{"id":"https://openalex.org/W2148335222","doi":"https://doi.org/10.1242/dev.123.1.293","title":"Mutations affecting the cardiovascular system and other internal organs in zebrafish","display_name":"Mutations affecting the cardiovascular system and other internal organs in zebrafish","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2148335222","doi":"https://doi.org/10.1242/dev.123.1.293","mag":"2148335222","pmid":"https://pubmed.ncbi.nlm.nih.gov/9007249"},"language":"en","primary_location":{"id":"doi:10.1242/dev.123.1.293","doi":"https://doi.org/10.1242/dev.123.1.293","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.123.1.293","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050097883","display_name":"Jau\u2010Nian Chen","orcid":"https://orcid.org/0000-0001-8807-3607","observed_orcids":["https://orcid.org/0000-0001-8807-3607"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Jau-Nian Chen","raw_affiliation_strings":["Cardiovascular Research Center 2 , Massachusetts General Hospital, 149 13th Street, Charlestown, MA02129, USA and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","Max-Planck-Institut fur Entwicklungsbiologie, Tubingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center 2 , Massachusetts General Hospital, 149 13th Street, Charlestown, MA02129, USA and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Max-Planck-Institut fur Entwicklungsbiologie, Tubingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060665595","display_name":"Pascal Haffter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Pascal Haffter","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111507788","display_name":"J\u00f6rg Odenthal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J\u00f6rg Odenthal","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039463063","display_name":"Elisabeth Vogelsang","orcid":"https://orcid.org/0000-0002-6817-5953","observed_orcids":["https://orcid.org/0000-0002-6817-5953"]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Elisabeth Vogelsang","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050047419","display_name":"Michael Brand","orcid":"https://orcid.org/0000-0001-5711-6512","observed_orcids":["https://orcid.org/0000-0001-5711-6512","https://orcid.org/0000-0002-3917-0416"]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michael Brand","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068045953","display_name":"Fredericus J. M. van Eeden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Fredericus J. M. van Eeden","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009495120","display_name":"Makoto Furutani\u2010Seiki","orcid":"https://orcid.org/0000-0002-0885-4778","observed_orcids":["https://orcid.org/0000-0002-0885-4778"]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Makoto Furutani-Seiki","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021174896","display_name":"Michael Granato","orcid":"https://orcid.org/0000-0003-3878-9468","observed_orcids":["https://orcid.org/0000-0003-3878-9468"]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michael Granato","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005574733","display_name":"Matthias Hammerschmidt","orcid":"https://orcid.org/0000-0002-3709-8166","observed_orcids":["https://orcid.org/0000-0002-3709-8166"]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias Hammerschmidt","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015647802","display_name":"Carl\u2010Philipp Heisenberg","orcid":"https://orcid.org/0000-0002-0912-4566","observed_orcids":["https://orcid.org/0000-0002-0912-4566"]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Carl-Philipp Heisenberg","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010582556","display_name":"Yun\u2010Jin Jiang","orcid":"https://orcid.org/0000-0003-0499-7306","observed_orcids":["https://orcid.org/0000-0003-0499-7306"]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Yun-Jin Jiang","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085611535","display_name":"Donald A. Kane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Donald A. Kane","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044327929","display_name":"Robert Neil Kelsh","orcid":"https://orcid.org/0000-0002-9381-0066","observed_orcids":["https://orcid.org/0000-0002-9381-0066"]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Robert N. Kelsh","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072410833","display_name":"Mary C. Mullins","orcid":"https://orcid.org/0000-0002-9979-1564","observed_orcids":["https://orcid.org/0000-0002-9979-1564"]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mary C. Mullins","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072765144","display_name":"Christiane N\u00fcsslein\u2010Volhard","orcid":"https://orcid.org/0000-0002-7688-1401","observed_orcids":["https://orcid.org/0000-0002-7688-1401"]},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christiane N\u00fcsslein-Volhard","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35/III, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005574733","https://openalex.org/A5009495120","https://openalex.org/A5010582556","https://openalex.org/A5015647802","https://openalex.org/A5021174896","https://openalex.org/A5039463063","https://openalex.org/A5044327929","https://openalex.org/A5050047419","https://openalex.org/A5050097883","https://openalex.org/A5060665595","https://openalex.org/A5068045953","https://openalex.org/A5072410833","https://openalex.org/A5072765144","https://openalex.org/A5085611535","https://openalex.org/A5111507788"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210112458"],"apc_list":null,"apc_paid":null,"fwci":4.9278,"has_fulltext":false,"cited_by_count":447,"citation_normalized_percentile":{"value":0.96153846,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"123","issue":"1","first_page":"293","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebrafish-mutants","display_name":"zebrafish mutants","score":0.902999997138977},{"id":"https://openalex.org/keywords/cardiovascular-system","display_name":"cardiovascular system","score":0.6230000257492065},{"id":"https://openalex.org/keywords/heart-morphogenesis","display_name":"cardiac morphogenesis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/heart-contractility","display_name":"heart contractility","score":0.7260000109672546},{"id":"https://openalex.org/keywords/heart-rhythm","display_name":"cardiac rhythm","score":0.8019999861717224},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.39800000190734863},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.4099999964237213},{"id":"https://openalex.org/keywords/intestine","display_name":"intestine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.9990000128746033},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/developmental-genetics","display_name":"developmental genetics","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8673616647720337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8572187423706055},{"id":"https://openalex.org/C2779617070","wikidata":"https://www.wikidata.org/wiki/Q4739730","display_name":"Sinus venosus","level":2,"score":0.6166844964027405},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5714280009269714},{"id":"https://openalex.org/C2777837822","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Embryonic heart","level":4,"score":0.5512267351150513},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.5172858238220215},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41333794593811035},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4080659747123718},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3568655252456665},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35658973455429077},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3071978688240051},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.1209401786327362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08812794089317322}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/dev.123.1.293","doi":"https://doi.org/10.1242/dev.123.1.293","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.123.1.293","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:9007249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9007249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:develop:123/1/293","doi":null,"is_oa":false,"landing_page_url":"http://dev.biologists.org/cgi/content/short/123/1/293","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4542400621","display_name":"Heart Development and Genetics","funder_award_id":"R01HL049579","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W584246574","https://openalex.org/W1857560941","https://openalex.org/W1859795936","https://openalex.org/W1862773335","https://openalex.org/W1871313898","https://openalex.org/W1874287342","https://openalex.org/W1906119900","https://openalex.org/W1947859348","https://openalex.org/W1964860693","https://openalex.org/W1965509658","https://openalex.org/W1969743070","https://openalex.org/W1971156818","https://openalex.org/W1973749378","https://openalex.org/W1974908490","https://openalex.org/W1977746306","https://openalex.org/W1980110416","https://openalex.org/W1986559037","https://openalex.org/W1996430165","https://openalex.org/W2018425216","https://openalex.org/W2023176914","https://openalex.org/W2046516822","https://openalex.org/W2056794607","https://openalex.org/W2067897538","https://openalex.org/W2075346359","https://openalex.org/W2076600697","https://openalex.org/W2084065797","https://openalex.org/W2087554888","https://openalex.org/W2106000284","https://openalex.org/W2111525541","https://openalex.org/W2123938765","https://openalex.org/W2125349610","https://openalex.org/W2136238643","https://openalex.org/W2140459348","https://openalex.org/W2141279088","https://openalex.org/W2155321073","https://openalex.org/W2159562139","https://openalex.org/W2163307259","https://openalex.org/W2165936034","https://openalex.org/W2188422153","https://openalex.org/W2189058568","https://openalex.org/W2315337958"],"related_works":["https://openalex.org/W2141279088","https://openalex.org/W68690508","https://openalex.org/W2023811028","https://openalex.org/W1968398950","https://openalex.org/W2218305762","https://openalex.org/W7098685043","https://openalex.org/W7100857310","https://openalex.org/W2500735440","https://openalex.org/W1969743070","https://openalex.org/W2110905373"],"abstract_inverted_index":{"In":[0,55,73,96,209,230],"a":[1,41,119,170,270],"screen":[2,240],"for":[3,241,244],"early":[4],"developmental":[5],"mutants":[6,158],"of":[7,28,33,46,80,110,121,126,149,157,174,192,222,249,269],"the":[8,16,24,44,47,64,70,74,77,81,93,103,107,111,124,127,147,150,154,183,189,193,206,212,220,223,225,228,245,254,267],"zebrafish,":[9],"we":[10,215,233],"have":[11],"identified":[12,20,118,216],"mutations":[13,22,122,130,180,218,257],"specifically":[14,187],"affecting":[15,23,123,131,141,146,219],"internal":[17,251],"organs.":[18],"We":[19,116],"53":[21],"cardiovascular":[25],"system.":[26,208],"Nine":[27],"them":[29],"affect":[30,188],"specific":[31,203,243],"landmarks":[32],"heart":[34,49,59,83,88,112,132,142,151,163,172,213],"morphogenesis.":[35],"Mutations":[36,195],"in":[37,43,52,92,182,196,205,253],"four":[38],"genes":[39,242],"cause":[40,202],"failure":[42],"fusion":[45],"bilateral":[48],"primordia,":[50],"resulting":[51],"cardia":[53],"bifida.":[54],"lonely":[56],"atrium,":[57],"no":[58,162],"venticle":[60],"is":[61,66,85,89,113,237],"visible":[62],"and":[63,101,144,167,186,200],"atrium":[65],"directly":[67],"fused":[68],"to":[69,211,239,266],"outflow":[71],"tract.":[72],"overlooped":[75],"mutant,":[76],"relative":[78],"position":[79],"two":[82,97,108,138,197],"chambers":[84],"distorted.":[86],"The":[87,129,256],"enormously":[90],"enlarged":[91],"santa":[94],"mutant.":[95],"mutants,":[98,214],"scotch":[99],"tape":[100],"superglue,":[102],"cardiac":[104],"jelly":[105],"between":[106],"layers":[109],"significantly":[114],"reduced.":[115],"also":[117],"number":[120],"function":[125,133,248],"heart.":[128,194],"can":[134],"be":[135],"subdivided":[136],"into":[137],"groups,":[139],"one":[140,175],"contraction":[143],"another":[145],"rhythm":[148],"beat.":[152],"Among":[153],"contractility":[155],"group":[156,185],"are":[159,181],"5":[160],"with":[161,169],"beat":[164,173],"at":[165],"all":[166],"15":[168],"reduced":[171],"or":[176,227,247],"both":[177],"chambers.":[178],"6":[179],"rhythmicity":[184],"beating":[190],"pattern":[191],"genes,":[198],"bypass":[199],"kurzschluss,":[201],"defects":[204],"circulatory":[207],"addition":[210],"23":[217],"integrity":[221],"liver,":[224],"intestine":[226],"kidney.":[229],"this":[231],"report,":[232],"demonstrate":[234],"that":[235],"it":[236],"feasible":[238],"patterning":[246],"certain":[250],"organs":[252],"zebrafish.":[255],"presented":[258],"here":[259],"could":[260],"serve":[261],"as":[262],"an":[263],"entry":[264],"point":[265],"establishment":[268],"genetic":[271],"hierarchy":[272],"underlying":[273],"organogenesis.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}