{"id":"https://openalex.org/W2148386309","doi":"https://doi.org/10.1002/pro.5560070805","title":"Analysis of zinc binding sites in protein crystal structures","display_name":"Analysis of zinc binding sites in protein crystal structures","publication_year":1998,"publication_date":"1998-08-01","ids":{"openalex":"https://openalex.org/W2148386309","doi":"https://doi.org/10.1002/pro.5560070805","mag":"2148386309","pmid":"https://pubmed.ncbi.nlm.nih.gov/10082367","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2144076"},"language":"en","primary_location":{"id":"doi:10.1002/pro.5560070805","doi":"https://doi.org/10.1002/pro.5560070805","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.5560070805","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.5560070805","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.5560070805","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075915311","display_name":"Ian L. Alberts","orcid":"https://orcid.org/0000-0002-8992-4407","observed_orcids":["https://orcid.org/0000-0002-8992-4407"]},"institutions":[{"id":"https://openalex.org/I12093191","display_name":"University of Stirling","ror":"https://ror.org/045wgfr59","country_code":"GB","type":"education","lineage":["https://openalex.org/I12093191"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian L. Alberts","raw_affiliation_strings":["EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, England","Department of Biological and Molecular Sciences, University of Stirling, Stirling FK94LA. Scotland","EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CBl0 1SD, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, England","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Department of Biological and Molecular Sciences, University of Stirling, Stirling FK94LA. Scotland","institution_ids":["https://openalex.org/I12093191"]},{"raw_affiliation_string":"EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CBl0 1SD, England","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003762981","display_name":"Katalin Nadassy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12093191","display_name":"University of Stirling","ror":"https://ror.org/045wgfr59","country_code":"GB","type":"education","lineage":["https://openalex.org/I12093191"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katalin Nadassy","raw_affiliation_strings":["Department of Biological and Molecular Sciences, University of Stirling, Stirling FK94LA. Scotland","EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CBl0 1SD, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Molecular Sciences, University of Stirling, Stirling FK94LA. Scotland","institution_ids":["https://openalex.org/I12093191"]},{"raw_affiliation_string":"EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CBl0 1SD, England","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074905519","display_name":"Shoshana J. Wodak","orcid":"https://orcid.org/0000-0002-0701-6545","observed_orcids":["https://orcid.org/0000-0002-0701-6545"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["BE","GB"],"is_corresponding":true,"raw_author_name":"Shoshana J. Wodak","raw_affiliation_strings":["EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CBl0 1SD, England","Unite\u0301 de Conformation des Macromole\u0301cules Biologiques, Universite\u0301 Libre de Bruxelles, Avenue F. Roosevelt, CP 160/16, B1050, Bruxelles, Belgium","Unit\u00e9 de Conformation des Macromol\u00e9cules Biologiques, Universit\u00e9 Libre de Bruxelles, Avenue F. Roosevelt, CP 160/16, B1050, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CBl0 1SD, England","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Unite\u0301 de Conformation des Macromole\u0301cules Biologiques, Universite\u0301 Libre de Bruxelles, Avenue F. Roosevelt, CP 160/16, B1050, Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Unit\u00e9 de Conformation des Macromol\u00e9cules Biologiques, Universit\u00e9 Libre de Bruxelles, Avenue F. Roosevelt, CP 160/16, B1050, Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074905519"],"corresponding_institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I132053463","https://openalex.org/I87048295"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":6.9462,"has_fulltext":true,"cited_by_count":425,"citation_normalized_percentile":{"value":0.98917749,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"7","issue":"8","first_page":"1700","last_page":"1716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.03790000081062317,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10464","display_name":"Crystal structures of chemical compounds","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-binding-site","display_name":"zinc binding site","score":0.9959999918937683},{"id":"https://openalex.org/keywords/zinc-coordination-geometry","display_name":"zinc coordination geometry","score":0.8220000267028809},{"id":"https://openalex.org/keywords/primary-coordination-sphere","display_name":"primary coordination sphere","score":0.7429999709129333},{"id":"https://openalex.org/keywords/endopeptidase","display_name":"endopeptidase","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hydrophobic-residues","display_name":"hydrophobic residues","score":0.6840000152587891},{"id":"https://openalex.org/keywords/protein-data-bank","display_name":"Protein Data Bank","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.8866432905197144},{"id":"https://openalex.org/C11111787","wikidata":"https://www.wikidata.org/wiki/Q675972","display_name":"Coordination sphere","level":3,"score":0.7471895813941956},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.6887068748474121},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6516443490982056},{"id":"https://openalex.org/C178516000","wikidata":"https://www.wikidata.org/wiki/Q3023362","display_name":"Denticity","level":3,"score":0.5809244513511658},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.5160365104675293},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4964209198951721},{"id":"https://openalex.org/C194196696","wikidata":"https://www.wikidata.org/wiki/Q1753378","display_name":"Coordination geometry","level":4,"score":0.4818781316280365},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4170224666595459},{"id":"https://openalex.org/C33559828","wikidata":"https://www.wikidata.org/wiki/Q397226","display_name":"Coordination number","level":3,"score":0.41216641664505005},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38914498686790466},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.22699174284934998},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.22362101078033447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11892703175544739},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09874546527862549},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.09866666793823242}],"mesh":[{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002713","descriptor_name":"Chlorine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013455","descriptor_name":"Sulfur","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/pro.5560070805","doi":"https://doi.org/10.1002/pro.5560070805","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.5560070805","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.5560070805","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2144076","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2144076","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmid:10082367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10082367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/116635","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/116635","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Protein science, 7 (8","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/pro.5560070805","doi":"https://doi.org/10.1002/pro.5560070805","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.5560070805","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.5560070805","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313288","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52"},{"id":"https://openalex.org/F4320321096","display_name":"University of Stirling","ror":"https://ror.org/045wgfr59"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148386309.pdf","grobid_xml":"https://content.openalex.org/works/W2148386309.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W160102508","https://openalex.org/W1487053853","https://openalex.org/W1509956720","https://openalex.org/W1518416799","https://openalex.org/W1523417784","https://openalex.org/W1531791809","https://openalex.org/W1539251517","https://openalex.org/W1585936714","https://openalex.org/W1802135738","https://openalex.org/W1844893699","https://openalex.org/W1937983574","https://openalex.org/W1951248594","https://openalex.org/W1954690293","https://openalex.org/W1966041739","https://openalex.org/W1966721068","https://openalex.org/W1967092414","https://openalex.org/W1968539554","https://openalex.org/W1971838382","https://openalex.org/W1972154782","https://openalex.org/W1972459599","https://openalex.org/W1975073708","https://openalex.org/W1975760681","https://openalex.org/W1978846531","https://openalex.org/W1986894327","https://openalex.org/W1991063206","https://openalex.org/W1992144736","https://openalex.org/W1992661805","https://openalex.org/W1997060814","https://openalex.org/W1997670079","https://openalex.org/W2000794695","https://openalex.org/W2006516293","https://openalex.org/W2007618885","https://openalex.org/W2008710334","https://openalex.org/W2010162199","https://openalex.org/W2013638533","https://openalex.org/W2016065841","https://openalex.org/W2018210594","https://openalex.org/W2018258775","https://openalex.org/W2021116136","https://openalex.org/W2021586664","https://openalex.org/W2028129929","https://openalex.org/W2028864844","https://openalex.org/W2031422149","https://openalex.org/W2034007433","https://openalex.org/W2034860266","https://openalex.org/W2036805996","https://openalex.org/W2037813023","https://openalex.org/W2042404460","https://openalex.org/W2047514291","https://openalex.org/W2049115197","https://openalex.org/W2050186088","https://openalex.org/W2050585755","https://openalex.org/W2051564131","https://openalex.org/W2052979701","https://openalex.org/W2055727158","https://openalex.org/W2061119810","https://openalex.org/W2062254347","https://openalex.org/W2062772486","https://openalex.org/W2065074615","https://openalex.org/W2070198392","https://openalex.org/W2070571039","https://openalex.org/W2071726755","https://openalex.org/W2077294102","https://openalex.org/W2078546877","https://openalex.org/W2080048885","https://openalex.org/W2081399318","https://openalex.org/W2085277871","https://openalex.org/W2090133370","https://openalex.org/W2091662140","https://openalex.org/W2092836574","https://openalex.org/W2097035920","https://openalex.org/W2108348687","https://openalex.org/W2115732278","https://openalex.org/W2120087635","https://openalex.org/W2136339729","https://openalex.org/W2137502578","https://openalex.org/W2137882621","https://openalex.org/W2148150393","https://openalex.org/W2152733087","https://openalex.org/W2153023761","https://openalex.org/W2158022532","https://openalex.org/W2158198055","https://openalex.org/W2159554322","https://openalex.org/W2160181867","https://openalex.org/W2417022531","https://openalex.org/W2496211198","https://openalex.org/W2915190566","https://openalex.org/W3026250385","https://openalex.org/W4237766996","https://openalex.org/W4241372364","https://openalex.org/W4242425343","https://openalex.org/W4244930290","https://openalex.org/W4249231186"],"related_works":["https://openalex.org/W7128324553","https://openalex.org/W4211065183","https://openalex.org/W4210956497","https://openalex.org/W1966479051","https://openalex.org/W2007457931","https://openalex.org/W2145144268","https://openalex.org/W2522003684","https://openalex.org/W7131878107","https://openalex.org/W2971032613","https://openalex.org/W4211119237"],"abstract_inverted_index":{"The":[0],"geometrical":[1,180],"properties":[2],"of":[3,10,82,122,140,162,189,234],"zinc":[4,30,49,63,72,147,203,215,236,260,263],"binding":[5,131,264],"sites":[6,31],"in":[7,17,36,47,70,91,97,153,213,217,248,266],"a":[8,42,80,186,198,210],"dataset":[9,155],"high":[11],"quality":[12],"protein":[13,128,267],"crystal":[14,268],"structures":[15,269],"deposited":[16],"the":[18,48,75,92,101,123,158,163,178,214,225,231,235,249,258],"Protein":[19],"Data":[20],"Bank":[21],"have":[22,185,221],"been":[23],"examined":[24],"to":[25,100,116,120,127,146,254,256],"identify":[26,244],"important":[27],"differences":[28],"between":[29],"that":[32,40,87,138,166,240,251],"are":[33,53,66,96,114,170],"directly":[34],"involved":[35],"catalysis":[37],"and":[38,62,89,113,133,156,238,243],"those":[39,69],"play":[41],"structural":[43,194],"role.":[44],"Coordination":[45],"angles":[46,90],"primary":[50,93],"coordination":[51,60,64,94],"sphere":[52,95],"compared":[54,67],"with":[55,68],"ideal":[56],"values":[57],"for":[58,109,202],"each":[59],"geometry,":[61],"distances":[65,88],"small":[71,211],"complexes":[73],"from":[74,272],"Cambridge":[76],"Structural":[77],"Database":[78],"as":[79,209],"guide":[81],"expected":[83,102],"trends.":[84],"We":[85,136,228],"find":[86,137],"general":[98],"close":[99],"(or":[103,144],"ideal)":[104],"values.":[105],"Deviations":[106],"occur":[107],"primarily":[108],"oxygen":[110,124,141],"coordinating":[111,125],"atoms":[112,192],"found":[115],"be":[117],"mainly":[118],"due":[119],"H-bonding":[121,139],"ligand":[126],"residues,":[129],"bidentate":[130],"arrangements,":[132],"multi-zinc":[134],"sites.":[135],"containing":[142],"residues":[143,239,247],"water)":[145],"bound":[148],"histidines":[149],"is":[150,206,270],"almost":[151],"universal":[152],"our":[154],"defines":[157],"elec-His-Zn":[159,168,175],"motif.":[160],"Analysis":[161],"stereochemistry":[164],"shows":[165],"carboxyl":[167,190],"motifs":[169,176,184],"geometrically":[171],"rigid,":[172],"while":[173],"water":[174],"show":[177],"most":[179],"variation.":[181],"As":[182],"catalytic":[183,259],"higher":[187],"proportion":[188],"elec":[191],"than":[193],"motifs,":[195],"they":[196],"provide":[197,241],"more":[199],"rigid":[200],"framework":[201],"binding.":[204],"This":[205],"understood":[207],"biologically,":[208],"distortion":[212],"position":[216],"an":[218],"enzyme":[219],"can":[220],"serious":[222],"consequences":[223],"on":[224],"enzymatic":[226],"reaction.":[227],"also":[229,252],"analyze":[230],"sequence":[232],"pattern":[233],"ligands":[237],"elecs,":[242],"conserved":[245],"hydrophobic":[246],"endopeptidases":[250],"appear":[253],"contribute":[255],"stabilizing":[257],"site.":[261],"A":[262],"template":[265],"derived":[271],"these":[273],"observations.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
