{"id":"https://openalex.org/W2148564763","doi":"https://doi.org/10.1128/iai.55.12.3103-3110.1987","title":"Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement","display_name":"Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement","publication_year":1987,"publication_date":"1987-12-01","ids":{"openalex":"https://openalex.org/W2148564763","doi":"https://doi.org/10.1128/iai.55.12.3103-3110.1987","mag":"2148564763","pmid":"https://pubmed.ncbi.nlm.nih.gov/3679545"},"language":"en","primary_location":{"id":"doi:10.1128/iai.55.12.3103-3110.1987","doi":"https://doi.org/10.1128/iai.55.12.3103-3110.1987","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.55.12.3103-3110.1987","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/260034","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053053781","display_name":"Arvind H. Patel","orcid":"https://orcid.org/0000-0003-4600-2047","observed_orcids":["https://orcid.org/0000-0003-4600-2047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A H Patel","raw_affiliation_strings":["Microbiology Department, Moyne Institute, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Moyne Institute, Dublin, Ireland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058206797","display_name":"Peter Nowlan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Nowlan","raw_affiliation_strings":["Microbiology Department, Moyne Institute, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Moyne Institute, Dublin, Ireland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082610432","display_name":"Edwin Weavers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E D Weavers","raw_affiliation_strings":["Microbiology Department, Moyne Institute, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Moyne Institute, Dublin, Ireland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102729823","display_name":"Timothy J. Foster","orcid":"https://orcid.org/0000-0003-3827-689X","observed_orcids":["https://orcid.org/0000-0003-3827-689X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Foster","raw_affiliation_strings":["Microbiology Department, Moyne Institute, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Moyne Institute, Dublin, Ireland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9941,"has_fulltext":false,"cited_by_count":280,"citation_normalized_percentile":{"value":0.9561565,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"55","issue":"12","first_page":"3103","last_page":"3110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/protein-a","display_name":"protein A","score":0.9039999842643738},{"id":"https://openalex.org/keywords/spa-gene","display_name":"spa gene","score":0.7990000247955322},{"id":"https://openalex.org/keywords/alpha-toxin","display_name":"alpha-toxin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hly-gene","display_name":"hly gene","score":0.9850000143051147},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.8970000147819519},{"id":"https://openalex.org/keywords/allele-replacement","display_name":"allele replacement","score":0.8830000162124634},{"id":"https://openalex.org/keywords/subcutaneous-lesions","display_name":"subcutaneous lesions","score":0.7730000019073486},{"id":"https://openalex.org/keywords/murine-infection","display_name":"mouse infection","score":0.6679999828338623},{"id":"https://openalex.org/keywords/transduction","display_name":"transduction","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8154882192611694},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.8066562414169312},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6909559369087219},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6691874861717224},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.624264657497406},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4321729242801666},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.414181113243103},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.4138692319393158},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4108412265777588},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3648350238800049},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2542063593864441},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10379505157470703}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004996","descriptor_name":"Ethidium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004996","descriptor_name":"Ethidium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004996","descriptor_name":"Ethidium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006460","descriptor_name":"Hemolysin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006460","descriptor_name":"Hemolysin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006460","descriptor_name":"Hemolysin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013205","descriptor_name":"Staphylococcal Protein A","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013205","descriptor_name":"Staphylococcal Protein A","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013205","descriptor_name":"Staphylococcal Protein A","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013205","descriptor_name":"Staphylococcal Protein A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013205","descriptor_name":"Staphylococcal Protein A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013205","descriptor_name":"Staphylococcal Protein A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/iai.55.12.3103-3110.1987","doi":"https://doi.org/10.1128/iai.55.12.3103-3110.1987","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.55.12.3103-3110.1987","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmid:3679545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3679545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:223293","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC260034","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:260034","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/260034","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmh:oai:eprints.gla.ac.uk:83535","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/83535/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:260034","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/260034","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infect Immun","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W158724292","https://openalex.org/W588812189","https://openalex.org/W965758366","https://openalex.org/W1546783991","https://openalex.org/W1569217615","https://openalex.org/W1601256941","https://openalex.org/W1839855594","https://openalex.org/W1914525889","https://openalex.org/W1916739711","https://openalex.org/W1935585615","https://openalex.org/W1967568816","https://openalex.org/W1973507084","https://openalex.org/W1978227254","https://openalex.org/W1979947199","https://openalex.org/W1982285611","https://openalex.org/W1993981895","https://openalex.org/W2000969921","https://openalex.org/W2022276686","https://openalex.org/W2026220836","https://openalex.org/W2028622989","https://openalex.org/W2029677323","https://openalex.org/W2030367990","https://openalex.org/W2034655819","https://openalex.org/W2035499888","https://openalex.org/W2037862546","https://openalex.org/W2042215185","https://openalex.org/W2051846416","https://openalex.org/W2059297512","https://openalex.org/W2063450941","https://openalex.org/W2070549745","https://openalex.org/W2070665102","https://openalex.org/W2071570894","https://openalex.org/W2081802739","https://openalex.org/W2082836578","https://openalex.org/W2100837269","https://openalex.org/W2105536061","https://openalex.org/W2111817213","https://openalex.org/W2121500846","https://openalex.org/W2127513157","https://openalex.org/W2128227848","https://openalex.org/W2134011061","https://openalex.org/W2141653906","https://openalex.org/W2144634347","https://openalex.org/W2144659626","https://openalex.org/W2147524002","https://openalex.org/W2172029739","https://openalex.org/W2415327560"],"related_works":["https://openalex.org/W2951035914","https://openalex.org/W2201859025","https://openalex.org/W2124139792","https://openalex.org/W2134930711","https://openalex.org/W3212434704","https://openalex.org/W50609149","https://openalex.org/W2139426682","https://openalex.org/W4238120107","https://openalex.org/W3030861211","https://openalex.org/W2350813442"],"abstract_inverted_index":{"The":[0,31,109],"gene":[1,73],"coding":[2,20],"for":[3,22],"protein":[4,177],"A":[5,100,178],"(spa)":[6],"of":[7,17,70,111,121,160,184],"Staphylococcus":[8],"aureus":[9,42],"8325-4":[10],"has":[11],"been":[12],"inactivated":[13],"by":[14,44,75,107,118],"substituting":[15],"part":[16],"the":[18,40,53,60,68,71,158],"spa":[19,62],"sequence":[21],"a":[23,131,139,148,181],"DNA":[24],"fragment":[25],"specifying":[26],"resistance":[27],"to":[28,146],"ethidium":[29],"bromide.":[30],"in":[32,54,59,80,151,156],"vitro-constructed":[33,55,81],"spa::EtBrr":[34],"substitution":[35],"mutation":[36,56,85],"was":[37,57,105,116,144],"introduced":[38],"into":[39],"S.":[41,91,185],"chromosome":[43],"recombinational":[45],"allele":[46,76],"replacement.":[47],"Southern":[48],"blot":[49],"hybridization":[50],"showed":[51],"that":[52,176],"present":[58],"chromosomal":[61],"locus.":[63],"We":[64],"have":[65],"previously":[66],"reported":[67],"inactivation":[69],"alpha-toxin":[72],"(hly)":[74],"replacement":[77],"with":[78],"an":[79],"hly::Emr":[82],"(erythromycin":[83],"resistance)":[84],"(M.":[86],"O'Reilly,":[87],"J.C.S.":[88],"de":[89],"Azavedo,":[90],"Kennedy,":[92],"and":[93,113,155],"T.J.":[94],"Foster,":[95],"Microb.":[96],"Pathogen.":[97],"1:125-138,":[98],"1986).":[99],"double":[101],"Spa-":[102,112,164],"Hly-":[103,114,128],"mutant":[104],"constructed":[106],"transduction.":[108],"virulence":[110,182],"mutants":[115,129,165],"tested":[117],"experimental":[119],"infection":[120],"mice.":[122],"When":[123],"subcutaneous":[124,153],"injections":[125],"were":[126,166],"given,":[127],"formed":[130],"flat,":[132],"darkened":[133],"lesion,":[134],"whereas":[135],"Hly+":[136],"strains":[137],"caused":[138],"raised,":[140],"cream":[141],"lesion.":[142],"Alpha-toxin":[143],"shown":[145],"be":[147],"major":[149],"factor":[150,183],"forming":[152],"lesions":[154],"causing":[157],"death":[159],"mice":[161],"injected":[162],"intraperitoneally.":[163],"slightly":[167],"less":[168],"virulent":[169],"than":[170],"their":[171],"Spa+":[172],"counterparts,":[173],"which":[174],"suggests":[175],"is":[179],"also":[180],"aureus.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":17}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}