{"id":"https://openalex.org/W2148139015","doi":"https://doi.org/10.2337/diab.46.12.2044","title":"Method of Insulin Administration Has No Effect on Insulin Sensitivity Estimates From the Insulin-Modified Minimal Model Protocol","display_name":"Method of Insulin Administration Has No Effect on Insulin Sensitivity Estimates From the Insulin-Modified Minimal Model Protocol","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W2148139015","doi":"https://doi.org/10.2337/diab.46.12.2044","mag":"2148139015","pmid":"https://pubmed.ncbi.nlm.nih.gov/9392494"},"language":"en","primary_location":{"id":"doi:10.2337/diab.46.12.2044","doi":"https://doi.org/10.2337/diab.46.12.2044","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.46.12.2044","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101765750","display_name":"Mohammed F. Saad","orcid":"https://orcid.org/0000-0002-8680-3706","observed_orcids":["https://orcid.org/0000-0002-8680-3706"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed F Saad","raw_affiliation_strings":["Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070771680","display_name":"Garry M. Steil","orcid":"https://orcid.org/0000-0001-5418-5256","observed_orcids":["https://orcid.org/0000-0001-5418-5256"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garry M Steil","raw_affiliation_strings":["Physiology and Biophysics, University of Southern California Medical School\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics, University of Southern California Medical School\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026261999","display_name":"Maggy G. Riad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maggy Riad-Gabriel","raw_affiliation_strings":["Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071204710","display_name":"Arshad M. Khan","orcid":"https://orcid.org/0000-0003-0254-3546","observed_orcids":["https://orcid.org/0000-0003-0254-3546"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arshad Khan","raw_affiliation_strings":["Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111904474","display_name":"Alok Sharma","orcid":"https://orcid.org/0000-0002-3349-3580","observed_orcids":["https://orcid.org/0000-0002-3349-3580"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alok Sharma","raw_affiliation_strings":["Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009134715","display_name":"Rima Boyadjian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rima Boyadjian","raw_affiliation_strings":["Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044459667","display_name":"Sujata D. Jinagouda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujata D Jinagouda","raw_affiliation_strings":["Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, University of Southern California Medical School\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030791389","display_name":"Richard N. Bergman","orcid":"https://orcid.org/0000-0003-1539-4471","observed_orcids":["https://orcid.org/0000-0003-1539-4471"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard N Bergman","raw_affiliation_strings":["Physiology and Biophysics, University of Southern California Medical School\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics, University of Southern California Medical School\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":0.7116,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.71316076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"46","issue":"12","first_page":"2044","last_page":"2048"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.16830000281333923,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.06509999930858612,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/frequently-sampled-intravenous-glucose-tolerance-test","display_name":"frequently sampled intravenous glucose tolerance test","score":0.8489999771118164},{"id":"https://openalex.org/keywords/insulin-sensitivity-index","display_name":"insulin sensitivity index","score":0.8299999833106995},{"id":"https://openalex.org/keywords/non-diabetic-men","display_name":"non-diabetic men","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.8960669636726379},{"id":"https://openalex.org/C2776054734","wikidata":"https://www.wikidata.org/wiki/Q414275","display_name":"Tolbutamide","level":3,"score":0.8908033967018127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7026495933532715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5788753032684326},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.5624710321426392},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5590211153030396},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5217893123626709},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4176868796348572},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.21970611810684204}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diab.46.12.2044","doi":"https://doi.org/10.2337/diab.46.12.2044","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.46.12.2044","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"doi:10.2337/diabetes.46.12.2044","doi":"https://doi.org/10.2337/diabetes.46.12.2044","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.46.12.2044","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:9392494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9392494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1009124840","display_name":"INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS)","funder_award_id":"U01HL047902","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5265078770","display_name":null,"funder_award_id":"HL-47902","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6775933354","display_name":"Quantitation of Factors Regulating Glucose Tolerance","funder_award_id":"R01DK029867","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7578835922","display_name":null,"funder_award_id":"DK27619","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8458361167","display_name":null,"funder_award_id":"DK29867","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2119886572","https://openalex.org/W51950288","https://openalex.org/W1759025867","https://openalex.org/W2155059543","https://openalex.org/W2021000824","https://openalex.org/W2085766271","https://openalex.org/W2133137653","https://openalex.org/W126831661","https://openalex.org/W7096352241","https://openalex.org/W3143300178"],"abstract_inverted_index":{"The":[0,29,85,206],"effect":[1],"of":[2,5,46,90,192,209,222],"the":[3,13,23,68,104,118,121,152,166,184,190,203],"method":[4,191,208],"insulin":[6,9,14,70,86,169,186,199,210],"administration":[7,194,211],"on":[8,198],"sensitivity":[10,87,101,200],"estimates":[11,201],"from":[12,95,103,117,202],"modified":[15],"minimal":[16],"model":[17],"(MINMOD)":[18],"protocol":[19,25],"was":[20,93],"evaluated":[21],"using":[22],"tolbutamide-boosted":[24],"as":[26,75],"a":[27,44,76],"reference.":[28],"study":[30,219],"included":[31],"21":[32,131],"nondiabetic":[33],"men":[34],"ages":[35],"40":[36],"+/-":[37,41,48,132,135,139],"2":[38],"years":[39],"(mean":[40],"SE)":[42],"with":[43,63,67,98],"BMI":[45],"26.6":[47],"1.1":[49],"kg/m2.":[50],"Each":[51],"subject":[52,92],"underwent":[53],"four":[54,105,153],"frequently":[55],"sampled":[56],"intravenous":[57],"glucose":[58],"tolerance":[59],"tests":[60],"(FSIGTT),":[61],"one":[62],"tolbutamide":[64,167],"and":[65,120,123,137,146,155,168],"three":[66],"same":[69,185,207],"dosage":[71,187],"(0.03":[72],"U/kg)":[73],"given":[74],"bolus":[77,119],"or":[78,82,180],"infusion":[79,125],"over":[80],"5":[81],"10":[83],"min.":[84],"index":[88],"(SI)":[89],"each":[91,96],"calculated":[94],"FSIGTT":[97],"MINMOD.":[99],"Insulin":[100],"indexes":[102],"FSIGTTs":[106],"were":[107,127,130,148,156],"highly":[108],"correlated":[109,158],"(r":[110,159],">":[111,160],"0.85,":[112],"P":[113,162],"<":[114,163],"0.001).":[115],"SI(insulin)":[116],"5-":[122],"10-min":[124],"protocols":[126,154,170],"similar,":[128],"but":[129],"5,":[133,136],"29":[134],"23":[138],"4%":[140],"lower":[141],"than":[142],"SI(tolbutamide),":[143],"respectively.":[144],"SG(tolbutamide)":[145],"SG(insulin)":[147],"not":[149,172],"different":[150],"among":[151],"significantly":[157],"0.55,":[161],"0.01).":[164],"Thus":[165],"must":[171],"be":[173,213],"used":[174],"interchangeably":[175],"in":[176,216],"any":[177,217],"single":[178,218],"cross-sectional":[179],"longitudinal":[181],"study.":[182],"When":[183],"is":[188],"used,":[189,214],"its":[193],"has":[195],"no":[196],"bearing":[197],"insulin-modified":[204],"FSIGTT.":[205],"should":[212],"however,":[215],"for":[220],"purpose":[221],"standardization.":[223]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
