W2316716290","https://openalex.org/W2331176038","https://openalex.org/W2999065750","https://openalex.org/W4319308505"],"related_works":["https://openalex.org/W7027158553","https://openalex.org/W7045280879","https://openalex.org/W416278390","https://openalex.org/W2083920615","https://openalex.org/W6989802309","https://openalex.org/W7049298473","https://openalex.org/W612280205","https://openalex.org/W7061725768","https://openalex.org/W1878988474","https://openalex.org/W2090269097"],"abstract_inverted_index":{"Baumstark-Khan,":[0],"C.,":[1],"Hellweg,":[2],"C.":[3],"E.,":[4],"Arenz,":[5],"A.":[6],"and":[7,77],"Meier,":[8],"M.":[9,10],"Cellular":[11],"Monitoring":[12],"of":[13,21,35,43,59,66,74,79,81],"the":[14,33,40,44,56,113],"Nuclear":[15],"Factor":[16],"\u03baB":[17],"Pathway":[18],"for":[19,32,54],"Assessment":[20],"Space":[22],"Environmental":[23],"Radiation.":[24],"Radiat.":[25],"Res.":[26],"164,":[27],"527\u2013530":[28],"(2005).A":[29],"screening":[30],"assay":[31],"detection":[34],"NF-\u03baB-dependent":[36,82],"gene":[37,83],"induction":[38],"using":[39,95],"destabilized":[41],"variant":[42],"reporter":[45],"protein":[46,50],"enhanced":[47],"green":[48],"fluorescent":[49],"(d2EGFP)":[51],"is":[52],"used":[53],"assessing":[55],"biological":[57],"effects":[58],"accelerated":[60,104],"heavy":[61],"ions":[62,106],"as":[63,128,130],"a":[64],"model":[65],"space":[67],"environmental":[68],"radiation":[69],"conditions.":[70],"The":[71,98],"time":[72],"course":[73],"d2EGFP":[75],"expression":[76,84],"therefore":[78],"activation":[80],"was":[85],"measured":[86],"after":[87,92],"treatment":[88],"with":[89],"TNFA":[90],"or":[91],"heavy-ion":[93],"exposure":[94],"flow":[96],"cytometry.":[97],"reported":[99],"experiments":[100],"clearly":[101],"show":[102],"that":[103],"argon":[105],"(95":[107],"MeV/nucleon,":[108],"LET":[109],"230":[110],"keV/\u03bcm)":[111],"induce":[112],"NF-\u03baB":[114],"pathway":[115],"at":[116],"low":[117],"particle":[118,121],"densities":[119],"(1\u20132":[120],"hits":[122],"per":[123,134],"nucleus),":[124],"which":[125],"result":[126],"in":[127],"few":[129],"5\u201350":[131],"induced":[132],"DSBs":[133],"cell.":[135]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}