{"id":"https://openalex.org/W2148132267","doi":"https://doi.org/10.1093/protein/10.6.665","title":"Sequence and homology model of 3-isopropylmalate dehydrogenase from the psychrotrophic bacterium Vibrio sp. I5 suggest reasons for thermal instability","display_name":"Sequence and homology model of 3-isopropylmalate dehydrogenase from the psychrotrophic bacterium Vibrio sp. I5 suggest reasons for thermal instability","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W2148132267","doi":"https://doi.org/10.1093/protein/10.6.665","mag":"2148132267","pmid":"https://pubmed.ncbi.nlm.nih.gov/9278279"},"language":"en","primary_location":{"id":"doi:10.1093/protein/10.6.665","doi":"https://doi.org/10.1093/protein/10.6.665","is_oa":false,"landing_page_url":"https://doi.org/10.1093/protein/10.6.665","pdf_url":null,"source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering Design and Selection","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077441415","display_name":"Gerlind Wallon","orcid":"https://orcid.org/0000-0003-3312-9006","observed_orcids":["https://orcid.org/0000-0003-3312-9006"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Wallon","raw_affiliation_strings":["Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254, USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055450661","display_name":"Susan T. Lovett","orcid":"https://orcid.org/0000-0003-2792-1857","observed_orcids":["https://orcid.org/0000-0003-2792-1857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. T. Lovett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C. Magyar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Magyar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073770725","display_name":"\u00c1d\u00e1m Svingor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Svingor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090705771","display_name":"Andr\u00e1s Szil\u00e1gyi","orcid":"https://orcid.org/0000-0002-1773-6861","observed_orcids":["https://orcid.org/0000-0002-1773-6861"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Szilagyi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065944362","display_name":"P\u00e9ter Z\u00e1vodszky","orcid":"https://orcid.org/0000-0002-5936-4330","observed_orcids":["https://orcid.org/0000-0002-5936-4330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Zavodszky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014900252","display_name":"Dagmar Ringe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Ringe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007934367","display_name":"Gregory A. Petsko","orcid":"https://orcid.org/0000-0003-3668-3694","observed_orcids":["https://orcid.org/0000-0003-3668-3694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. A. Petsko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4656,"currency":"USD","value_usd":4656},"apc_paid":null,"fwci":1.1908,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.77935542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"6","first_page":"665","last_page":"672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.2590000033378601,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3-isopropylmalate-dehydrogenase","display_name":"3-isopropylmalate dehydrogenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/psychrotrophic-bacteria","display_name":"psychrotrophic bacteria","score":0.9539999961853027},{"id":"https://openalex.org/keywords/protein-thermostability","display_name":"protein thermal stability","score":0.7559999823570251},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"homology modeling","score":0.6899999976158142},{"id":"https://openalex.org/keywords/leucine-biosynthesis","display_name":"leucine biosynthesis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/salt-bridges","display_name":"salt bridges","score":0.7609999775886536},{"id":"https://openalex.org/keywords/aromatic-aromatic-interactions","display_name":"aromatic-aromatic interactions","score":0.9520000219345093},{"id":"https://openalex.org/keywords/proline-residues","display_name":"proline residues","score":0.8859999775886536},{"id":"https://openalex.org/keywords/surface-loops","display_name":"surface loops","score":0.8740000128746033},{"id":"https://openalex.org/keywords/conserved-residues","display_name":"conserved residues","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2781216036","wikidata":"https://www.wikidata.org/wiki/Q902494","display_name":"Thermostability","level":3,"score":0.9097524285316467},{"id":"https://openalex.org/C27911776","wikidata":"https://www.wikidata.org/wiki/Q834023","display_name":"Thermophile","level":3,"score":0.7971029877662659},{"id":"https://openalex.org/C63223902","wikidata":"https://www.wikidata.org/wiki/Q669652","display_name":"Mesophile","level":3,"score":0.5973427295684814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5577558875083923},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.506878674030304},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.4888865053653717},{"id":"https://openalex.org/C205458427","wikidata":"https://www.wikidata.org/wiki/Q206912","display_name":"Extremophile","level":4,"score":0.46275991201400757},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.453596293926239},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41502317786216736},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3583945035934448},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27494585514068604},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2699393928050995}],"mesh":[{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001110","descriptor_name":"Arctic Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012623","descriptor_name":"Seawater","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014733","descriptor_name":"Vibrio","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014733","descriptor_name":"Vibrio","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050539","descriptor_name":"3-Isopropylmalate Dehydrogenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/protein/10.6.665","doi":"https://doi.org/10.1093/protein/10.6.665","is_oa":false,"landing_page_url":"https://doi.org/10.1093/protein/10.6.665","pdf_url":null,"source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering Design and Selection","raw_type":"journal-article"},{"id":"pmid:9278279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9278279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6997404690","display_name":"Structural Basis for Bridged Bimetallic Enzyme Catalysis","funder_award_id":"R01GM026788","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2053473804","https://openalex.org/W4312280761","https://openalex.org/W2068410698","https://openalex.org/W1995682190","https://openalex.org/W2062129432","https://openalex.org/W2104259052","https://openalex.org/W2125163052","https://openalex.org/W1969864945","https://openalex.org/W2115277345","https://openalex.org/W2076272124"],"abstract_inverted_index":{"The":[0,15],"leuB":[1],"gene":[2,16],"from":[3,40],"the":[4,27,54,60,72,93,96],"psychrotrophic":[5,55,73],"strain":[6],"Vibrio":[7],"sp.":[8],"I5":[9],"has":[10],"been":[11,46,88],"cloned":[12],"and":[13,42,57,82,99,116],"sequenced.":[14],"codes":[17],"for":[18,53,64],"3-isopropylmalate":[19],"dehydrogenase,":[20],"a":[21,50,103,108,124],"360-residue,":[22],"dimeric":[23],"enzyme":[24],"involved":[25],"in":[26,92,110],"biosynthesis":[28],"of":[29,95,106,126,128],"leucine.":[30],"Three":[31],"recently":[32],"solved":[33],"homologous":[34],"isopropylmalate":[35],"dehydrogenase":[36],"(IPMDH)":[37],"crystal":[38],"structures":[39],"thermophilic":[41,83,100],"mesophilic":[43,81,98],"organisms":[44],"have":[45,87],"used":[47],"to":[48,58,69,137],"build":[49],"homology":[51],"model":[52,71],"IPMDH":[56,74],"deduce":[59],"possible":[61],"structural":[62],"reasons":[63],"its":[65,80],"decreased":[66],"thermostability.":[67,138],"According":[68],"our":[70],"contains":[75],"fewer":[76,113],"stabilizing":[77],"interactions":[78],"than":[79],"counterparts.":[84],"Elements":[85],"that":[86,133],"identified":[89],"as":[90],"destabilizing":[91],"comparison":[94],"psychrotrophic,":[97],"IPMDHs":[101],"are":[102,123],"smaller":[104],"number":[105,125],"salt-bridges,":[107],"reduction":[109],"aromatic-aromatic":[111],"interactions,":[112],"proline":[114],"residues":[115,132],"longer":[117],"surface":[118],"loops.":[119],"In":[120],"addition,":[121],"there":[122],"substitutions":[127],"otherwise":[129],"strictly":[130],"conserved":[131],"can":[134],"be":[135],"linked":[136]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
