{"id":"https://openalex.org/W2148328443","doi":"https://doi.org/10.4049/jimmunol.1103035","title":"Decitabine and Vorinostat Cooperate To Sensitize Colon Carcinoma Cells to Fas Ligand-Induced Apoptosis In Vitro and Tumor Suppression In Vivo","display_name":"Decitabine and Vorinostat Cooperate To Sensitize Colon Carcinoma Cells to Fas Ligand-Induced Apoptosis In Vitro and Tumor Suppression In Vivo","publication_year":2012,"publication_date":"2012-03-30","ids":{"openalex":"https://openalex.org/W2148328443","doi":"https://doi.org/10.4049/jimmunol.1103035","mag":"2148328443","pmid":"https://pubmed.ncbi.nlm.nih.gov/22461695","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3398838"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1103035","doi":"https://doi.org/10.4049/jimmunol.1103035","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1103035","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3398838","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020584166","display_name":"Dafeng Yang","orcid":"https://orcid.org/0009-0008-7774-0847","observed_orcids":["https://orcid.org/0009-0008-7774-0847","https://orcid.org/0000-0002-8320-8215"]},"institutions":[{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dafeng Yang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Georgia Health Sciences University , Augusta, GA 30912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Georgia Health Sciences University , Augusta, GA 30912","institution_ids":["https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christina M Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina M Torres","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Georgia Health Sciences University , Augusta, GA 30912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Georgia Health Sciences University , Augusta, GA 30912","institution_ids":["https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055123505","display_name":"Kankana Bardhan","orcid":"https://orcid.org/0000-0002-6995-1205","observed_orcids":["https://orcid.org/0000-0002-6995-1205"]},"institutions":[{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kankana Bardhan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Georgia Health Sciences University , Augusta, GA 30912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Georgia Health Sciences University , Augusta, GA 30912","institution_ids":["https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110218154","display_name":"Mary Ann Zimmerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary Zimmerman","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Georgia Health Sciences University , Augusta, GA 30912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Georgia Health Sciences University , Augusta, GA 30912","institution_ids":["https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080210527","display_name":"Tracy L. McGaha","orcid":"https://orcid.org/0000-0003-4721-9301","observed_orcids":["https://orcid.org/0000-0003-4721-9301"]},"institutions":[{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy L McGaha","raw_affiliation_strings":["Cancer Center, Georgia Health Sciences University , Augusta, GA 30912","Department of Medicine, Georgia Health Sciences University , Augusta, GA 30912","\u00a7Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912","\u2021Cancer Center, Georgia Health Sciences University, Augusta, GA 30912; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Georgia Health Sciences University , Augusta, GA 30912","institution_ids":["https://openalex.org/I4210087454"]},{"raw_affiliation_string":"Department of Medicine, Georgia Health Sciences University , Augusta, GA 30912","institution_ids":[]},{"raw_affiliation_string":"\u00a7Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912","institution_ids":[]},{"raw_affiliation_string":"\u2021Cancer Center, Georgia Health Sciences University, Augusta, GA 30912; and","institution_ids":["https://openalex.org/I4210087454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016580028","display_name":"Kebin Liu","orcid":"https://orcid.org/0000-0003-1965-7240","observed_orcids":["https://orcid.org/0000-0003-1965-7240"]},"institutions":[{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kebin Liu","raw_affiliation_strings":["Cancer Center, Georgia Health Sciences University , Augusta, GA 30912","Department of Biochemistry and Molecular Biology, Georgia Health Sciences University , Augusta, GA 30912","\u2021Cancer Center, Georgia Health Sciences University, Augusta, GA 30912; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Georgia Health Sciences University , Augusta, GA 30912","institution_ids":["https://openalex.org/I4210087454"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Georgia Health Sciences University , Augusta, GA 30912","institution_ids":["https://openalex.org/I4210087454"]},{"raw_affiliation_string":"\u2021Cancer Center, Georgia Health Sciences University, Augusta, GA 30912; and","institution_ids":["https://openalex.org/I4210087454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016580028","https://openalex.org/A5020584166","https://openalex.org/A5055123505","https://openalex.org/A5110218154"],"corresponding_institution_ids":["https://openalex.org/I4210087454"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.8846,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.95445463,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"188","issue":"9","first_page":"4441","last_page":"4449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":1.0},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.9210000038146973},{"id":"https://openalex.org/keywords/fas-mediated-apoptosis","display_name":"Fas-mediated apoptosis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.6850000023841858},{"id":"https://openalex.org/keywords/colorectal-cancer-metastasis","display_name":"colorectal cancer metastasis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/epigenetic-inhibitors","display_name":"epigenetic inhibitors","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bnip3","display_name":"BNIP3","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bik","display_name":"BIK","score":0.9160000085830688},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.984000027179718},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.8910112380981445},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.7489527463912964},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6842992305755615},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5414575934410095},{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.5327024459838867},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5012609958648682},{"id":"https://openalex.org/C2777847059","wikidata":"https://www.wikidata.org/wiki/Q6537255","display_name":"Lewis lung carcinoma","level":4,"score":0.46494191884994507},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44960126280784607},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4156845808029175},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37080127000808716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28619980812072754},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.21156200766563416},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.15209567546844482},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.13727256655693054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13063648343086243},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.10003963112831116},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.1103035","doi":"https://doi.org/10.4049/jimmunol.1103035","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1103035","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:22461695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22461695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2635207","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3398838","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3398838","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3398838","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2635207","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3398838","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1142816981","display_name":"Role of IRF8 in Tumor Rejection and Suppression","funder_award_id":"R01CA133085","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1518604502","https://openalex.org/W1530044612","https://openalex.org/W1530982587","https://openalex.org/W1601864483","https://openalex.org/W1603579181","https://openalex.org/W1625007357","https://openalex.org/W1637262118","https://openalex.org/W1667997885","https://openalex.org/W1906040944","https://openalex.org/W1921796284","https://openalex.org/W1942178888","https://openalex.org/W1948246720","https://openalex.org/W1965354428","https://openalex.org/W1966248219","https://openalex.org/W1970962289","https://openalex.org/W1972082238","https://openalex.org/W1975078133","https://openalex.org/W1977454730","https://openalex.org/W1988466148","https://openalex.org/W1991094196","https://openalex.org/W1994362040","https://openalex.org/W1996174406","https://openalex.org/W2002503549","https://openalex.org/W2003177433","https://openalex.org/W2018366633","https://openalex.org/W2023983787","https://openalex.org/W2026421375","https://openalex.org/W2028512857","https://openalex.org/W2050671044","https://openalex.org/W2053010671","https://openalex.org/W2056924500","https://openalex.org/W2057731803","https://openalex.org/W2065413461","https://openalex.org/W2067534266","https://openalex.org/W2074377913","https://openalex.org/W2084495964","https://openalex.org/W2084654470","https://openalex.org/W2093154215","https://openalex.org/W2093608608","https://openalex.org/W2094201721","https://openalex.org/W2096964576","https://openalex.org/W2103638548","https://openalex.org/W2106196422","https://openalex.org/W2106584820","https://openalex.org/W2107111117","https://openalex.org/W2110252464","https://openalex.org/W2111181668","https://openalex.org/W2112920527","https://openalex.org/W2113026440","https://openalex.org/W2114870968","https://openalex.org/W2117409731","https://openalex.org/W2126189518","https://openalex.org/W2130029734","https://openalex.org/W2130466966","https://openalex.org/W2134013248","https://openalex.org/W2134398620","https://openalex.org/W2136293604","https://openalex.org/W2136798443","https://openalex.org/W2142296404","https://openalex.org/W2142300779","https://openalex.org/W2142979257","https://openalex.org/W2146770470","https://openalex.org/W2148200419","https://openalex.org/W2149860981","https://openalex.org/W2157269800","https://openalex.org/W2159719957","https://openalex.org/W2167787789","https://openalex.org/W2167864358","https://openalex.org/W2400765893"],"related_works":["https://openalex.org/W2080497990","https://openalex.org/W2107749541","https://openalex.org/W3011991621","https://openalex.org/W2315451884","https://openalex.org/W2130054085","https://openalex.org/W2013438353","https://openalex.org/W2901476790","https://openalex.org/W2165796624","https://openalex.org/W1974643691","https://openalex.org/W2045012339"],"abstract_inverted_index":{"The":[0],"death":[1],"receptor":[2],"Fas":[3,34,51,77],"and":[4,61,72,89,103,130,155,157,179,193,227],"its":[5],"physiological":[6],"ligand":[7],"(FasL)":[8],"regulate":[9],"apoptosis":[10,190,226],"of":[11,20,44,54,99,109,139,148,199,217,237],"cancerous":[12],"cells,":[13],"thereby":[14],"functioning":[15],"as":[16],"a":[17,42,145,172],"critical":[18,55,173],"component":[19],"the":[21,110,197,221,235],"host":[22],"cancer":[23,30,59,239],"immunosurveillance":[24],"system.":[25],"To":[26],"evade":[27],"Fas-mediated":[28,225],"apoptosis,":[29],"cells":[31,115,152],"often":[32],"downregulate":[33],"to":[35,75,116,133,219,224],"acquire":[36],"an":[37,120,205,231],"apoptosis-resistant":[38],"phenotype,":[39],"which":[40],"is":[41,53,230],"hallmark":[43],"metastatic":[45,80,111],"human":[46,81,112],"colorectal":[47],"cancer.":[48],"Therefore,":[49],"targeting":[50],"resistance":[52],"importance":[56],"in":[57,79,106,164,177,183,189,204],"Fas-based":[58],"therapy":[60],"immunotherapy.":[62],"In":[63],"this":[64],"study,":[65],"we":[66,125],"demonstrated":[67,127],"that":[68,128,144,214],"epigenetic":[69],"inhibitors":[70],"decitabine":[71,129,156,178,192],"vorinostat":[73,93,131,194],"cooperate":[74,132],"upregulate":[76],"expression":[78,98],"colon":[82,113,135,238],"carcinoma":[83,114,136],"cells.":[84],"Decitabine":[85],"also":[86],"upregulates":[87],"BNIP3":[88],"Bik":[90],"expression,":[91],"whereas":[92],"decreased":[94,163],"Bcl-x(L)":[95,104],"expression.":[96],"Altered":[97],"Fas,":[100],"BNIP3,":[101],"Bik,":[102],"resulted":[105],"effective":[107,232],"sensitization":[108],"FasL-induced":[117],"apoptosis.":[118],"Using":[119],"experimental":[121,206],"metastasis":[122,207],"mouse":[123,208],"model,":[124],"further":[126],"suppress":[134],"metastasis.":[137,240],"Analysis":[138],"tumor-bearing":[140],"lung":[141],"tissues":[142],"revealed":[143],"large":[146],"portion":[147],"tumor-infiltrating":[149],"CD8(+)":[150],"T":[151],"are":[153],"FasL(+),":[154],"vorinostat-mediated":[158,180],"tumor-suppression":[159],"efficacy":[160,198],"was":[161],"significantly":[162,195],"Fas(gld)":[165],"mice":[166],"compared":[167],"with":[168,186],"wild-type":[169],"mice,":[170],"suggesting":[171],"role":[174],"for":[175,234],"FasL":[176],"tumor":[181,222],"suppression":[182,236],"vivo.":[184],"Consistent":[185],"their":[187],"function":[188],"sensitization,":[191],"increased":[196],"CTL":[200,228],"adoptive":[201],"transfer":[202],"immunotherapy":[203,229],"model.":[209],"Thus,":[210],"our":[211],"data":[212],"suggest":[213],"combined":[215],"modalities":[216],"chemotherapy":[218],"sensitize":[220],"cell":[223],"approach":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
