{"id":"https://openalex.org/W2148643349","doi":"https://doi.org/10.1172/jci60644","title":"The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice","display_name":"The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice","publication_year":2012,"publication_date":"2012-04-16","ids":{"openalex":"https://openalex.org/W2148643349","doi":"https://doi.org/10.1172/jci60644","mag":"2148643349","pmid":"https://pubmed.ncbi.nlm.nih.gov/22505458","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3336984"},"language":"en","primary_location":{"id":"doi:10.1172/jci60644","doi":"https://doi.org/10.1172/jci60644","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci60644","pdf_url":"http://www.jci.org/articles/view/60644/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/60644/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033885599","display_name":"Santiago Zelenay","orcid":"https://orcid.org/0000-0002-6865-3978","observed_orcids":["https://orcid.org/0000-0002-6865-3978"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Santiago Zelenay","raw_affiliation_strings":["Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK","Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK","institution_ids":["https://openalex.org/I2801316944"]},{"raw_affiliation_string":"Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085095990","display_name":"Anna M. Keller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna M. Keller","raw_affiliation_strings":["Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056464620","display_name":"Paul G. Whitney","orcid":"https://orcid.org/0000-0003-3836-7601","observed_orcids":["https://orcid.org/0000-0003-3836-7601"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul G. Whitney","raw_affiliation_strings":["Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041629175","display_name":"Barbara U. Schraml","orcid":"https://orcid.org/0000-0002-5801-0151","observed_orcids":["https://orcid.org/0000-0002-5801-0151"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barbara U. Schraml","raw_affiliation_strings":["Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017173830","display_name":"Safia Deddouche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Safia Deddouche","raw_affiliation_strings":["Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081237813","display_name":"Neil C. Rogers","orcid":"https://orcid.org/0000-0001-8977-7585","observed_orcids":["https://orcid.org/0000-0001-8977-7585"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil C. Rogers","raw_affiliation_strings":["Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072204509","display_name":"Oliver Schulz","orcid":"https://orcid.org/0000-0002-1493-3341","observed_orcids":["https://orcid.org/0000-0002-1493-3341"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oliver Schulz","raw_affiliation_strings":["Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047641235","display_name":"David Sancho","orcid":"https://orcid.org/0000-0003-2890-3984","observed_orcids":["https://orcid.org/0000-0003-2890-3984"]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Sancho","raw_affiliation_strings":["Department of Vascular Biology and Inflammation, CNIC-Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Biology and Inflammation, CNIC-Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039240766","display_name":"Caetano Reis e Sousa","orcid":"https://orcid.org/0000-0001-7392-2119","observed_orcids":["https://orcid.org/0000-0001-7392-2119"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Caetano Reis e Sousa","raw_affiliation_strings":["Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039240766"],"corresponding_institution_ids":["https://openalex.org/I2801316944"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":12.344,"has_fulltext":true,"cited_by_count":290,"citation_normalized_percentile":{"value":0.99321371,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"122","issue":"5","first_page":"1615","last_page":"1627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dngr-1","display_name":"DNGR-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/clec9a","display_name":"CLEC9A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cross-priming","display_name":"cross-priming","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/endosomal-recycling","display_name":"endosomal recycling","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cross-presentation","display_name":"cross-presentation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/adjuvant-effect","display_name":"adjuvant effect","score":0.7630000114440918},{"id":"https://openalex.org/keywords/antigenicity","display_name":"antigenicity","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.7284418344497681},{"id":"https://openalex.org/C2778973524","wikidata":"https://www.wikidata.org/wiki/Q3910755","display_name":"Cross-presentation","level":5,"score":0.7108604311943054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6781872510910034},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6045710444450378},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5492100119590759},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.4846346974372864},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47176316380500793},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.43427222967147827},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.41773533821105957},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.40890243649482727},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.400465190410614},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39133918285369873},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018354","descriptor_name":"Alphavirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018354","descriptor_name":"Alphavirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D045142","descriptor_name":"Cross-Priming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci60644","doi":"https://doi.org/10.1172/jci60644","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci60644","pdf_url":"http://www.jci.org/articles/view/60644/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3336984","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3336984","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:22505458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22505458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/191417","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11343/191417","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/cf8c8f3e-b6ea-4548-bc6e-804e2561d5f8","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/cf8c8f3e-b6ea-4548-bc6e-804e2561d5f8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zelenay, S, Keller, A M, Whitney, P G, Schraml, B U, Deddouche, S, Rogers, N C, Schulz, O, Sancho, D & Reis e Sousa, C 2012, 'The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice.', The Journal of clinical investigation, vol. 122, no. 5. https://doi.org/10.1172/JCI60644","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci60644","doi":"https://doi.org/10.1172/jci60644","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci60644","pdf_url":"http://www.jci.org/articles/view/60644/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4354806077","display_name":null,"funder_award_id":"15689","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148643349.pdf","grobid_xml":"https://content.openalex.org/works/W2148643349.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1526209767","https://openalex.org/W1578114463","https://openalex.org/W1827525224","https://openalex.org/W1960924921","https://openalex.org/W1961222220","https://openalex.org/W1964465182","https://openalex.org/W1964472422","https://openalex.org/W1964493928","https://openalex.org/W1966689370","https://openalex.org/W1969119554","https://openalex.org/W1970839329","https://openalex.org/W1973362572","https://openalex.org/W1977298268","https://openalex.org/W1988136067","https://openalex.org/W1988869609","https://openalex.org/W1989402394","https://openalex.org/W1997337311","https://openalex.org/W1997951134","https://openalex.org/W2000952771","https://openalex.org/W2001656273","https://openalex.org/W2007071879","https://openalex.org/W2009887653","https://openalex.org/W2013277175","https://openalex.org/W2021943943","https://openalex.org/W2022293786","https://openalex.org/W2031170422","https://openalex.org/W2036138390","https://openalex.org/W2038859753","https://openalex.org/W2046098930","https://openalex.org/W2046505430","https://openalex.org/W2048784307","https://openalex.org/W2051731494","https://openalex.org/W2053346961","https://openalex.org/W2065429310","https://openalex.org/W2067853799","https://openalex.org/W2068206773","https://openalex.org/W2068853695","https://openalex.org/W2072691337","https://openalex.org/W2073003128","https://openalex.org/W2077215378","https://openalex.org/W2079794444","https://openalex.org/W2093424661","https://openalex.org/W2102135396","https://openalex.org/W2106826370","https://openalex.org/W2108765339","https://openalex.org/W2112284938","https://openalex.org/W2113896298","https://openalex.org/W2114695580","https://openalex.org/W2117379708","https://openalex.org/W2117395989","https://openalex.org/W2120315525","https://openalex.org/W2121726659","https://openalex.org/W2123469465","https://openalex.org/W2133006186","https://openalex.org/W2136883776","https://openalex.org/W2137169090","https://openalex.org/W2137670912","https://openalex.org/W2138879809","https://openalex.org/W2139871947","https://openalex.org/W2142084466","https://openalex.org/W2145736817","https://openalex.org/W2148317624","https://openalex.org/W2157095212","https://openalex.org/W2158924104","https://openalex.org/W2158981143","https://openalex.org/W2161472648","https://openalex.org/W2161702641","https://openalex.org/W2163226696","https://openalex.org/W2166676682","https://openalex.org/W2168401979","https://openalex.org/W2169324807","https://openalex.org/W2169344740","https://openalex.org/W2170191276","https://openalex.org/W2171986697","https://openalex.org/W2172266795"],"related_works":["https://openalex.org/W2172266795","https://openalex.org/W4319827361","https://openalex.org/W4415667116","https://openalex.org/W2345814889","https://openalex.org/W3113464424","https://openalex.org/W3011215300","https://openalex.org/W2000952771","https://openalex.org/W2136883776","https://openalex.org/W3004421791","https://openalex.org/W2526605295"],"abstract_inverted_index":{"DNGR-1":[0,25,36,62,96],"(CLEC9A)":[1],"is":[2,21,97],"a":[3,52,98],"receptor":[4,100],"for":[5,101],"necrotic":[6,48],"cells":[7,44,140],"required":[8],"by":[9,42,125],"DCs":[10],"to":[11,30,58,152],"cross-prime":[12],"CTLs":[13],"against":[14],"dead":[15,27,43,73],"cell":[16,28,49],"antigens":[17],"in":[18,65,78,114],"mice.":[19],"It":[20],"currently":[22],"unknown":[23],"how":[24],"couples":[26],"recognition":[29],"cross-priming.":[31],"Here":[32],"we":[33],"found":[34],"that":[35,95,118,135,146],"did":[37],"not":[38],"mediate":[39],"DC":[40],"activation":[41],"but":[45],"rather":[46],"diverted":[47],"cargo":[50],"into":[51],"recycling":[53],"endosomal":[54],"compartment,":[55],"favoring":[56],"cross-presentation":[57,102],"CD8(+)":[59],"T":[60],"cells.":[61],"regulated":[63],"cross-priming":[64,113],"non-infectious":[66],"settings":[67],"such":[68,82],"as":[69,75,77,83],"immunization":[70],"with":[71,85],"antigen-bearing":[72],"cells,":[74],"well":[76],"highly":[79],"immunogenic":[80],"situations":[81],"infection":[84,153],"herpes":[86],"simplex":[87],"virus":[88],"type":[89],"1.":[90],"Together,":[91],"these":[92],"results":[93],"suggest":[94],"dedicated":[99],"of":[103,112,132,138,143],"cell-associated":[104],"antigens.":[105],"Our":[106],"work":[107],"thus":[108],"underscores":[109],"the":[110,149],"importance":[111],"immunity":[115,145],"and":[116,120,154],"indicates":[117],"antigenicity":[119,137],"adjuvanticity":[121],"can":[122],"be":[123],"decoded":[124],"distinct":[126],"innate":[127],"immune":[128],"receptors.":[129],"The":[130],"identification":[131],"specialized":[133],"receptors":[134],"regulate":[136],"virus-infected":[139],"reveals":[141],"determinants":[142],"antiviral":[144],"might":[147],"underlie":[148],"human":[150],"response":[151],"vaccination.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":31},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}