{"id":"https://openalex.org/W2148182397","doi":null,"title":"Ability of systemic interleukin-12 to hamper progressive stages of mammary carcinogenesis in HER2/neu transgenic mice.","display_name":"Ability of systemic interleukin-12 to hamper progressive stages of mammary carcinogenesis in HER2/neu transgenic mice.","publication_year":2000,"publication_date":"2000-01-15","ids":{"openalex":"https://openalex.org/W2148182397","mag":"2148182397","pmid":"https://pubmed.ncbi.nlm.nih.gov/10667588"},"language":"en","primary_location":{"id":"pmid:10667588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10667588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111466339","display_name":"Katia Boggio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"K Boggio","raw_affiliation_strings":["Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000626730","display_name":"Emma Di Carlo","orcid":"https://orcid.org/0000-0001-7778-1042","observed_orcids":["https://orcid.org/0000-0001-7778-1042"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Di Carlo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046462626","display_name":"Stefania Rovero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Rovero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001532055","display_name":"Federica Cavallo","orcid":"https://orcid.org/0000-0003-4571-1060","observed_orcids":["https://orcid.org/0000-0003-4571-1060","https://orcid.org/0000-0003-2047-1099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Cavallo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010091644","display_name":"Elena Quaglino","orcid":"https://orcid.org/0000-0002-8151-9124","observed_orcids":["https://orcid.org/0000-0002-8151-9124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Quaglino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043283322","display_name":"Pier\u2010Luigi Lollini","orcid":"https://orcid.org/0000-0003-1702-4108","observed_orcids":["https://orcid.org/0000-0003-1702-4108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L Lollini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013677367","display_name":"Patrizia Nanni","orcid":"https://orcid.org/0000-0001-5319-0803","observed_orcids":["https://orcid.org/0000-0001-5319-0803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Nanni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059360279","display_name":"Gianfranco Nicoletti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Nicoletti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Wolf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Wolf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021131686","display_name":"Piero Musiani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Musiani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113612286","display_name":"G Forni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Forni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7142,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.9043769,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"60","issue":"2","first_page":"359","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.271699994802475,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.271699994802475,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.10869999974966049,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.09939999878406525,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":1.0},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/her2-neu-oncogene","display_name":"HER2/neu oncogene","score":0.9399999976158142},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.6359999775886536},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5759999752044678},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.8083022832870483},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6569045782089233},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5518284440040588},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5155618190765381},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.5054759979248047},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4835214614868164},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.45185840129852295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4496130645275116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4431871175765991},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.43571019172668457},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.43059250712394714},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.42178159952163696},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39644259214401245},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33541929721832275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28046607971191406},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.26232481002807617},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.0849590003490448},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0665048360824585},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008324","descriptor_name":"Mammary Tumor Virus, Mouse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018734","descriptor_name":"Genes, erbB-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:10667588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10667588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/43192","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/43192","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/97514","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/97514","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2148182397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10667588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1042403926","https://openalex.org/W1485835599","https://openalex.org/W1498677439","https://openalex.org/W1598996496","https://openalex.org/W1609474951","https://openalex.org/W1644502582","https://openalex.org/W1814386028","https://openalex.org/W1974251248","https://openalex.org/W1977084677","https://openalex.org/W1978340181","https://openalex.org/W1981158471","https://openalex.org/W1982093899","https://openalex.org/W1985528986","https://openalex.org/W1990293928","https://openalex.org/W2010925210","https://openalex.org/W2015809080","https://openalex.org/W2027069370","https://openalex.org/W2051379819","https://openalex.org/W2053548809","https://openalex.org/W2058629447","https://openalex.org/W2065134760","https://openalex.org/W2081901687","https://openalex.org/W2090996581","https://openalex.org/W2103636788","https://openalex.org/W2105604304","https://openalex.org/W2108221597","https://openalex.org/W2116094134","https://openalex.org/W2151707711","https://openalex.org/W2403132932"],"related_works":["https://openalex.org/W7217518630","https://openalex.org/W7217569300","https://openalex.org/W1596030943","https://openalex.org/W2023987078","https://openalex.org/W7217505385","https://openalex.org/W1580591403","https://openalex.org/W6982494686","https://openalex.org/W146221228","https://openalex.org/W2157199343","https://openalex.org/W7217163293"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"in":[2,173,181,197,218],"mice":[3,55],"have":[4],"shown":[5],"that":[6,24,164,210,226],"chronic":[7],"administration":[8,229],"of":[9,16,38,48,78,81,85,92,107,110,121,133,150,159,184,200,206,221],"recombinant":[10],"interleukin-12":[11],"(IL-12)":[12],"hampers":[13],"the":[14,57,64,68,93,119,131,187,198,219],"progression":[15,120,208],"both":[17,99],"chemical-":[18],"and":[19,53,89,101,147,152,186,225],"oncogene-dependent":[20],"carcinogenesis.":[21],"This":[22],"suggests":[23,163],"a":[25,35],"new":[26],"preventive":[27],"strategy":[28],"may":[29],"be":[30,167,214],"envisaged":[31],"for":[32],"individuals":[33,174,222],"with":[34,118,137],"genetic":[36],"risk":[37,224],"cancer":[39],"or":[40,63],"carrying":[41,56],"preneoplastic":[42,123,202],"lesions.":[43,124,203],"Starting":[44],"at":[45,175,223],"progressive":[46],"stages":[47,183],"mammary":[49,70,113,171],"carcinogenesis,":[50],"female":[51],"BALB/c":[52],"FVB":[54],"activated":[58],"rat":[59],"HER2/neu":[60],"oncogene":[61],"(BALB-neuT)":[62],"proto-oncogene":[65],"(FVB-neuN)":[66],"under":[67],"mouse":[69],"tumor":[71,86,139,207],"virus":[72],"promoter":[73],"received":[74],"multiple":[75],"5-day":[76,104],"courses":[77,106,162],"different":[79],"doses":[80,149],"IL-12.":[82],"The":[83,157],"times":[84],"appearance,":[87],"multiplicity,":[88],"histopathological":[90],"features":[91],"neoplastic":[94],"lesions":[95],"were":[96],"evaluated.":[97],"In":[98],"BALB-neuT":[100],"FVB-neuN":[102],"mice,":[103],"i.p.":[105],"50/100":[108],"ng":[109,154],"IL-12/day":[111],"inhibited":[112],"carcinogenesis":[114,185],"when":[115],"they":[116,165],"coincided":[117],"early":[122,138,160],"Inhibition":[125],"appears":[126],"to":[127,135,169],"depend":[128],"primarily":[129],"on":[130,194],"ability":[132],"IL-12":[134,161],"interfere":[136],"angiogenesis.":[140],"Later":[141],"treatments":[142,212],"are":[143,155],"much":[144],"less":[145],"effective,":[146],"daily":[148],"10":[151],"2":[153],"useless.":[156],"efficacy":[158,180],"could":[166],"used":[168],"prevent":[170],"tumors":[172],"risk,":[176],"whereas":[177],"their":[178,195],"lower":[179],"later":[182],"dose":[188],"range":[189],"required":[190],"pose":[191],"some":[192],"constraints":[193],"use":[196],"management":[199],"overt":[201],"Precise":[204],"understanding":[205],"means":[209],"effective":[211],"can":[213],"commenced":[215],"relatively":[216],"late":[217],"life":[220],"no":[227],"lifetime":[228],"is":[230],"required.":[231]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
