{"id":"https://openalex.org/W2148500352","doi":"https://doi.org/10.1046/j.1365-2265.2003.01963.x","title":"Vasopressin responsiveness of subclinical Cushing's syndrome due to ACTH\u2010independent macronodular adrenocortical hyperplasia","display_name":"Vasopressin responsiveness of subclinical Cushing's syndrome due to ACTH\u2010independent macronodular adrenocortical hyperplasia","publication_year":2003,"publication_date":"2003-12-10","ids":{"openalex":"https://openalex.org/W2148500352","doi":"https://doi.org/10.1046/j.1365-2265.2003.01963.x","mag":"2148500352","pmid":"https://pubmed.ncbi.nlm.nih.gov/14725680"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2265.2003.01963.x","doi":"https://doi.org/10.1046/j.1365-2265.2003.01963.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2265.2003.01963.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007519585","display_name":"Ichiro Tatsuno","orcid":"https://orcid.org/0000-0002-7200-7952","observed_orcids":["https://orcid.org/0000-0002-7200-7952"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ichiro Tatsuno","raw_affiliation_strings":["Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba, Japan. ichiro-tatsuno@faculty.chiba-u.jp","Departments of Clinical Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba, Japan. ichiro-tatsuno@faculty.chiba-u.jp","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Departments of Clinical Cell Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110394829","display_name":"Daigaku Uchida","orcid":"https://orcid.org/0000-0001-9115-8089","observed_orcids":["https://orcid.org/0000-0001-9115-8089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daigaku Uchida","raw_affiliation_strings":["Departments of Clinical Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical Cell Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035001251","display_name":"Tomoaki Tanaka","orcid":"https://orcid.org/0000-0002-9761-1750","observed_orcids":["https://orcid.org/0000-0002-9761-1750"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoaki Tanaka","raw_affiliation_strings":["Departments of Clinical Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical Cell Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019445952","display_name":"Hisashi Koide","orcid":"https://orcid.org/0000-0002-8545-7530","observed_orcids":["https://orcid.org/0000-0002-8545-7530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisashi Koide","raw_affiliation_strings":["Departments of Clinical Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical Cell Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006266337","display_name":"Azusa Shigeta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azusa Shigeta","raw_affiliation_strings":["Departments of Clinical Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical Cell Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039530102","display_name":"Tomohiko Ichikawa","orcid":"https://orcid.org/0000-0002-8637-4163","observed_orcids":["https://orcid.org/0000-0002-8637-4163"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiko Ichikawa","raw_affiliation_strings":["Urology, Chiba University Graduate School of Medicine, Chiba and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology, Chiba University Graduate School of Medicine, Chiba and","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015575554","display_name":"Hironobu Sasano","orcid":"https://orcid.org/0000-0002-6600-8641","observed_orcids":["https://orcid.org/0000-0002-6600-8641"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironobu Sasano","raw_affiliation_strings":["Department of Pathology, Tohoku University School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103484910","display_name":"Yasushi Sait\u014d","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasushi Saito","raw_affiliation_strings":["Departments of Clinical Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical Cell Biology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007519585"],"corresponding_institution_ids":["https://openalex.org/I159385669"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":2.834,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.88660437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"2","first_page":"192","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.07680000364780426,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subclinical-cushing-syndrome","display_name":"subclinical Cushing's syndrome","score":0.9589999914169312},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/vasopressin-v1-receptor","display_name":"V1 vasopressin receptor","score":0.878000020980835},{"id":"https://openalex.org/keywords/cortisol-secretion","display_name":"cortisol secretion","score":0.8640000224113464},{"id":"https://openalex.org/keywords/autonomous-cortisol-secretion","display_name":"autonomous cortisol secretion","score":0.6919999718666077},{"id":"https://openalex.org/keywords/desmopressin","display_name":"desmopressin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.6930000185966492},{"id":"https://openalex.org/keywords/adrenal-nodules","display_name":"adrenal nodules","score":0.7049999833106995},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.5}],"concepts":[{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.7310816645622253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6856187582015991},{"id":"https://openalex.org/C2780455818","wikidata":"https://www.wikidata.org/wiki/Q1207196","display_name":"Dexamethasone suppression test","level":3,"score":0.6756970882415771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6441640853881836},{"id":"https://openalex.org/C2779435821","wikidata":"https://www.wikidata.org/wiki/Q219102","display_name":"Cushing syndrome","level":2,"score":0.631151020526886},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5985920429229736},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.5091981291770935},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.43795543909072876},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.415807843208313},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.38673993945121765},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.16499033570289612}],"mesh":[{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017483","descriptor_name":"Receptors, Vasopressin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033162","descriptor_name":"Incidental Findings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2265.2003.01963.x","doi":"https://doi.org/10.1046/j.1365-2265.2003.01963.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2265.2003.01963.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},{"id":"pmid:14725680","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14725680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W158957975","https://openalex.org/W1547407688","https://openalex.org/W1967719516","https://openalex.org/W1974538793","https://openalex.org/W1978253611","https://openalex.org/W1992954253","https://openalex.org/W2026712100","https://openalex.org/W2032317802","https://openalex.org/W2051364718","https://openalex.org/W2056574301","https://openalex.org/W2059783931","https://openalex.org/W2060562248","https://openalex.org/W2086830316","https://openalex.org/W2090912797","https://openalex.org/W2115569823","https://openalex.org/W2119417114","https://openalex.org/W2121771845","https://openalex.org/W2123170730","https://openalex.org/W2133569968","https://openalex.org/W2159647120","https://openalex.org/W2166126589","https://openalex.org/W2289239016","https://openalex.org/W2317769924","https://openalex.org/W2320000533","https://openalex.org/W2332386539","https://openalex.org/W2336931002","https://openalex.org/W2418876525"],"related_works":["https://openalex.org/W1982246787","https://openalex.org/W2123170730","https://openalex.org/W2115569823","https://openalex.org/W4235003008","https://openalex.org/W7098464609","https://openalex.org/W2164586342","https://openalex.org/W2407137875","https://openalex.org/W2165812438","https://openalex.org/W2070617618","https://openalex.org/W2114418724"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Vasopressin":[1],"(AVP)":[2],"is":[3,317],"reported":[4],"to":[5,20,38,53,71,147,167,215,245,261,307,313],"be":[6],"an":[7,55,116],"important":[8],"factor":[9],"for":[10],"regulating":[11],"cortisol":[12,65,103,149,198,212,253,263,270,311],"secretion":[13,63,150,210,254,271,279],"in":[14,40,60,66,136,181,255,293],"patients":[15,227],"with":[16,80,240,283,302],"Cushing's":[17,35,68,82,233,242,304],"syndrome":[18,36,69,83,243,305],"due":[19,37,70,244,306],"ACTH-independent":[21],"macronodular":[22],"adrenocortical":[23],"hyperplasia":[24],"(AIMAH).":[25],"Recently,":[26],"there":[27],"have":[28,168],"been":[29,48],"several":[30],"case":[31,121,266],"reports":[32],"of":[33,45,58,64,78,108,131,153,196,202,211,218,220,232,289,322],"subclinical":[34,67,81,241,303],"AIMAH,":[39],"which":[41,185],"the":[42,61,128,140,154,193],"pathophysiological":[43],"role":[44],"AVP":[46,59,117,251,268],"has":[47],"unknown.":[49],"The":[50,225],"aim":[51],"was":[52,125,133,145,213,296],"conduct":[54],"extensive":[56],"investigation":[57],"autonomous":[62,209],"AIMAH.":[72,246],"PATIENTS":[73],"AND":[74],"MEASUREMENTS:":[75],"Five":[76],"cases":[77,163],"AIMAH":[79,132,142,274,294,308],"underwent":[84],"prospective":[85],"study":[86],"including":[87],"physical":[88],"examination,":[89],"imaging":[90],"(MRI,":[91],"CT":[92,176],"and":[93,96,105,115,127,151,175,199,235,315],"131I-adosterol":[94,190],"scintigraphy)":[95],"endocrinological":[97],"evaluation":[98],"that":[99],"comprised":[100],"basal":[101,194],"plasma":[102,197],"levels":[104],"urinary":[106,200],"excretions":[107,201],"steroid":[109,203],"metabolites,":[110],"a":[111],"dexamethasone":[112,223],"suppression":[113,221],"test":[114],"stimulation":[118],"test.":[119],"In":[120,247,265,286],"1,":[122,267],"left":[123],"adrenalectomy":[124],"performed":[126],"pathological":[129],"diagnosis":[130],"established.":[134],"An":[135],"vitro":[137],"experiment":[138],"using":[139],"cultured":[141,273],"adrenal":[143,170,183,275],"cells":[144],"conducted":[146],"investigate":[148],"expression":[152],"V1-AVP":[155,290,324],"receptor,":[156],"mRNA":[157,292],"by":[158,173,298],"RT-PCR.":[159,299],"RESULTS:":[160],"All":[161],"five":[162,226,249],"were":[164,205,237],"discovered":[165],"incidentally":[166],"bilateral":[169],"nodules.":[171],"Imaging":[172],"MRI":[174],"revealed":[177],"large":[178],"multinodular":[179],"lesions":[180],"both":[182],"glands,":[184],"showed":[186],"positive":[187],"uptake":[188],"on":[189],"scintigraphy.":[191],"Although":[192],"values":[195],"metabolites":[204],"within":[206],"normal":[207],"limits,":[208],"assumed":[214],"occur":[216],"because":[217],"lack":[219],"during":[222],"suppression.":[224],"had":[228,280],"no":[229,281],"overt":[230],"signs":[231],"syndrome,":[234],"they":[236],"therefore":[238],"diagnosed":[239],"all":[248],"patients,":[250],"stimulated":[252,269],"vivo,":[256],"whereas":[257],"desmopressin":[258],"acetate":[259],"failed":[260],"affect":[262],"secretion.":[264],"from":[272],"cells,":[276],"but":[277],"this":[278,316],"relationship":[282],"cAMP":[284],"production.":[285],"addition,":[287],"over-expression":[288],"receptor":[291],"tissue":[295],"determined":[297],"CONCLUSION:":[300],"Patients":[301],"commonly":[309],"exhibit":[310],"responsiveness":[312],"AVP,":[314],"probably":[318],"mediated":[319],"through":[320],"activation":[321],"overexpressed":[323],"receptors.":[325]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}