{"id":"https://openalex.org/W2148340102","doi":null,"title":"Progressive pigmented purpuric dermatitis and alopecia areata as unusual skin manifestations in recognizing hereditary hemochromatosis.","display_name":"Progressive pigmented purpuric dermatitis and alopecia areata as unusual skin manifestations in recognizing hereditary hemochromatosis.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2148340102","mag":"2148340102","pmid":"https://pubmed.ncbi.nlm.nih.gov/23069304"},"language":"en","primary_location":{"id":"pmid:23069304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23069304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta dermatovenerologica Croatica : ADC","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026669494","display_name":"Vesna Sredoja Ti\u0161ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800813048","display_name":"University Hospital Dubrava","ror":"https://ror.org/00mgfdc89","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I2800813048"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Vesna Sredoja Ti\u0161ma","raw_affiliation_strings":["Polyclinic Department of Dermatology and Venereology, Dubrava University Hospital, Zagreb, Croatia. vesna.tisma@mail.inet.hr","Polyclinic Department of Dermatology and Venereology Dubrava University Hospital Avenija Gojka \u0160u\u0161ka 6 HR-10000 Zagreb Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polyclinic Department of Dermatology and Venereology, Dubrava University Hospital, Zagreb, Croatia. vesna.tisma@mail.inet.hr","institution_ids":["https://openalex.org/I2800813048"]},{"raw_affiliation_string":"Polyclinic Department of Dermatology and Venereology Dubrava University Hospital Avenija Gojka \u0160u\u0161ka 6 HR-10000 Zagreb Croatia","institution_ids":["https://openalex.org/I2800813048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039976153","display_name":"Stela Bulimba\u0161i\u0107","orcid":"https://orcid.org/0000-0002-1038-0540","observed_orcids":["https://orcid.org/0000-0002-1038-0540"]},"institutions":[{"id":"https://openalex.org/I2800813048","display_name":"University Hospital Dubrava","ror":"https://ror.org/00mgfdc89","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I2800813048"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Stela Bulimba\u0161i\u0107","raw_affiliation_strings":["Department of Pathology, Dubrava University Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dubrava University Hospital;","institution_ids":["https://openalex.org/I2800813048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078029883","display_name":"Morana Jaganjac","orcid":"https://orcid.org/0000-0001-5051-1843","observed_orcids":["https://orcid.org/0000-0001-5051-1843"]},"institutions":[{"id":"https://openalex.org/I4210123216","display_name":"Ru\u0111er Bo\u0161kovi\u0107 Institute","ror":"https://ror.org/02mw21745","country_code":"HR","type":"facility","lineage":["https://openalex.org/I4210123216"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Morana Jaganjac","raw_affiliation_strings":["Divison of Molecular Medicine, Laboratory for Oxidative Stress, Ru\u0111er Bo\u0161kovi\u0107 Institute, Zagreb;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divison of Molecular Medicine, Laboratory for Oxidative Stress, Ru\u0111er Bo\u0161kovi\u0107 Institute, Zagreb;","institution_ids":["https://openalex.org/I4210123216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068525386","display_name":"Marica Stjepandi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marica Stjepandi\u0107","raw_affiliation_strings":["Department of Internal Medicine, Pakrac General Hospital, Pakrac, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Pakrac General Hospital, Pakrac, Croatia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078869294","display_name":"Miljana Larma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miljana Larma","raw_affiliation_strings":["Department of Internal Medicine, Pakrac General Hospital, Pakrac, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Pakrac General Hospital, Pakrac, Croatia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6133,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.73006589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"3","first_page":"181","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-hemochromatosis","display_name":"hereditary hemochromatosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alopecia-areata","display_name":"alopecia areata","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hfe-gene","display_name":"HFE gene","score":0.5889999866485596},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.9539999961853027},{"id":"https://openalex.org/keywords/serum-ferritin","display_name":"serum ferritin","score":0.7950000166893005},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.7540000081062317},{"id":"https://openalex.org/keywords/phlebotomy","display_name":"phlebotomy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cutaneous-manifestations","display_name":"cutaneous manifestations","score":0.5350000262260437},{"id":"https://openalex.org/keywords/phenotypic-heterogeneity","display_name":"phenotypic heterogeneity","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9014959335327148},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.7216225266456604},{"id":"https://openalex.org/C3018783601","wikidata":"https://www.wikidata.org/wiki/Q3144934","display_name":"Hereditary hemochromatosis","level":3,"score":0.66234290599823},{"id":"https://openalex.org/C2777524370","wikidata":"https://www.wikidata.org/wiki/Q5075435","display_name":"Alopecia areata","level":2,"score":0.6612624526023865},{"id":"https://openalex.org/C2776590208","wikidata":"https://www.wikidata.org/wiki/Q2025687","display_name":"Hemochromatosis","level":2,"score":0.6067721843719482},{"id":"https://openalex.org/C2780439664","wikidata":"https://www.wikidata.org/wiki/Q7535376","display_name":"Skin biopsy","level":3,"score":0.5805420279502869},{"id":"https://openalex.org/C2909381827","wikidata":"https://www.wikidata.org/wiki/Q1641068","display_name":"Skin hyperpigmentation","level":3,"score":0.44237416982650757},{"id":"https://openalex.org/C12125453","wikidata":"https://www.wikidata.org/wiki/Q5156837","display_name":"Compound heterozygosity","level":4,"score":0.42766839265823364},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.37177056074142456},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36829277873039246},{"id":"https://openalex.org/C2776728111","wikidata":"https://www.wikidata.org/wiki/Q1641068","display_name":"Hyperpigmentation","level":2,"score":0.19080540537834167},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.1643458902835846},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13534322381019592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000506","descriptor_name":"Alopecia Areata","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000506","descriptor_name":"Alopecia Areata","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000506","descriptor_name":"Alopecia Areata","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010859","descriptor_name":"Pigmentation Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010859","descriptor_name":"Pigmentation Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010859","descriptor_name":"Pigmentation Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23069304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23069304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta dermatovenerologica Croatica : ADC","raw_type":"Case Reports"},{"id":"mag:2148340102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23069304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W201365377","https://openalex.org/W1506564072","https://openalex.org/W1728469544","https://openalex.org/W1981217027","https://openalex.org/W1982637438","https://openalex.org/W1982951760","https://openalex.org/W1985533627","https://openalex.org/W1994004487","https://openalex.org/W1995207232","https://openalex.org/W2002605005","https://openalex.org/W2003764905","https://openalex.org/W2015428868","https://openalex.org/W2023981089","https://openalex.org/W2024809965","https://openalex.org/W2026774674","https://openalex.org/W2041816798","https://openalex.org/W2052809501","https://openalex.org/W2057363730","https://openalex.org/W2060945328","https://openalex.org/W2069628684","https://openalex.org/W2072757420","https://openalex.org/W2088674386","https://openalex.org/W2096568945","https://openalex.org/W2097657869","https://openalex.org/W2109308277","https://openalex.org/W2111382860","https://openalex.org/W2114030946","https://openalex.org/W2165813494","https://openalex.org/W2219686961","https://openalex.org/W2398908289","https://openalex.org/W4229952436","https://openalex.org/W4323237725"],"related_works":["https://openalex.org/W4309502686","https://openalex.org/W3556414","https://openalex.org/W2978323578","https://openalex.org/W2460147824","https://openalex.org/W2993649677","https://openalex.org/W3143458428","https://openalex.org/W2007297810","https://openalex.org/W4404567742","https://openalex.org/W6979070232","https://openalex.org/W2613582375"],"abstract_inverted_index":{"Hereditary":[0],"hemochromatosis":[1,210],"(HHC)":[2],"is":[3,50],"a":[4,56,62,69],"common":[5],"genetic":[6,120,161],"disorder":[7,54],"of":[8,22,37,64,99,108,115,133,143,157,174,178,185,200,206],"iron":[9,23],"overload,":[10],"caused":[11],"by":[12,119],"mutations":[13],"in":[14,34,42,68,145,171],"the":[15,35,81,106,126,172,182],"HFE":[16],"gene.":[17],"If":[18],"untreated,":[19],"abnormal":[20],"accumulation":[21],"may":[24,193],"lead":[25],"to":[26],"organ":[27],"damage":[28],"and":[29,45,77,88,160,165,180,190,212],"premature":[30],"death.":[31],"Significant":[32],"changes":[33,103],"symptomatology":[36],"HHC":[38,67,116,144],"have":[39],"been":[40],"observed":[41],"recent":[43],"years,":[44],"its":[46],"full":[47],"clinical":[48,151,197],"expression":[49],"rarely":[51],"seen.":[52],"The":[53,113,141,202],"presents":[55],"large":[57],"phenotypic":[58],"heterogeneity.":[59],"We":[60],"report":[61],"case":[63],"newly":[65],"identified":[66],"56-year-old":[70],"man":[71],"presenting":[72],"as":[73],"pigmented":[74,110,216],"purpuric":[75,111,188,217],"dermatitis":[76,189,218],"alopecia":[78,191,220],"areata":[79,192,221],"affecting":[80],"beard,":[82],"accompanied":[83],"with":[84,105,122],"elevated":[85,89],"liver":[86],"enzymes":[87],"serum":[90],"ferritin":[91],"level":[92],"on":[93,150],"screening":[94],"chemistry":[95],"panels.":[96],"Histopathologic":[97],"examination":[98,156],"skin":[100,158,198],"biopsy":[101,159],"revealed":[102],"consistent":[104],"diagnosis":[107,114,142,164],"progressive":[109,215],"dermatitis.":[112],"was":[117,148],"confirmed":[118],"testing,":[121],"compound":[123],"heterozygosity":[124],"for":[125,214],"C282Y/H63D":[127],"mutation.":[128],"He":[129],"had":[130],"no":[131],"signs":[132],"cardiomyopathy,":[134],"gonadal":[135],"insufficiency,":[136],"arthropathy,":[137],"or":[138,208,219],"glucose":[139],"intolerance.":[140],"our":[146],"patient":[147],"based":[149],"findings,":[152,154],"laboratory":[153],"histopathologic":[155],"tests.":[162],"Early":[163],"therapeutic":[166],"phlebotomy":[167],"are":[168,181],"very":[169],"important":[170],"prevention":[173],"all":[175],"known":[176],"complications":[177],"HHC,":[179],"major":[183],"determinants":[184],"survival.":[186],"Pigmented":[187],"be":[194],"unusual":[195],"early":[196],"presentations":[199],"HHC.":[201],"relation":[203],"between":[204],"inheritance":[205],"one":[207],"more":[209],"genes":[211],"susceptibility":[213],"needs":[222],"further":[223],"investigation.":[224]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
