{"id":"https://openalex.org/W2148244672","doi":"https://doi.org/10.1093/ndt/gfh233","title":"Does dose matter?","display_name":"Does dose matter?","publication_year":2004,"publication_date":"2004-05-18","ids":{"openalex":"https://openalex.org/W2148244672","doi":"https://doi.org/10.1093/ndt/gfh233","mag":"2148244672","pmid":"https://pubmed.ncbi.nlm.nih.gov/15150368"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfh233","doi":"https://doi.org/10.1093/ndt/gfh233","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfh233","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053104305","display_name":"Y. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086984","display_name":"Medical Technology and Practice Patterns Institute","ror":"https://ror.org/001hsnn10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210086984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Zhang","raw_affiliation_strings":["Medical Technology and Practice Patterns Institute, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Technology and Practice Patterns Institute, MD, USA","institution_ids":["https://openalex.org/I4210086984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059642911","display_name":"Mae Thamer","orcid":"https://orcid.org/0000-0002-7559-7193","observed_orcids":["https://orcid.org/0000-0002-7559-7193"]},"institutions":[{"id":"https://openalex.org/I4210086984","display_name":"Medical Technology and Practice Patterns Institute","ror":"https://ror.org/001hsnn10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210086984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Thamer","raw_affiliation_strings":["Medical Technology and Practice Patterns Institute, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Technology and Practice Patterns Institute, MD, USA","institution_ids":["https://openalex.org/I4210086984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058848944","display_name":"Kevin Stefanik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086984","display_name":"Medical Technology and Practice Patterns Institute","ror":"https://ror.org/001hsnn10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210086984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Stefanik","raw_affiliation_strings":["Medical Technology and Practice Patterns Institute, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Technology and Practice Patterns Institute, MD, USA","institution_ids":["https://openalex.org/I4210086984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103398558","display_name":"Dennis J. Cotter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086984","display_name":"Medical Technology and Practice Patterns Institute","ror":"https://ror.org/001hsnn10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210086984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. J. Cotter","raw_affiliation_strings":["Medical Technology and Practice Patterns Institute, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Technology and Practice Patterns Institute, MD, USA","institution_ids":["https://openalex.org/I4210086984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210086984"],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"6","first_page":"1658","last_page":"1658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin-levels","display_name":"hemoglobin levels","score":0.7400000095367432},{"id":"https://openalex.org/keywords/epoetin","display_name":"epoetin","score":0.8050000071525574},{"id":"https://openalex.org/keywords/surrogate-endpoints","display_name":"surrogate endpoints","score":0.7080000042915344},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.6420000195503235},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.734000027179718},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dialysis-outcomes-and-practice-patterns-study","display_name":"DOPPS","score":0.7300000190734863},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7680000066757202},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9539999961853027},{"id":"https://openalex.org/keywords/clinical-trial-interpretation","display_name":"clinical trial interpretation","score":0.4490000009536743},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9478048086166382}],"mesh":[{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006397","descriptor_name":"Hematinics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ndt/gfh233","doi":"https://doi.org/10.1093/ndt/gfh233","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfh233","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmid:15150368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15150368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1967972391","https://openalex.org/W1973949442","https://openalex.org/W2018780022","https://openalex.org/W2080675410","https://openalex.org/W2107215009","https://openalex.org/W2109081740","https://openalex.org/W2130864435","https://openalex.org/W2155949904","https://openalex.org/W2332849411","https://openalex.org/W2520163263","https://openalex.org/W2614168425"],"related_works":["https://openalex.org/W2109081740","https://openalex.org/W4235542644","https://openalex.org/W2109593849","https://openalex.org/W2037384126","https://openalex.org/W1993774557","https://openalex.org/W2143080059","https://openalex.org/W2241311495","https://openalex.org/W2088064793","https://openalex.org/W2103350412","https://openalex.org/W1976510563"],"abstract_inverted_index":{"Sir,":[0],"We":[1,71],"read":[2],"the":[3,13,33,99,162,169,176,182,188,192,195,202,247,257,273,311,318,323,336,340,354,375,419,452,460,470],"recently":[4],"published":[5],"paper":[6],"by":[7,122,244],"Locatelli":[8,388],"et":[9,389],"al.":[10,390],"[1]":[11],"on":[12,194,287,465],"Dialysis":[14],"Outcomes":[15],"and":[16,41,45,62,97,104,137,180,234,284,308,360,381,407,411,431,440,467,494,519,524],"Practice":[17,495],"Patterns":[18,496],"Study":[19],"(DOPPS)":[20],"with":[21,59,69,126,175,217,228],"great":[22],"interest.":[23],"The":[24,130,147,446,491],"researchers":[25],"used":[26,295],"a":[27,85,115,144,241],"Cox":[28],"regression":[29],"analysis":[30,305],"to":[31,74,201,209,266,282,317,331,365,372,404,507,512,539],"evaluate":[32],"relationships":[34],"between":[35,102,358,377],"haemoglobin":[36,55,78,124,224,237,341,379,406],"concentration":[37,79],"at":[38],"study":[39,415,472],"entry":[40],"rates":[42],"of":[43,114,132,155,161,191,213,260,275,313,325,353,374,400,459,462,488,522],"mortality":[44,63,89,107,233,307,412,448],"hospitalization":[46,410,441],"across":[47,320],"five":[48],"European":[49,65],"countries.":[50],"They":[51],"concluded":[52],"that":[53,77,118,159,222,263,339,394,422,436],"lower":[54],"concentrations":[56,225,380],"were":[57,215,226,280],"associated":[58,227],"higher":[60,223],"morbidity":[61,91,105,382,466],"among":[64,442,451],"haemodialysis":[66,454],"patients":[67,444],"treated":[68],"epoetin.":[70],"would":[72,478],"like":[73],"point":[75],"out":[76],"has":[80,396,529],"not":[81,109,245,294,530],"been":[82],"validated":[83],"as":[84,112,240,296],"surrogate":[86,133,170,183,242],"endpoint":[87,171,184,243],"for":[88,232,367,413,457,474,536],"or":[90,95,106,143,299,383,533],"in":[92,256,302,322,425,484],"either":[93],"CKD":[94],"ESRD,":[96],"therefore":[98],"observed":[100,378],"association":[101],"anaemia":[103],"should":[108],"be":[110,120,166,173,315],"accepted":[111,150],"evidence":[113],"clinical":[116,178,196,269,514],"benefit":[117],"can":[119],"achieved":[121],"increasing":[123],"levels":[125],"epoetin":[127,288,314,350,359,368,395,463,475],"treatment":[128,193,464],"[2].":[129],"validation":[131,151],"endpoints":[134,270],"is":[135,206,499,506],"complex":[136],"usually":[138,207],"entails":[139],"conducting":[140],"interventional":[141],"trials":[142],"meta-analysis":[145],"[3,4].":[146],"most":[148],"widely":[149],"criteria":[152],"are":[153,253],"those":[154],"Prentice,":[156],"who":[157],"stipulates":[158],"both":[160],"following":[163],"conditions":[164],"must":[165,172,185],"satisfied:":[167],"(i)":[168],"correlated":[174],"true":[177],"outcome;":[179],"(ii)":[181],"fully":[186,343],"capture":[187],"net":[189],"effect":[190],"outcome":[197],"[5].":[198],"With":[199],"regard":[200],"first":[203],"criterion,":[204],"which":[205],"easy":[208],"verify":[210],"[3],":[211],"results":[212],"DOPPS":[214,471],"consistent":[216],"previous":[218],"studies":[219],"[6,7]":[220],"confirming":[221],"decreased":[229],"relative":[230],"risk":[231],"hospitalization.":[235,309],"However,":[236],"may":[238,428,437],"fail":[239],"satisfying":[246],"second,":[248],"more":[249],"stringent":[250],"criterion.":[251],"There":[252],"numerous":[254],"examples":[255],"medical":[258,526],"literature":[259],"putative":[261],"surrogates":[262],"have":[264,391,479],"failed":[265],"adequately":[267],"predict":[268],"[8\u201310].":[271],"In":[272,362,385],"case":[274],"DOPPS,":[276],"although":[277],"considerable":[278],"resources":[279],"devoted":[281],"collecting":[283],"analysing":[285],"data":[286],"dosing,":[289],"this":[290,485,540],"information":[291,342,347],"was":[292],"inexplicably":[293],"an":[297,481,500],"explanatory":[298],"confounding":[300],"variable":[301],"their":[303],"multivariate":[304],"predicting":[306],"Could":[310],"exclusion":[312],"due":[316],"variability":[319],"countries":[321],"route":[324],"administration,":[326],"thereby":[327],"making":[328],"it":[329,477],"difficult":[330],"compare":[332],"dosing?":[333],"Or,":[334],"did":[335],"authors":[337],"assume":[338],"captures":[344],"any":[345],"additional":[346],"obtained":[348],"from":[349],"dosing":[351],"because":[352],"well":[355],"established":[356],"relationship":[357],"haemoglobin?":[361],"summary,":[363],"failure":[364],"control":[366],"dose":[369],"will":[370],"lead":[371],"misinterpretation":[373],"correlation":[376],"mortality.":[384,468],"doing":[386],"so,":[387],"implicitly":[392],"assumed":[393],"no":[397],"other":[398,402,433],"mechanisms":[399],"action":[401],"than":[403],"increase":[405],"thus":[408],"decrease":[409],"all":[414],"participants.":[416],"This":[417],"ignores":[418],"important":[420,482],"concern":[421],"epoetin,":[423],"particularly":[424,450],"large":[426],"doses,":[427],"exacerbate":[429],"hypertension":[430],"cause":[432],"cardiovascular":[434],"complications":[435],"affect":[438],"survival":[439],"ESRD":[443],"[11,12].":[445],"high":[447],"rates,":[449],"US":[453],"patients,":[455],"call":[456],"clarification":[458],"role":[461],"Had":[469],"controlled":[473],"dose,":[476],"made":[480],"contribution":[483],"regard.":[486],"Conflict":[487],"interest":[489],"statement.":[490],"Medical":[492],"Technology":[493],"Institute":[497],"(MTPPI)":[498],"independent":[501],"non-profit":[502],"institute":[503],"whose":[504],"mission":[505],"provide":[508],"research":[509],"services":[510],"related":[511,538],"safety,":[513],"effectiveness,":[515],"patient":[516],"outcomes,":[517],"cost":[518,520],"effectiveness":[521],"new":[523],"emerging":[525],"technologies.":[527],"MTPPI":[528],"received":[531],"public":[532],"private":[534],"funding":[535],"work":[537],"topic.":[541]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
