{"id":"https://openalex.org/W2148480947","doi":"https://doi.org/10.2967/jnumed.113.131474","title":"11 C-Cetrozole: An Improved C- 11 C-Methylated PET Probe for Aromatase Imaging in the Brain","display_name":"11 C-Cetrozole: An Improved C- 11 C-Methylated PET Probe for Aromatase Imaging in the Brain","publication_year":2014,"publication_date":"2014-03-27","ids":{"openalex":"https://openalex.org/W2148480947","doi":"https://doi.org/10.2967/jnumed.113.131474","mag":"2148480947","pmid":"https://pubmed.ncbi.nlm.nih.gov/24676756"},"language":"en","primary_location":{"id":"doi:10.2967/jnumed.113.131474","doi":"https://doi.org/10.2967/jnumed.113.131474","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.113.131474","pdf_url":"http://jnm.snmjournals.org/content/55/5/852.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://jnm.snmjournals.org/content/55/5/852.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103490727","display_name":"Kayo Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kayo Takahashi","raw_affiliation_strings":["RIKEN Center for Life Science Technologies, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Life Science Technologies, Hyogo, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052698930","display_name":"Takamitsu Hosoya","orcid":"https://orcid.org/0000-0002-7270-351X","observed_orcids":["https://orcid.org/0000-0002-7270-351X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takamitsu Hosoya","raw_affiliation_strings":["Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan; and","Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan; and","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085231768","display_name":"Kayo Onoe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kayo Onoe","raw_affiliation_strings":["RIKEN Center for Life Science Technologies, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Life Science Technologies, Hyogo, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080918987","display_name":"Hisashi Doi","orcid":"https://orcid.org/0000-0001-9778-5841","observed_orcids":["https://orcid.org/0000-0001-9778-5841"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi Doi","raw_affiliation_strings":["RIKEN Center for Life Science Technologies, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Life Science Technologies, Hyogo, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039701558","display_name":"Hiroko Nagata","orcid":"https://orcid.org/0000-0002-0958-8504","observed_orcids":["https://orcid.org/0000-0002-0958-8504"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Nagata","raw_affiliation_strings":["RIKEN Center for Life Science Technologies, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Life Science Technologies, Hyogo, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015547978","display_name":"Toshiyuki Hiramatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Hiramatsu","raw_affiliation_strings":["Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086348738","display_name":"Xiao-Le Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Xiao-Le Li","raw_affiliation_strings":["Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101677231","display_name":"Yumiko Watanabe","orcid":"https://orcid.org/0000-0001-6747-0590","observed_orcids":["https://orcid.org/0000-0001-6747-0590"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumiko Watanabe","raw_affiliation_strings":["RIKEN Center for Life Science Technologies, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Life Science Technologies, Hyogo, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022193039","display_name":"Yasuhiro Wada","orcid":"https://orcid.org/0000-0003-2096-1602","observed_orcids":["https://orcid.org/0000-0003-2096-1602"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Wada","raw_affiliation_strings":["RIKEN Center for Life Science Technologies, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Life Science Technologies, Hyogo, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109136153","display_name":"Tadayuki Takashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadayuki Takashima","raw_affiliation_strings":["RIKEN Center for Life Science Technologies, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Life Science Technologies, Hyogo, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100860009","display_name":"Masaaki Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Suzuki","raw_affiliation_strings":["RIKEN Center for Life Science Technologies, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Life Science Technologies, Hyogo, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036006060","display_name":"Hirotaka Onoe","orcid":"https://orcid.org/0000-0001-8416-6259","observed_orcids":["https://orcid.org/0000-0001-8416-6259"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Onoe","raw_affiliation_strings":["RIKEN Center for Life Science Technologies, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Life Science Technologies, Hyogo, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037300111","display_name":"Yasuyoshi Watanabe","orcid":"https://orcid.org/0000-0003-2623-5599","observed_orcids":["https://orcid.org/0000-0003-2623-5599"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyoshi Watanabe","raw_affiliation_strings":["RIKEN Center for Life Science Technologies, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Life Science Technologies, Hyogo, Japan","institution_ids":["https://openalex.org/I4210110652"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6879,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.92879736,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"55","issue":"5","first_page":"852","last_page":"857"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.5044000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.5044000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.2777999937534332,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.06960000097751617,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-aromatase","display_name":"brain aromatase","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.6539999842643738},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.734000027179718},{"id":"https://openalex.org/keywords/estrogen-biosynthesis","display_name":"estrogen synthesis","score":0.3930000066757202},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"neuroimaging","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.5494977831840515},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4851751923561096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4555957317352295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22541314363479614}],"mesh":[{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001141","descriptor_name":"Aromatase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2967/jnumed.113.131474","doi":"https://doi.org/10.2967/jnumed.113.131474","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.113.131474","pdf_url":"http://jnm.snmjournals.org/content/55/5/852.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},{"id":"pmid:24676756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24676756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2967/jnumed.113.131474","doi":"https://doi.org/10.2967/jnumed.113.131474","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.113.131474","pdf_url":"http://jnm.snmjournals.org/content/55/5/852.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2525637198","display_name":"PET study on the association between brain sex steroid system and human emotion","funder_award_id":"25830024","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7946972851","display_name":null,"funder_award_id":"25242070","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320324799","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148480947.pdf","grobid_xml":"https://content.openalex.org/works/W2148480947.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1971692687","https://openalex.org/W1975616007","https://openalex.org/W1993453391","https://openalex.org/W1996789805","https://openalex.org/W2002653885","https://openalex.org/W2003207008","https://openalex.org/W2004124667","https://openalex.org/W2011506847","https://openalex.org/W2018515476","https://openalex.org/W2022493124","https://openalex.org/W2024017898","https://openalex.org/W2024089136","https://openalex.org/W2030727754","https://openalex.org/W2032446088","https://openalex.org/W2034323087","https://openalex.org/W2038490212","https://openalex.org/W2054929374","https://openalex.org/W2055131068","https://openalex.org/W2057967341","https://openalex.org/W2058741810","https://openalex.org/W2062965019","https://openalex.org/W2062967169","https://openalex.org/W2063017390","https://openalex.org/W2063846619","https://openalex.org/W2072992561","https://openalex.org/W2087789777","https://openalex.org/W2088957209","https://openalex.org/W2097155470","https://openalex.org/W2097345512","https://openalex.org/W2120130577","https://openalex.org/W2122109972","https://openalex.org/W2136406425","https://openalex.org/W2143500251","https://openalex.org/W2155504290"],"related_works":["https://openalex.org/W4200571579","https://openalex.org/W2058741810","https://openalex.org/W3047939527","https://openalex.org/W656537571","https://openalex.org/W2031759535","https://openalex.org/W2906257618","https://openalex.org/W2218029709","https://openalex.org/W2088957209","https://openalex.org/W2122109972","https://openalex.org/W2526160357"],"abstract_inverted_index":{"UNLABELLED:":[0],"Aromatase":[1],"(an":[2],"enzyme":[3],"that":[4,142,199],"converts":[5],"androgens":[6],"to":[7,88,105],"estrogens)":[8],"in":[9,14,34,38,109,116,124,128,174,184,215,227],"the":[10,27,35,43,65,90,94,107,110,156,165,175,185,192,210,222],"brain":[11,84,125,213],"is":[12,206],"involved":[13],"neuroprotection,":[15],"synaptic":[16],"plasticity,":[17],"and":[18,22,29,78,93,115,132,177,179,230],"regulation":[19],"of":[20,32,45,57,75,130,159,170,188,212,225],"sexual":[21],"emotional":[23,231],"behaviors.":[24],"To":[25],"investigate":[26],"physiologic":[28],"pathologic":[30],"importance":[31],"aromatase":[33,58,126,214,226],"brain,":[36],"including":[37],"humans,":[39],"we":[40,180],"here":[41],"report":[42],"development":[44],"a":[46,79,145,150],"novel":[47],"PET":[48,97,139,200],"probe":[49],"for":[50,191,208],"aromatase,":[51],"(11)C-cetrozole,":[52],"which":[53],"allows":[54],"noninvasive":[55],"quantification":[56],"expression.":[59],"METHODS:":[60],"(11)C-cetrozole":[61,120,143,171,205],"was":[62,161,172],"synthesized":[63],"by":[64,69],"C-(11)C-methylation":[66],"method":[67],"developed":[68,137,204],"our":[70],"group.":[71],"In":[72,113],"vitro":[73,114],"autoradiography":[74],"frozen":[76],"sections":[77],"binding":[80,92,169,183],"study":[81],"with":[82,99,135,202],"rat":[83],"homogenates":[85],"were":[86,103],"conducted":[87],"demonstrate":[89],"specific":[91,168],"dissociation":[95],"constant.":[96],"studies":[98,118,140],"anesthetized":[100],"rhesus":[101,189],"monkeys":[102,190],"performed":[104],"analyze":[106],"dynamics":[108],"brain.":[111,166],"RESULTS:":[112],"vivo":[117],"using":[119],"showed":[121,141],"its":[122],"superiority":[123],"imaging":[127,201],"terms":[129],"specificity":[131],"selectivity,":[133],"compared":[134],"previously":[136],"(11)C-vorozole.":[138],"had":[144],"higher":[146],"signal-to-noise":[147],"ratio,":[148],"providing":[149,218],"sharper":[151],"image":[152],"than":[153],"(11)C-vorozole,":[154],"because":[155],"radioactive":[157],"metabolite":[158],"(11)C-vorozole":[160],"taken":[162],"up":[163],"into":[164],"High":[167],"observed":[173],"amygdala":[176],"hypothalamus,":[178],"also":[181],"noted":[182],"nucleus":[186],"accumbens":[187],"first":[193],"time.":[194],"CONCLUSION:":[195],"These":[196],"results":[197],"suggest":[198],"newly":[203],"suitable":[207],"quantifying":[209],"expression":[211],"vivo,":[216],"possibly":[217],"critical":[219],"information":[220],"regarding":[221],"functional":[223],"roles":[224],"human":[228],"neurologic":[229],"disorders.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
