{"id":"https://openalex.org/W2148574255","doi":"https://doi.org/10.1212/wnl.34.10.1378","title":"Extra\u2010 and intrathecal production of antinerve and antibrain antibodies in Guillain\u2010Bare syndrome","display_name":"Extra\u2010 and intrathecal production of antinerve and antibrain antibodies in Guillain\u2010Bare syndrome","publication_year":1984,"publication_date":"1984-10-01","ids":{"openalex":"https://openalex.org/W2148574255","doi":"https://doi.org/10.1212/wnl.34.10.1378","mag":"2148574255","pmid":"https://pubmed.ncbi.nlm.nih.gov/6541314"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.34.10.1378","doi":"https://doi.org/10.1212/wnl.34.10.1378","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.34.10.1378","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087961883","display_name":"Bj\u00f6rn Ryberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Bjo\u0308rn Ryberg","raw_affiliation_strings":["From the Department of Neurology, University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology, University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087961883"],"corresponding_institution_ids":["https://openalex.org/I4210137844"],"apc_list":null,"apc_paid":null,"fwci":2.9603,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.91605915,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"10","first_page":"1378","last_page":"1378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guillain-barre-syndrome","display_name":"Guillain-Barr\u00e9 syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-brain-antibodies","display_name":"anti-brain antibodies","score":0.9160000085830688},{"id":"https://openalex.org/keywords/intrathecal-antibody-production","display_name":"intrathecal antibody synthesis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9259999990463257},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antibody-index","display_name":"antibody index","score":0.6010000109672546},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2778691916","wikidata":"https://www.wikidata.org/wiki/Q205214","display_name":"Guillain-Barre syndrome","level":2,"score":0.8310168981552124},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7682786583900452},{"id":"https://openalex.org/C157820659","wikidata":"https://www.wikidata.org/wiki/Q1320251","display_name":"Intrathecal","level":2,"score":0.7220485806465149},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6666197180747986},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6598415374755859},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.6414024233818054},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.519814133644104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.51668381690979},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.412891685962677},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.41057834029197693},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3474121689796448},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2744563817977905},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.14521309733390808}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011129","descriptor_name":"Polyradiculoneuropathy","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011129","descriptor_name":"Polyradiculoneuropathy","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D011129","descriptor_name":"Polyradiculoneuropathy","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.34.10.1378","doi":"https://doi.org/10.1212/wnl.34.10.1378","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.34.10.1378","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:6541314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6541314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1997385403","https://openalex.org/W2074744601","https://openalex.org/W1999307465","https://openalex.org/W2482055798","https://openalex.org/W2050307985","https://openalex.org/W2168569726","https://openalex.org/W3210420944","https://openalex.org/W2068086947","https://openalex.org/W1991736093","https://openalex.org/W2094784936"],"abstract_inverted_index":{"In":[0],"serum":[1,30],"and":[2,21,31],"CSF":[3,32],"samples":[4,33],"from":[5],"19":[6],"patients":[7],"with":[8,19,35],"the":[9,29,48,72,88],"Guillain-Barr\u00e9":[10],"syndrome":[11],"(GBS),":[12],"we":[13],"assayed":[14],"complement-fixing":[15],"autoantibodies":[16],"that":[17],"react":[18],"peripheral":[20],"central":[22],"nervous":[23],"tissue.":[24],"About":[25],"two":[26],"thirds":[27],"of":[28,37,44,76,87],"reacted":[34],"preparations":[36],"one":[38],"or":[39],"both":[40,85],"tissues.":[41],"The":[42],"distribution":[43],"antibodies,":[45],"evaluated":[46],"by":[47,54],"antibody":[49],"index":[50],"(CSF/serum":[51],"titer":[52],"divided":[53],"CSF/serum":[55],"albumin),":[56],"suggested":[57],"predominantly":[58],"extrathecal":[59],"production":[60],"in":[61,79],"most":[62],"patients,":[63],"but":[64],"an":[65],"intrathecal":[66],"contribution":[67],"was":[68],"also":[69],"seen.":[70],"Thus,":[71],"possible":[73],"pathogenic":[74],"effects":[75],"antineural":[77],"antibodies":[78],"GBS":[80],"may":[81],"be":[82],"exerted":[83],"on":[84],"sides":[86],"blood-brain":[89],"barrier.":[90]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}