{"id":"https://openalex.org/W2148474172","doi":"https://doi.org/10.1016/j.theochem.2003.08.048","title":"Molecular chaperones, evolution and medicine","display_name":"Molecular chaperones, evolution and medicine","publication_year":2003,"publication_date":"2003-10-09","ids":{"openalex":"https://openalex.org/W2148474172","doi":"https://doi.org/10.1016/j.theochem.2003.08.048","mag":"2148474172"},"language":"en","primary_location":{"id":"doi:10.1016/j.theochem.2003.08.048","doi":"https://doi.org/10.1016/j.theochem.2003.08.048","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.theochem.2003.08.048","pdf_url":null,"source":{"id":"https://openalex.org/S207713678","display_name":"Journal of Molecular Structure THEOCHEM","issn_l":"0166-1280","issn":["0166-1280","1872-7999"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Structure: THEOCHEM","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081215274","display_name":"P\u00e9ter Csermely","orcid":"https://orcid.org/0000-0001-9234-0659","observed_orcids":["https://orcid.org/0000-0001-9234-0659"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Peter Csermely","raw_affiliation_strings":["Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074743400","display_name":"Csaba S\u0151ti","orcid":"https://orcid.org/0000-0002-4057-7678","observed_orcids":["https://orcid.org/0000-0002-4057-7678"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Csaba S\u0151ti","raw_affiliation_strings":["Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057769318","display_name":"\u00c9va Kalm\u00e1r","orcid":"https://orcid.org/0000-0003-4616-8047","observed_orcids":["https://orcid.org/0000-0003-4616-8047"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Eva Kalmar","raw_affiliation_strings":["Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032105675","display_name":"Eszter Papp","orcid":"https://orcid.org/0000-0002-6075-8468","observed_orcids":["https://orcid.org/0000-0002-6075-8468","https://orcid.org/0000-0002-5720-9695","https://orcid.org/0009-0005-0206-8230"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Eszter Papp","raw_affiliation_strings":["Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Balint Pato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Balint Pato","raw_affiliation_strings":["Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019970027","display_name":"\u00c1kos Vermes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Akos Vermes","raw_affiliation_strings":["Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111492176","display_name":"Amere Subbarao Sreedhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Amere S. Sreedhar","raw_affiliation_strings":["Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary","institution_ids":["https://openalex.org/I101202996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081215274"],"corresponding_institution_ids":["https://openalex.org/I101202996"],"apc_list":null,"apc_paid":null,"fwci":0.5657,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.59744551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"666-667","issue":null,"first_page":"373","last_page":"380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chaperone-inhibition","display_name":"chaperone inhibition","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/origin-of-cells","display_name":"origin of cells","score":0.5550000071525574},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.7602012157440186},{"id":"https://openalex.org/C141109615","wikidata":"https://www.wikidata.org/wiki/Q5137430","display_name":"Co-chaperone","level":5,"score":0.6828656196594238},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5473771095275879},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5139719843864441},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5087726712226868},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.49597153067588806},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3903995752334595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2959396243095398},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.23729172348976135},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.18016156554222107},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14458683133125305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13052991032600403},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.theochem.2003.08.048","doi":"https://doi.org/10.1016/j.theochem.2003.08.048","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.theochem.2003.08.048","pdf_url":null,"source":{"id":"https://openalex.org/S207713678","display_name":"Journal of Molecular Structure THEOCHEM","issn_l":"0166-1280","issn":["0166-1280","1872-7999"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Structure: THEOCHEM","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.420.1422","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.420.1422","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.linkgroup.hu/docs/pcs/03theochem.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W153442697","https://openalex.org/W174663226","https://openalex.org/W1554180547","https://openalex.org/W1973094516","https://openalex.org/W1975405079","https://openalex.org/W1977388184","https://openalex.org/W1983194893","https://openalex.org/W1983274737","https://openalex.org/W1986606329","https://openalex.org/W1986834353","https://openalex.org/W1988176696","https://openalex.org/W1990403227","https://openalex.org/W1991977835","https://openalex.org/W1992909271","https://openalex.org/W2001150802","https://openalex.org/W2001546169","https://openalex.org/W2004792969","https://openalex.org/W2009115466","https://openalex.org/W2010335064","https://openalex.org/W2013944211","https://openalex.org/W2024625285","https://openalex.org/W2026001691","https://openalex.org/W2026356979","https://openalex.org/W2029128612","https://openalex.org/W2038853625","https://openalex.org/W2040004060","https://openalex.org/W2042699875","https://openalex.org/W2042923888","https://openalex.org/W2047003662","https://openalex.org/W2051636589","https://openalex.org/W2054290614","https://openalex.org/W2066264348","https://openalex.org/W2067708969","https://openalex.org/W2070986880","https://openalex.org/W2073388334","https://openalex.org/W2077405632","https://openalex.org/W2079321385","https://openalex.org/W2082390299","https://openalex.org/W2089473305","https://openalex.org/W2107126967","https://openalex.org/W2107276905","https://openalex.org/W2111214440","https://openalex.org/W2114173273","https://openalex.org/W2114873132","https://openalex.org/W2119999468","https://openalex.org/W2123187537","https://openalex.org/W2123781000","https://openalex.org/W2128736563","https://openalex.org/W2134257758","https://openalex.org/W2139327615","https://openalex.org/W2141539220","https://openalex.org/W2152254940","https://openalex.org/W2153112470","https://openalex.org/W2154078492","https://openalex.org/W2161383869","https://openalex.org/W2164635606","https://openalex.org/W2165360511","https://openalex.org/W2175029576","https://openalex.org/W2177343774","https://openalex.org/W2186655833","https://openalex.org/W2335445771"],"related_works":["https://openalex.org/W7097918139","https://openalex.org/W2065362324","https://openalex.org/W2058658547","https://openalex.org/W2990035409","https://openalex.org/W4240201344","https://openalex.org/W4239727325","https://openalex.org/W2462249495","https://openalex.org/W6941160369","https://openalex.org/W3198872210","https://openalex.org/W2902177978"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}