{"id":"https://openalex.org/W2148124674","doi":"https://doi.org/10.1016/j.canlet.2004.06.025","title":"p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations","display_name":"p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations","publication_year":2004,"publication_date":"2004-12-15","ids":{"openalex":"https://openalex.org/W2148124674","doi":"https://doi.org/10.1016/j.canlet.2004.06.025","mag":"2148124674","pmid":"https://pubmed.ncbi.nlm.nih.gov/15617840"},"language":"en","primary_location":{"id":"doi:10.1016/j.canlet.2004.06.025","doi":"https://doi.org/10.1016/j.canlet.2004.06.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2004.06.025","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027204574","display_name":"Laura J. Hardie","orcid":"https://orcid.org/0000-0001-5039-2100","observed_orcids":["https://orcid.org/0000-0001-5039-2100"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Laura J. Hardie","raw_affiliation_strings":["Molecular Epidemiology Unit and Health Services Research, School of Medicine, Algernon Firth Building, University of Leeds, Leeds LS2 9JT, UK. medljh@leeds.ac.uk","Molecular Epidemiology Unit and Health Services Research, School of Medicine, Algernon Firth Building, University of Leeds, Leeds LS2 9JT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Epidemiology Unit and Health Services Research, School of Medicine, Algernon Firth Building, University of Leeds, Leeds LS2 9JT, UK. medljh@leeds.ac.uk","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Molecular Epidemiology Unit and Health Services Research, School of Medicine, Algernon Firth Building, University of Leeds, Leeds LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083669502","display_name":"S. Jane Darnton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Jane Darnton","raw_affiliation_strings":["Oesophageal Research Laboratory, Heartlands Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oesophageal Research Laboratory, Heartlands Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050261696","display_name":"Yvonne Wallis","orcid":"https://orcid.org/0000-0002-5079-967X","observed_orcids":["https://orcid.org/0000-0002-5079-967X"]},"institutions":[{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yvonne L. Wallis","raw_affiliation_strings":["Oesophageal Research Laboratory, Heartlands Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oesophageal Research Laboratory, Heartlands Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077864806","display_name":"Anita Chauhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anita Chauhan","raw_affiliation_strings":["Oesophageal Research Laboratory, Heartlands Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oesophageal Research Laboratory, Heartlands Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070367652","display_name":"Pierre L. Hainaut","orcid":"https://orcid.org/0000-0002-1303-1610","observed_orcids":["https://orcid.org/0000-0002-1303-1610"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Hainaut","raw_affiliation_strings":["Group of Molecular Carcinogenesis, International Agency for Research on Cancer, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group of Molecular Carcinogenesis, International Agency for Research on Cancer, Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043239257","display_name":"Christopher Paul Wild","orcid":"https://orcid.org/0000-0003-0249-8669","observed_orcids":["https://orcid.org/0000-0003-0249-8669"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher P. Wild","raw_affiliation_strings":["Molecular Epidemiology Unit and Health Services Research, School of Medicine, Algernon Firth Building, University of Leeds, Leeds LS2 9JT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Epidemiology Unit and Health Services Research, School of Medicine, Algernon Firth Building, University of Leeds, Leeds LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108549519","display_name":"Alan G. Casson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I2800264117","display_name":"Queen Elizabeth II Health Sciences Centre","ror":"https://ror.org/025qrzc85","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800264117","https://openalex.org/I2802394193"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alan G. Casson","raw_affiliation_strings":["Division of Thoracic Surgery, Dalhousie University and QE II Health Sciences Centre, Halifax, Nova Scotia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Thoracic Surgery, Dalhousie University and QE II Health Sciences Centre, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397","https://openalex.org/I2800264117"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5027204574"],"corresponding_institution_ids":["https://openalex.org/I130828816"],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":null,"fwci":5.729,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.95949585,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"217","issue":"2","first_page":"221","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.8500000238418579},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.9620000123977661},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8489999771118164},{"id":"https://openalex.org/keywords/p16-mutation","display_name":"p16 mutation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8230000138282776},{"id":"https://openalex.org/keywords/molecular-progression","display_name":"molecular progression","score":0.4440000057220459},{"id":"https://openalex.org/keywords/esophageal-squamous-epithelium","display_name":"esophageal squamous epithelium","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.6935542225837708},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6600335240364075},{"id":"https://openalex.org/C2778589982","wikidata":"https://www.wikidata.org/wiki/Q808892","display_name":"Barrett's esophagus","level":4,"score":0.6130234599113464},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6108241677284241},{"id":"https://openalex.org/C2780323790","wikidata":"https://www.wikidata.org/wiki/Q2912193","display_name":"Esophageal disease","level":3,"score":0.584930956363678},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5814507007598877},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5653809905052185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.542209267616272},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5339454412460327},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.528348982334137},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4620610475540161},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4486801028251648},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32910972833633423},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30962803959846497},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.25547006726264954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2503160238265991},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24069583415985107},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07286009192466736},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.canlet.2004.06.025","doi":"https://doi.org/10.1016/j.canlet.2004.06.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2004.06.025","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:15617840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15617840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1514674020","https://openalex.org/W1529605718","https://openalex.org/W1531180106","https://openalex.org/W1557175916","https://openalex.org/W1586414137","https://openalex.org/W1686733339","https://openalex.org/W1929295557","https://openalex.org/W1964010321","https://openalex.org/W1982028494","https://openalex.org/W1989454681","https://openalex.org/W1994465394","https://openalex.org/W1998758789","https://openalex.org/W1999223967","https://openalex.org/W2004567377","https://openalex.org/W2006316372","https://openalex.org/W2007618242","https://openalex.org/W2015871659","https://openalex.org/W2020746205","https://openalex.org/W2022375598","https://openalex.org/W2041250686","https://openalex.org/W2049418423","https://openalex.org/W2056470036","https://openalex.org/W2064269319","https://openalex.org/W2066903373","https://openalex.org/W2068825032","https://openalex.org/W2069803573","https://openalex.org/W2071219133","https://openalex.org/W2074899532","https://openalex.org/W2076273397","https://openalex.org/W2080213393","https://openalex.org/W2082963587","https://openalex.org/W2085023377","https://openalex.org/W2085040479","https://openalex.org/W2095608027","https://openalex.org/W2097406667","https://openalex.org/W2098750893","https://openalex.org/W2101603900","https://openalex.org/W2101947806","https://openalex.org/W2105428856","https://openalex.org/W2106088192","https://openalex.org/W2115222368","https://openalex.org/W2115810695","https://openalex.org/W2117661585","https://openalex.org/W2134908923","https://openalex.org/W2141254313","https://openalex.org/W2147977885","https://openalex.org/W2155649184","https://openalex.org/W2165419403","https://openalex.org/W2169858868","https://openalex.org/W2268045557","https://openalex.org/W2324870347","https://openalex.org/W2408244426","https://openalex.org/W2409749163","https://openalex.org/W2412499326","https://openalex.org/W2422941329","https://openalex.org/W6631814418","https://openalex.org/W6631851845","https://openalex.org/W6634980425","https://openalex.org/W6637446507","https://openalex.org/W6671338923","https://openalex.org/W6674856196","https://openalex.org/W6675331743","https://openalex.org/W6677342089","https://openalex.org/W6684870577","https://openalex.org/W6714448700","https://openalex.org/W6715386936"],"related_works":["https://openalex.org/W2155649184","https://openalex.org/W2012977617","https://openalex.org/W1529605718","https://openalex.org/W2101603900","https://openalex.org/W2020848716","https://openalex.org/W1500026439","https://openalex.org/W2085040479","https://openalex.org/W2001831165","https://openalex.org/W2082396164","https://openalex.org/W2045002992"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}