{"id":"https://openalex.org/W2148657070","doi":"https://doi.org/10.1093/ndt/gfm216","title":"Erythropoietin ameliorates renal dysfunction during endotoxaemia","display_name":"Erythropoietin ameliorates renal dysfunction during endotoxaemia","publication_year":2007,"publication_date":"2007-03-29","ids":{"openalex":"https://openalex.org/W2148657070","doi":"https://doi.org/10.1093/ndt/gfm216","mag":"2148657070","pmid":"https://pubmed.ncbi.nlm.nih.gov/17438005"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfm216","doi":"https://doi.org/10.1093/ndt/gfm216","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfm216","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017626381","display_name":"Amit Mitra","orcid":"https://orcid.org/0000-0003-4046-7070","observed_orcids":["https://orcid.org/0000-0003-4046-7070"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Mitra","raw_affiliation_strings":["University of Colorado Health Sciences Center, 4200 East 9th Ave. Box C-281, Denver, CO 80262, USA","University of Colorado Health Sciences Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Health Sciences Center, 4200 East 9th Ave. Box C-281, Denver, CO 80262, USA","institution_ids":["https://openalex.org/I4210087413"]},{"raw_affiliation_string":"University of Colorado Health Sciences Center, Denver, Colorado","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080211899","display_name":"Shweta Bansal","orcid":"https://orcid.org/0000-0002-3306-2799","observed_orcids":["https://orcid.org/0000-0002-3306-2799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Bansal","raw_affiliation_strings":["University of Colorado Health Sciences Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Health Sciences Center, Denver, Colorado","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076646981","display_name":"W. Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Wang","raw_affiliation_strings":["University of Colorado Health Sciences Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Health Sciences Center, Denver, Colorado","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040065258","display_name":"Sandor A. Falk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Falk","raw_affiliation_strings":["University of Colorado Health Sciences Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Health Sciences Center, Denver, Colorado","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001702929","display_name":"Einath Zolty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Zolty","raw_affiliation_strings":["University of Colorado Health Sciences Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Health Sciences Center, Denver, Colorado","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108449499","display_name":"Robert W. Schrier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. W. Schrier","raw_affiliation_strings":["University of Colorado Health Sciences Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Health Sciences Center, Denver, Colorado","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":4.8412,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.94799761,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"8","first_page":"2349","last_page":"2353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.06790000200271606,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":1.0},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9509999752044678},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.972000002861023},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.75},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8790000081062317},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9584022760391235},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.9131056070327759},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8754258155822754},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7741129398345947},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.5704795122146606},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5417711138725281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39196765422821045},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3773898482322693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35675036907196045},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.347150981426239}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ndt/gfm216","doi":"https://doi.org/10.1093/ndt/gfm216","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfm216","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmid:17438005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17438005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1510846940","https://openalex.org/W1966245864","https://openalex.org/W1974106801","https://openalex.org/W1976455881","https://openalex.org/W2003423899","https://openalex.org/W2022525830","https://openalex.org/W2035765103","https://openalex.org/W2049927822","https://openalex.org/W2058141781","https://openalex.org/W2059034777","https://openalex.org/W2060282267","https://openalex.org/W2065578442","https://openalex.org/W2070743921","https://openalex.org/W2081820417","https://openalex.org/W2089093162","https://openalex.org/W2120967762","https://openalex.org/W2122823145","https://openalex.org/W2125806058","https://openalex.org/W2136270624","https://openalex.org/W2143880941","https://openalex.org/W2151517451","https://openalex.org/W2154986839","https://openalex.org/W2160713807","https://openalex.org/W2162264368","https://openalex.org/W2167890215","https://openalex.org/W2170568009","https://openalex.org/W2302448715","https://openalex.org/W4254674135","https://openalex.org/W4301891889"],"related_works":["https://openalex.org/W7099945906","https://openalex.org/W1490641754","https://openalex.org/W11766024","https://openalex.org/W2132590612","https://openalex.org/W1533115818","https://openalex.org/W2007541656","https://openalex.org/W2154986839","https://openalex.org/W7037714539","https://openalex.org/W2355734067","https://openalex.org/W7037137770"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sepsis":[1],"has":[2,32],"a":[3,135,165],"high":[4],"mortality":[5],"(50-80%)":[6],"when":[7],"associated":[8,49,133,147],"with":[9,26,50,134,148],"acute":[10],"renal":[11,93,128,138,144,156,166,173],"failure":[12],"(ARF).":[13],"Oxidant":[14],"injury":[15],"and":[16,19,38,65,115],"proinflammatory":[17],"cytokines":[18],"chemokines":[20],"have":[21,43],"been":[22,33],"shown":[23],"to":[24,35,73,89],"increase":[25],"endotoxaemia-related":[27],"ARF.":[28],"Since":[29],"erythropoietin":[30],"(EPO)":[31],"demonstrated":[34],"possess":[36],"anti-oxidant":[37],"anti-inflammatory":[39],"properties,":[40],"EPO":[41,80,86,170],"may":[42],"therapeutic":[44],"efficacy":[45],"for":[46],"treating":[47],"ARF":[48],"endotoxaemia.":[51],"METHODS:":[52],"Wild-type":[53],"mice":[54,76],"were":[55,77,119],"given":[56,78],"2.5":[57],"mg/kg":[58],"of":[59,150,153,164,169],"intraperitoneal":[60],"(i.p.)":[61],"endotoxin,":[62],"lipopolysaccharide":[63],"(LPS),":[64],"studied":[66],"16":[67],"h":[68],"later.":[69],"Thirty":[70],"minutes":[71],"prior":[72],"LPS,":[74],"the":[75,92,124,151,161],"either":[79],"or":[81],"vehicle.":[82],"RESULTS:":[83],"During":[84],"endotoxaemia,":[85],"was":[87,132,146],"found":[88],"significantly":[90,121],"attenuate":[91],"dysfunction,":[94],"as":[95],"assessed":[96],"by":[97],"glomerular":[98],"filtration":[99],"rate":[100],"(48.1":[101],"+/-":[102,107],"12.4":[103],"microl/min":[104],"vs":[105],"136.7":[106],"30.2,":[108],"P":[109],"<":[110],"0.05).":[111],"Renal":[112],"blood":[113],"flow":[114],"mean":[116],"arterial":[117],"pressure":[118],"not":[120],"different":[122],"between":[123],"two":[125],"groups.":[126],"The":[127,142],"dysfunction":[129],"during":[130],"endotoxaemia":[131],"decrease":[136],"in":[137],"superoxide":[139],"dismutase":[140],"(SOD).":[141],"EPO-related":[143],"protection":[145],"reversal":[149],"effects":[152],"endotoxin":[154],"on":[155,171],"SOD.":[157],"CONCLUSION:":[158],"This":[159],"is":[160],"first":[162],"demonstration":[163],"protective":[167],"effect":[168],"endotoxin-related":[172],"dysfunction.":[174]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}