{"id":"https://openalex.org/W2148354356","doi":"https://doi.org/10.1186/1742-4690-2-53","title":"CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection","display_name":"CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection","publication_year":2005,"publication_date":"2005-08-18","ids":{"openalex":"https://openalex.org/W2148354356","doi":"https://doi.org/10.1186/1742-4690-2-53","mag":"2148354356","pmid":"https://pubmed.ncbi.nlm.nih.gov/16109172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1199620"},"language":"en","primary_location":{"id":"doi:10.1186/1742-4690-2-53","doi":"https://doi.org/10.1186/1742-4690-2-53","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-2-53","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-2-53","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-2-53","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010572953","display_name":"Joseph S. Anderson","orcid":"https://orcid.org/0000-0001-6001-1156","observed_orcids":["https://orcid.org/0000-0001-6001-1156"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Anderson","raw_affiliation_strings":["Dept. Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA. lacrosse@colostate.edu","Dept. Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA. lacrosse@colostate.edu","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Dept. Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051787949","display_name":"Ramesh Akkina","orcid":"https://orcid.org/0000-0002-1577-5154","observed_orcids":["https://orcid.org/0000-0002-1577-5154"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramesh Akkina","raw_affiliation_strings":["Dept. Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051787949"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":4.6748,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.9562827,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"1","first_page":"53","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.1462000012397766,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-coreceptor","display_name":"HIV-1 coreceptor","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.8629999756813049},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":1.0},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.6549999713897705},{"id":"https://openalex.org/keywords/macrophage-tropism","display_name":"macrophage tropism","score":0.5569999814033508},{"id":"https://openalex.org/keywords/hiv-1-resistance","display_name":"HIV-1 resistance","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cd34-hematopoietic-progenitor-cells","display_name":"CD34+ hematopoietic progenitor cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/stem-cell-gene-therapy","display_name":"stem cell gene therapy","score":0.8560000061988831},{"id":"https://openalex.org/keywords/macrophage-function","display_name":"macrophage function","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.643589198589325},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.5827046036720276},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.556398868560791},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5314399600028992},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.5180637836456299},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4979102611541748},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.48588842153549194},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4629908800125122},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4591161608695984},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.44413435459136963},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.43869149684906006},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.43424785137176514},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.4221426248550415},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4005435109138489},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3953648805618286},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.35120394825935364},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.32965826988220215},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28097617626190186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23037299513816833},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.21799445152282715},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15716564655303955},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08842122554779053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D065100","descriptor_name":"CCR5 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1742-4690-2-53","doi":"https://doi.org/10.1186/1742-4690-2-53","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-2-53","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-2-53","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1199620","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1199620","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Text"},{"id":"pmid:16109172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16109172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d72f09a5d7fb43ecaa3867ec1b8b8a87","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d72f09a5d7fb43ecaa3867ec1b8b8a87","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Retrovirology, Vol 2, Iss 1, p 53 (2005)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1742-4690-2-53","doi":"https://doi.org/10.1186/1742-4690-2-53","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-2-53","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-2-53","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1691243131","display_name":null,"funder_award_id":"P30-AI-054907","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1707366094","display_name":"SiRNA Gene Therapy for HIV/AIDS","funder_award_id":"R01AI057066","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1920715851","display_name":"Modeling RNA-based HIV gene therapeutics in SCID-hu mice","funder_award_id":"R21AI050492","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3856033402","display_name":null,"funder_award_id":"AI 50492","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4965047958","display_name":"U of Colorado Center for AIDS Research","funder_award_id":"5p30ai054907-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6427640688","display_name":"Modeling RNA-based HIV gene therapeutics in SCID-hu mice","funder_award_id":"R01AI050492","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7615590775","display_name":null,"funder_award_id":"AI057066","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148354356.pdf","grobid_xml":"https://content.openalex.org/works/W2148354356.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W26333867","https://openalex.org/W42594459","https://openalex.org/W1480555318","https://openalex.org/W1488192195","https://openalex.org/W1516358214","https://openalex.org/W1530538102","https://openalex.org/W1590468645","https://openalex.org/W1611419331","https://openalex.org/W1647075334","https://openalex.org/W1826322599","https://openalex.org/W1982944348","https://openalex.org/W1986574361","https://openalex.org/W1992411993","https://openalex.org/W1994122530","https://openalex.org/W1994207095","https://openalex.org/W1995677833","https://openalex.org/W1998513236","https://openalex.org/W2009412962","https://openalex.org/W2026102468","https://openalex.org/W2028571259","https://openalex.org/W2037067282","https://openalex.org/W2045663070","https://openalex.org/W2045772303","https://openalex.org/W2046126827","https://openalex.org/W2050621394","https://openalex.org/W2062346545","https://openalex.org/W2062407001","https://openalex.org/W2066701930","https://openalex.org/W2067520621","https://openalex.org/W2073905027","https://openalex.org/W2084851425","https://openalex.org/W2084903745","https://openalex.org/W2090630729","https://openalex.org/W2098509726","https://openalex.org/W2103809350","https://openalex.org/W2105824105","https://openalex.org/W2108330459","https://openalex.org/W2112349562","https://openalex.org/W2113657260","https://openalex.org/W2118182695","https://openalex.org/W2126357434","https://openalex.org/W2135135539","https://openalex.org/W2140091023","https://openalex.org/W2144266543","https://openalex.org/W2147169218","https://openalex.org/W2147896158","https://openalex.org/W2152922582","https://openalex.org/W2170771513","https://openalex.org/W2171790482","https://openalex.org/W2172243146","https://openalex.org/W2173401606","https://openalex.org/W2365625027","https://openalex.org/W4211039187","https://openalex.org/W4231718818","https://openalex.org/W4254038279","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7097107071","https://openalex.org/W1984854468","https://openalex.org/W2066547625","https://openalex.org/W2121996458","https://openalex.org/W1480517694","https://openalex.org/W2137180811","https://openalex.org/W1998513236","https://openalex.org/W7095966591","https://openalex.org/W2560920915","https://openalex.org/W1590468645"],"abstract_inverted_index":{"BACKGROUND:":[0],"Stable":[1],"simultaneous":[2],"knock":[3],"down":[4,71,162,318],"of":[5,38,85,106,164,221,344,350,376],"the":[6,168,200,222,246,268,284],"HIV-1":[7,86,122,180,329,373],"coreceptors":[8,74,166,305,320],"CCR5":[9,66,133,302],"and":[10,24,65,75,82,132,178,213,231,255,275,303,311,326,337],"CXCR4":[11,64,131,304],"is":[12,354],"a":[13,59,96,160,288,380],"promising":[14],"strategy":[15],"to":[16,79,95,112,121,148,175,207,261,272,295,300,323,357,367],"protect":[17],"cells":[18,111,117,145,310,333],"from":[19],"both":[20,73,80,165,176,301,324],"R5":[21,177,325],"macrophage":[22],"tropic":[23,28,33,328],"X4":[25,81,179,327],"T":[26],"cell":[27,89,98,382],"as":[29,31,46],"well":[30],"dual":[32],"viral":[34,77],"infections.":[35,330],"The":[36,125,143,238,331],"potency":[37],"shRNAs":[39,67,192,298,345,365],"in":[40,70,87,139,155,167,183,244,259,372,379],"targeted":[41,299,366],"gene":[42,53,99,359,390],"silencing":[43],"qualifies":[44],"them":[45],"powerful":[47],"tools":[48],"for":[49,283,387],"long":[50],"term":[51],"HIV":[52],"therapy.":[54,391],"Our":[55],"previous":[56],"work":[57],"with":[58,317],"bispecific":[60,126,289],"lentiviral":[61,128,290,361],"vector":[62,129,291],"containing":[63],"showed":[68,173,218],"efficacy":[69],"regulating":[72],"conferring":[76],"resistance":[78,174],"R5-tropic":[83],"strains":[84,181],"cultured":[88,154],"lines.":[90],"To":[91],"extend":[92],"these":[93,377],"results":[94],"stem":[97,351,381],"therapy":[100],"setting,":[101],"here":[102],"we":[103],"show":[104],"transduction":[105],"primary":[107],"CD34+":[108,141,307],"hematopoietic":[109,308],"progenitor":[110,309],"derive":[113,312],"normal":[114,150,219,242,339],"end":[115],"stage":[116],"that":[118,287,370],"are":[119,211],"resistant":[120,322],"infection.":[123,374],"RESULTS:":[124],"XHR":[127],"harboring":[130],"shRNA":[134],"expression":[135],"cassettes":[136],"was":[137,159,264],"efficient":[138],"transducing":[140],"cells.":[142,352],"transduced":[144,170,202],"gave":[146],"rise":[147],"morphologically":[149],"transgenic":[151,198,239,269,313],"macrophages":[152,171,203,240,270,316],"when":[153],"cytokine":[156,257],"media.":[157],"There":[158],"marked":[161],"regulation":[163],"stably":[169,201,296],"which":[172],"upon":[182,250],"vitro":[184],"challenge.":[185],"Since":[186],"off":[187],"target":[188],"effects":[189,196,343],"by":[190],"some":[191],"may":[193],"have":[194,281],"adverse":[195,342],"on":[197,346],"cells,":[199],"were":[204,235,321,334],"further":[205],"analyzed":[206],"determine":[208],"if":[209],"they":[210],"phenotypically":[212,274,336],"functionally":[214,276,338],"normal.":[215,237,266,277],"FACS":[216],"evaluation":[217],"levels":[220],"characteristic":[223],"surface":[224],"markers":[225],"CD14,":[226],"CD4,":[227],"MHC":[228],"class":[229],"II,":[230],"B7.1.":[232],"Phagocytic":[233],"functions":[234],"also":[236,265,335],"demonstrated":[241,282],"abilities":[243],"up-regulating":[245],"costimulatory":[247],"molecule":[248],"B7.1":[249],"LPS":[251,262],"stimulation.":[252],"Furthermore,":[253],"IL-1":[254],"TNFalpha":[256],"secretion":[258],"response":[260],"stimulation":[263],"Thus,":[267],"appear":[271],"be":[273,293],"CONCLUSION:":[278],"These":[279],"studies":[280],"first":[285],"time":[286],"could":[292],"used":[294],"deliver":[297],"into":[306],"macrophages.":[314],"Transgenic":[315],"regulated":[319],"differentiated":[332],"indicating":[340],"no":[341],"lineage":[347],"specific":[348],"differentiation":[349],"It":[353],"now":[355],"possible":[356],"construct":[358],"therapeutic":[360],"vectors":[362,378],"incorporating":[363],"multiple":[364],"cellular":[368],"molecules":[369],"aid":[371],"Use":[375],"setting":[383],"shows":[384],"great":[385],"promise":[386],"sustained":[388],"HIV/AIDS":[389]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
