{"id":"https://openalex.org/W2148109935","doi":null,"title":"GC factor represses transcription of several growth factor/receptor genes and causes growth inhibition of human gastric carcinoma cell lines.","display_name":"GC factor represses transcription of several growth factor/receptor genes and causes growth inhibition of human gastric carcinoma cell lines.","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W2148109935","mag":"2148109935","pmid":"https://pubmed.ncbi.nlm.nih.gov/8494791"},"language":"en","primary_location":{"id":"pmid:8494791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8494791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043200769","display_name":"Yasuhiko Kitadai","orcid":"https://orcid.org/0000-0002-8743-3815","observed_orcids":["https://orcid.org/0000-0002-8743-3815"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Kitadai","raw_affiliation_strings":["First Department of Pathology, Hiroshima University, School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Hiroshima University, School of Medicine, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Yamazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046204028","display_name":"Wataru Yasui","orcid":"https://orcid.org/0000-0002-8647-8405","observed_orcids":["https://orcid.org/0000-0002-8647-8405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Yasui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086387049","display_name":"Eikai Kyo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Kyo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086373969","display_name":"Hiroshi Yokozaki","orcid":"https://orcid.org/0000-0001-5276-3331","observed_orcids":["https://orcid.org/0000-0001-5276-3331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Yokozaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110476106","display_name":"Goro Kajiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Kajiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102780098","display_name":"Alfred C. Johnson","orcid":"https://orcid.org/0000-0003-2285-4923","observed_orcids":["https://orcid.org/0000-0003-2285-4923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056573254","display_name":"Ira H Pastan","orcid":"https://orcid.org/0000-0002-9223-0270","observed_orcids":["https://orcid.org/0000-0002-9223-0270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Pastan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109496215","display_name":"Eiichi Tahara","orcid":"https://orcid.org/0009-0001-7063-7563","observed_orcids":["https://orcid.org/0009-0001-7063-7563"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Tahara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0901,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.81145082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":"4","first_page":"291","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.3544999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.3544999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.156700000166893,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.08950000256299973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.4390000104904175},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9670000076293945},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.8080000281333923},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.968999981880188},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9929999709129333},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5580000281333923},{"id":"https://openalex.org/keywords/nude-mouse-xenograft","display_name":"nude mouse xenograft","score":0.5870000123977661},{"id":"https://openalex.org/keywords/mkn-28-cells","display_name":"MKN28 cells","score":1.0}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8016957640647888},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7462849020957947},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6273692846298218},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.611395537853241},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6106616258621216},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.5851023197174072},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5741925835609436},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.572776198387146},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5500874519348145},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.5151563882827759},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.5021553039550781},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.49205082654953003},{"id":"https://openalex.org/C47170353","wikidata":"https://www.wikidata.org/wiki/Q4649310","display_name":"A431 cells","level":5,"score":0.4746330976486206},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4732059836387634},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46654415130615234},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4445739686489105},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.4235001802444458},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39528852701187134},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3212994337081909},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29392120242118835},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2630348205566406},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2225070595741272},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.10237258672714233},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8494791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8494791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2148109935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8494791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W76526832","https://openalex.org/W95069854","https://openalex.org/W129828474","https://openalex.org/W1193981567","https://openalex.org/W1484049504","https://openalex.org/W1501820245","https://openalex.org/W1563225650","https://openalex.org/W1677389743","https://openalex.org/W1767075578","https://openalex.org/W1974682713","https://openalex.org/W1975122645","https://openalex.org/W1977579221","https://openalex.org/W1979877257","https://openalex.org/W1981306795","https://openalex.org/W1982002509","https://openalex.org/W1982558048","https://openalex.org/W1987653805","https://openalex.org/W1991198967","https://openalex.org/W2001663882","https://openalex.org/W2004535553","https://openalex.org/W2009918227","https://openalex.org/W2010791130","https://openalex.org/W2014569682","https://openalex.org/W2018117114","https://openalex.org/W2021795851","https://openalex.org/W2025723633","https://openalex.org/W2026548183","https://openalex.org/W2029529223","https://openalex.org/W2031368014","https://openalex.org/W2032365199","https://openalex.org/W2032455696","https://openalex.org/W2036261154","https://openalex.org/W2037968180","https://openalex.org/W2041639550","https://openalex.org/W2056463259","https://openalex.org/W2069982395","https://openalex.org/W2076149108","https://openalex.org/W2082677148","https://openalex.org/W2092229345","https://openalex.org/W2127207727","https://openalex.org/W2133638944","https://openalex.org/W2139995230","https://openalex.org/W2144634347","https://openalex.org/W2246566531"],"related_works":["https://openalex.org/W2045398367","https://openalex.org/W2009918227","https://openalex.org/W2428998276","https://openalex.org/W1976913341","https://openalex.org/W2135482779","https://openalex.org/W2136965332","https://openalex.org/W7099845503","https://openalex.org/W2037031174","https://openalex.org/W2103566122","https://openalex.org/W2069828507"],"abstract_inverted_index":{"The":[0,53,83,122],"GC":[1],"factor":[2,13,74,79,116,211],"(GCF)":[3],"binds":[4],"to":[5,169,190],"specific":[6],"GC-rich":[7],"sequences":[8],"in":[9,117,133,157,188,223],"the":[10,26,36,68,91,105,138,147,150,170,183,204,218],"epidermal":[11,114],"growth":[12,42,48,73,78,115,148,167,210,219],"receptor":[14,213],"(EGFR)":[15],"gene":[16,37,199],"promoter":[17,184],"and":[18,44,46,65,81,110,212,215],"represses":[19,35],"its":[20],"transcription.":[21],"In":[22],"this":[23],"study,":[24],"by":[25,94,113],"use":[27],"of":[28,39,50,55,71,85,99,149,186,201,220],"GCF":[29,34,56,100,127,181,196],"transfection,":[30],"we":[31],"examined":[32],"whether":[33],"expression":[38,57,87,101,128,200],"several":[40,208],"other":[41,209],"factors":[43],"receptors":[45],"causes":[47],"inhibition":[49],"cancer":[51],"cells.":[52],"transfection":[54],"vector":[58,102,129],"into":[59],"gastric":[60,118,151,221],"carcinoma":[61,119,123,152,161],"cell":[62,120,153],"lines":[63,154],"(TMK-1":[64],"MKN-28)":[66],"decreased":[67],"mRNA":[69,106],"levels":[70],"transforming":[72],"(TGF)":[75],"alpha,":[76],"insulin-like":[77],"II,":[80],"c-met.":[82],"reduction":[84],"TGF-alpha":[86,187],"was":[88,155],"confirmed":[89],"at":[90],"protein":[92],"level":[93],"enzyme-linked":[95],"immunosorbent":[96],"assay.":[97],"Transfection":[98],"interfered":[103],"with":[104,126,176],"accumulation":[107],"for":[108],"EGFR":[109,205],"TGF-beta":[111],"induced":[112],"lines.":[121],"cells":[124,140,162,178],"transfected":[125],"did":[130,141],"not":[131,202],"grow":[132,142],"a":[134,164],"serum-free":[135,144],"medium,":[136],"whereas":[137],"control":[139,171],"under":[143],"conditions.":[145],"When":[146],"studied":[156],"nude":[158],"mice,":[159],"GCF-transfected":[160],"showed":[163],"significantly":[165],"slower":[166],"compared":[168],"tumor.":[172],"Transient":[173],"cotransfection":[174],"analysis":[175],"NIH3T3":[177],"revealed":[179],"that":[180,195],"repressed":[182],"activity":[185],"addition":[189],"EGFR.":[191],"These":[192],"findings":[193],"indicate":[194],"negatively":[197],"regulates":[198],"only":[203],"but":[206],"also":[207],"genes":[214],"can":[216],"inhibit":[217],"carcinomas":[222],"immunodeficient":[224],"mice.":[225]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}