{"id":"https://openalex.org/W2148261763","doi":"https://doi.org/10.1016/j.jalz.2014.05.1129","title":"P3\u2010042: USING FAMILIAL ALZHEIMER'S DISEASE AND ISOGENIC CONTROL IPSC\u2010DERIVED BASAL FOREBRAIN NEURONS TO MODEL AD","display_name":"P3\u2010042: USING FAMILIAL ALZHEIMER'S DISEASE AND ISOGENIC CONTROL IPSC\u2010DERIVED BASAL FOREBRAIN NEURONS TO MODEL AD","publication_year":2014,"publication_date":"2014-07-01","ids":{"openalex":"https://openalex.org/W2148261763","doi":"https://doi.org/10.1016/j.jalz.2014.05.1129","mag":"2148261763"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2014.05.1129","doi":"https://doi.org/10.1016/j.jalz.2014.05.1129","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2014.05.1129","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024780477","display_name":"Andrew A. Sproul","orcid":"https://orcid.org/0000-0001-6972-1592","observed_orcids":["https://orcid.org/0000-0001-6972-1592"]},"institutions":[{"id":"https://openalex.org/I2801610018","display_name":"New York Stem Cell Foundation","ror":"https://ror.org/03n2a3p06","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2801610018"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew Sproul","raw_affiliation_strings":["The New York Stem Cell Foundation Research Institute, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The New York Stem Cell Foundation Research Institute, New York, New York, United States","institution_ids":["https://openalex.org/I2801610018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108641867","display_name":"Samson Jacob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801610018","display_name":"New York Stem Cell Foundation","ror":"https://ror.org/03n2a3p06","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2801610018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samson Jacob","raw_affiliation_strings":["The New York Stem Cell Foundation Research Institute, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The New York Stem Cell Foundation Research Institute, New York, New York, United States","institution_ids":["https://openalex.org/I2801610018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002488831","display_name":"Dominik Paquet","orcid":"https://orcid.org/0000-0003-2065-1639","observed_orcids":["https://orcid.org/0000-0003-2065-1639"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominik Paquet","raw_affiliation_strings":["The Rockefeller University, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, New York, New York, United States","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005674537","display_name":"Maitane Ortiz\u2010Virumbrales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maitane Ortiz\u2010Virumbrales","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, New York, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002543165","display_name":"Brian A. Campos","orcid":"https://orcid.org/0009-0004-1999-9173","observed_orcids":["https://orcid.org/0009-0004-1999-9173"]},"institutions":[{"id":"https://openalex.org/I2801610018","display_name":"New York Stem Cell Foundation","ror":"https://ror.org/03n2a3p06","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2801610018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Campos","raw_affiliation_strings":["The New York Stem Cell Foundation Research Institute, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The New York Stem Cell Foundation Research Institute, New York, New York, United States","institution_ids":["https://openalex.org/I2801610018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103144641","display_name":"Sam Gandy","orcid":"https://orcid.org/0000-0001-6455-4721","observed_orcids":["https://orcid.org/0000-0001-6455-4721"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sam Gandy","raw_affiliation_strings":["Mount Sinai, New York City, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai, New York City, New York, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055429344","display_name":"Marc Tessier\u2010Lavigne","orcid":"https://orcid.org/0000-0003-4403-1514","observed_orcids":["https://orcid.org/0000-0003-4403-1514"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Tessier\u2010Lavigne","raw_affiliation_strings":["The Rockefeller University, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, New York, New York, United States","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085004189","display_name":"Scott Noggle","orcid":"https://orcid.org/0000-0002-0374-2240","observed_orcids":["https://orcid.org/0000-0002-0374-2240"]},"institutions":[{"id":"https://openalex.org/I2801610018","display_name":"New York Stem Cell Foundation","ror":"https://ror.org/03n2a3p06","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2801610018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Noggle","raw_affiliation_strings":["The New York Stem Cell Foundation Research Institute, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The New York Stem Cell Foundation Research Institute, New York, New York, United States","institution_ids":["https://openalex.org/I2801610018"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024780477"],"corresponding_institution_ids":["https://openalex.org/I2801610018"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.4152,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66693676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"4S_Part_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.09239999949932098,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.9670000076293945},{"id":"https://openalex.org/keywords/basal-forebrain-cholinergic-neurons","display_name":"basal forebrain cholinergic neurons","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7675392627716064},{"id":"https://openalex.org/C2776287375","wikidata":"https://www.wikidata.org/wiki/Q3407681","display_name":"Basal forebrain","level":3,"score":0.6194510459899902},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5993990302085876},{"id":"https://openalex.org/C2776485563","wikidata":"https://www.wikidata.org/wiki/Q18253272","display_name":"PSEN1","level":5,"score":0.5469657182693481},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4731674790382385},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4415876567363739},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.4275820553302765},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.35600709915161133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3138663172721863},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.18746337294578552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18206876516342163},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.17782384157180786},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16219568252563477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14040300250053406},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13348129391670227}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2014.05.1129","doi":"https://doi.org/10.1016/j.jalz.2014.05.1129","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2014.05.1129","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2535653762","https://openalex.org/W4252272838","https://openalex.org/W2122157093","https://openalex.org/W3112399819","https://openalex.org/W7096896905","https://openalex.org/W2073252618","https://openalex.org/W2159422594","https://openalex.org/W2157073241","https://openalex.org/W7038742050","https://openalex.org/W2980834043"],"abstract_inverted_index":{"The":[0],"lack":[1],"of":[2,12,17,103,138,171,224,236,253,261,269,291,301,305,323,329],"effective":[3],"treatments":[4],"for":[5,28,142,199,248,271,312],"Alzheimer's":[6,42],"disease":[7,22,43],"(AD)":[8],"underscores":[9],"the":[10,101,148,164,222,267,317,324,336],"importance":[11],"developing":[13,69,286],"better":[14,26],"human-specific":[15],"models":[16],"AD":[18,307],"to":[19,57,162,229,263,280],"further":[20,315],"understand":[21],"mechanism":[23],"and":[24,76,147,203,211,275,314],"provide":[25],"platforms":[27],"therapeutic":[29],"screening.":[30],"We":[31,206,219,255,284],"recently":[32],"published":[33],"a":[34,40,104,156,169,186,197,216,231,244,302],"study":[35,126],"in":[36,73,100,123,129,153,209],"which":[37,74,180,239,309],"we":[38,67,95],"created":[39],"familial":[41],"(FAD)":[44],"induced":[45],"pluripotent":[46],"stem":[47],"cell":[48,108],"(iPSC)":[49],"model":[50,290],"analyzing":[51],"neural":[52,176],"progenitors":[53],"(NPCs).":[54],"In":[55,93],"order":[56],"reduce":[58],"inherent":[59],"variability":[60],"between":[61],"iPSCs":[62],"derived":[63],"from":[64],"different":[65],"patients,":[66],"are":[68,96,256,285],"an":[70,85,130,173,281,287],"allelic":[71],"series,":[72],"heterozygous":[75,210],"homozygous":[77,212],"presenilin-1":[78],"(PSEN1)":[79],"mutations":[80,214],"can":[81,181,192],"be":[82,183,193,333],"introduced":[83],"into":[84,196,215],"unaffected":[86],"control":[87,119,217],"line":[88,121],"via":[89],"TALEN-mediated":[90],"gene":[91],"editing.":[92],"addition,":[94],"studying":[97],"FAD":[98,289,330],"phenotypes":[99],"context":[102],"more":[105,319],"specific":[106],"disease-relevant":[107],"type,":[109],"namely":[110],"basal":[111],"forebrain":[112,246],"cholinergic":[113],"neurons":[114],"(BFCNs).":[115],"A":[116],"FAD4":[117],"family":[118],"fibroblast":[120],"used":[122,152,161],"our":[124,277],"previous":[125],"was":[127,151],"reprogrammed":[128],"integration-free":[131],"manner.":[132],"TALEN":[133],"constructs":[134],"targeting":[135],"exon":[136],"5":[137],"PSEN1":[139],"were":[140,160],"screened":[141],"target":[143],"site":[144],"cutting":[145],"efficacy,":[146],"best":[149],"pair":[150],"combination":[154],"with":[155],"DNA":[157],"oligo":[158],"donor":[159],"introduce":[163],"M146L":[165],"mutation.We":[166],"have":[167,220],"developed":[168],"method":[170],"isolating":[172],"iPSC-derived":[174],"BFCN":[175,225,265,292,296],"progenitor":[177],"by":[178],"FACS,":[179],"then":[182],"propagated":[184,240],"as":[185,241],"neuronal":[187],"embryoid":[188],"body":[189],"(NEB).":[190],"NEBs":[191,242],"subsequently":[194],"dissociated":[195],"monolayer":[198],"subsequent":[200],"terminal":[201,273],"differentiation":[202,227,278,297],"phenotypic":[204,327],"analysis.":[205],"successfully":[207],"knocked":[208],"M46L":[213],"background.":[218],"improved":[221],"efficacy":[223],"directed":[226],"protocol":[228,279],"allow":[230,299],"greater":[232],">":[233],"90%":[234],"yield":[235],"Nkx2.1+":[237],"NPCs,":[238],"maintain":[243],"ventral":[245],"identity":[247],"at":[249,335],"least":[250],"100":[251],"days":[252],"culture.":[254],"currently":[257],"testing":[258],"forced":[259],"overexpression":[260],"Lhx8":[262],"improve":[264],"patterning,":[266],"role":[268],"NGF":[270],"improving":[272],"differentiation,":[274],"translating":[276],"automated":[282,295],"platform.":[283],"isogenic":[288],"neurons.":[293],"Furthermore,":[294],"will":[298,332],"investigation":[300],"large":[303],"cohort":[304],"late-onset":[306],"iPSCs,":[308],"is":[310],"critical":[311],"understanding":[313],"dissecting":[316],"far":[318],"common":[320],"sporadic":[321],"forms":[322],"disease.":[325],"Recent":[326],"analysis":[328],"BFCNs":[331],"presented":[334],"meeting.":[337]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
