{"id":"https://openalex.org/W2148421703","doi":"https://doi.org/10.4049/jimmunol.170.6.2833","title":"IL-1 Receptor-Associated Kinase 1 Regulates Susceptibility to Organ-Specific Autoimmunity","display_name":"IL-1 Receptor-Associated Kinase 1 Regulates Susceptibility to Organ-Specific Autoimmunity","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2148421703","doi":"https://doi.org/10.4049/jimmunol.170.6.2833","mag":"2148421703","pmid":"https://pubmed.ncbi.nlm.nih.gov/12626533"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.170.6.2833","doi":"https://doi.org/10.4049/jimmunol.170.6.2833","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.170.6.2833","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100850445","display_name":"Caishu Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Caishu Deng","raw_affiliation_strings":["Department of Neurology, University of Texas Southwestern Medical Center , Dallas, TX 75390","* Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Texas Southwestern Medical Center , Dallas, TX 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"* Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018755772","display_name":"Caius G. Radu","orcid":"https://orcid.org/0000-0002-9338-5397","observed_orcids":["https://orcid.org/0000-0002-9338-5397"]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caius Radu","raw_affiliation_strings":["Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390","\u2021Pediatrics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"\u2021Pediatrics, and","institution_ids":["https://openalex.org/I4210147155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088170616","display_name":"Asim Diab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Asim Diab","raw_affiliation_strings":["Department of Neurology, University of Texas Southwestern Medical Center , Dallas, TX 75390","* Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Texas Southwestern Medical Center , Dallas, TX 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"* Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109240982","display_name":"May F. Tsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"May F Tsen","raw_affiliation_strings":["Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390","\u2021Pediatrics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"\u2021Pediatrics, and","institution_ids":["https://openalex.org/I4210147155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089538984","display_name":"Rehana Z. Hussain","orcid":"https://orcid.org/0000-0002-7700-913X","observed_orcids":["https://orcid.org/0000-0002-7700-913X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rehana Hussain","raw_affiliation_strings":["Department of Neurology, University of Texas Southwestern Medical Center , Dallas, TX 75390","* Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Texas Southwestern Medical Center , Dallas, TX 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"* Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109863861","display_name":"John S. Cowdery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S Cowdery","raw_affiliation_strings":["\u00b6Department of Internal Medicine and Immunology Program, Department of Veterans Affairs Medical Center and The Carver College of Medicine, University of Iowa, Iowa City, IA 52246"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Department of Internal Medicine and Immunology Program, Department of Veterans Affairs Medical Center and The Carver College of Medicine, University of Iowa, Iowa City, IA 52246","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021514185","display_name":"Michael K. Racke","orcid":"https://orcid.org/0000-0002-1231-4694","observed_orcids":["https://orcid.org/0000-0002-1231-4694"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael K Racke","raw_affiliation_strings":["Department of Center for Immunology, University of Texas Southwestern Medical Center , Dallas, TX 75390","Department of Neurology, University of Texas Southwestern Medical Center , Dallas, TX 75390","* Neurology,","\u2020Center for Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Center for Immunology, University of Texas Southwestern Medical Center , Dallas, TX 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Neurology, University of Texas Southwestern Medical Center , Dallas, TX 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"* Neurology,","institution_ids":[]},{"raw_affiliation_string":"\u2020Center for Immunology,","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"James A Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A Thomas","raw_affiliation_strings":["Department of Molecular Biology, University of Texas Southwestern Medical Center , Dallas, TX 75390","Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390","\u00a7Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390; and","\u2021Pediatrics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, University of Texas Southwestern Medical Center , Dallas, TX 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"\u00a7Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390; and","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"\u2021Pediatrics, and","institution_ids":["https://openalex.org/I4210147155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088170616","https://openalex.org/A5089538984","https://openalex.org/A5100850445"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.518,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.82246239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"170","issue":"6","first_page":"2833","last_page":"2842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.48190000653266907,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.48190000653266907,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.33719998598098755,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.11949999630451202,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irak1","display_name":"IRAK1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.7329999804496765},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/t-cell-priming","display_name":"T cell priming","score":0.7580000162124634},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.7369999885559082},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/infection-and-autoimmunity","display_name":"infection and autoimmunity","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.871794581413269},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7519747018814087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6401854157447815},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.6270720362663269},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5400534272193909},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.5385469198226929},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5175185203552246},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4986255168914795},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.49849629402160645},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.444366991519928},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41562458872795105},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.41077959537506104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20354780554771423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14666208624839783},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1324785053730011}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005620","descriptor_name":"Freund's Adjuvant","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005620","descriptor_name":"Freund's Adjuvant","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007399","descriptor_name":"Interphase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007399","descriptor_name":"Interphase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053592","descriptor_name":"Interleukin-1 Receptor-Associated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063308","descriptor_name":"Myelin-Oligodendrocyte Glycoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.170.6.2833","doi":"https://doi.org/10.4049/jimmunol.170.6.2833","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.170.6.2833","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:12626533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12626533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W642251971","https://openalex.org/W1485179699","https://openalex.org/W1514540900","https://openalex.org/W1525833221","https://openalex.org/W1525912444","https://openalex.org/W1542728222","https://openalex.org/W1549853453","https://openalex.org/W1553161314","https://openalex.org/W1769737355","https://openalex.org/W1932588934","https://openalex.org/W1966419386","https://openalex.org/W1971521446","https://openalex.org/W1977830503","https://openalex.org/W1979514172","https://openalex.org/W1984364811","https://openalex.org/W1986920722","https://openalex.org/W1988563171","https://openalex.org/W1988820544","https://openalex.org/W1990204841","https://openalex.org/W1996120614","https://openalex.org/W2009660986","https://openalex.org/W2014954180","https://openalex.org/W2034101794","https://openalex.org/W2039616622","https://openalex.org/W2041170922","https://openalex.org/W2041928346","https://openalex.org/W2046657152","https://openalex.org/W2056859114","https://openalex.org/W2058582479","https://openalex.org/W2070597700","https://openalex.org/W2079020047","https://openalex.org/W2081877146","https://openalex.org/W2082649398","https://openalex.org/W2093942918","https://openalex.org/W2095343230","https://openalex.org/W2103312963","https://openalex.org/W2108473659","https://openalex.org/W2114737175","https://openalex.org/W2117761826","https://openalex.org/W2118011548","https://openalex.org/W2134453100","https://openalex.org/W2134472621","https://openalex.org/W2135373024","https://openalex.org/W2138589906","https://openalex.org/W2143774231","https://openalex.org/W2149160053","https://openalex.org/W2152318693","https://openalex.org/W2156642970","https://openalex.org/W2160546595","https://openalex.org/W2161485037","https://openalex.org/W2162076795","https://openalex.org/W2163558504","https://openalex.org/W2164870425","https://openalex.org/W2167727281","https://openalex.org/W2169293700","https://openalex.org/W2504670807","https://openalex.org/W3126895827","https://openalex.org/W4235509947","https://openalex.org/W4239945583","https://openalex.org/W4313308301","https://openalex.org/W4316500424"],"related_works":["https://openalex.org/W2118484891","https://openalex.org/W2371146098","https://openalex.org/W2153450401","https://openalex.org/W2080709645","https://openalex.org/W2119506058","https://openalex.org/W4210935329","https://openalex.org/W4280586202","https://openalex.org/W2084454490","https://openalex.org/W2129070672","https://openalex.org/W3000607767"],"abstract_inverted_index":{"Infections":[0],"often":[1],"precede":[2],"the":[3,74,80,84,159,190,196],"development":[4,81,181,197],"of":[5,28,38,54,76,82,86,98,182,200],"autoimmunity.":[6,183],"Correlation":[7],"between":[8,192],"infection":[9,194],"with":[10,110],"a":[11,15,39,59],"specific":[12],"pathogen":[13],"and":[14,67,90,105,158,170,195],"particular":[16],"autoimmune":[17,100,129,202],"disease":[18,147],"ranges":[19],"from":[20,35],"moderately":[21],"strong":[22],"to":[23,43,51,96,127],"quite":[24],"weak.":[25],"This":[26],"lack":[27],"correspondence":[29],"suggests":[30],"that":[31,156],"autoimmunity":[32],"may":[33,186],"result":[34],"microbial":[36,55],"activation":[37],"generic,":[40],"as":[41],"opposed":[42],"pathogen-specific":[44],"host-defense":[45],"response.":[46],"The":[47],"Toll-like":[48],"receptors,":[49],"essential":[50,164],"host":[52],"recognition":[53],"invasion,":[56],"signal":[57],"through":[58,174],"common,":[60],"highly":[61],"conserved":[62],"pathway,":[63],"activate":[64],"innate":[65,176],"immunity,":[66],"control":[68,179],"adaptive":[69],"immune":[70],"responses.":[71],"To":[72],"determine":[73],"influence":[75],"Toll/IL-1":[77,160],"signaling":[78],"on":[79],"autoimmunity,":[83],"responses":[85],"wild-type":[87],"(WT)":[88],"mice":[89,95,107,124],"IL-1R-associated":[91],"kinase":[92],"1":[93],"(IRAK1)-deficient":[94],"induction":[97],"experimental":[99,128],"encephalomyelitis":[101],"were":[102,108,125],"compared.":[103],"C57BL/6":[104],"B6.IRAK1-deficient":[106],"immunized":[109],"MOG":[111,114],"35-55/CFA":[112],"or":[113,133,198],"35-55/CpG":[115],"DNA/IFA.":[116],"WT":[117],"animals":[118],"developed":[119],"severe":[120],"disease,":[121],"whereas":[122],"IRAK1-deficient":[123,137],"resistant":[126],"encephalomyelitis,":[130],"exhibiting":[131],"little":[132],"no":[134],"CNS":[135],"inflammation.":[136],"T":[138,167],"cells":[139],"also":[140,187],"displayed":[141],"impaired":[142],"Th1":[143],"development,":[144],"particularly":[145],"during":[146],"induction,":[148],"despite":[149],"normal":[150],"TCR":[151],"signaling.":[152],"These":[153,184],"results":[154],"suggest":[155],"IRAK1":[157],"pathway":[161],"play":[162],"an":[163],"role":[165],"in":[166],"cell":[168],"priming,":[169],"demonstrate":[171],"one":[172],"means":[173],"which":[175],"immunity":[177],"can":[178],"subsequent":[180],"findings":[185],"help":[188],"explain":[189],"association":[191],"antecedent":[193],"exacerbations":[199],"some":[201],"diseases.":[203]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}