{"id":"https://openalex.org/W2148213360","doi":"https://doi.org/10.1111/j.1524-4741.2004.101s3.x","title":"Efficacy of Risk-Reducing Salpingo-Oophorectomy in Women with BRCA-1 and BRCA-2 Mutations","display_name":"Efficacy of Risk-Reducing Salpingo-Oophorectomy in Women with BRCA-1 and BRCA-2 Mutations","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2148213360","doi":"https://doi.org/10.1111/j.1524-4741.2004.101s3.x","mag":"2148213360","pmid":"https://pubmed.ncbi.nlm.nih.gov/14984481"},"language":"en","primary_location":{"id":"doi:10.1111/j.1524-4741.2004.101s3.x","doi":"https://doi.org/10.1111/j.1524-4741.2004.101s3.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1524-4741.2004.101s3.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1524-4741.2004.101S3.x","source":{"id":"https://openalex.org/S169520197","display_name":"The Breast Journal","issn_l":"1075-122X","issn":["1075-122X","1524-4741"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Breast Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1524-4741.2004.101S3.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057209864","display_name":"Olufunmilayo Ibironke Olopade","orcid":"https://orcid.org/0000-0002-9936-1599","observed_orcids":["https://orcid.org/0000-0002-9936-1599"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Olufunmilayo I. Olopade","raw_affiliation_strings":["Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA","Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA","institution_ids":["https://openalex.org/I4210087865"]},{"raw_affiliation_string":"Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011959585","display_name":"Grazia Artioli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grazia Artioli","raw_affiliation_strings":["Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210087865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057209864"],"corresponding_institution_ids":["https://openalex.org/I4210087865"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":null,"fwci":0.8716,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.63576159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"s1","first_page":"S5","last_page":"S9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prophylactic-salpingo-oophorectomy","display_name":"prophylactic salpingo-oophorectomy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hereditary-breast-and-ovarian-cancer-syndrome","display_name":"hereditary breast and ovarian cancer","score":0.8650000095367432},{"id":"https://openalex.org/keywords/ovarian-cancer-risk-reduction","display_name":"ovarian cancer risk reduction","score":0.7310000061988831},{"id":"https://openalex.org/keywords/breast-cancer-risk-reduction","display_name":"breast cancer risk reduction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/intensive-surveillance","display_name":"intensive surveillance","score":0.7260000109672546},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9250591993331909},{"id":"https://openalex.org/C2780194787","wikidata":"https://www.wikidata.org/wiki/Q4836333","display_name":"BRCA mutation","level":4,"score":0.7615729570388794},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7167528867721558},{"id":"https://openalex.org/C2910584544","wikidata":"https://www.wikidata.org/wiki/Q65042430","display_name":"Prophylactic Surgery","level":4,"score":0.6302143335342407},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6238413453102112},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.5849311947822571},{"id":"https://openalex.org/C2777696064","wikidata":"https://www.wikidata.org/wiki/Q1751597","display_name":"Oophorectomy","level":3,"score":0.5744085311889648},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5700029730796814},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5059384703636169},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4732523560523987},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43072205781936646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4110090732574463},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.3849629759788513},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23188742995262146},{"id":"https://openalex.org/C2779494336","wikidata":"https://www.wikidata.org/wiki/Q550675","display_name":"Hysterectomy","level":2,"score":0.1630939245223999}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012489","descriptor_name":"Salpingostomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019398","descriptor_name":"Genes, BRCA1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024522","descriptor_name":"Genes, BRCA2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1524-4741.2004.101s3.x","doi":"https://doi.org/10.1111/j.1524-4741.2004.101s3.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1524-4741.2004.101s3.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1524-4741.2004.101S3.x","source":{"id":"https://openalex.org/S169520197","display_name":"The Breast Journal","issn_l":"1075-122X","issn":["1075-122X","1524-4741"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Breast Journal","raw_type":"journal-article"},{"id":"pmid:14984481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14984481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The breast journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1524-4741.2004.101s3.x","doi":"https://doi.org/10.1111/j.1524-4741.2004.101s3.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1524-4741.2004.101s3.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1524-4741.2004.101S3.x","source":{"id":"https://openalex.org/S169520197","display_name":"The Breast Journal","issn_l":"1075-122X","issn":["1075-122X","1524-4741"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Breast Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5299999713897705}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310642","display_name":"Dr. Ralph and Marian Falk Medical Research Trust","ror":"https://ror.org/01ctnwa22"},{"id":"https://openalex.org/F4320338280","display_name":"Medical Research and Materiel Command","ror":"https://ror.org/03cd02q50"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148213360.pdf","grobid_xml":"https://content.openalex.org/works/W2148213360.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1776948253","https://openalex.org/W1967289771","https://openalex.org/W1969447467","https://openalex.org/W1973690102","https://openalex.org/W1983247267","https://openalex.org/W2008293816","https://openalex.org/W2024652909","https://openalex.org/W2025460005","https://openalex.org/W2028682388","https://openalex.org/W2038793520","https://openalex.org/W2045733577","https://openalex.org/W2045776246","https://openalex.org/W2069457741","https://openalex.org/W2101699473","https://openalex.org/W2103970959","https://openalex.org/W2113098178","https://openalex.org/W2134389439","https://openalex.org/W2141647078","https://openalex.org/W2144624092","https://openalex.org/W2169555960","https://openalex.org/W2181500988","https://openalex.org/W2266375201","https://openalex.org/W2328105863","https://openalex.org/W2338185498","https://openalex.org/W2402807031","https://openalex.org/W4213260525","https://openalex.org/W4236095073","https://openalex.org/W4243119702","https://openalex.org/W4293570160"],"related_works":["https://openalex.org/W2087331960","https://openalex.org/W2045733577","https://openalex.org/W2077992695","https://openalex.org/W4367548231","https://openalex.org/W2137167442","https://openalex.org/W3007070686","https://openalex.org/W4213033823","https://openalex.org/W178814203","https://openalex.org/W2073882469","https://openalex.org/W4293900139"],"abstract_inverted_index":{"Recognizing":[0],"the":[1,11,40,96,104,114,131,146,208,215,228],"emerging":[2],"role":[3],"of":[4,14,42,55,93,123,133,150,204,210,217],"genetics":[5],"in":[6,9,39,52,58,161,169,222,227],"clinical":[7,65],"care,":[8],"1996":[10],"American":[12],"Society":[13],"Clinical":[15],"Oncology":[16],"established":[17],"a":[18,79,90,158,166],"Task":[19],"Force":[20],"on":[21],"Cancer":[22],"Genetics":[23],"Education":[24],"to":[25,45,185],"develop":[26],"educational":[27],"opportunities":[28],"and":[29,36,47,72,85,89,111,143,148,165,175,212,219,230],"resources":[30],"for":[31,103,113],"its":[32],"members.":[33],"These":[34,136],"efforts,":[35],"recent":[37],"advances":[38],"understanding":[41],"genetic":[43,59],"predisposition":[44],"breast":[46,170,218],"ovarian":[48,126,162,205,220],"cancers,":[49],"have":[50],"resulted":[51],"growing":[53],"numbers":[54],"women":[56,68,106,116,223],"participating":[57],"testing":[60],"protocols.":[61],"The":[62],"first":[63],"prospective":[64,80],"trial":[66],"involving":[67,82],"with":[69,140,224],"known":[70],"BRCA-1":[71,84,174,229],"BRCA-2":[73,86,176,231],"mutations":[74,226],"was":[75],"recently":[76],"published.":[77],"In":[78],"study":[81,154],"170":[83],"mutation":[87,177],"carriers":[88,178],"mean":[91],"follow-up":[92],"2":[94],"years,":[95],"estimated":[97],"5-year":[98],"cancer-free":[99],"estimates":[100],"were":[101,128],"96%":[102,159],"98":[105],"choosing":[107,117],"prophylactic":[108,134,181,189],"bilateral":[109,182,190],"salpingo-oophorectomy":[110,191],"69%":[112],"72":[115],"intensive":[118],"surveillance":[119],"(p=0.006).":[120],"Three":[121],"cases":[122],"stage":[124],"I":[125],"cancers":[127],"diagnosed":[129],"at":[130,207],"time":[132,209],"surgery.":[135],"results":[137],"are":[138],"consistent":[139],"published":[141],"literature":[142],"data":[144],"from":[145],"Prevention":[147],"Observation":[149],"Surgical":[151],"Endpoints":[152],"(PROSE)":[153],"group,":[155],"which":[156],"reported":[157],"reduction":[160,168],"cancer":[163,171,206,221],"risk":[164,172,216],"53%":[167],"among":[173],"who":[179],"had":[180],"oophorectomy":[183],"compared":[184],"matched":[186],"controls.":[187],"Thus":[188],"can":[192],"be":[193],"regarded":[194],"as":[195],"an":[196],"effective":[197],"risk-reducing":[198],"procedure":[199],"that":[200],"permits":[201],"early":[202],"diagnosis":[203],"surgery":[211],"significantly":[213],"reduces":[214],"germ-line":[225],"genes.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}