{"id":"https://openalex.org/W2148656198","doi":"https://doi.org/10.1002/ijc.24304","title":"Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age","display_name":"Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age","publication_year":2009,"publication_date":"2009-02-03","ids":{"openalex":"https://openalex.org/W2148656198","doi":"https://doi.org/10.1002/ijc.24304","mag":"2148656198","pmid":"https://pubmed.ncbi.nlm.nih.gov/19291797"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.24304","doi":"https://doi.org/10.1002/ijc.24304","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24304","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24304","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24304","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077549519","display_name":"Zumin Shi","orcid":"https://orcid.org/0000-0002-3099-3299","observed_orcids":["https://orcid.org/0000-0002-3099-3299"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Zumin Shi","raw_affiliation_strings":["Research Centre for Gender, Health and Ageing, University of Newcastle, Callaghan, Australia","The first two authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Gender, Health and Ageing, University of Newcastle, Callaghan, Australia","institution_ids":["https://openalex.org/I78757542"]},{"raw_affiliation_string":"The first two authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036386407","display_name":"Daniel M. Johnstone","orcid":"https://orcid.org/0000-0003-2876-3299","observed_orcids":["https://orcid.org/0000-0003-2876-3299"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Daniel Johnstone","raw_affiliation_strings":["Research Centre for Gender, Health and Ageing, University of Newcastle, Callaghan, Australia","School of Biomedical Sciences, University of Newcastle, Callaghan, Australia","The first two authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Gender, Health and Ageing, University of Newcastle, Callaghan, Australia","institution_ids":["https://openalex.org/I78757542"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Newcastle, Callaghan, Australia","institution_ids":["https://openalex.org/I78757542"]},{"raw_affiliation_string":"The first two authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056125067","display_name":"Bente A. Talseth\u2010Palmer","orcid":"https://orcid.org/0000-0003-0286-7161","observed_orcids":["https://orcid.org/0000-0003-0286-7161"]},"institutions":[{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bente A. Talseth\u2010Palmer","raw_affiliation_strings":["Hunter Medical Research Institute, New South Wales, Australia","School of Biomedical Sciences, University of Newcastle, Callaghan, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunter Medical Research Institute, New South Wales, Australia","institution_ids":["https://openalex.org/I4210087646"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Newcastle, Callaghan, Australia","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041291673","display_name":"Tiffany\u2010Jane Evans","orcid":"https://orcid.org/0000-0001-7525-461X","observed_orcids":["https://orcid.org/0000-0001-7525-461X"]},"institutions":[{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tiffany\u2010Jane Evans","raw_affiliation_strings":["Hunter Medical Research Institute, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunter Medical Research Institute, New South Wales, Australia","institution_ids":["https://openalex.org/I4210087646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067322164","display_name":"Allan D. Spigelman","orcid":"https://orcid.org/0000-0002-7409-1684","observed_orcids":["https://orcid.org/0000-0002-7409-1684"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Allan D. Spigelman","raw_affiliation_strings":["Surgical Professorial Unit, UNSW St. Vincent's Hospital Clinical School, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Professorial Unit, UNSW St. Vincent's Hospital Clinical School, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001378231","display_name":"Claire Groombridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154888","display_name":"Hunter New England Local Health District","ror":"https://ror.org/050b31k83","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210154888"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Claire Groombridge","raw_affiliation_strings":["Hunter Family Cancer Service, Hunter New England Health, Newcastle, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunter Family Cancer Service, Hunter New England Health, Newcastle, New South Wales, Australia","institution_ids":["https://openalex.org/I4210154888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045700662","display_name":"Elizabeth A. Milward","orcid":"https://orcid.org/0000-0002-1023-7795","observed_orcids":["https://orcid.org/0000-0002-1023-7795"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Milward","raw_affiliation_strings":["Research Centre for Gender, Health and Ageing, University of Newcastle, Callaghan, Australia","School of Biomedical Sciences, University of Newcastle, Callaghan, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Gender, Health and Ageing, University of Newcastle, Callaghan, Australia","institution_ids":["https://openalex.org/I78757542"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Newcastle, Callaghan, Australia","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032701736","display_name":"John Kevin Olynyk","orcid":"https://orcid.org/0000-0003-0417-3411","observed_orcids":["https://orcid.org/0000-0003-0417-3411"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2799971621","display_name":"Harry Perkins Institute of Medical Research","ror":"https://ror.org/02xz7d723","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799971621"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John K. Olynyk","raw_affiliation_strings":["School of Medicine and Pharmacology, University of Western Australia, and The Western Australian Institute of Medical Research, Nedlands, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Pharmacology, University of Western Australia, and The Western Australian Institute of Medical Research, Nedlands, Australia","institution_ids":["https://openalex.org/I177877127","https://openalex.org/I2799971621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006490816","display_name":"Janina Suchy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160155","display_name":"International Hereditary Cancer Center","ror":"https://ror.org/04qfjb814","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210160155"]},{"id":"https://openalex.org/I79833322","display_name":"Pomeranian Medical University","ror":"https://ror.org/01v1rak05","country_code":"PL","type":"education","lineage":["https://openalex.org/I79833322"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Janina Suchy","raw_affiliation_strings":["Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Academy of Medicine, Szczecin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Academy of Medicine, Szczecin, Poland","institution_ids":["https://openalex.org/I4210160155","https://openalex.org/I79833322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008182935","display_name":"Grzegorz Kurzawski","orcid":"https://orcid.org/0000-0002-2414-9868","observed_orcids":["https://orcid.org/0000-0002-2414-9868"]},"institutions":[{"id":"https://openalex.org/I4210160155","display_name":"International Hereditary Cancer Center","ror":"https://ror.org/04qfjb814","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210160155"]},{"id":"https://openalex.org/I79833322","display_name":"Pomeranian Medical University","ror":"https://ror.org/01v1rak05","country_code":"PL","type":"education","lineage":["https://openalex.org/I79833322"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Grzegorz Kurzawski","raw_affiliation_strings":["Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Academy of Medicine, Szczecin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Academy of Medicine, Szczecin, Poland","institution_ids":["https://openalex.org/I4210160155","https://openalex.org/I79833322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023115923","display_name":"Jan Lubi\u0144ski","orcid":"https://orcid.org/0000-0003-2931-3003","observed_orcids":["https://orcid.org/0000-0003-2931-3003"]},"institutions":[{"id":"https://openalex.org/I4210160155","display_name":"International Hereditary Cancer Center","ror":"https://ror.org/04qfjb814","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210160155"]},{"id":"https://openalex.org/I79833322","display_name":"Pomeranian Medical University","ror":"https://ror.org/01v1rak05","country_code":"PL","type":"education","lineage":["https://openalex.org/I79833322"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jan Lubinski","raw_affiliation_strings":["Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Academy of Medicine, Szczecin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Academy of Medicine, Szczecin, Poland","institution_ids":["https://openalex.org/I4210160155","https://openalex.org/I79833322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016817677","display_name":"Rodney J. Scott","orcid":"https://orcid.org/0000-0001-7724-3404","observed_orcids":["https://orcid.org/0000-0001-7724-3404"]},"institutions":[{"id":"https://openalex.org/I2800479947","display_name":"John Hunter Hospital","ror":"https://ror.org/0187t0j49","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800479947","https://openalex.org/I4210154888"]},{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Rodney J. Scott","raw_affiliation_strings":["","Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia","Hunter Medical Research Institute, New South Wales, Australia","School of Biomedical Sciences, University of Newcastle, Callaghan, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia","institution_ids":["https://openalex.org/I2800479947"]},{"raw_affiliation_string":"Hunter Medical Research Institute, New South Wales, Australia","institution_ids":["https://openalex.org/I4210087646"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Newcastle, Callaghan, Australia","institution_ids":["https://openalex.org/I78757542"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5016817677"],"corresponding_institution_ids":["https://openalex.org/I2800479947","https://openalex.org/I4210087646","https://openalex.org/I78757542"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":3.7029,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.93139535,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"125","issue":"1","first_page":"78","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lynch-syndrome","display_name":"Lynch syndrome","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hfe-gene","display_name":"HFE gene","score":0.8199999928474426},{"id":"https://openalex.org/keywords/modifier-genes","display_name":"genetic modifiers","score":0.6949999928474426},{"id":"https://openalex.org/keywords/colorectal-cancer-risk","display_name":"colorectal cancer risk","score":0.9409999847412109},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.7289999723434448},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.7429999709129333},{"id":"https://openalex.org/keywords/sex-differences-in-cancer-risk","display_name":"sex differences in cancer risk","score":0.7900000214576721},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.6812143921852112},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6302125453948975},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.533153235912323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5184745192527771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5012490749359131},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.49648505449295044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46437421441078186},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41321861743927},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.41052064299583435},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4003562033176422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3902178108692169},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.35571128129959106},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3389712870121002},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23919418454170227},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.10783615708351135}],"mesh":[{"descriptor_ui":"D000071020","descriptor_name":"Hemochromatosis Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001315","descriptor_name":"Australia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003123","descriptor_name":"Colorectal Neoplasms, Hereditary Nonpolyposis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011044","descriptor_name":"Poland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1002/ijc.24304","doi":"https://doi.org/10.1002/ijc.24304","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24304","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24304","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:19291797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19291797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:alma.61MUN_INST:11135383500007891","doi":null,"is_oa":true,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Haemochromatosis-HFE-gene-polymorphisms-as-potential/991005541117707891","pdf_url":"https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12135383490007891/13136861140007891","source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:publications/3174a372-1242-458f-a68e-f8deb9414cc3","doi":null,"is_oa":false,"landing_page_url":"https://admin.research-repository.uwa.edu.au/en/publications/3174a372-1242-458f-a68e-f8deb9414cc3","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Shi, S, Johnstone, D, Talseth-Palmer, B A, Evans, T, Spigelman, A D, Groombridge, C, Milward, E A, Olynyk, J, Suchy, J, Kurzawski, G, Lubinski, J & Scott, R J 2009, 'Haemochromatosis HFE gene polymorphisms as potential modifiers of herediatry nonpolyposis colorectal cancer risk and onset age', International Journal of Cancer, vol. 125, no. 1, pp. 78-83.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:researchrepository.murdoch.edu.au:17208","doi":null,"is_oa":false,"landing_page_url":"http://researchrepository.murdoch.edu.au/id/eprint/17208/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Shi, Z., Johnstone, D., Talseth-Palmer, B.A., Evans, T-J, Spigelman, A.D., Groombridge, C., Milward, E.A., Olynyk, J.K. <http://researchrepository.murdoch.edu.au/view/author/Olynyk, John.html>, Suchy, J., Kurzawski, G., Lubinski, J. and Scott, R.J. (2009) Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age. International Journal of Cancer, 125 (1). pp. 78-83.","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/64431","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2440/64431","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1002/ijc.24304","raw_type":"Journal article"},{"id":"pmh:oai:espace.curtin.edu.au:20.500.11937/32494","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11937/32494","pdf_url":null,"source":{"id":"https://openalex.org/S4306401790","display_name":"eSpace (Curtin University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205640436","host_organization_name":"Curtin University","host_organization_lineage":["https://openalex.org/I205640436"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ijc.24304","doi":"https://doi.org/10.1002/ijc.24304","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24304","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24304","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148656198.pdf","grobid_xml":"https://content.openalex.org/works/W2148656198.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W145627573","https://openalex.org/W294724981","https://openalex.org/W1562509294","https://openalex.org/W1966778627","https://openalex.org/W1968087008","https://openalex.org/W1990637583","https://openalex.org/W1998872310","https://openalex.org/W2000442055","https://openalex.org/W2001494923","https://openalex.org/W2015111051","https://openalex.org/W2020719350","https://openalex.org/W2023397971","https://openalex.org/W2027664072","https://openalex.org/W2035374907","https://openalex.org/W2039875081","https://openalex.org/W2043724060","https://openalex.org/W2048706423","https://openalex.org/W2053827853","https://openalex.org/W2054401837","https://openalex.org/W2060299847","https://openalex.org/W2075169470","https://openalex.org/W2085843873","https://openalex.org/W2088512451","https://openalex.org/W2097700734","https://openalex.org/W2102691588","https://openalex.org/W2116858428","https://openalex.org/W2119030852","https://openalex.org/W2120398292","https://openalex.org/W2120541263","https://openalex.org/W2121242732","https://openalex.org/W2127093048","https://openalex.org/W2135082158","https://openalex.org/W2139964075","https://openalex.org/W2145387706","https://openalex.org/W2147119810","https://openalex.org/W2148669815","https://openalex.org/W2149456232","https://openalex.org/W2150262444","https://openalex.org/W2152634212","https://openalex.org/W2155181797","https://openalex.org/W2157950756","https://openalex.org/W2160039260","https://openalex.org/W2160400039","https://openalex.org/W2164017889","https://openalex.org/W2169749262","https://openalex.org/W4210710380","https://openalex.org/W4235735146"],"related_works":["https://openalex.org/W7029042525","https://openalex.org/W2135082158","https://openalex.org/W2150667605","https://openalex.org/W3080906952","https://openalex.org/W3191215618","https://openalex.org/W1996508745","https://openalex.org/W2086155534","https://openalex.org/W2116858428","https://openalex.org/W2042572788","https://openalex.org/W4284664937"],"abstract_inverted_index":{"Hereditary":[0],"nonpolyposis":[1],"colorectal":[2,51,254],"cancer":[3,52],"(HNPCC)":[4],"is":[5],"characterized":[6],"by":[7,155,249],"germline":[8],"mutations":[9,82],"in":[10,17,127,244,263],"DNA":[11],"mismatch":[12],"repair":[13],"genes;":[14],"however,":[15],"variation":[16],"disease":[18,60,242,261],"expression":[19,243],"suggests":[20],"that":[21],"there":[22],"are":[23],"potential":[24,44],"modifying":[25],"factors.":[26],"Polymorphisms":[27],"of":[28,50,64,70,96,134,149,178,186,204,219,241,260],"the":[29,34,48,56,65,86,194,231,247],"HFE":[30,66,87,220,232,251],"gene,":[31,67],"which":[32,250],"cause":[33],"iron":[35],"overload":[36],"disorder":[37],"hereditary":[38],"haemochromatosis,":[39],"have":[40],"been":[41],"proposed":[42],"as":[43],"risk":[45,95,203,262],"factors":[46],"for":[47,85,101,120,176,222,230],"development":[49],"(CRC).":[53],"To":[54],"understand":[55],"relationship":[57],"between":[58],"HNPCC":[59],"phenotype":[61],"and":[62,75,89,110,181],"polymorphisms":[63],"a":[68,131,200,238],"total":[69],"362":[71],"individuals":[72],"from":[73],"Australia":[74],"Poland":[76],"with":[77,106,130,209,253],"confirmed":[78],"causative":[79],"MMR":[80],"gene":[81],"were":[83],"genotyped":[84],"C282Y":[88,187],"H63D":[90,102,128,233],"polymorphisms.":[91,226],"A":[92],"significantly":[93,201],"increased":[94],"developing":[97,205],"CRC":[98,122,206],"was":[99,124,153,174],"observed":[100,126],"homozygotes":[103,109,129],"when":[104,207],"compared":[105,208],"combined":[107],"wild-type":[108],"heterozygotes":[111],"(hazard":[112,211],"ratio":[113,212],"=":[114,117,162,166,170,213,216],"2.93,":[115],"p":[116,161,165,169,215],"0.007).":[118],"Evidence":[119],"earlier":[121,138],"onset":[123,135],"also":[125],"median":[132],"age":[133],"6":[136],"years":[137,148],"than":[139],"wild":[140],"type":[141],"or":[142,189],"heterozygous":[143],"participants":[144],"(44":[145],"vs.":[146],"50":[147],"age).":[150],"This":[151],"effect":[152],"significant":[154],"all":[156],"tests":[157],"used":[158],"(log-rank":[159],"test":[160],"0.026,":[163],"Wilcoxon":[164],"0.044,":[167],"Tarone-Ware":[168],"0.035).":[171],"No":[172],"association":[173],"identified":[175],"heterozygosity":[177],"either":[179,223],"polymorphism":[180,234],"limitations":[182],"on":[183],"power-prevented":[184],"investigation":[185],"homozygosity":[188,229],"compound":[190],"C282Y/H63D":[191],"heterozygosity.":[192],"In":[193,227],"Australian":[195],"sample":[196],"only,":[197],"women":[198],"had":[199],"reduced":[202],"men":[210],"0.58,":[214],"0.012)":[217],"independent":[218],"genotype":[221],"single":[224],"nucleotide":[225],"conclusion,":[228],"seems":[235],"to":[236,258],"be":[237],"genetic":[239],"modifier":[240],"HNPCC.":[245,264],"Understanding":[246],"mechanisms":[248],"interrelates":[252],"malignancies":[255],"could":[256],"lead":[257],"reduction":[259]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}