{"id":"https://openalex.org/W2148259422","doi":"https://doi.org/10.1016/s0025-7125(05)70486-7","title":"LIVER-DIRECTED GENE THERAPY","display_name":"LIVER-DIRECTED GENE THERAPY","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W2148259422","doi":"https://doi.org/10.1016/s0025-7125(05)70486-7","mag":"2148259422","pmid":"https://pubmed.ncbi.nlm.nih.gov/8804381"},"language":"en","primary_location":{"id":"doi:10.1016/s0025-7125(05)70486-7","doi":"https://doi.org/10.1016/s0025-7125(05)70486-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0025-7125(05)70486-7","pdf_url":null,"source":{"id":"https://openalex.org/S33396077","display_name":"Medical Clinics of North America","issn_l":"0025-7125","issn":["0025-7125","1557-9859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Clinics of North America","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110200646","display_name":"Frederick A. Nunes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick A. Nunes","raw_affiliation_strings":["Division of Gastroenterology, University of Pennslyvania School of Medicine, Philadelphia 19104, USA","Division of Gastroenterology (FAN), the Department of Surgery (SER), and the Institute for Human Gene Therapy (FAN, SER), University of Pennslyvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Pennslyvania School of Medicine, Philadelphia 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Gastroenterology (FAN), the Department of Surgery (SER), and the Institute for Human Gene Therapy (FAN, SER), University of Pennslyvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108437486","display_name":"Steven E. Raper","orcid":"https://orcid.org/0000-0001-9191-4681","observed_orcids":["https://orcid.org/0000-0001-9191-4681"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E. Raper","raw_affiliation_strings":["Division of Gastroenterology (FAN), the Department of Surgery (SER), and the Institute for Human Gene Therapy (FAN, SER), University of Pennslyvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology (FAN), the Department of Surgery (SER), and the Institute for Human Gene Therapy (FAN, SER), University of Pennslyvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":null,"fwci":0.182,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.19946092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"80","issue":"5","first_page":"1201","last_page":"1213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-directed-gene-therapy","display_name":"liver-directed gene therapy","score":0.953000009059906},{"id":"https://openalex.org/keywords/somatic-gene-therapy","display_name":"somatic gene therapy","score":0.8730000257492065},{"id":"https://openalex.org/keywords/germline-gene-therapy","display_name":"germline gene therapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.843999981880188},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.824999988079071},{"id":"https://openalex.org/keywords/inherited-liver-disease","display_name":"inherited liver disease","score":0.8090000152587891},{"id":"https://openalex.org/keywords/gene-delivery-vectors","display_name":"gene delivery vectors","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8954194784164429},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5690756440162659},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4883877635002136},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3950190842151642},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3639003038406372},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3527269959449768},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.056428879499435425}],"mesh":[{"descriptor_ui":"D004992","descriptor_name":"Ethics, Medical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0025-7125(05)70486-7","doi":"https://doi.org/10.1016/s0025-7125(05)70486-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0025-7125(05)70486-7","pdf_url":null,"source":{"id":"https://openalex.org/S33396077","display_name":"Medical Clinics of North America","issn_l":"0025-7125","issn":["0025-7125","1557-9859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Clinics of North America","raw_type":"journal-article"},{"id":"pmid:8804381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8804381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Medical clinics of North America","raw_type":"Journal Article"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/529646","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10822/529646","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"167615","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6250006964","display_name":null,"funder_award_id":"47757","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W25236442","https://openalex.org/W43014397","https://openalex.org/W46095723","https://openalex.org/W140890592","https://openalex.org/W260828612","https://openalex.org/W437178797","https://openalex.org/W856065083","https://openalex.org/W1483242733","https://openalex.org/W1552687651","https://openalex.org/W1554330891","https://openalex.org/W1580329779","https://openalex.org/W1756236371","https://openalex.org/W1929630117","https://openalex.org/W1963846182","https://openalex.org/W1969941346","https://openalex.org/W1971290197","https://openalex.org/W1980311482","https://openalex.org/W1987137825","https://openalex.org/W1988537267","https://openalex.org/W1988723846","https://openalex.org/W1994294116","https://openalex.org/W1994361021","https://openalex.org/W1995612506","https://openalex.org/W1997482819","https://openalex.org/W1998290936","https://openalex.org/W1999369189","https://openalex.org/W2002517161","https://openalex.org/W2005920135","https://openalex.org/W2009303445","https://openalex.org/W2013359336","https://openalex.org/W2016138321","https://openalex.org/W2016200465","https://openalex.org/W2017593380","https://openalex.org/W2019612944","https://openalex.org/W2021971921","https://openalex.org/W2038807691","https://openalex.org/W2051742401","https://openalex.org/W2060228717","https://openalex.org/W2062723580","https://openalex.org/W2064169768","https://openalex.org/W2065875349","https://openalex.org/W2067985097","https://openalex.org/W2068691401","https://openalex.org/W2078321284","https://openalex.org/W2084210336","https://openalex.org/W2084744450","https://openalex.org/W2086584640","https://openalex.org/W2086932144","https://openalex.org/W2090864647","https://openalex.org/W2096808350","https://openalex.org/W2097072158","https://openalex.org/W2104475038","https://openalex.org/W2110393059","https://openalex.org/W2121397816","https://openalex.org/W2129399211","https://openalex.org/W2137693314","https://openalex.org/W2151902657","https://openalex.org/W2157646788","https://openalex.org/W2158744232","https://openalex.org/W2161340273","https://openalex.org/W2163835478","https://openalex.org/W2166797660","https://openalex.org/W2321689187","https://openalex.org/W2334694763","https://openalex.org/W2397901283","https://openalex.org/W2401598797","https://openalex.org/W2402754630","https://openalex.org/W2443845705","https://openalex.org/W2468263231","https://openalex.org/W2479751307","https://openalex.org/W2890241270","https://openalex.org/W3024578665","https://openalex.org/W4246230315","https://openalex.org/W6605726218","https://openalex.org/W6607828777","https://openalex.org/W6713511045"],"related_works":["https://openalex.org/W1911841216","https://openalex.org/W2081818479","https://openalex.org/W2038871996","https://openalex.org/W2415294928","https://openalex.org/W2123914968","https://openalex.org/W1999635867","https://openalex.org/W2401688406","https://openalex.org/W2046083532","https://openalex.org/W884438342","https://openalex.org/W2073517257"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}