{"id":"https://openalex.org/W2148658259","doi":"https://doi.org/10.1080/15287394.2014.951594","title":"Negligible Pharmacokinetic Interaction of Red Ginseng and Antihypertensive Agent Amlodipine in Sprague-Dawley Rats","display_name":"Negligible Pharmacokinetic Interaction of Red Ginseng and Antihypertensive Agent Amlodipine in Sprague-Dawley Rats","publication_year":2014,"publication_date":"2014-10-24","ids":{"openalex":"https://openalex.org/W2148658259","doi":"https://doi.org/10.1080/15287394.2014.951594","mag":"2148658259","pmid":"https://pubmed.ncbi.nlm.nih.gov/25343287"},"language":"en","primary_location":{"id":"doi:10.1080/15287394.2014.951594","doi":"https://doi.org/10.1080/15287394.2014.951594","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287394.2014.951594","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health, Part A","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2148658259"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109837192","display_name":"Sung Ha Ryu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Ha Ryu","raw_affiliation_strings":["a College of Pharmacy, Dankook University , 119 Dandae-ro, Cheonan-si, Chungnam 330-714 , Republic of Korea","College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a College of Pharmacy, Dankook University , 119 Dandae-ro, Cheonan-si, Chungnam 330-714 , Republic of Korea","institution_ids":["https://openalex.org/I89015989"]},{"raw_affiliation_string":"College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359901","display_name":"Ji Won Kim","orcid":"https://orcid.org/0000-0002-3117-3698","observed_orcids":["https://orcid.org/0000-0002-3117-3698"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Won Kim","raw_affiliation_strings":["College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085695905","display_name":"Yong Soon Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270216","display_name":"Korea Ginseng Corporation (South Korea)","ror":"https://ror.org/008qtev21","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405270216"]},{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong Soon Kim","raw_affiliation_strings":["Botanical Drug Laboratory, R&D Headquarters, Korea Ginseng Corp., 30, Gajeong-ro, Yuseong-gu, Daejeon 308-805, Korea","College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botanical Drug Laboratory, R&D Headquarters, Korea Ginseng Corp., 30, Gajeong-ro, Yuseong-gu, Daejeon 308-805, Korea","institution_ids":["https://openalex.org/I4405270216"]},{"raw_affiliation_string":"College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363395","display_name":"Seung\u2010Ho Lee","orcid":"https://orcid.org/0000-0001-6958-7581","observed_orcids":["https://orcid.org/0000-0001-6958-7581","https://orcid.org/0000-0002-3149-8433"]},"institutions":[{"id":"https://openalex.org/I4405270216","display_name":"Korea Ginseng Corporation (South Korea)","ror":"https://ror.org/008qtev21","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405270216"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Ho Lee","raw_affiliation_strings":["Botanical Drug Laboratory, R&D Headquarters, Korea Ginseng Corp., 30, Gajeong-ro, Yuseong-gu, Daejeon 308-805, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botanical Drug Laboratory, R&D Headquarters, Korea Ginseng Corp., 30, Gajeong-ro, Yuseong-gu, Daejeon 308-805, Korea","institution_ids":["https://openalex.org/I4405270216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082448603","display_name":"Yong-Baik Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270216","display_name":"Korea Ginseng Corporation (South Korea)","ror":"https://ror.org/008qtev21","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405270216"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Baik Cho","raw_affiliation_strings":["Botanical Drug Laboratory, R&D Headquarters, Korea Ginseng Corp., 30, Gajeong-ro, Yuseong-gu, Daejeon 308-805, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botanical Drug Laboratory, R&D Headquarters, Korea Ginseng Corp., 30, Gajeong-ro, Yuseong-gu, Daejeon 308-805, Korea","institution_ids":["https://openalex.org/I4405270216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013181291","display_name":"Hyo Keun Lee","orcid":"https://orcid.org/0000-0001-5209-7658","observed_orcids":["https://orcid.org/0000-0001-5209-7658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyo Keun Lee","raw_affiliation_strings":["Gyeonwoo Korean Medical Clinic, Manrijae-ro 15, Mapo-gu, Seoul 121-803, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gyeonwoo Korean Medical Clinic, Manrijae-ro 15, Mapo-gu, Seoul 121-803, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022941061","display_name":"Yoon Gyoon Kim","orcid":"https://orcid.org/0000-0002-2171-9941","observed_orcids":["https://orcid.org/0000-0002-2171-9941"]},"institutions":[{"id":"https://openalex.org/I4405270216","display_name":"Korea Ginseng Corporation (South Korea)","ror":"https://ror.org/008qtev21","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405270216"]},{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon Gyoon Kim","raw_affiliation_strings":["Botanical Drug Laboratory, R&D Headquarters, Korea Ginseng Corp., 30, Gajeong-ro, Yuseong-gu, Daejeon 308-805, Korea","College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botanical Drug Laboratory, R&D Headquarters, Korea Ginseng Corp., 30, Gajeong-ro, Yuseong-gu, Daejeon 308-805, Korea","institution_ids":["https://openalex.org/I4405270216"]},{"raw_affiliation_string":"College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091034884","display_name":"Woo\u2010Sik Jeong","orcid":"https://orcid.org/0000-0002-7717-3626","observed_orcids":["https://orcid.org/0000-0002-7717-3626"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Woo-Sik Jeong","raw_affiliation_strings":["Department of Food and Life Sciences, College of Biomedical Science and Engineering, Inje University, Gimhae, Gyeongnam 621-749, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Life Sciences, College of Biomedical Science and Engineering, Inje University, Gimhae, Gyeongnam 621-749, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077614062","display_name":"Kyu\u2010Bong Kim","orcid":"https://orcid.org/0000-0003-2139-2296","observed_orcids":["https://orcid.org/0000-0003-2139-2296"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyu-Bong Kim","raw_affiliation_strings":["College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea; Department of Medical Laser, Graduate School, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Korea","College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea","Department of Medical Laser, Graduate School, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea; Department of Medical Laser, Graduate School, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Korea","institution_ids":["https://openalex.org/I89015989"]},{"raw_affiliation_string":"College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]},{"raw_affiliation_string":"Department of Medical Laser, Graduate School, Dankook University, 119 Dandae-ro, Cheonan-si, Chungnam 330-714, Korea","institution_ids":["https://openalex.org/I89015989"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5077614062","https://openalex.org/A5091034884"],"corresponding_institution_ids":["https://openalex.org/I104338594","https://openalex.org/I89015989"],"apc_list":null,"apc_paid":null,"fwci":1.1028,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.70788567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"77","issue":"22-24","first_page":"1372","last_page":"1383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/red-ginseng","display_name":"red ginseng","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.8659999966621399},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8270000219345093},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8880000114440918},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.6140000224113464},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7129999995231628},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.6499999761581421},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.8650000095367432},{"id":"https://openalex.org/keywords/herbal-medicine-safety","display_name":"herbal medicine safety","score":0.4650000035762787},{"id":"https://openalex.org/keywords/drug-metabolism-induction","display_name":"drug metabolism induction","score":0.35499998927116394},{"id":"https://openalex.org/keywords/cyp3a4-inhibition","display_name":"CYP3A4 inhibition","score":0.5379999876022339},{"id":"https://openalex.org/keywords/cyp2c9-inhibition","display_name":"CYP2C9 inhibition","score":0.6010000109672546},{"id":"https://openalex.org/keywords/cyp2c19-inhibition","display_name":"CYP2C19 inhibition","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2779646130","wikidata":"https://www.wikidata.org/wiki/Q411347","display_name":"Amlodipine","level":3,"score":0.9448798894882202},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.8047827482223511},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7614924311637878},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5943620204925537},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5845102071762085},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5715221166610718},{"id":"https://openalex.org/C2779232237","wikidata":"https://www.wikidata.org/wiki/Q20817212","display_name":"Ginseng","level":3,"score":0.5592117309570312},{"id":"https://openalex.org/C2992379925","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Pharmacokinetic interaction","level":4,"score":0.4558694064617157},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.39801955223083496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2799913287162781},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.2472415566444397},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23868796229362488},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005894","descriptor_name":"Panax","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D041743","descriptor_name":"Herb-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15287394.2014.951594","doi":"https://doi.org/10.1080/15287394.2014.951594","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287394.2014.951594","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health, Part A","raw_type":"journal-article"},{"id":"pmid:25343287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25343287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicology and environmental health. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1924522868","https://openalex.org/W1963655699","https://openalex.org/W1968994172","https://openalex.org/W1973201505","https://openalex.org/W1980101667","https://openalex.org/W1983298526","https://openalex.org/W1984757189","https://openalex.org/W1984909355","https://openalex.org/W1984988499","https://openalex.org/W1987118114","https://openalex.org/W1992746042","https://openalex.org/W1995888369","https://openalex.org/W2003556240","https://openalex.org/W2004281677","https://openalex.org/W2009494586","https://openalex.org/W2013848453","https://openalex.org/W2016188249","https://openalex.org/W2023187960","https://openalex.org/W2026684480","https://openalex.org/W2034615747","https://openalex.org/W2041080192","https://openalex.org/W2042257745","https://openalex.org/W2045280877","https://openalex.org/W2048312777","https://openalex.org/W2048848534","https://openalex.org/W2049129255","https://openalex.org/W2049985148","https://openalex.org/W2062913054","https://openalex.org/W2063075907","https://openalex.org/W2069069910","https://openalex.org/W2074279004","https://openalex.org/W2075773961","https://openalex.org/W2087713662","https://openalex.org/W2112146600","https://openalex.org/W2114738513","https://openalex.org/W2122342236","https://openalex.org/W2124571990","https://openalex.org/W2124662083","https://openalex.org/W2131892826","https://openalex.org/W2139051233","https://openalex.org/W2139480984","https://openalex.org/W2141659719","https://openalex.org/W2144997134","https://openalex.org/W2146768388","https://openalex.org/W2148861687","https://openalex.org/W2159602314","https://openalex.org/W4250535067"],"related_works":["https://openalex.org/W2137610146","https://openalex.org/W2191489996","https://openalex.org/W2891440387","https://openalex.org/W4386847601","https://openalex.org/W3024870515","https://openalex.org/W4385638348","https://openalex.org/W3125993910","https://openalex.org/W2157476060","https://openalex.org/W3003871410","https://openalex.org/W2936273436"],"abstract_inverted_index":{"Red":[0],"ginseng":[1],"(RG)":[2],"is":[3,11],"the":[4,25,170,173,206,219,230],"top-selling":[5],"functional":[6],"food":[7],"in":[8,16,218,245],"Korea,":[9],"but":[10],"not":[12,202],"recommended":[13],"for":[14,46,95],"use":[15],"hypertensive":[17],"patients.":[18],"This":[19],"study":[20],"was":[21,43,54,62,89,186,201],"performed":[22],"to":[23,57,92,128,179],"determine":[24],"pharmacokinetic":[26],"(PK)":[27],"interaction":[28],"between":[29],"RG":[30,36,83,238],"and":[31,49,73,136,143,147,158,165,190,197,226],"amlodipine,":[32],"an":[33,124],"antihypertensive":[34],"drug.":[35],"(0,":[37,84],"0.5,":[38,141,163,195],"1,":[39,67,85,142,164,196],"or":[40,86],"2":[41,47,87,96,144,166,198],"g/kg/d)":[42,88],"administered":[44,90],"orally":[45,91],"wk,":[48,97],"then":[50],"amlodipine":[51,77,100,108,122,212,243],"(10":[52],"mg/kg)":[53,102],"given":[55],"orally,":[56],"Sprague-Dawley":[58],"(SD)":[59],"rats.":[60,246],"Blood":[61],"collected":[63],"at":[64,139,161,193],"0.08,":[65],"0.25,":[66],"1.5,":[68],"2,":[69],"3,":[70],"6,":[71],"12,":[72],"24":[74,180],"h":[75,138,181,185],"after":[76],"administration.":[78],"In":[79],"intravenous":[80],"(iv)":[81],"study,":[82],"SD":[93],"rats":[94],"followed":[98],"by":[99],"(2":[101],"intravenously":[103],"(iv).":[104],"Plasma":[105],"concentrations":[106],"of":[107,121,126,150,211,224],"were":[109],"analyzed":[110],"using":[111],"a":[112,148],"high-pressure":[113],"liquid":[114],"chromatography-tandem":[115],"mass":[116],"system":[117],"(LC-MS/MS).":[118],"Oral":[119],"administration":[120],"produced":[123,214],"increase":[125],"time":[127,177],"maximum":[129,151],"plasma":[130,152],"concentration":[131,153,183],"(tmax:":[132],"2.6,":[133],"4.1,":[134],"8.3,":[135],"8.9":[137],"0,":[140,162,194],"g/kg/d,":[145,167],"respectively),":[146],"decrease":[149],"(Cmax:":[154],"278.5,":[155],"212.4,":[156],"232.1,":[157],"238.7":[159],"ng/ml":[160],"respectively.).":[168],"However,":[169],"area":[171],"under":[172],"concentration-time":[174],"curve":[175],"from":[176],"0":[178],"measurable":[182],"(AUC0-24":[184],"3487.4,":[187],"2895.4,":[188],"3158.2,":[189],"3495":[191],"ng/h/ml":[192],"g/kg/d":[199],"respectively)":[200],"significantly":[203],"changed":[204],"among":[205,229],"different":[207,231],"dose":[208,232],"groups.":[209,233],"Administration":[210],"iv":[213],"no":[215],"significant":[216],"changes":[217],"apparent":[220],"terminal":[221],"half-life,":[222],"volume":[223],"distribution,":[225],"AUC0-24":[227],"hr":[228],"These":[234],"results":[235],"suggest":[236],"that":[237],"induced":[239],"negligible":[240],"influence":[241],"on":[242],"pharmacokinetically":[244]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}